SCARNA18

Summary

SCARNA18 (small Cajal body-specific RNA 18, HGNC:32559) is a small nucleolar RNA gene on chromosome 5q14.2.

Small nucleolar RNAs (snoRNAs) are small noncoding RNAs involved in RNA processing. Box H/ACA snoRNAs, such as SCARNA18, direct the conversion of uridine to pseudouridine at specific residues of ribosomal RNAs or small nuclear RNAs (snRNAs) (Gu et al., 2005).

Source: NCBI Gene 677765 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32559
Approved symbol	SCARNA18
Name	small Cajal body-specific RNA 18
Location	5q14.2
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U109, SCARNA18A
Ensembl gene	ENSG00000238835
Ensembl biotype	snoRNA
OMIM	611329
Entrez	677765
RNAcentral	URS00005A2612 — ncRNA, 134 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000459004

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000459004 — 1 exons

Exon	Start	End
ENSE00001806896	83064204	83064337

Expression profiles

Bgee: expression breadth ubiquitous, 101 present calls, max score 99.09.

Top tissues by expression

101 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	99.09	gold quality
sural nerve	UBERON:0015488	96.71	gold quality
adrenal tissue	UBERON:0018303	91.07	gold quality
liver	UBERON:0002107	86.37	gold quality
corpus callosum	UBERON:0002336	85.08	gold quality
calcaneal tendon	UBERON:0003701	83.80	gold quality
monocyte	CL:0000576	78.61	gold quality
kidney	UBERON:0002113	78.45	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	77.87	gold quality
blood	UBERON:0000178	77.40	gold quality
bone marrow	UBERON:0002371	76.13	gold quality
adult mammalian kidney	UBERON:0000082	75.43	gold quality
prefrontal cortex	UBERON:0000451	74.29	gold quality
stomach	UBERON:0000945	74.28	gold quality
endometrium	UBERON:0001295	74.25	gold quality
lymph node	UBERON:0000029	74.08	gold quality
fundus of stomach	UBERON:0001160	73.16	gold quality
islet of Langerhans	UBERON:0000006	71.91	gold quality
lung	UBERON:0002048	71.48	gold quality
heart	UBERON:0000948	71.47	gold quality
gastrocnemius	UBERON:0001388	70.91	gold quality
adrenal gland	UBERON:0002369	69.82	gold quality
endocervix	UBERON:0000458	69.65	gold quality
vermiform appendix	UBERON:0001154	69.57	gold quality
body of pancreas	UBERON:0001150	68.88	gold quality
heart left ventricle	UBERON:0002084	68.49	gold quality
placenta	UBERON:0001987	68.36	gold quality
tibial artery	UBERON:0007610	68.32	gold quality
frontal cortex	UBERON:0001870	68.10	gold quality
ascending aorta	UBERON:0001496	67.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.11

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm24507	ENSMUSG00000088308
rattus_norvegicus	Scarna18	ENSRNOG00000061788

Paralogs (7): (ENSG00000238410), (ENSG00000238575), SCARNA18B (ENSG00000238754), (ENSG00000238832), (ENSG00000239197), (ENSG00000252040), (ENSG00000252640)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.