SCART1

Summary

SCART1 (scavenger receptor family member expressed on T cells 1, HGNC:32411) is a protein-coding gene on chromosome 10q26.3, encoding Scavenger receptor cysteine-rich domain-containing protein SCART1 (Q4G0T1). May play a role in the immune system, perhaps as a co-receptor on alphabeta and gammadelta T-cells.

Predicted to enable scavenger receptor activity. Predicted to be involved in gamma-delta T cell lineage commitment. Located in brush border and cytoplasm.

Source: NCBI Gene 619207 — automated summary from GO annotations (Alliance of Genome Resources).

At a glance

• GTEx eGene: eQTL in 46 tissues, sQTL in 16 (q < 0.05)
• MANE Select transcript: NM_001396050

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32411
Approved symbol	SCART1
Name	scavenger receptor family member expressed on T cells 1
Location	10q26.3
Locus type	gene with protein product
Status	Approved
Aliases	CD163c-alpha
Ensembl gene	ENSG00000214279
Ensembl biotype	protein_coding
Entrez	619207

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 5 retained_intron, 2 protein_coding

MANE Select: ENST00000640237

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 2: 5, TSL 5: 1

ENST00000640237, ENST00000462252, ENST00000463137, ENST00000475114, ENST00000482993, ENST00000488261, ENST00001136530

RefSeq mRNA: 1 — MANE Select: NM_001396050 NM_001396050

CCDS: CCDS91391

Canonical transcript exons

ENST00000640237 — 12 exons

Exon	Start	End
ENSE00001628808	133457279	133457575
ENSE00003802017	133459021	133459326
ENSE00003803573	133456237	133456554
ENSE00003805075	133458360	133458656
ENSE00003805472	133466235	133466381
ENSE00003805698	133459487	133460170
ENSE00003806019	133465106	133465174
ENSE00003807120	133465251	133465565
ENSE00003807709	133464606	133464911
ENSE00003809737	133467198	133467353
ENSE00003978156	133467847	133469760
ENSE00003978157	133453945	133454064

Expression profiles

Bgee: expression breadth ubiquitous, 158 present calls, max score 81.95.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3231 / max 66.2479, expressed in 89 samples.

Highest expression (Bgee): uterine tube, lower esophagus mucosa, male germ line stem cell (sensu Vertebrata) in testis, stromal cell of endometrium, esophagus mucosa.

Genetic regulation across tissues (GTEx eQTL / sQTL)

SCART1 is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 46 tissues and its splicing (sQTL) in 16 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

showing 20 of 62 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Nerve Tibial	eqtl	1.8e-22	-0.44	10:133419150:C:T
Testis	eqtl	4.1e-20	-0.57	10:133419150:C:T
Pituitary	eqtl	2.0e-19	-0.70	10:133419150:C:T
Brain Frontal Cortex BA9	eqtl	5.0e-17	-0.62	10:133429144:C:CAG
Thyroid	eqtl	7.5e-17	-0.37	10:133411456:A:G
Brain Cortex	eqtl	4.4e-16	+0.67	10:133449883:A:G
Brain Nucleus accumbens basal ganglia	eqtl	2.8e-15	+0.56	10:133429369:G:A
Brain Caudate basal ganglia	eqtl	2.4e-14	-0.49	10:133419150:C:T
Lung	eqtl	1.5e-13	-0.33	10:133411456:A:G
Brain Hypothalamus	eqtl	4.3e-12	-0.45	10:133421866:C:A
Adrenal Gland	eqtl	6.2e-12	-0.57	10:133403471:G:A
Adipose Subcutaneous	eqtl	8.7e-12	-0.65	10:133463654:G:A
Cells Cultured fibroblasts	eqtl	8.9e-12	-0.31	10:133419150:C:T
Brain Cerebellum	eqtl	3.6e-11	-0.61	10:133419150:C:T
Testis	sqtl	7.0e-11	+0.78	10:133469269:T:G
Artery Tibial	sqtl	9.1e-11	+0.45	10:133419150:C:T
Brain Anterior cingulate cortex BA24	eqtl	9.8e-11	+0.49	10:133419430:C:T
Artery Tibial	eqtl	3.1e-10	-0.50	10:133458260:G:A
Muscle Skeletal	eqtl	5.6e-10	-0.55	10:133397517:C:T
Adipose Visceral Omentum	eqtl	1.1e-09	-0.34	10:133411456:A:G

FANTOM5 promoters

2 alternative TSS:

Promoter ID	TPM avg	Samples expressed
107803	0.3060	88
107802	0.0171	5

Top tissues by expression

showing 100 of 246 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	81.95	gold quality
lower esophagus mucosa	UBERON:0035834	79.98	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.04	gold quality
stromal cell of endometrium	CL:0002255	73.53	gold quality
esophagus mucosa	UBERON:0002469	72.14	gold quality
right adrenal gland cortex	UBERON:0035827	71.76	gold quality
body of pancreas	UBERON:0001150	71.39	gold quality
body of uterus	UBERON:0009853	70.99	gold quality
body of stomach	UBERON:0001161	70.95	gold quality
granulocyte	CL:0000094	70.85	gold quality
right adrenal gland	UBERON:0001233	70.38	gold quality
popliteal artery	UBERON:0002250	70.21	gold quality
tibial artery	UBERON:0007610	70.21	gold quality
esophagus	UBERON:0001043	70.15	gold quality
muscle layer of sigmoid colon	UBERON:0035805	70.09	gold quality
right lobe of liver	UBERON:0001114	70.04	gold quality
left adrenal gland cortex	UBERON:0035825	69.37	gold quality
metanephros cortex	UBERON:0010533	69.28	gold quality
spleen	UBERON:0002106	69.24	gold quality
aorta	UBERON:0000947	69.20	gold quality
sural nerve	UBERON:0015488	69.14	gold quality
left lobe of thyroid gland	UBERON:0001120	69.03	gold quality
skin of abdomen	UBERON:0001416	68.86	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.83	gold quality
left adrenal gland	UBERON:0001234	68.61	gold quality
bone marrow cell	CL:0002092	68.55	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.46	gold quality
left coronary artery	UBERON:0001626	68.45	gold quality
right frontal lobe	UBERON:0002810	68.45	gold quality
lower esophagus	UBERON:0013473	68.40	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.37	gold quality
thoracic aorta	UBERON:0001515	68.24	gold quality
ascending aorta	UBERON:0001496	68.20	gold quality
right coronary artery	UBERON:0001625	68.08	gold quality
left uterine tube	UBERON:0001303	68.05	gold quality
minor salivary gland	UBERON:0001830	68.03	gold quality
right ovary	UBERON:0002118	67.82	gold quality
adrenal cortex	UBERON:0001235	67.80	gold quality
right lobe of thyroid gland	UBERON:0001119	67.71	gold quality
skin of leg	UBERON:0001511	67.70	gold quality
small intestine Peyer’s patch	UBERON:0003454	67.56	gold quality
ectocervix	UBERON:0012249	67.54	gold quality
transverse colon	UBERON:0001157	67.46	gold quality
stomach	UBERON:0000945	67.30	gold quality
descending thoracic aorta	UBERON:0002345	67.19	gold quality
thyroid gland	UBERON:0002046	67.17	gold quality
endocervix	UBERON:0000458	67.10	gold quality
coronary artery	UBERON:0001621	66.89	gold quality
tibial nerve	UBERON:0001323	66.83	gold quality
gall bladder	UBERON:0002110	66.67	gold quality
left ovary	UBERON:0002119	66.60	gold quality
hindlimb stylopod muscle	UBERON:0004252	66.50	gold quality
colonic epithelium	UBERON:0000397	66.45	silver quality
mucosa of stomach	UBERON:0001199	66.20	gold quality
spinal cord	UBERON:0002240	65.90	gold quality
omental fat pad	UBERON:0010414	65.73	gold quality
peritoneum	UBERON:0002358	65.66	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.65	gold quality
adrenal gland	UBERON:0002369	65.35	gold quality
small intestine	UBERON:0002108	65.33	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.15	gold quality
right lung	UBERON:0002167	65.04	gold quality
zone of skin	UBERON:0000014	65.03	gold quality
upper lobe of left lung	UBERON:0008952	65.03	gold quality
cortex of kidney	UBERON:0001225	64.77	gold quality
uterine cervix	UBERON:0000002	64.72	gold quality
mouth mucosa	UBERON:0003729	64.45	gold quality
adenohypophysis	UBERON:0002196	64.43	gold quality
adipose tissue of abdominal region	UBERON:0007808	64.38	gold quality
saliva-secreting gland	UBERON:0001044	64.21	gold quality
gastrocnemius	UBERON:0001388	64.13	gold quality
pituitary gland	UBERON:0000007	64.07	gold quality
muscle of leg	UBERON:0001383	64.00	gold quality
smooth muscle tissue	UBERON:0001135	63.99	gold quality
colon	UBERON:0001155	63.80	gold quality
cerebellar hemisphere	UBERON:0002245	63.77	gold quality
vagina	UBERON:0000996	63.67	gold quality
apex of heart	UBERON:0002098	63.66	gold quality
cerebellar cortex	UBERON:0002129	63.66	gold quality
fundus of stomach	UBERON:0001160	63.52	gold quality
upper lobe of lung	UBERON:0008948	63.46	gold quality
intestine	UBERON:0000160	63.28	gold quality
vermiform appendix	UBERON:0001154	63.22	gold quality
large intestine	UBERON:0000059	62.99	gold quality
subcutaneous adipose tissue	UBERON:0002190	62.54	gold quality
prostate gland	UBERON:0002367	62.29	gold quality
ovary	UBERON:0000992	62.22	gold quality
cerebellum	UBERON:0002037	62.07	gold quality
mucosa of transverse colon	UBERON:0004991	62.00	gold quality
lymph node	UBERON:0000029	61.85	gold quality
rectum	UBERON:0001052	61.84	gold quality
anterior cingulate cortex	UBERON:0009835	61.70	gold quality
right atrium auricular region	UBERON:0006631	61.64	gold quality
endothelial cell	CL:0000115	61.53	gold quality
pancreas	UBERON:0001264	61.53	gold quality
heart left ventricle	UBERON:0002084	61.24	gold quality
Ammon’s horn	UBERON:0001954	61.23	gold quality
anatomical system	UBERON:0000467	61.16	gold quality
cardiac atrium	UBERON:0002081	61.10	gold quality
liver	UBERON:0002107	60.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.29

HPA expression

RNA tissue specificity: Low tissue specificity

43 HPA tissues / cells by nTPM:

Tissue / cell	Axis	nTPM	Protein (IHC)
Hippocampus	tissue	13.4	not detected
Postcentral gyrus	tissue	9.6
Choroid plexus	tissue	7.6
Nucleus accumbens	tissue	7.5
Locus coeruleus	tissue	6.3
Skin 1	tissue	0.8	not detected
Bone marrow	tissue	0.8	not detected
Epididymis	tissue	0.7	not detected
Spleen	tissue	0.7	medium
Retina	tissue	0.6
Breast	tissue	0.5	not detected
Skeletal muscle	tissue	0.5	not detected
Liver	tissue	0.5	not detected
Small intestine	tissue	0.5	not detected
Duodenum	tissue	0.5	not detected
Lymph node	tissue	0.4	medium
Testis	tissue	0.3	not detected
Stomach 1	tissue	0.3	not detected
Adipose tissue	tissue	0.3	not detected
Lung	tissue	0.3	low
Appendix	tissue	0.3	not detected
Salivary gland	tissue	0.2	not detected
Rectum	tissue	0.2	not detected
Colon	tissue	0.2	not detected
Pancreas	tissue	0.2	not detected
Endometrium 1	tissue	0.2	not detected
Placenta	tissue	0.2	not detected
Gallbladder	tissue	0.2	not detected
Kidney	tissue	0.2	not detected
Prostate	tissue	0.2	not detected
Adrenal gland	tissue	0.2	not detected
Tonsil	tissue	0.2	medium
Cervix	tissue	0.1	not detected
Pituitary gland	tissue	0.1
Heart muscle	tissue	0.1	not detected
Ovary	tissue	0.1	not detected
Seminal vesicle	tissue	0.1	not detected
Esophagus	tissue	0.1	not detected
Parathyroid gland	tissue	0.1	not detected
Smooth muscle	tissue	0.1	not detected
Thyroid gland	tissue	0.1	not detected
Thymus	tissue	0.1
Fallopian tube	tissue	0.1	not detected

Brain sub-regions (HPA Brain Atlas): detected in 183; highest nTPM — Posterior cingulate cortex (17.7), Hippocampus, CA3 (17.6), Dentate gyrus (13.6), Hippocampus, CA1 (13.1), Flocculonodular lobe (11.8).

Regulation

Is transcription factor: no

Functional genomics

Regional missense constraint (gnomAD RMC): no regional variation along ENST00000640237 — one region, missense o/e 1.93.

Literature-anchored findings (GeneRIF, showing 1)

• the characterization of hSCART1 at the mRNA and protein level suggests that the protein plays a role in the immune system, perhaps as a co-receptor on alphabeta and gammadelta T cells. (PMID:22795646)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Scart1	ENSMUSG00000025461
rattus_norvegicus	Scart1	ENSRNOG00000018978

Paralogs (15): CD6 (ENSG00000013725), CD5L (ENSG00000073754), LGALS3BP (ENSG00000108679), CD5 (ENSG00000110448), LOX (ENSG00000113083), LOXL3 (ENSG00000115318), LOXL1 (ENSG00000129038), LOXL2 (ENSG00000134013), LOXL4 (ENSG00000138131), SSC4D (ENSG00000146700), PRSS12 (ENSG00000164099), CD163 (ENSG00000177575), CD163L1 (ENSG00000177675), SSC5D (ENSG00000179954), DMBT1 (ENSG00000187908)

Additional cross-species homologs

Sequence homologs in species beyond Ensembl Compara’s model organisms, by Diamond local protein alignment (% sequence identity; best hit per species). Lower-identity rows are more distant homologs. The matched accessions’ gene symbols aren’t in biobtree yet, so each row shows the UniProt accession.

Organism	UniProt	Identity	Method
Pongo abelii	Q5RDA4	99.5%	Diamond
Pan troglodytes	Q5G271	99.2%	Diamond
Nomascus leucogenys	Q5G268	98.5%	Diamond
Gorilla gorilla gorilla	Q5G270	98.5%	Diamond
Trachypithecus phayrei	Q5G266	98.3%	Diamond
Macaca mulatta	Q5G267	98.3%	Diamond
Pongo pygmaeus	Q5G269	96.7%	Diamond
Chlorocebus aethiops	Q2VLG4	95.8%	Diamond
Saguinus labiatus	Q5G265	95.5%	Diamond
Bos taurus	A6H737	92.9%	Diamond
Xenopus tropicalis	B4F6N6	91.4%	Diamond
Xenopus laevis	Q08B63	91.4%	Diamond
Sus scrofa	Q2VL90	84.0%	Diamond
Canis lupus familiaris	Q2VLG6	84.0%	Diamond
Mesocricetus auratus	P70117	82.3%	Diamond
Gallus gallus	E1C3U7	79.4%	Diamond
Danio rerio	Q24JV9	78.8%	Diamond
Oryctolagus cuniculus	Q05585	78.4%	Diamond
Patiria pectinifera	F7J220	54.5%	Diamond
Drosophila melanogaster	M9NDE3	41.9%	Diamond

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
CYP2E1	protein-coding	1571
SYCE1	protein-coding	93426
PAOX	protein-coding	196743
SPRN	protein-coding	503542
MTG1	protein-coding	92170

Protein

Protein identifiers

Scavenger receptor cysteine-rich domain-containing protein SCART1 — Q4G0T1 (reviewed: Q4G0T1)

Alternative names: Scavenger receptor family member expressed on T cells 1

All UniProt accessions (1): Q4G0T1

UniProt curated annotations — full annotation on UniProt →

Function. May play a role in the immune system, perhaps as a co-receptor on alphabeta and gammadelta T-cells.

Subcellular location. Membrane.

Tissue specificity. Mainly expressed by CD4(+) and CD8(+) T lymphocytes. Also highly expressed in small intestine and colon. Expressed (at protein level) in small intestine, stomach, gall bladder, and placental villi.

Isoforms (3)

UniProt ID	Names	Canonical?
Q4G0T1-1	1	yes
Q4G0T1-2	Gamma
Q4G0T1-3	Alpha

RefSeq proteins (1): NP_001382979* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001190	SRCR	Domain
IPR036772	SRCR-like_dom_sf	Homologous_superfamily

Pfam: PF00530

UniProt features (40 total): disulfide bond 18, domain 8, splice variant 4, glycosylation site 3, topological domain 2, sequence conflict 2, signal peptide 1, chain 1, transmembrane region 1

Structure

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q4G0T1-F1	70.15	0.17

Human Protein Atlas

Protein class: Predicted membrane proteins

Protein evidence: Evidence at protein level

Antibody reliability (HPA): IH supported

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (18)

Type	Positions
Disulfide bond	53–117, 66–127, 97–107, 160–216, 171–226, 196–206, 253–315, 266–325, 297–307, 353–417, 366–427, 397–407, 472–533, 503–513, 594–655, 625–635, 824–885, 855–865

Glycosylation sites (3)

Type	Positions
N-linked (glcnac…) asparagine	94, 129, 332

Function

Pathways and Gene Ontology

Reactome pathways

0 curated (TAS) of 0; 0 disease pathways. Curated-first; evidence = TAS (manually curated) vs IEA (electronic inference).

MSigDB gene sets: 51 (showing top): GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_LEUKOCYTE_MEDIATED_IMMUNITY, CADWELL_ATG16L1_TARGETS_DN, GOBP_LYMPHOCYTE_MEDIATED_IMMUNITY, GOBP_ADAPTIVE_IMMUNE_RESPONSE, GOBP_IMMUNE_EFFECTOR_PROCESS, GOBP_T_CELL_LINEAGE_COMMITMENT, GOBP_T_CELL_MEDIATED_IMMUNITY, GOBP_CELL_FATE_COMMITMENT, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, GOBP_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS, GOCC_APICAL_PART_OF_CELL, GAVIN_FOXP3_TARGETS_CLUSTER_T7, GAVIN_FOXP3_TARGETS_CLUSTER_P3, GOCC_CLUSTER_OF_ACTIN_BASED_CELL_PROJECTIONS

GO Biological Process (4): gamma-delta T cell lineage commitment (GO:0002365), T cell mediated immunity (GO:0002456), immune system process (GO:0002376), vesicle-mediated transport (GO:0016192)

GO Molecular Function (1): scavenger receptor activity (GO:0005044)

GO Cellular Component (4): cytoplasm (GO:0005737), plasma membrane (GO:0005886), brush border (GO:0005903), membrane (GO:0016020)

GO top-level categories

15 GO namespaces:

Category	Terms
cellular anatomical structure	2
T cell lineage commitment	1
gamma-delta T cell differentiation	1
lymphocyte mediated immunity	1
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	1
biological_process	1
transport	1
cellular process	1
cargo receptor activity	1
intracellular anatomical structure	1
membrane	1
cell periphery	1
microvillus	1
apical part of cell	1
cluster of actin-based cell projections	1

Experimentally-supported GO annotations

GO terms backed by direct experimental evidence (ECO experimental codes) — 2 of 9 annotations. The rest are phylogenetic / computational / electronic (IEA).

2 experimentally-supported GO terms:

GO term	NS	Evidence
brush border	CC	direct assay
cytoplasm	CC	direct assay

Protein interactions and networks

STRING

showing 15 of 262 interactions by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SCART1	SYCE1	Q8N0S2	389
SCART1	OR7A17	O14581	384
SCART1	FHOD1	Q9Y613	356
SCART1	EFCAB14	O75071	340
SCART1	SOX13	Q9UN79	338
SCART1	BMP1	P13497	321
SCART1	GP2	P55259	301
SCART1	CD151	P48509	297
SCART1	FUOM	A2VDF0	295
SCART1	LDLRAD2	Q5SZI1	285
SCART1	CD5	P06127	277
SCART1	TEX101	Q9BY14	271
SCART1	GK3	Q14409	260
SCART1	SCARF2	Q96GP6	241
SCART1	CASKIN2	Q8WXE0	240

Disease & clinical

Genetic variants

ClinVar

No ClinVar records for this gene.

SpliceAI

Top 10 splice-impact sites by Δscore (adjacent positions with the same effect merged into one range; 34 predictions of 1,016):

Position(s)	Effect	Δscore	Sites
10:133467196–133467197	acceptor_loss	1.0000	2
10:133467354–133467355	donor_loss	1.0000	5
10:133454065–133454066	donor_loss	0.9900	5
10:133457576–133457577	donor_loss	0.9900	5
10:133459485–133459486	acceptor_loss	0.9900	6
10:133460171–133460172	donor_loss	0.9900	5
10:133467196–133467197	acceptor_loss	0.9900	3
10:133467355	donor_loss	0.9800
10:133467774	acceptor_gain	0.9800
10:133467358	donor_gain	0.9600

AlphaMissense

1,378 missense substitutions predicted likely pathogenic (of 6,543 scored), across 388 residues. Top 20 hotspot residues, ranked by the number of likely-pathogenic substitutions (of those reachable by a single-nucleotide change), then by mean score:

Residue	Likely-pathogenic substitutions	Mean am_pathogenicity	Max am_pathogenicity
F170	8	0.812	0.970
D38	8	0.806	0.915
D528	8	0.754	0.856
C66	7	0.963	0.984
C366	7	0.960	0.983
C171	7	0.959	0.984
W57	7	0.955	0.998
C97	7	0.955	0.981
C53	7	0.953	0.977
C206	7	0.949	0.973
C226	7	0.947	0.976
C71	7	0.946	0.980
C297	7	0.945	0.981
C127	7	0.944	0.978
C397	7	0.943	0.976
C513	7	0.943	0.984
C176	7	0.941	0.979
C196	7	0.940	0.972
C37	7	0.939	0.963
C407	7	0.937	0.963

HPA cancer prognostics

RNA cancer specificity: Not detected

Human Protein Atlas survival analysis — favorable = higher expression predicts better survival.

1 prognostic cancer types:

Cancer	Prognostic	p-value
Glioblastoma Multiforme (validation)	favorable	2.87e-05

Disease associations

OMIM: gene `` | disease phenotypes:

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (CPIC guideline: no)

CTD chemical–gene interactions

14 total (human), top 14 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression	2
methyleugenol	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	affects cotreatment, decreases methylation	1
fipronil	affects cotreatment, decreases expression	1
bisphenol S	increases methylation	1
Fulvestrant	affects cotreatment, decreases methylation	1
DEET	decreases expression, affects cotreatment	1
Endosulfan	decreases expression	1
N-Nitrosopyrrolidine	decreases expression	1
Smoke	increases expression	1
Valproic Acid	increases methylation	1
Aflatoxin B1	decreases expression	1
Permethrin	increases expression	1

Clinical trials (associated diseases)

Via MONDO — disease-level, not drug-specific.