SCEL

Summary

SCEL (sciellin, HGNC:10573) is a protein-coding gene on chromosome 13q22.3, encoding Sciellin (O95171). May function in the assembly or regulation of proteins in the cornified envelope.

The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined.

Source: NCBI Gene 8796 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 140 total — 1 likely-pathogenic
• MANE Select transcript: NM_144777

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10573
Approved symbol	SCEL
Name	sciellin
Location	13q22.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ21667, MGC22531
Ensembl gene	ENSG00000136155
Ensembl biotype	protein_coding
OMIM	604112
Entrez	8796

Gene structure

Transcript identifiers

Ensembl transcripts: 111 — 109 protein_coding, 1 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000349847, ENST00000377246, ENST00000469982, ENST00000471491, ENST00000535157, ENST00000856126, ENST00000856127, ENST00000856128, ENST00000856129, ENST00000856130, ENST00000856131, ENST00000856132, ENST00000856133, ENST00000856134, ENST00000856135, ENST00000856136, ENST00000856137, ENST00000856138, ENST00000856139, ENST00000856140, ENST00000856141, ENST00000856142, ENST00000856143, ENST00000856144, ENST00000856145, ENST00000856146, ENST00000856147, ENST00000856148, ENST00000856149, ENST00000856150, ENST00000856151, ENST00000856152, ENST00000856153, ENST00000856154, ENST00000856155, ENST00000856156, ENST00000856157, ENST00000856158, ENST00000856159, ENST00000856160, ENST00000856161, ENST00000856162, ENST00000856163, ENST00000856164, ENST00000856165, ENST00000856166, ENST00000856167, ENST00000856168, ENST00000856169, ENST00000856170, ENST00000856171, ENST00000856172, ENST00000856173, ENST00000856174, ENST00000856175, ENST00000856176, ENST00000856177, ENST00000856178, ENST00000856179, ENST00000856180, ENST00000856181, ENST00000856182, ENST00000856183, ENST00000856184, ENST00000856185, ENST00000856186, ENST00000856187, ENST00000856188, ENST00000856189, ENST00000965413, ENST00000965414, ENST00000965415, ENST00000965416, ENST00000965417, ENST00000965418, ENST00000965419, ENST00000965420, ENST00000965421, ENST00000965422, ENST00000965423, ENST00000965424, ENST00000965425, ENST00000965426, ENST00000965427, ENST00000965428, ENST00000965429, ENST00000965430, ENST00000965431, ENST00000965432, ENST00000965433, ENST00000965434, ENST00000965435, ENST00000965436, ENST00000965437, ENST00000965438, ENST00000965439, ENST00000965440, ENST00000965441, ENST00000965442, ENST00000965443, ENST00000965444, ENST00000965445, ENST00000965446, ENST00000965447, ENST00000965448, ENST00000965449, ENST00000965450, ENST00000965451, ENST00000965452, ENST00000965453, ENST00000965454

RefSeq mRNA: 3 — MANE Select: NM_144777 NM_001160706, NM_003843, NM_144777

CCDS: CCDS53877, CCDS9458, CCDS9459

Canonical transcript exons

ENST00000349847 — 33 exons

Exon	Start	End
ENSE00000500842	77568295	77568333
ENSE00000684634	77567680	77567748
ENSE00000684637	77569371	77569451
ENSE00000802625	77556596	77556713
ENSE00000802626	77559804	77559863
ENSE00000923756	77563831	77563899
ENSE00000923757	77572124	77572189
ENSE00000923758	77589144	77589224
ENSE00000923759	77591395	77591460
ENSE00000923761	77599329	77599388
ENSE00001235005	77593514	77593573
ENSE00001610270	77617803	77617862
ENSE00001612041	77618004	77618060
ENSE00001639532	77627947	77628009
ENSE00001697658	77603076	77603135
ENSE00001724733	77634379	77634450
ENSE00001731512	77602654	77602713
ENSE00001756550	77617599	77617658
ENSE00001783485	77640676	77640784
ENSE00001783944	77642706	77642808
ENSE00001802637	77637120	77637194
ENSE00001835447	77535706	77535824
ENSE00001881989	77644258	77645263
ENSE00002157127	77555857	77555918
ENSE00003500096	77609058	77609117
ENSE00003543621	77608056	77608115
ENSE00003544100	77610047	77610106
ENSE00003546334	77599689	77599748
ENSE00003583696	77602065	77602124
ENSE00003604499	77612891	77612941
ENSE00003635974	77597545	77597589
ENSE00003665732	77604356	77604415
ENSE00003676309	77613893	77613955

Expression profiles

Bgee: expression breadth ubiquitous, 183 present calls, max score 99.58.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 4.0350 / max 606.2895, expressed in 169 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
135506	1.8815	144
135509	1.6863	133
135507	0.1974	69
135508	0.1506	59
135505	0.1192	44

Top tissues by expression

282 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tongue squamous epithelium	UBERON:0006919	99.58	gold quality
lower esophagus mucosa	UBERON:0035834	99.52	gold quality
upper leg skin	UBERON:0004262	99.39	gold quality
oral cavity	UBERON:0000167	99.07	gold quality
upper arm skin	UBERON:0004263	98.92	gold quality
pharyngeal mucosa	UBERON:0000355	98.56	gold quality
skin of hip	UBERON:0001554	98.08	gold quality
esophagus mucosa	UBERON:0002469	97.98	gold quality
skin of abdomen	UBERON:0001416	97.94	gold quality
buccal mucosa cell	CL:0002336	97.83	gold quality
skin of leg	UBERON:0001511	97.73	gold quality
esophagus squamous epithelium	UBERON:0006920	97.57	gold quality
zone of skin	UBERON:0000014	97.50	gold quality
amniotic fluid	UBERON:0000173	97.49	gold quality
squamous epithelium	UBERON:0006914	96.85	gold quality
epithelium of esophagus	UBERON:0001976	96.74	gold quality
gingiva	UBERON:0001828	96.24	gold quality
penis	UBERON:0000989	95.48	gold quality
body of tongue	UBERON:0011876	95.29	gold quality
gingival epithelium	UBERON:0001949	95.27	gold quality
right lung	UBERON:0002167	95.26	gold quality
mammalian vulva	UBERON:0000997	95.22	gold quality
cervix squamous epithelium	UBERON:0006922	95.12	gold quality
cervix epithelium	UBERON:0004801	94.26	gold quality
upper lobe of left lung	UBERON:0008952	93.22	gold quality
upper lobe of lung	UBERON:0008948	92.95	gold quality
palpebral conjunctiva	UBERON:0001812	90.95	gold quality
tongue	UBERON:0001723	88.11	gold quality
lung	UBERON:0002048	86.95	gold quality
vagina	UBERON:0000996	86.09	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-MTAB-7249	yes	690.44
E-GEOD-130148	yes	9.58
E-ANND-3	yes	9.09
E-CURD-10	no	64.17

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

66 targeting SCEL, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-3682-5P	99.93	67.97	1163
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-380-3P	99.89	70.18	1978
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-8062	99.88	68.43	995
HSA-MIR-3919	99.87	69.45	2489
HSA-MIR-5582-3P	99.86	72.48	4221
HSA-MIR-202-3P	99.84	71.41	1290
HSA-MIR-4495	99.82	72.08	3080
HSA-MIR-3133	99.81	70.92	3506
HSA-MIR-4760-5P	99.80	69.88	1619
HSA-MIR-577	99.78	69.13	2479
HSA-MIR-4517	99.76	69.19	1867

Literature-anchored findings (GeneRIF, showing 8)

• VDUP1 and sciellin were more highly expressed in keratinocytes undergoing differentiation and colocalization of the proteins could be demonstrated (PMID:14632196)
• Single nucleotide polymorphisms were detected in both matching tumor and normal esophageal tissues but no disease-associated mutations suggesting that SCEL is not a major factor in esophageal squamous cell carcinogenesis. (PMID:15274303)
• Sciellin, SPRR3, and periplakin transcripts were all upregulated (4.67-, 4.95-, 2.77-fold, respectively) by prolonged exposure to cyclic strain (24-72 h), but not at earlier time points. (PMID:19211270)
• These results demonstrate that SCEL is a mesenchymal-to-epithelial transition inducer dynamically regulated through the metastasis process (PMID:27013588)
• Down-regulation of long non-coding RNA HOTAIR promotes angiogenesis via regulating miR-126/SCEL pathways in burn wound healing. (PMID:31974341)
• Clinical significance and diagnostic value of QPCT, SCEL and TNFRSF12A in papillary thyroid cancer. (PMID:37060824)
• CBX8 promotes lung adenocarcinoma growth and metastasis through transcriptional repression of CDKN2C and SCEL. (PMID:37733753)
• Sciellin promotes the development and progression of thyroid cancer through the JAK2/STAT3 signaling pathway. (PMID:38411346)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Scel	ENSMUSG00000022123
rattus_norvegicus	Scel	ENSRNOG00000024237

Paralogs (1): ZNF185 (ENSG00000147394)

Protein

Protein identifiers

Sciellin — O95171 (reviewed: O95171)

All UniProt accessions (2): O95171, F2Z2X8

UniProt curated annotations — full annotation on UniProt →

Function. May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.

Subcellular location. Cytoplasm. Membrane.

Tissue specificity. Highly expressed in esophagus. It is also expressed in keratinocytes, amniotic tissue, foreskin stratum spinosum and stratum granulosum, hair follicle and nail.

Isoforms (3)

UniProt ID	Names	Canonical?
O95171-1	1	yes
O95171-2	2
O95171-3	3

RefSeq proteins (3): NP_001154178, NP_003834, NP_659001* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001781	Znf_LIM	Domain
IPR052621	Cell_Prolif/Cornif_Regul	Family

UniProt features (41 total): repeat 16, sequence conflict 6, region of interest 4, compositionally biased region 4, modified residue 3, splice variant 3, sequence variant 3, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O95171-F1	45.48	0.02

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 83, 289, 389

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 153 (showing top): AP1_01, GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, GOBP_EPITHELIUM_DEVELOPMENT, GOBP_REGULATION_OF_WNT_SIGNALING_PATHWAY, ONDER_CDH1_TARGETS_3_DN, GOBP_EPIDERMAL_CELL_DIFFERENTIATION, FONTAINE_PAPILLARY_THYROID_CARCINOMA_UP, GOBP_CANONICAL_WNT_SIGNALING_PATHWAY, TGANTCA_AP1_C, GOBP_EPIDERMIS_DEVELOPMENT, GOBP_RESPONSE_TO_ABIOTIC_STIMULUS, GOBP_POSITIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY, AIGNER_ZEB1_TARGETS, GOBP_EMBRYO_DEVELOPMENT, AML1_01

GO Biological Process (5): epidermis development (GO:0008544), response to mechanical stimulus (GO:0009612), embryo development ending in birth or egg hatching (GO:0009792), keratinocyte differentiation (GO:0030216), positive regulation of canonical Wnt signaling pathway (GO:0090263)

GO Molecular Function (2): metal ion binding (GO:0046872), protein binding (GO:0005515)

GO Cellular Component (5): cornified envelope (GO:0001533), cytoplasm (GO:0005737), perinuclear region of cytoplasm (GO:0048471), extracellular exosome (GO:0070062), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
tissue development	1
response to external stimulus	1
response to abiotic stimulus	1
embryo development	1
epidermal cell differentiation	1
skin development	1
positive regulation of Wnt signaling pathway	1
canonical Wnt signaling pathway	1
regulation of canonical Wnt signaling pathway	1
cation binding	1
binding	1
plasma membrane	1
intracellular anatomical structure	1
cytoplasm	1
extracellular vesicle	1

Protein interactions and networks

STRING

1332 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SCEL	SULF1	Q8IWU6	752
SCEL	YIPF3	Q9GZM5	711
SCEL	SYNPO	Q8N3V7	705
SCEL	CYP26A1	O43174	693
SCEL	ACTN4	O43707	637
SCEL	NPHS1	O60500	598
SCEL	SPRR2A	P35326	559
SCEL	POU4F2	Q12837	547
SCEL	LCE3D	Q9BYE3	543
SCEL	PODXL	O00592	513
SCEL	WT1	P19544	511
SCEL	LHX9	Q9NQ69	503
SCEL	TJP1	Q07157	502
SCEL	PAX2	Q02962	492
SCEL	TGM3	Q08188	487

IntAct

55 interactions, top by confidence:

A	B	Type	Score
FXR2	SCEL	psi-mi:“MI:0915”(physical association)	0.670
SCEL	GOLGA2	psi-mi:“MI:0915”(physical association)	0.670
SCEL	NMI	psi-mi:“MI:0915”(physical association)	0.670
SCEL	FXR2	psi-mi:“MI:0915”(physical association)	0.670
NMI	SCEL	psi-mi:“MI:0915”(physical association)	0.670
SCEL	MTUS2	psi-mi:“MI:0915”(physical association)	0.560
SCEL	KIFC3	psi-mi:“MI:0915”(physical association)	0.560
SCEL	TSGA10	psi-mi:“MI:0915”(physical association)	0.560
MTUS2	SCEL	psi-mi:“MI:0915”(physical association)	0.560
KIFC3	SCEL	psi-mi:“MI:0915”(physical association)	0.560
TBC1D22B	A2ML1	psi-mi:“MI:0914”(association)	0.530
FRMD1	A2ML1	psi-mi:“MI:0914”(association)	0.530
SCEL	LRRK2	psi-mi:“MI:0407”(direct interaction)	0.440
SCEL	DAPK1	psi-mi:“MI:0407”(direct interaction)	0.440
ENG	SCEL	psi-mi:“MI:0407”(direct interaction)	0.440
	SCEL	psi-mi:“MI:0407”(direct interaction)	0.440

BioGRID (43): SCEL (Two-hybrid), SCEL (Two-hybrid), NMI (Two-hybrid), FXR2 (Two-hybrid), MTUS2 (Two-hybrid), TSGA10 (Two-hybrid), SCEL (Reconstituted Complex), SCEL (Two-hybrid), NMI (Two-hybrid), SCEL (Two-hybrid), SCEL (Proximity Label-MS), SCEL (Affinity Capture-MS), RAB11B (Affinity Capture-MS), SCEL (Reconstituted Complex), SCEL (Reconstituted Complex)

ESM2 similar proteins: A0JPP4, A1KXM5, A1YGK6, A2T7F2, A4FU69, A6NE01, A6X8Z9, E9Q0C6, E9Q5F9, E9Q7D5, F6XZJ7, O60057, O95171, P88825, Q03661, Q2T9M9, Q2YDJ5, Q32MG2, Q3URU2, Q3V0C1, Q53TS8, Q5BI31, Q5R7U0, Q5SRN2, Q66H38, Q6AXV6, Q6AYN3, Q70KF4, Q710D7, Q80Y39, Q810T2, Q8BUY8, Q8K4E0, Q8N3K9, Q8NEV8, Q8TC56, Q8TCU4, Q95J40, Q95JY5, Q95K27

Diamond homologs: O15231, O95171, Q62394, Q9EQG3, Q3KQW7, Q3UH68, Q9UPQ0, B9G8P1, F4HZF0, O81635, P26932, P37397, P37803, P51911, P52735, Q08091, Q08092, Q08093, Q08094, Q08290, Q15052, Q15417, Q24799, Q2HJ38, Q32L92, Q3SYU6, Q54TK8, Q55E26, Q55GV9, Q5RFN6, Q5XXR3, Q60992, Q7YRL2, Q8K4I3, Q8WWI1, Q99439, Q9DAW9, Q9GK38, Q921G6, Q9Y2L9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

140 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	100
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
982220	NM_144777.3(SCEL):c.175G>A (p.Gly59Ser)	Likely pathogenic

SpliceAI

4486 predictions. Top by Δscore:

Variant	Effect	Δscore
13:77556595:GA:G	acceptor_gain	1.0000
13:77556709:GAAAA:G	donor_gain	1.0000
13:77556714:G:GG	donor_gain	1.0000
13:77559802:A:AG	acceptor_gain	1.0000
13:77559803:G:GG	acceptor_gain	1.0000
13:77563810:T:TA	acceptor_gain	1.0000
13:77563819:T:G	acceptor_gain	1.0000
13:77569368:CAGG:C	acceptor_loss	1.0000
13:77569369:A:AG	acceptor_gain	1.0000
13:77569369:AGGCA:A	acceptor_loss	1.0000
13:77569370:G:GG	acceptor_gain	1.0000
13:77569447:AAGAG:A	donor_loss	1.0000
13:77569448:AGAGG:A	donor_loss	1.0000
13:77569449:GAG:G	donor_gain	1.0000
13:77569450:AGGTA:A	donor_loss	1.0000
13:77569451:GG:G	donor_loss	1.0000
13:77569452:GTAG:G	donor_loss	1.0000
13:77569453:T:A	donor_loss	1.0000
13:77589140:AAAG:A	acceptor_gain	1.0000
13:77597541:A:AG	acceptor_gain	1.0000
13:77597542:A:G	acceptor_gain	1.0000
13:77597543:A:G	acceptor_gain	1.0000
13:77597544:G:GA	acceptor_gain	1.0000
13:77597544:GT:G	acceptor_gain	1.0000
13:77597588:AGGT:A	donor_loss	1.0000
13:77597590:GTA:G	donor_loss	1.0000
13:77599687:A:AG	acceptor_gain	1.0000
13:77599688:G:GG	acceptor_gain	1.0000
13:77599688:GA:G	acceptor_gain	1.0000
13:77599747:GG:G	donor_gain	1.0000

AlphaMissense

4624 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
13:77640698:T:A	C621S	0.999
13:77640698:T:C	C621R	0.999
13:77640699:G:C	C621S	0.999
13:77640700:C:G	C621W	0.998
13:77642706:T:A	C650S	0.997
13:77642706:T:C	C650R	0.997
13:77642707:G:C	C650S	0.997
13:77640699:G:A	C621Y	0.996
13:77640707:T:A	C624S	0.996
13:77640708:G:C	C624S	0.996
13:77640707:T:C	C624R	0.995
13:77640776:T:C	C647R	0.995
13:77640778:C:G	C647W	0.995
13:77640708:G:A	C624Y	0.994
13:77640709:C:G	C624W	0.994
13:77640780:T:C	F648S	0.994
13:77642708:T:G	C650W	0.994
13:77642715:T:A	C653S	0.994
13:77642716:G:C	C653S	0.994
13:77642792:C:G	C678W	0.994
13:77640699:G:T	C621F	0.993
13:77640766:C:G	C643W	0.993
13:77640769:T:A	H644Q	0.993
13:77640769:T:G	H644Q	0.993
13:77642715:T:C	C653R	0.993
13:77642790:T:A	C678S	0.993
13:77642790:T:C	C678R	0.993
13:77642791:G:C	C678S	0.993
13:77572131:T:A	W163R	0.992
13:77572131:T:C	W163R	0.992

dbSNP variants (sampled 300 via entrez): RS1000035019 (13:77594938 G>A), RS1000039649 (13:77550776 T>A), RS1000045521 (13:77558129 A>G), RS1000064980 (13:77537038 T>C), RS1000136695 (13:77549362 T>A,C), RS1000145391 (13:77628520 A>G), RS1000147775 (13:77640747 A>G), RS1000225491 (13:77595856 T>C), RS1000227872 (13:77623386 C>T), RS1000243566 (13:77562909 G>A), RS1000321449 (13:77576308 C>G), RS1000336954 (13:77569787 C>A), RS1000339685 (13:77616291 A>G,T), RS1000429972 (13:77602529 A>G,T), RS1000454688 (13:77557059 C>G,T)

Disease associations

OMIM: gene MIM:604112 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (1): Moyamoya angiopathy (Orphanet:477768)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST004412_10	Craniofacial microsomia	8.000000e-06
GCST007565_111	Morning person	4.000000e-19
GCST007576_398	Chronotype	4.000000e-19
GCST008477_17	Emphysema annual change measurement in smokers (adjusted lung density)	6.000000e-06

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0008328	chronotype measurement
EFO:0007626	emphysema imaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	3
Particulate Matter	increases expression, decreases expression, increases abundance	3
Benzo(a)pyrene	decreases expression, decreases methylation, increases methylation	2
Estradiol	affects cotreatment, decreases expression	2
Tobacco Smoke Pollution	affects expression, increases expression	2
aristolochic acid I	decreases expression	1
urushiol	increases expression	1
bisphenol A	increases expression	1
pyrogallol 1,3-dimethyl ether	affects cotreatment, decreases expression, affects localization	1
ethyl-p-hydroxybenzoate	increases expression	1
beta-lapachone	increases expression	1
cylindrospermopsin	increases expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
NSC 689534	affects binding, increases expression	1
Zoledronic Acid	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Vehicle Emissions	increases abundance, increases expression	1
Cadmium	increases expression	1
Calcitriol	decreases expression	1
Copper	affects binding, increases expression	1
Dexamethasone	increases expression	1
Diuron	decreases expression	1
Furaldehyde	affects cotreatment, decreases expression, affects localization, increases expression	1
Phenylmercuric Acetate	increases expression, affects cotreatment	1
Smoke	decreases expression	1
Sodium Chloride	decreases expression, affects localization, increases expression, affects cotreatment	1
Tretinoin	increases expression	1
Valproic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.