SCGB1C2

Summary

SCGB1C2 (secretoglobin family 1C member 2, HGNC:51242) is a protein-coding gene on chromosome 17p13.3, encoding Secretoglobin family 1C member 2 (P0DMR2).

Predicted to be located in extracellular region.

Source: NCBI Gene 653486 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 7 total
• MANE Select transcript: NM_001097610

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51242
Approved symbol	SCGB1C2
Name	secretoglobin family 1C member 2
Location	17p13.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000268320
Ensembl biotype	protein_coding
Entrez	653486

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000595228

RefSeq mRNA: 1 — MANE Select: NM_001097610 NM_001097610

CCDS: CCDS73933

Canonical transcript exons

ENST00000595228 — 3 exons

Exon	Start	End
ENSE00003048661	138910	139067
ENSE00003084811	137569	137645
ENSE00003122047	138203	138402

Expression profiles

Bgee: expression breadth broad, 82 present calls, max score 72.64.

Top tissues by expression

119 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	72.64	gold quality
leukocyte	CL:0000738	69.80	gold quality
granulocyte	CL:0000094	55.49	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	49.27	gold quality
cerebellar hemisphere	UBERON:0002245	47.95	gold quality
cerebellar cortex	UBERON:0002129	47.59	gold quality
cerebellum	UBERON:0002037	47.36	gold quality
right hemisphere of cerebellum	UBERON:0014890	46.47	gold quality
blood	UBERON:0000178	45.73	gold quality
body of pancreas	UBERON:0001150	42.97	gold quality
tonsil	UBERON:0002372	42.96	gold quality
bone marrow cell	CL:0002092	39.41	gold quality
pancreas	UBERON:0001264	38.10	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
bone marrow	UBERON:0002371	37.01	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
sural nerve	UBERON:0015488	34.94	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
adult mammalian kidney	UBERON:0000082	33.28	gold quality
descending thoracic aorta	UBERON:0002345	32.74	gold quality
muscle tissue	UBERON:0002385	32.66	silver quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
kidney	UBERON:0002113	31.12	gold quality
urinary bladder	UBERON:0001255	31.01	silver quality
omental fat pad	UBERON:0010414	30.06	gold quality
prefrontal cortex	UBERON:0000451	29.89	silver quality
muscle of leg	UBERON:0001383	29.89	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.15

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Scgb1c1	ENSMUSG00000038801
rattus_norvegicus	Scgb1c1	ENSRNOG00000012847

Paralogs (2): SCGB1A1 (ENSG00000149021), SCGB1C1 (ENSG00000188076)

Protein

Protein identifiers

Secretoglobin family 1C member 2 — P0DMR2 (reviewed: P0DMR2)

All UniProt accessions (1): P0DMR2

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Secreted.

Similarity. Belongs to the secretoglobin family.

RefSeq proteins (1): NP_001091079* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR016126	Secretoglobin	Family
IPR035960	Secretoglobin_sf	Homologous_superfamily
IPR043215	Secretoglobin_1C-like	Family

Pfam: PF01099

UniProt features (2 total): signal peptide 1, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DMR2-F1	75.66	0.01

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 3 (showing top): HAY_BONE_MARROW_PLATELET, TRAVAGLINI_LUNG_PLATELET_MEGAKARYOCYTE_CELL, chr17p13

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (1): extracellular region (GO:0005576)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1
cellular anatomical structure	1

Protein interactions and networks

STRING

364 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SCGB1C2	TBC1D3K	A0A087X1G2	542
SCGB1C2	TBC1D3H	P0C7X1	471
SCGB1C2	SCGB3A2	Q96PL1	464
SCGB1C2	TBC1D3D	A0A087WVF3	419
SCGB1C2	CACNA1B	Q00975	416
SCGB1C2	MST1	P26927	416
SCGB1C2	TCAF1	Q9Y4C2	412
SCGB1C2	PTPN20	Q4JDL3	410
SCGB1C2	BET1L	Q9NYM9	396
SCGB1C2	GPRIN2	O60269	387
SCGB1C2	GNAZ	P19086	379
SCGB1C2	NPY4R2	P0DQD5	378
SCGB1C2	GNAO1	P09471	377
SCGB1C2	A0A1B0GVM2	A0A1B0GVM2	375
SCGB1C2	ARHGEF5	Q12774	374

IntAct

5 interactions, top by confidence:

A	B	Type	Score
SCGB1C2	ASPH	psi-mi:“MI:0915”(physical association)	0.560
M		psi-mi:“MI:0914”(association)	0.350
ASPH	SCGB1C2	psi-mi:“MI:0915”(physical association)	0.000

ESM2 similar proteins: A0A1B0GTC6, A0A2U3Y4D7, A0A2Y9HRM2, G5BQH4, G5BWH8, G8F204, P01257, P01261, P02652, P02656, P06759, P0CE37, P0CE39, P0CF78, P0DJD2, P0DJG2, P0DKV2, P0DKV3, P0DKV4, P0DM95, P0DM96, P0DMP9, P0DMR2, P0DMT9, P0DN36, P0DP50, P0DP84, P0DP85, P0DP86, P0DP87, P0DTQ3, P0DTQ5, P0DTR6, P0DTS5, P18656, P18659, P33622, P40148, P41547, P70160

Diamond homologs: P0DMR2, Q05702, Q2VPS3, Q7M742, Q8TD33, P02779, P06913, P11684, P17559, Q06318, Q8MKG2, Q8VD96, Q9TS45

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

7 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	7
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

618 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:138244:T:C	F33L	0.795
17:138246:C:A	F33L	0.795
17:138246:C:G	F33L	0.795
17:138235:T:C	F30L	0.683
17:138237:C:A	F30L	0.683
17:138237:C:G	F30L	0.683
17:138381:G:C	K78N	0.667
17:138381:G:T	K78N	0.667
17:138327:G:C	K60N	0.633
17:138327:G:T	K60N	0.633
17:138331:G:C	A62P	0.633
17:138265:G:T	G40W	0.608
17:138322:G:C	A59P	0.582
17:138332:C:A	A62E	0.579

dbSNP variants (sampled 300 via entrez): RS1157456115 (17:138545 A>C,G), RS1157695691 (17:139275 T>A,C), RS1157728867 (17:136866 G>A), RS1157805913 (17:137681 G>A), RS1158168635 (17:136153 T>C), RS1158918575 (17:139557 C>G), RS1159259851 (17:138057 T>G), RS1159390941 (17:137359 C>G), RS1160141734 (17:138909 G>A,C), RS1161061014 (17:137699 G>A), RS1161071384 (17:138626 CAT>C), RS1161196389 (17:136289 C>A), RS1161198048 (17:136882 CT>C), RS1161661486 (17:139285 G>C,T), RS1162369203 (17:138918 G>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.