SCGB2B2

Summary

SCGB2B2 (secretoglobin family 2B member 2, HGNC:27616) is a protein-coding gene on chromosome 19q13.12, encoding Secretoglobin family 2B member 2 (Q4G0G5).

Predicted to be located in extracellular region.

Source: NCBI Gene 284402 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 21 total
• MANE Select transcript: NM_001025591

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27616
Approved symbol	SCGB2B2
Name	secretoglobin family 2B member 2
Location	19q13.12
Locus type	gene with protein product
Status	Approved
Aliases	SCGB4A2
Ensembl gene	ENSG00000205209
Ensembl biotype	protein_coding
OMIM	615063
Entrez	284402

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000379204, ENST00000595326, ENST00000601241

RefSeq mRNA: 1 — MANE Select: NM_001025591 NM_001025591

CCDS: CCDS32989

Canonical transcript exons

ENST00000601241 — 4 exons

Exon	Start	End
ENSE00001480067	34594175	34594359
ENSE00002984581	34675630	34677159
ENSE00003154989	34594503	34596594
ENSE00003918625	34590644	34593599

Expression profiles

Bgee: expression breadth ubiquitous, 157 present calls, max score 78.66.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0366 / max 6.9691, expressed in 15 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
180443	0.0312	14
180442	0.0054	2

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.66	gold quality
epithelium of nasopharynx	UBERON:0001951	70.22	gold quality
right lobe of liver	UBERON:0001114	69.04	gold quality
apex of heart	UBERON:0002098	68.76	gold quality
skin of leg	UBERON:0001511	67.59	gold quality
body of pancreas	UBERON:0001150	66.91	gold quality
hindlimb stylopod muscle	UBERON:0004252	66.79	gold quality
right uterine tube	UBERON:0001302	66.49	gold quality
germinal epithelium of ovary	UBERON:0001304	66.47	gold quality
right lobe of thyroid gland	UBERON:0001119	66.29	gold quality
gastrocnemius	UBERON:0001388	66.22	gold quality
muscle of leg	UBERON:0001383	66.03	gold quality
gingival epithelium	UBERON:0001949	65.88	gold quality
left testis	UBERON:0004533	65.62	gold quality
skin of abdomen	UBERON:0001416	65.57	gold quality
right testis	UBERON:0004534	65.57	gold quality
zone of skin	UBERON:0000014	64.85	gold quality
left adrenal gland	UBERON:0001234	64.81	gold quality
right adrenal gland cortex	UBERON:0035827	64.67	gold quality
right adrenal gland	UBERON:0001233	64.62	gold quality
left lobe of thyroid gland	UBERON:0001120	64.55	gold quality
left adrenal gland cortex	UBERON:0035825	64.51	gold quality
pancreas	UBERON:0001264	63.88	gold quality
testis	UBERON:0000473	63.87	gold quality
thyroid gland	UBERON:0002046	63.65	gold quality
adrenal cortex	UBERON:0001235	62.84	gold quality
adrenal gland	UBERON:0002369	62.72	gold quality
adrenal tissue	UBERON:0018303	62.71	gold quality
colonic epithelium	UBERON:0000397	62.46	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	62.00	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-6142	no	28.13
E-ANND-3	no	2.47

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

105 targeting SCGB2B2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-4500	99.99	72.72	2367
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-4487	99.96	64.58	1252
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-544A	99.84	68.66	1965
HSA-MIR-1321	99.84	65.30	1811
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-11181-3P	99.75	66.38	2205
HSA-MIR-6745	99.74	65.33	1321
HSA-MIR-149-3P	99.72	68.22	3963

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Secretoglobin family 2B member 2 — Q4G0G5 (reviewed: Q4G0G5)

Alternative names: Secretoglobin-like protein

All UniProt accessions (1): Q4G0G5

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Secreted.

Similarity. Belongs to the secretoglobin family.

RefSeq proteins (1): NP_001020762* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR016126	Secretoglobin	Family
IPR035960	Secretoglobin_sf	Homologous_superfamily
IPR053723	Secretoglobin_Domain_sf	Homologous_superfamily

Pfam: PF01099

UniProt features (2 total): signal peptide 1, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q4G0G5-F1	81.71	0.16

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 23 (showing top): PAX3_TARGET_GENES, PAX7_TARGET_GENES, MIR3658, MIR4728_5P, MIR6785_5P, MIR494_3P, MIR4516, MIR4723_5P, MIR6870_5P, MIR7111_5P, MIR5698, MIR5703, MIR4434, MIR20A_3P, MIR889_5P

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (1): extracellular region (GO:0005576)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1
cellular anatomical structure	1

Protein interactions and networks

STRING

150 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SCGB2B2	ZNF599	Q96NL3	507
SCGB2B2	WTIP	A6NIX2	507
SCGB2B2	ZNF181	Q2M3W8	505
SCGB2B2	ZNF30	P17039	475
SCGB2B2	UBA2	Q9UBT2	446
SCGB2B2	E7EVR1	E7EVR1	417
SCGB2B2	SCGB1D2	O95969	398
SCGB2B2	PAXBP1	Q9Y5B6	398
SCGB2B2	SCGB2A1	O75556	371
SCGB2B2	SCGB2A2	Q13296	348
SCGB2B2	CYTH4	Q9UIA0	323
SCGB2B2	RIT2	Q99578	321
SCGB2B2	KLHL41	O60662	311
SCGB2B2	ZSCAN30	Q86W11	301
SCGB2B2	EOLA1	Q8TE69	284

IntAct

4 interactions, top by confidence:

A	B	Type	Score
SCGB2B2	UBQLN2	psi-mi:“MI:0915”(physical association)	0.560
SCGB2B2	UBQLN2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (3): SCGB2B2 (Affinity Capture-RNA), SCGB2B2 (Two-hybrid), SCGB2B2 (Positive Genetic)

ESM2 similar proteins: A0A8M9PDM1, A0JNP2, O09051, O75556, O95968, O95969, P02779, P02780, P02781, P02782, P04769, P06913, P09320, P0DMR2, P11684, P17559, P28902, P30438, P30440, P33578, P33579, P33580, P33680, P70664, P70668, P79897, Q02747, Q05702, Q06318, Q0PGP2, Q13296, Q16661, Q28358, Q2VPS3, Q4G0G5, Q6UGQ3, Q6XE38, Q7M742, Q7M747, Q8CGZ9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

21 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	21
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1397 predictions. Top by Δscore:

Variant	Effect	Δscore
19:34623269:T:A	donor_gain	1.0000
19:34637598:C:CT	acceptor_gain	1.0000
19:34637604:C:CT	acceptor_gain	1.0000
19:34675625:CTGA:C	donor_loss	1.0000
19:34675627:GAC:G	donor_loss	1.0000
19:34675628:ACC:A	donor_loss	1.0000
19:34593600:C:CC	acceptor_gain	0.9900
19:34594173:A:AC	donor_gain	0.9900
19:34594174:C:CC	donor_gain	0.9900
19:34594356:TCCCC:T	acceptor_loss	0.9900
19:34594357:CCC:C	acceptor_gain	0.9900
19:34594357:CCCCT:C	acceptor_loss	0.9900
19:34594358:CCC:C	acceptor_gain	0.9900
19:34594358:CCCTG:C	acceptor_loss	0.9900
19:34594360:C:G	acceptor_loss	0.9900
19:34594361:T:C	acceptor_loss	0.9900
19:34594369:A:C	acceptor_gain	0.9900
19:34632641:C:CC	acceptor_gain	0.9900
19:34637599:A:T	acceptor_gain	0.9900
19:34637605:A:C	acceptor_gain	0.9900
19:34675644:CTG:C	donor_gain	0.9900
19:34594196:T:C	donor_gain	0.9800
19:34594249:C:CA	donor_gain	0.9800
19:34594356:TCCC:T	acceptor_gain	0.9800
19:34594357:CCCC:C	acceptor_gain	0.9800
19:34594358:CC:C	acceptor_gain	0.9800
19:34594359:CC:C	acceptor_gain	0.9800
19:34594360:C:CC	acceptor_gain	0.9800
19:34594369:A:AC	acceptor_gain	0.9800
19:34632639:CA:C	acceptor_gain	0.9800

AlphaMissense

626 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:34594220:A:C	F67L	0.939
19:34594220:A:T	F67L	0.939
19:34594222:A:G	F67L	0.939
19:34594223:G:C	C66W	0.935
19:34594221:A:C	F67C	0.920
19:34593573:G:C	C91W	0.916
19:34594225:A:G	C66R	0.911
19:34594242:A:C	F60C	0.909
19:34594224:C:G	C66S	0.905
19:34594225:A:T	C66S	0.905
19:34594241:G:C	F60L	0.903
19:34594241:G:T	F60L	0.903
19:34594243:A:G	F60L	0.903
19:34594281:A:G	L47P	0.895
19:34594513:G:C	S17R	0.883
19:34594513:G:T	S17R	0.883
19:34594515:T:G	S17R	0.883
19:34594221:A:G	F67S	0.880
19:34594281:A:T	L47H	0.879
19:34594526:G:T	A13D	0.859
19:34594518:A:G	C16R	0.858
19:34593575:A:G	C91R	0.857
19:34594233:A:T	V63D	0.856
19:34594229:C:A	Q64H	0.846
19:34594229:C:G	Q64H	0.846
19:34594224:C:T	C66Y	0.841
19:34594242:A:G	F60S	0.837
19:34594538:G:T	A9D	0.823
19:34593592:A:G	I85T	0.814
19:34594224:C:A	C66F	0.802

dbSNP variants (sampled 300 via entrez): RS1000081389 (19:34613281 T>A), RS1000099324 (19:34655141 C>T), RS1000217505 (19:34658877 C>A,T), RS1000219234 (19:34605684 T>C), RS1000288721 (19:34611098 T>C), RS1000293843 (19:34593918 G>C), RS1000297697 (19:34649309 G>A), RS1000344115 (19:34623124 T>C), RS1000377613 (19:34621939 G>T), RS1000392498 (19:34614991 T>C), RS1000438698 (19:34616332 A>G), RS1000442751 (19:34628186 C>T), RS1000496653 (19:34626913 G>A), RS1000501502 (19:34644740 A>G), RS1000546319 (19:34591412 G>C,T)

Disease associations

OMIM: gene MIM:615063 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST012490_225	Femur bone mineral density x serum urate levels interaction	3.000000e-10

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004531	urate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
abrine	decreases expression	1
Benzo(a)pyrene	increases methylation	1
Diethylhexyl Phthalate	decreases expression	1
Nickel	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.