SCIRT

Summary

SCIRT (stem cell inhibitory RNA transcript, HGNC:55341) is a long non-coding RNA gene on chromosome 6p21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55341
Approved symbol	SCIRT
Name	stem cell inhibitory RNA transcript
Location	6p21.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	DATOC-1, AL109615.3
Ensembl gene	ENSG00000237686
Ensembl biotype	lncRNA
Entrez	101929705
RNAcentral	URS00007E3D3D — lncRNA, 2246 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 57 — 57 lncRNA

ENST00000422059, ENST00000607590, ENST00000652850, ENST00000655938, ENST00000687158, ENST00000687275, ENST00000687455, ENST00000687843, ENST00000719327, ENST00000719328, ENST00000719329, ENST00000719330, ENST00000719331, ENST00000719332, ENST00000719333, ENST00000719334, ENST00000719335, ENST00000719336, ENST00000719337, ENST00000719338, ENST00000719339, ENST00000719340, ENST00000719341, ENST00000719342, ENST00000719343, ENST00000719344, ENST00000719345, ENST00000719346, ENST00000719347, ENST00000719348, ENST00000719349, ENST00000719350, ENST00000719351, ENST00000719352, ENST00000719353, ENST00000719354, ENST00000719355, ENST00000719356, ENST00000719357, ENST00000719358, ENST00000719359, ENST00000719360, ENST00000719361, ENST00000719362, ENST00000719363, ENST00000719364, ENST00000719365, ENST00000719366, ENST00000719367, ENST00000719368, ENST00000719369, ENST00000719370, ENST00000719371, ENST00000719372, ENST00000719373, ENST00000719374, ENST00000719375

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000422059 — 5 exons

Exon	Start	End
ENSE00001703144	43995723	43997308
ENSE00001723281	44074497	44074652
ENSE00001724150	43999218	43999508
ENSE00001757899	44000591	44000715
ENSE00001792027	44001043	44001116

Expression profiles

Bgee: expression breadth ubiquitous, 153 present calls, max score 81.08.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2633 / max 54.2742, expressed in 122 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
73735	0.2633	122

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.08	gold quality
left lobe of thyroid gland	UBERON:0001120	73.80	gold quality
right lobe of thyroid gland	UBERON:0001119	73.69	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	73.07	gold quality
thyroid gland	UBERON:0002046	72.75	gold quality
apex of heart	UBERON:0002098	69.16	gold quality
muscle of leg	UBERON:0001383	66.98	gold quality
right atrium auricular region	UBERON:0006631	66.66	gold quality
gastrocnemius	UBERON:0001388	66.56	gold quality
hindlimb stylopod muscle	UBERON:0004252	66.06	gold quality
cardiac atrium	UBERON:0002081	65.99	gold quality
right uterine tube	UBERON:0001302	65.74	gold quality
cortical plate	UBERON:0005343	65.04	gold quality
heart left ventricle	UBERON:0002084	64.22	gold quality
nucleus accumbens	UBERON:0001882	63.70	gold quality
islet of Langerhans	UBERON:0000006	63.63	gold quality
cardiac ventricle	UBERON:0002082	63.40	gold quality
hypothalamus	UBERON:0001898	63.39	gold quality
ganglionic eminence	UBERON:0004023	62.87	gold quality
anterior cingulate cortex	UBERON:0009835	62.83	gold quality
adenohypophysis	UBERON:0002196	62.61	gold quality
heart	UBERON:0000948	62.55	gold quality
right testis	UBERON:0004534	62.46	gold quality
body of uterus	UBERON:0009853	62.30	gold quality
ventricular zone	UBERON:0003053	62.28	gold quality
bone marrow cell	CL:0002092	62.02	silver quality
pituitary gland	UBERON:0000007	61.65	gold quality
left testis	UBERON:0004533	61.62	gold quality
putamen	UBERON:0001874	61.37	gold quality
testis	UBERON:0000473	60.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• LncRNA SCIRT absorbs miR-221 to advance the expression of lncRNA GAS5 in oral squamous cell carcinoma to inhibit cancer cell apoptosis. (PMID:34547134)
• LncRNA SCIRT is downregulated in atherosclerosis and suppresses the proliferation of human aortic smooth muscle cells (HAOSMCs) by sponging miR-146a in cytoplasm. (PMID:34742341)
• Long Noncoding RNA SCIRT Promotes HUVEC Angiogenesis via Stabilizing VEGFA mRNA Induced by Hypoxia. (PMID:35698607)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.