SCML2

Summary

SCML2 (Scm polycomb group protein like 2, HGNC:10581) is a protein-coding gene on chromosome Xp22.13, encoding Sex comb on midleg-like protein 2 (Q9UQR0). Putative Polycomb group (PcG) protein.

This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development.

Source: NCBI Gene 10389 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 180 total — 1 likely-pathogenic
• MANE Select transcript: NM_006089

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10581
Approved symbol	SCML2
Name	Scm polycomb group protein like 2
Location	Xp22.13
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000102098
Ensembl biotype	protein_coding
OMIM	300208
Entrez	10389

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 7 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000251900, ENST00000398048, ENST00000420857, ENST00000491988, ENST00000665583, ENST00000926833, ENST00000926834, ENST00000926835

RefSeq mRNA: 1 — MANE Select: NM_006089 NM_006089

CCDS: CCDS14185

Canonical transcript exons

ENST00000251900 — 15 exons

Exon	Start	End
ENSE00000666137	18242439	18242590
ENSE00001341544	18354592	18354688
ENSE00001632032	18246577	18246828
ENSE00001692459	18260171	18260291
ENSE00001720943	18256848	18257030
ENSE00001722015	18324907	18324977
ENSE00001740872	18330587	18330655
ENSE00001761590	18323859	18324093
ENSE00001776891	18247769	18247882
ENSE00001780951	18304972	18305215
ENSE00001801055	18258044	18258247
ENSE00001802908	18320332	18320420
ENSE00002285630	18334050	18334095
ENSE00003545477	18239313	18241379
ENSE00003664153	18265585	18265802

Expression profiles

Bgee: expression breadth ubiquitous, 228 present calls, max score 96.57.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.9471 / max 165.9154, expressed in 1093 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
198589	4.9471	1093

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory bulb	UBERON:0002264	96.57	silver quality
diaphragm	UBERON:0001103	93.79	silver quality
type B pancreatic cell	CL:0000169	93.77	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.43	gold quality
parotid gland	UBERON:0001831	88.65	gold quality
pancreatic ductal cell	CL:0002079	88.25	silver quality
biceps brachii	UBERON:0001507	88.10	silver quality
oocyte	CL:0000023	88.06	gold quality
adrenal tissue	UBERON:0018303	87.29	gold quality
mucosa of urinary bladder	UBERON:0001259	87.24	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.18	gold quality
heart right ventricle	UBERON:0002080	85.90	silver quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	85.84	silver quality
upper leg skin	UBERON:0004262	85.70	gold quality
tibialis anterior	UBERON:0001385	85.44	silver quality
male germ cell	CL:0000015	85.14	silver quality
middle temporal gyrus	UBERON:0002771	84.84	silver quality
nephron tubule	UBERON:0001231	84.69	silver quality
endothelial cell	CL:0000115	84.58	silver quality
adult organism	UBERON:0007023	84.01	gold quality
sperm	CL:0000019	83.85	silver quality
tendon of biceps brachii	UBERON:0008188	83.73	silver quality
seminal vesicle	UBERON:0000998	83.63	silver quality
esophagus squamous epithelium	UBERON:0006920	83.62	silver quality
jejunal mucosa	UBERON:0000399	83.45	silver quality
epithelium of esophagus	UBERON:0001976	83.19	silver quality
secondary oocyte	CL:0000655	83.00	gold quality
pigmented layer of retina	UBERON:0001782	82.92	silver quality
Brodmann (1909) area 23	UBERON:0013554	82.83	silver quality
colonic mucosa	UBERON:0000317	82.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	5.25

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

161 targeting SCML2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-3148	99.97	75.06	6478

Literature-anchored findings (GeneRIF, showing 6)

• 1.78-A crystal structure of the two MBT repeats of SCML2 show significant structural similarities to the Tudor, PWWP, and chromo domains, suggesting probable evolutionary relationships and functional similarities between the MBT repeats and these domains. (PMID:12952983)
• The malignant brain tumor repeats of SCML2 preferentially bind histone peptides monomethylated at lysine residues. The crystal structure of the complex reveals that the modified amino acid binds to an aromatic rich pocket. (PMID:18706910)
• Because PRC1 complexes localize to the promoters of a specific subset of developmental genes in vivo, the SLED domain of Scml2 may provide an important link connecting the PRC1 complexes to their target genes. (PMID:24727478)
• SCML2A, an SCML2 isoform tightly associated to chromatin, contributes to PRC1 localization and also directly enforces repression of certain Polycomb target genes. (PMID:24986859)
• SCML2 directly interacts with USP7 and drives its localization. SCML2 connects USP7 to PRC1.4, allowing for the stabilization of BMI1, and USP7 is found on SCML2 and BMI1 target genes. (PMID:25605328)
• Sex Comb on Midleg Like-2 Accelerates Hepatocellular Carcinoma Cell Proliferation and Metastasis by Activating Wnt/beta-Catenin/EMT Signaling. (PMID:34816637)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	scml2	ENSDARG00000012949
mus_musculus	Scml2	ENSMUSG00000000037
rattus_norvegicus	Scml2	ENSRNOG00000003726
drosophila_melanogaster	l(3)mbt	FBGN0002441
drosophila_melanogaster	Sfmbt	FBGN0032475
caenorhabditis_elegans	lin-61	WBGENE00003041
caenorhabditis_elegans	mbtr-1	WBGENE00021661

Paralogs (18): SCMH1 (ENSG00000010803), MBTD1 (ENSG00000011258), SCML1 (ENSG00000047634), L3MBTL2 (ENSG00000100395), PHC1 (ENSG00000111752), THAP10 (ENSG00000129028), PHC2 (ENSG00000134686), SAMD1 (ENSG00000141858), SCML4 (ENSG00000146285), L3MBTL4 (ENSG00000154655), SFMBT1 (ENSG00000163935), PHC3 (ENSG00000173889), L3MBTL1 (ENSG00000185513), SAMD7 (ENSG00000187033), SAMD11 (ENSG00000187634), SFMBT2 (ENSG00000198879), L3MBTL3 (ENSG00000198945), SAMD13 (ENSG00000203943)

Protein

Protein identifiers

Sex comb on midleg-like protein 2 — Q9UQR0 (reviewed: Q9UQR0)

All UniProt accessions (3): Q9UQR0, B4DRC2, H0Y6S1

UniProt curated annotations — full annotation on UniProt →

Function. Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development.

Subcellular location. Nucleus.

Tissue specificity. Highly expressed in placenta, thymus and testis. Detected at lower levels in brain, liver, skeletal muscle, pancreas and ovary.

Similarity. Belongs to the SCM family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9UQR0-1	1	yes
Q9UQR0-2	2

RefSeq proteins (1): NP_006080* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001660	SAM	Domain
IPR004092	Mbt	Domain
IPR013761	SAM/pointed_sf	Homologous_superfamily
IPR021987	SLED	Domain
IPR033763	SCML2_RBR	Domain
IPR038348	SLED_sf	Homologous_superfamily
IPR047531	SAM_Scm-like	Domain
IPR050548	PcG_chromatin_remod_factors	Family

Pfam: PF00536, PF02820, PF12140, PF17208

UniProt features (60 total): strand 16, modified residue 14, helix 12, compositionally biased region 5, cross-link 4, region of interest 4, repeat 2, chain 1, domain 1, splice variant 1

Structure

Experimental structures (PDB)

5 structures.

PDB	Method	Resolution (Å)
2BIV	X-RAY DIFFRACTION	1.7
1OI1	X-RAY DIFFRACTION	1.78
2VYT	X-RAY DIFFRACTION	1.9
4EDU	X-RAY DIFFRACTION	2.58
2MEM	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UQR0-F1	69.43	0.44

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (18): 256, 261, 267, 299, 300, 305, 499, 503, 511, 522, 570, 583, 590, 594, 518, 536, 599, 605

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 145 (showing top): TGGTGCT_MIR29A_MIR29B_MIR29C, CMYB_01, CTATGCA_MIR153, DODD_NASOPHARYNGEAL_CARCINOMA_UP, DANG_BOUND_BY_MYC, AP2GAMMA_01, MODULE_204, GOMF_CHROMATIN_BINDING, GOCC_PCG_PROTEIN_COMPLEX, CTGAGCC_MIR24, BENPORATH_MYC_MAX_TARGETS, GOMF_HISTONE_BINDING, GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D, ATAAGCT_MIR21, MIKKELSEN_ES_ICP_WITH_H3K4ME3

GO Biological Process (3): anatomical structure morphogenesis (GO:0009653), negative regulation of DNA-templated transcription (GO:0045892), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (3): chromatin binding (GO:0003682), histone binding (GO:0042393), protein binding (GO:0005515)

GO Cellular Component (2): nucleus (GO:0005634), PcG protein complex (GO:0031519)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
DNA-templated transcription	2
binding	2
developmental process	1
anatomical structure development	1
regulation of DNA-templated transcription	1
negative regulation of RNA biosynthetic process	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
protein binding	1
intracellular membrane-bounded organelle	1
nuclear protein-containing complex	1

Protein interactions and networks

STRING

995 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SCML2	PPEF1	O14829	845
SCML2	MRPL3	P09001	769
SCML2	BMI1	P35226	765
SCML2	R4GMX3	R4GMX3	765
SCML2	PRTN3	P15637	743
SCML2	CBX4	O00257	740
SCML2	ARSF	P54793	719
SCML2	PCGF2	P35227	689
SCML2	CDKL5	O76039	679
SCML2	PCGF1	Q9BSM1	651
SCML2	RING1	Q06587	640
SCML2	HORMAD2	Q8N7B1	627
SCML2	HORMAD1	Q86X24	616
SCML2	PCGF6	Q9BYE7	604
SCML2	RYBP	Q8N488	597

IntAct

57 interactions, top by confidence:

A	B	Type	Score
CDK2	CDKN1A	psi-mi:“MI:0914”(association)	0.980
CCNE2	CDK2	psi-mi:“MI:0915”(physical association)	0.940
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
USP7	BCOR	psi-mi:“MI:0914”(association)	0.660
NCK2	SCML2	psi-mi:“MI:0915”(physical association)	0.560
LNX1	SCML2	psi-mi:“MI:0915”(physical association)	0.560
CAB39L	SCML2	psi-mi:“MI:0915”(physical association)	0.560
SFMBT2	SCML2	psi-mi:“MI:0915”(physical association)	0.560
SRGAP2B	SCML2	psi-mi:“MI:0915”(physical association)	0.560
RNF4	SCML2	psi-mi:“MI:0915”(physical association)	0.560
USP7	MCM4	psi-mi:“MI:0914”(association)	0.530
POTEB3	POTEF	psi-mi:“MI:0914”(association)	0.530
CBX6	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
SCML2	CDK2	psi-mi:“MI:0915”(physical association)	0.500
AURKA	CCNB2	psi-mi:“MI:0915”(physical association)	0.400
CCNB2	CCNE2	psi-mi:“MI:0915”(physical association)	0.400
RNF2	AKIP1	psi-mi:“MI:0914”(association)	0.350
CBX8	CMSS1	psi-mi:“MI:0914”(association)	0.350
Cbx7	E2F6	psi-mi:“MI:0914”(association)	0.350
USP7	STIL	psi-mi:“MI:0914”(association)	0.350
Ring1	CENPX	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
USP7		psi-mi:“MI:0914”(association)	0.350
SCMH1	CBX4	psi-mi:“MI:0914”(association)	0.350
SCML2	CSTA	psi-mi:“MI:0914”(association)	0.350
H2BC21	SMCHD1	psi-mi:“MI:0914”(association)	0.350
POTEB3	POTEB	psi-mi:“MI:0914”(association)	0.350

BioGRID (104): SCML2 (Affinity Capture-MS), BAG1 (Co-fractionation), USP7 (Affinity Capture-Western), SCML2 (Affinity Capture-Western), SCML2 (Reconstituted Complex), USP7 (Reconstituted Complex), SCML2 (Affinity Capture-Western), SCML2 (Affinity Capture-Western), SCML2 (Affinity Capture-MS), SCML2 (Affinity Capture-MS), SCML2 (Affinity Capture-MS), SCML2 (Affinity Capture-MS), SCML2 (Affinity Capture-MS), SCML2 (Affinity Capture-MS), SCML2 (Affinity Capture-MS)

ESM2 similar proteins: A8MYV0, D3Z8X7, D3ZR10, D3ZUI5, F8VPQ2, M0R2J8, O35867, O54916, O75128, O94988, O95810, Q08D35, Q13625, Q149C2, Q3U1C4, Q3UH68, Q3UHI4, Q3UMF0, Q53SF7, Q5DU00, Q5JSH3, Q5JV73, Q5NBX1, Q5R9S0, Q5XIN3, Q63679, Q6AY22, Q6IRU7, Q6NVE8, Q6P1H6, Q6PGZ3, Q6PL24, Q7TP65, Q7TQ95, Q80U16, Q8BGI4, Q8CG79, Q8HYW0, Q8TDR0, Q92833

Diamond homologs: A2A5N8, B1B1A0, D3YUG0, D3YXK1, D3ZWK4, E1C2V1, O02274, O60284, O95251, P39769, P59178, P70047, P70475, P78364, P97500, Q01538, Q05BQ5, Q1JQD9, Q1RNF8, Q29L50, Q32N90, Q3MIF2, Q4V7W5, Q5DTW2, Q5R737, Q5SVQ0, Q5VUG0, Q5VXD3, Q64028, Q6DIN3, Q6P5G3, Q6SPE9, Q6SPF0, Q7Z3H4, Q80TY4, Q810T5, Q8BLB7, Q8C8Y5, Q8CFC2, Q8CHP6

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 58 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	5	41.7×	2e-05
Regulation of PTEN gene transcription	6	29.7×	2e-05
Cellular Senescence	6	22.9×	2e-05
Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells)	5	20.3×	2e-04
Intracellular signaling by second messengers	6	15.2×	1e-04
Oxidative Stress Induced Senescence	6	15.1×	1e-04
PIP3 activates AKT signaling	7	13.0×	6e-05
Cell Cycle Checkpoints	5	12.3×	7e-04

GO biological processes:

GO term	Partners	Fold	FDR
G1/S transition of mitotic cell cycle	5	21.3×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

180 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	39
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
564795	GRCh37/hg19 Xp22.13(chrX:18275593-18653790)x1	Likely pathogenic

SpliceAI

3406 predictions. Top by Δscore:

Variant	Effect	Δscore
X:18241376:TTTC:T	acceptor_gain	1.0000
X:18241379:CCTA:C	acceptor_loss	1.0000
X:18241381:T:A	acceptor_loss	1.0000
X:18242437:A:AC	donor_gain	1.0000
X:18242438:C:CC	donor_gain	1.0000
X:18246743:T:TA	donor_gain	1.0000
X:18247880:TTG:T	acceptor_gain	1.0000
X:18247881:TG:T	acceptor_gain	1.0000
X:18247883:C:CC	acceptor_gain	1.0000
X:18247890:C:CT	acceptor_gain	1.0000
X:18247891:A:T	acceptor_gain	1.0000
X:18256842:TCTCA:T	donor_loss	1.0000
X:18256843:CTCA:C	donor_loss	1.0000
X:18256845:CA:C	donor_loss	1.0000
X:18256846:A:AT	donor_loss	1.0000
X:18256847:C:T	donor_loss	1.0000
X:18256847:CCTGA:C	donor_gain	1.0000
X:18257026:GGAGG:G	acceptor_gain	1.0000
X:18257027:GAGG:G	acceptor_gain	1.0000
X:18257028:AGG:A	acceptor_gain	1.0000
X:18257029:GG:G	acceptor_gain	1.0000
X:18257029:GGCTA:G	acceptor_loss	1.0000
X:18257030:GC:G	acceptor_loss	1.0000
X:18257031:C:CA	acceptor_loss	1.0000
X:18257031:C:CC	acceptor_gain	1.0000
X:18257034:T:TC	acceptor_gain	1.0000
X:18258055:T:TA	donor_gain	1.0000
X:18258204:C:CT	acceptor_gain	1.0000
X:18258224:CA:C	acceptor_gain	1.0000
X:18258225:A:C	acceptor_gain	1.0000

AlphaMissense

4602 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:18256997:A:G	L436P	0.999
X:18305127:G:T	A192E	0.999
X:18305164:C:G	A180P	0.999
X:18305169:A:G	L178P	0.999
X:18242522:A:G	W631R	0.998
X:18242522:A:T	W631R	0.998
X:18256997:A:T	L436H	0.998
X:18258049:A:T	I423K	0.998
X:18258142:A:G	L392P	0.998
X:18258205:A:G	L371P	0.998
X:18258241:A:T	V359D	0.998
X:18305017:A:G	W229R	0.998
X:18305017:A:T	W229R	0.998
X:18305128:C:G	A192P	0.998
X:18320395:C:A	W141C	0.998
X:18320395:C:G	W141C	0.998
X:18320397:A:G	W141R	0.998
X:18320397:A:T	W141R	0.998
X:18323969:C:G	R96P	0.998
X:18324002:A:T	V85D	0.998
X:18324008:G:T	A83D	0.998
X:18242449:A:G	F655S	0.997
X:18256997:A:C	L436R	0.997
X:18258091:A:T	V409D	0.997
X:18258166:C:T	G384D	0.997
X:18258167:C:G	G384R	0.997
X:18258181:A:G	L379P	0.997
X:18305012:A:C	C230W	0.997
X:18305097:A:T	V202D	0.997
X:18305163:G:T	A180D	0.997

dbSNP variants (sampled 300 via entrez): RS1000013675 (X:18247530 A>G), RS1000075187 (X:18298441 C>G), RS1000083478 (X:18247138 G>A), RS1000144884 (X:18310326 C>T), RS1000170210 (X:18282291 C>T), RS1000187737 (X:18288480 G>C), RS1000211313 (X:18301688 A>G), RS1000221114 (X:18281145 C>G,T), RS1000295223 (X:18283427 T>C), RS1000305660 (X:18256471 C>A,T), RS1000307596 (X:18301370 G>C), RS1000377213 (X:18292930 A>T), RS1000439925 (X:18310558 G>A), RS1000558558 (X:18283993 A>G), RS1000568408 (X:18335347 T>C)

Disease associations

OMIM: gene MIM:300208 | disease phenotypes: MIM:300672

GenCC curated gene-disease

Mondo (1): developmental and epileptic encephalopathy, 2 (MONDO:0010396)

Orphanet (3): Early infantile developmental and epileptic encephalopathy (Orphanet:1934), West syndrome (Orphanet:3451), CDKL5-deficiency disorder (Orphanet:505652)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C564064	CDKL5 deficiency disorder (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	2
Air Pollutants	increases abundance, increases expression	2
Benzo(a)pyrene	affects methylation	2
Tetrachlorodibenzodioxin	affects expression, decreases expression	2
aristolochic acid I	decreases expression	1
FR900359	affects phosphorylation	1
dicrotophos	increases expression	1
beauvericin	affects cotreatment, decreases expression	1
potassium chromate(VI)	increases expression	1
perfluorooctane sulfonic acid	decreases expression	1
enniatins	affects cotreatment, decreases expression	1
Leflunomide	decreases expression	1
Acetaminophen	increases expression	1
Caffeine	affects phosphorylation	1
Calcitriol	decreases expression, affects cotreatment	1
Coal	increases expression, increases abundance	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Quercetin	decreases expression	1
Selenium	decreases expression	1
Smoke	increases abundance, increases expression	1
Testosterone	affects cotreatment, decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	decreases expression	1
Valproic Acid	increases methylation	1
Vanadates	decreases expression	1
Cyclosporine	decreases expression	1
Gold Compounds	decreases expression	1
Particulate Matter	increases abundance, increases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TK14	HAP1 SCML2 (-) 1	Cancer cell line	Male
CVCL_XS50	HAP1 SCML2 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.