SCPPPQ1

Summary

SCPPPQ1 (secretory calcium-binding phosphoprotein proline-glutamine rich 1, HGNC:56851) is a protein-coding gene on chromosome 4q22.1, encoding Secretory calcium-binding phosphoprotein proline- and glutamine-rich 1 (A0A411D538). Tooth-associated epithelia protein that may participate in structuring the basal lamina at cell-tooth interface.

Predicted to be located in extracellular region.

Source: NCBI Gene 105377321 — RefSeq curated summary.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:56851
Approved symbol	SCPPPQ1
Name	secretory calcium-binding phosphoprotein proline-glutamine rich 1
Location	4q22.1
Locus type	gene with protein product
Status	Approved
OMIM	621324
Entrez	105377321

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Secretory calcium-binding phosphoprotein proline- and glutamine-rich 1 — A0A411D538 (reviewed: A0A411D538)

All UniProt accessions (0):

UniProt curated annotations — full annotation on UniProt →

Function. Tooth-associated epithelia protein that may participate in structuring the basal lamina at cell-tooth interface.

Subcellular location. Secreted.

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

UniProt features (2 total): signal peptide 1, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A411D538-F1	68.57	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 2 (showing top): chr4q22, SRSF9_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): extracellular region (GO:0005576)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A0G2K6Z9, A0A1D0BN92, A0A411D538, A1YQ92, B3A0Q4, D5L5Q8, H2A0M0, K9N4Q4, O08546, O15946, O35979, O35985, O36359, P06796, P07498, P0DMD3, P0DMD4, P11841, P13432, P15450, P18897, P34468, P54684, P55796, P79139, P81058, P81059, P83055, P83474, P86735, Q01493, Q09283, Q17RF5, Q28441, Q28451, Q28794, Q29135, Q29137, Q61900, Q7T6X1

Diamond homologs: A0A411D538, B9UIU9, D6QY17

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000259350 (4:87466833 C>A,T), RS1000457217 (4:87463544 A>G), RS1000714113 (4:87467091 G>C,T), RS1000847243 (4:87465568 A>C,G), RS1001199261 (4:87465191 A>G), RS1001259412 (4:87468130 C>T), RS1001304361 (4:87468966 G>T), RS1001358142 (4:87469313 A>G), RS10013990 (4:87464294 C>T), RS1001468576 (4:87462101 T>G), RS1001516382 (4:87462501 CTTTTTTTT>C), RS10017783 (4:87466042 C>T), RS1001858903 (4:87462282 A>G), RS10020411 (4:87466302 G>A,T), RS10020894 (4:87466839 G>A)

Disease associations

OMIM: gene MIM:621324 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.