SDAD1

Summary

SDAD1 (SDA1 domain containing 1, HGNC:25537) is a protein-coding gene on chromosome 4q21.1, encoding Protein SDA1 homolog (Q9NVU7). Required for 60S pre-ribosomal subunits export to the cytoplasm. It is a common-essential gene (DepMap: required in 94.6% of cancer cell lines).

Predicted to be involved in ribosomal large subunit biogenesis and ribosomal large subunit export from nucleus. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Located in nucleolus and nucleoplasm.

Source: NCBI Gene 55153 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 128 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 94.6% of screened cell lines (common-essential)
• MANE Select transcript: NM_018115

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25537
Approved symbol	SDAD1
Name	SDA1 domain containing 1
Location	4q21.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10498, Sda1, hSDA
Ensembl gene	ENSG00000198301
Ensembl biotype	protein_coding
Entrez	55153

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 5 protein_coding, 5 protein_coding_CDS_not_defined, 3 nonsense_mediated_decay

ENST00000356260, ENST00000395710, ENST00000395711, ENST00000502543, ENST00000503411, ENST00000504975, ENST00000507396, ENST00000513089, ENST00000514710, ENST00000515836, ENST00000860913, ENST00000918117, ENST00000958683

RefSeq mRNA: 3 — MANE Select: NM_018115 NM_001288983, NM_001288984, NM_018115

CCDS: CCDS3573, CCDS75147

Canonical transcript exons

ENST00000356260 — 22 exons

Exon	Start	End
ENSE00001790296	75990752	75990945
ENSE00001895725	75949915	75950797
ENSE00003459971	75955975	75956136
ENSE00003490146	75973317	75973391
ENSE00003490526	75975924	75975995
ENSE00003508074	75957847	75957941
ENSE00003509135	75981933	75982037
ENSE00003514430	75960066	75960192
ENSE00003526967	75974076	75974133
ENSE00003534949	75964135	75964211
ENSE00003543809	75961211	75961308
ENSE00003549547	75965764	75965822
ENSE00003552458	75957518	75957708
ENSE00003574410	75971357	75971458
ENSE00003587373	75961028	75961104
ENSE00003605589	75977646	75977756
ENSE00003624460	75967277	75967334
ENSE00003629859	75981372	75981470
ENSE00003630313	75969296	75969399
ENSE00003644482	75970309	75970378
ENSE00003645847	75975744	75975844
ENSE00003656296	75957325	75957409

Expression profiles

Bgee: expression breadth ubiquitous, 280 present calls, max score 97.50.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 28.7151 / max 338.3372, expressed in 1805 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
52611	28.7151	1805

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	97.50	gold quality
secondary oocyte	CL:0000655	93.79	gold quality
oocyte	CL:0000023	93.40	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	93.08	gold quality
calcaneal tendon	UBERON:0003701	92.82	gold quality
islet of Langerhans	UBERON:0000006	91.03	gold quality
CA1 field of hippocampus	UBERON:0003881	90.70	gold quality
body of pancreas	UBERON:0001150	90.49	gold quality
hair follicle	UBERON:0002073	90.42	silver quality
smooth muscle tissue	UBERON:0001135	89.98	gold quality
diaphragm	UBERON:0001103	89.97	silver quality
gastrocnemius	UBERON:0001388	89.95	gold quality
pancreas	UBERON:0001264	89.94	gold quality
postcentral gyrus	UBERON:0002581	89.50	gold quality
cortical plate	UBERON:0005343	89.49	gold quality
adrenal tissue	UBERON:0018303	89.34	gold quality
muscle of leg	UBERON:0001383	89.28	gold quality
popliteal artery	UBERON:0002250	89.20	gold quality
ventricular zone	UBERON:0003053	89.18	gold quality
tibial artery	UBERON:0007610	89.18	gold quality
lymph node	UBERON:0000029	89.13	gold quality
rectum	UBERON:0001052	89.08	gold quality
decidua	UBERON:0002450	89.08	gold quality
ganglionic eminence	UBERON:0004023	88.91	gold quality
parietal lobe	UBERON:0001872	88.86	gold quality
prefrontal cortex	UBERON:0000451	88.84	gold quality
leukocyte	CL:0000738	88.82	gold quality
tendon	UBERON:0000043	88.82	gold quality
monocyte	CL:0000576	88.74	gold quality
mononuclear cell	CL:0000842	88.73	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-134144	yes	26.44
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

58 targeting SDAD1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-129-5P	99.88	70.26	3273
HSA-MIR-5003-3P	99.85	69.29	2517
HSA-MIR-548AZ-5P	99.83	69.94	3230
HSA-MIR-548T-5P	99.83	69.91	3220
HSA-MIR-139-5P	99.80	69.50	1399
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248
HSA-MIR-34B-5P	99.78	67.56	1175
HSA-MIR-449C-5P	99.78	67.63	1168
HSA-MIR-3680-3P	99.75	72.51	3095
HSA-MIR-2682-5P	99.73	67.38	1055
HSA-MIR-3714	99.71	70.74	2671
HSA-MIR-1179	99.71	68.70	1040
HSA-MIR-548AU-3P	99.70	68.22	1373
HSA-MIR-1197	99.70	67.75	1027
HSA-MIR-466	99.67	70.85	2863
HSA-MIR-4328	99.57	71.06	4094
HSA-MIR-203A-3P	99.49	70.56	2806

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 94.6% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 3)

• hSDA is the human ortholog of the yeast SDA1 gene (PMID:14976432)
• PUM2 and DAZL, are capable of binding the same mRNA sequences in the 3’UTR of human SDAD1 mRNA. (PMID:15607425)
• miR-378 inhibits the proliferation, migration and invasion of colon cancer cells by targeting SDAD1. (PMID:28725241)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	sdad1	ENSDARG00000105117
mus_musculus	Sdad1	ENSMUSG00000029415
rattus_norvegicus	Sdad1	ENSRNOG00000022229
drosophila_melanogaster	Mys45A	FBGN0033379
caenorhabditis_elegans		WBGENE00012676

Protein

Protein identifiers

Protein SDA1 homolog — Q9NVU7 (reviewed: Q9NVU7)

Alternative names: Nucleolar protein 130, SDA1 domain-containing protein 1

All UniProt accessions (5): D6RC74, D6RIR5, E7EW05, Q9NVU7, F8W8T7

UniProt curated annotations — full annotation on UniProt →

Function. Required for 60S pre-ribosomal subunits export to the cytoplasm.

Subcellular location. Nucleus. Nucleolus.

Tissue specificity. Highly expressed in testis, kidney, spleen, brain and fetal tissues. Also expressed at lower level in heart, lung, liver, small intestine, ovary, uterus, mammary gland and placenta.

Polymorphism. Variations in SDAD1 may be a cause of susceptibility to seasonal allergic rhinitis (SAR). SAR is a common allergic disorder characterized by episodes of sneezing, rhinorrhea, and swelling of the nasal mucosa.

Miscellaneous. DAZL and PUM2 bind its 3’-UTR mRNA, suggesting that these proteins may regulate its translation.

Similarity. Belongs to the SDA1 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9NVU7-1	1	yes
Q9NVU7-2	2

RefSeq proteins (3): NP_001275912, NP_001275913, NP_060585* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007949	SDA1_MD	Domain
IPR012977	SDA1_N	Domain
IPR016024	ARM-type_fold	Homologous_superfamily
IPR027312	Sda1	Family
IPR048292	SDA1_C	Domain

Pfam: PF05285, PF08158, PF21638

UniProt features (23 total): sequence conflict 7, modified residue 6, sequence variant 4, region of interest 2, chain 1, splice variant 1, coiled-coil region 1, compositionally biased region 1

Structure

Experimental structures (PDB)

7 structures.

PDB	Method	Resolution (Å)
8FL3	ELECTRON MICROSCOPY	2.53
8FL2	ELECTRON MICROSCOPY	2.67
8FL4	ELECTRON MICROSCOPY	2.89
8IDY	ELECTRON MICROSCOPY	3
8INF	ELECTRON MICROSCOPY	3
8INK	ELECTRON MICROSCOPY	3.2
8IPY	ELECTRON MICROSCOPY	3.2

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NVU7-F1	78.64	0.34

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (6): 595, 232, 234, 236, 552, 585

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 117 (showing top): GOBP_RIBOSOME_BIOGENESIS, MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP, GOBP_NUCLEAR_TRANSPORT, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, GOBP_NUCLEAR_EXPORT, GOBP_ORGANELLE_LOCALIZATION, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, GOBP_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS, IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR, chr4q21, GOCC_NUCLEOLUS, MATSUDA_NATURAL_KILLER_DIFFERENTIATION, HAMAI_APOPTOSIS_VIA_TRAIL_UP, GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN, GOBP_RIBOSOMAL_LARGE_SUBUNIT_EXPORT_FROM_NUCLEUS

GO Biological Process (4): ribosomal large subunit export from nucleus (GO:0000055), protein transport (GO:0015031), ribosomal large subunit biogenesis (GO:0042273), ribosome biogenesis (GO:0042254)

GO Molecular Function (0):

GO Cellular Component (3): nucleoplasm (GO:0005654), nucleolus (GO:0005730), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
ribonucleoprotein complex biogenesis	2
nuclear lumen	2
ribosomal subunit export from nucleus	1
transport	1
intracellular protein localization	1
establishment of protein localization	1
ribosome biogenesis	1
cellular anatomical structure	1
intracellular membraneless organelle	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

2958 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SDAD1	ZNF512	Q96ME7	623
SDAD1	ZNF451	Q9Y4E5	606
SDAD1	DHRS9	Q9BPW9	571
SDAD1	RPF2	Q9H7B2	564
SDAD1	RRP15	Q9Y3B9	557
SDAD1	ZNF362	Q5T0B9	552
SDAD1	DCUN1D3	Q8IWE4	503
SDAD1	KLHL8	Q9P2G9	485
SDAD1	BYSL	Q13895	484
SDAD1	DCUN1D4	Q92564	473
SDAD1	FAM13C	Q8NE31	471
SDAD1	RSL24D1	Q9UHA3	470
SDAD1	NSA2	O95478	469
SDAD1	RRP7A	Q9Y3A4	459
SDAD1	LRIF1	Q5T3J3	455

IntAct

120 interactions, top by confidence:

A	B	Type	Score
NEMP1	RGPD8	psi-mi:“MI:0914”(association)	0.640
KPNA1	TCERG1	psi-mi:“MI:0914”(association)	0.640
PLEKHO1	UBA6	psi-mi:“MI:0914”(association)	0.530
MECP2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MAGEB10	GTPBP10	psi-mi:“MI:0914”(association)	0.530
ZNF512	ZNF724	psi-mi:“MI:0914”(association)	0.530
RBM34	NVL	psi-mi:“MI:0914”(association)	0.530
RPL18A	RRP8	psi-mi:“MI:0914”(association)	0.530
NAP1L1	RPL17	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
RBBP4	TNRC18	psi-mi:“MI:0914”(association)	0.530
NAP1L1	FNTB	psi-mi:“MI:0914”(association)	0.530
MAGEB2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
ABT1	ZNF316	psi-mi:“MI:0914”(association)	0.530
DDX21	MED19	psi-mi:“MI:2364”(proximity)	0.480
H3C1	SMCHD1	psi-mi:“MI:2364”(proximity)	0.410
GATA3	PRMT5	psi-mi:“MI:0914”(association)	0.350
MKI67	ARHGAP10	psi-mi:“MI:0914”(association)	0.350
		psi-mi:“MI:0914”(association)	0.350
OAS3	PTBP1	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
LRRK2		psi-mi:“MI:0914”(association)	0.350
TXNDC15	ORC4	psi-mi:“MI:0914”(association)	0.350
CDX1	ZNF724	psi-mi:“MI:0914”(association)	0.350
FGF8	ANKHD1	psi-mi:“MI:0914”(association)	0.350
RPS14	RRP8	psi-mi:“MI:0914”(association)	0.350

BioGRID (196): SDAD1 (Affinity Capture-MS), SDAD1 (Affinity Capture-MS), SDAD1 (Affinity Capture-MS), SDAD1 (Affinity Capture-MS), SDAD1 (Co-fractionation), SDAD1 (Co-fractionation), SDAD1 (Co-fractionation), SDAD1 (Co-fractionation), SDAD1 (Co-fractionation), SDAD1 (Co-fractionation), SDAD1 (Co-fractionation), SDAD1 (Affinity Capture-MS), SDAD1 (Affinity Capture-RNA), SDAD1 (Proximity Label-MS), SDAD1 (Proximity Label-MS)

ESM2 similar proteins: A4IIB1, A5D7C2, A7S6A5, A7SWH1, A8WWU0, B5X171, F4IDJ0, G0S215, O01757, O02328, O36021, O42832, O44411, P25582, P53313, P53569, P91136, Q03701, Q07896, Q10342, Q19753, Q2VPG3, Q4VBT2, Q55DE2, Q5RJT2, Q5XGZ8, Q5XIQ5, Q61LN7, Q6BNQ8, Q6C9Q1, Q6CV12, Q6DEV3, Q6FX63, Q6NRQ2, Q6NU91, Q6NV26, Q751U1, Q7KKH3, Q80UZ2, Q9C6I8

Diamond homologs: A4IIB1, A5D7C2, A7S6A5, G0S215, P53313, Q10342, Q2VPG3, Q55DE2, Q5XIQ5, Q6NV26, Q7KKH3, Q80UZ2, Q9NEU2, Q9NVU7

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 151 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Eukaryotic Translation Initiation	8	24.0×	3e-08
Cap-dependent Translation Initiation	8	24.0×	3e-08
SARS-CoV-1 modulates host translation machinery	8	24.0×	3e-08
Peptide chain elongation	19	23.4×	2e-19
Viral mRNA Translation	19	23.4×	2e-19
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	19	23.1×	3e-19
SRP-dependent cotranslational protein targeting to membrane	23	22.4×	2e-22
Selenocysteine synthesis	19	22.2×	5e-19

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	22	29.7×	8e-24
ribosomal small subunit biogenesis	12	19.9×	3e-10
ribosomal large subunit biogenesis	5	16.2×	2e-03
translation	20	15.0×	2e-15
rRNA processing	12	12.4×	6e-08
chromatin remodeling	9	4.8×	1e-02

Disease & clinical

Clinical variants and AI predictions

ClinVar

128 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	96
Likely benign	3
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

3570 predictions. Top by Δscore:

Variant	Effect	Δscore
4:75956132:CCAGC:C	acceptor_gain	1.0000
4:75956133:CAGCC:C	acceptor_gain	1.0000
4:75956135:GCCTA:G	acceptor_loss	1.0000
4:75956137:C:CC	acceptor_gain	1.0000
4:75957319:A:AC	donor_gain	1.0000
4:75957320:C:CC	donor_gain	1.0000
4:75957320:CT:C	donor_gain	1.0000
4:75957320:CTCA:C	donor_gain	1.0000
4:75957321:TCACC:T	donor_loss	1.0000
4:75957322:CA:C	donor_loss	1.0000
4:75957323:A:AC	donor_gain	1.0000
4:75957323:AC:A	donor_gain	1.0000
4:75957324:C:CA	donor_loss	1.0000
4:75957324:C:CC	donor_gain	1.0000
4:75957324:CC:C	donor_gain	1.0000
4:75957405:CACCC:C	acceptor_gain	1.0000
4:75957407:CCC:C	acceptor_gain	1.0000
4:75957408:CC:C	acceptor_gain	1.0000
4:75957408:CCC:C	acceptor_gain	1.0000
4:75957409:CC:C	acceptor_gain	1.0000
4:75957410:C:CC	acceptor_gain	1.0000
4:75957411:T:A	acceptor_loss	1.0000
4:75957415:G:C	acceptor_gain	1.0000
4:75957709:C:CC	acceptor_gain	1.0000
4:75957710:T:C	acceptor_gain	1.0000
4:75957710:T:TC	acceptor_gain	1.0000
4:75957843:TTA:T	donor_loss	1.0000
4:75957844:T:TG	donor_loss	1.0000
4:75957845:A:AC	donor_gain	1.0000
4:75957846:C:CT	donor_gain	1.0000

AlphaMissense

4627 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:75964171:A:T	V382D	1.000
4:75957340:T:A	R613S	0.999
4:75957340:T:G	R613S	0.999
4:75961089:G:T	A432D	0.999
4:75961301:C:G	A397P	0.999
4:75964135:C:T	G394E	0.999
4:75964136:C:G	G394R	0.999
4:75964136:C:T	G394R	0.999
4:75964173:A:C	F381L	0.999
4:75964173:A:T	F381L	0.999
4:75964174:A:G	F381S	0.999
4:75964175:A:G	F381L	0.999
4:75975745:A:G	W193R	0.999
4:75975745:A:T	W193R	0.999
4:75975762:A:G	L187P	0.999
4:75990786:A:G	L19P	0.999
4:75950782:C:G	A678P	0.998
4:75957341:C:G	R613T	0.998
4:75961240:A:G	L417P	0.998
4:75974116:A:T	V199D	0.998
4:75974133:C:A	W193C	0.998
4:75974133:C:G	W193C	0.998
4:75977650:C:G	R134P	0.998
4:75990777:C:G	R22P	0.998
4:75956033:A:G	M653T	0.997
4:75961065:C:G	R440P	0.997
4:75961090:C:G	A432P	0.997
4:75961101:A:T	V428E	0.997
4:75961297:A:T	I398K	0.997
4:75964135:C:A	G394V	0.997

dbSNP variants (sampled 300 via entrez): RS1000124122 (4:75949462 C>A), RS1000170419 (4:75950178 G>A), RS1000225081 (4:75949871 G>A), RS1000242925 (4:75991061 G>A,T), RS1000250167 (4:75960714 A>T), RS1000322121 (4:75978985 A>C,G), RS1000339139 (4:75966460 G>GACAA), RS1000378451 (4:75955881 C>T), RS1000485113 (4:75961972 A>G), RS1000504681 (4:75990284 C>A,G,T), RS1000531524 (4:75985073 T>C,G), RS1000640195 (4:75965103 A>G), RS1000680502 (4:75972770 C>G), RS1000681971 (4:75949558 C>G), RS1000788016 (4:75960661 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST000785_38	Longevity	1.000000e-06
GCST007009_3	Hippocampal volume	7.000000e-07
GCST009204_2	Total intracranial volume	7.000000e-07

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0005035	hippocampal volume
EFO:0004886	intracranial volume measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067199 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

4 potent at pChembl≥5 of 4 total, top 4 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
9.07	Kd	0.852	nM	CHEMBL5653589
9.02	ED50	0.949	nM	CHEMBL5653589
7.23	Kd	58.34	nM	CHEMBL3752910
7.19	ED50	65.03	nM	CHEMBL3752910

PubChem BioAssay actives

2 with measured affinity, of 4 total; 2 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149355: Binding affinity to human SDAD1 incubated for 45 mins by Kinobead based pull down assay	kd	0.0009	uM
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149355: Binding affinity to human SDAD1 incubated for 45 mins by Kinobead based pull down assay	kd	0.0583	uM

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	increases abundance, decreases expression, affects expression	2
Cyclosporine	increases expression	2
Cadmium Chloride	decreases expression	2
aristolochic acid I	decreases expression	1
FR900359	increases phosphorylation	1
bisphenol F	affects cotreatment, increases expression	1
alpha phellandrene	decreases expression	1
triphenyl phosphate	affects expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
K 7174	increases expression	1
bisphenol S	affects cotreatment, decreases expression	1
jinfukang	decreases expression	1
Resveratrol	affects cotreatment, decreases expression, increases expression	1
Sunitinib	increases expression	1
Acetaminophen	decreases expression	1
Air Pollutants, Occupational	decreases expression	1
Dexamethasone	affects cotreatment, increases expression, decreases expression	1
Diethylstilbestrol	increases expression	1
Estradiol	increases expression	1
Indomethacin	affects cotreatment, increases expression, decreases expression	1
Mustard Gas	increases phosphorylation	1
Nickel	decreases expression	1
Ozone	affects expression, increases abundance	1
Plant Extracts	affects cotreatment, decreases expression, increases expression	1
Ribonucleotides	affects binding	1
Rotenone	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	decreases expression	1
Valproic Acid	decreases methylation	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652397	Binding	Binding affinity to human SDAD1 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.