SDCBP2-AS1

Summary

SDCBP2-AS1 (SDCBP2 antisense RNA 1, HGNC:44314) is a long non-coding RNA gene on chromosome 20p13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44314
Approved symbol	SDCBP2-AS1
Name	SDCBP2 antisense RNA 1
Location	20p13
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000234684
Ensembl biotype	lncRNA
Entrez	100507495
RNAcentral	URS000075CB0D — lncRNA, 2509 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 lncRNA

ENST00000446423, ENST00000607947, ENST00000609285, ENST00000609470, ENST00000609745, ENST00000653665, ENST00000658491, ENST00000665859, ENST00000670879, ENST00000740644, ENST00000740645, ENST00000740646, ENST00000740647, ENST00000740648, ENST00000740649

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000446423 — 4 exons

Exon	Start	End
ENSE00001645549	1373078	1373178
ENSE00001700855	1374484	1374698
ENSE00003711363	1325419	1325529
ENSE00003986038	1376798	1378735

Expression profiles

Bgee: expression breadth ubiquitous, 203 present calls, max score 83.06.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.8905 / max 97.5973, expressed in 1783 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
183096	10.6349	1781
183097	0.2556	97

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	83.06	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.76	gold quality
colonic epithelium	UBERON:0000397	81.77	gold quality
bone marrow cell	CL:0002092	81.60	gold quality
adrenal tissue	UBERON:0018303	80.51	gold quality
adenohypophysis	UBERON:0002196	80.47	gold quality
right adrenal gland cortex	UBERON:0035827	79.74	gold quality
pituitary gland	UBERON:0000007	79.65	gold quality
right adrenal gland	UBERON:0001233	79.52	gold quality
left adrenal gland	UBERON:0001234	79.30	gold quality
left adrenal gland cortex	UBERON:0035825	79.02	gold quality
right lobe of thyroid gland	UBERON:0001119	78.40	gold quality
oviduct epithelium	UBERON:0004804	78.32	gold quality
left lobe of thyroid gland	UBERON:0001120	78.10	gold quality
adrenal gland	UBERON:0002369	77.98	gold quality
calcaneal tendon	UBERON:0003701	77.75	gold quality
adrenal cortex	UBERON:0001235	77.73	gold quality
thyroid gland	UBERON:0002046	77.41	gold quality
left ovary	UBERON:0002119	77.34	gold quality
right lung	UBERON:0002167	77.23	gold quality
metanephros cortex	UBERON:0010533	77.13	gold quality
monocyte	CL:0000576	77.04	gold quality
right ovary	UBERON:0002118	76.88	gold quality
islet of Langerhans	UBERON:0000006	76.86	gold quality
tendon	UBERON:0000043	76.83	gold quality
sperm	CL:0000019	76.61	gold quality
leukocyte	CL:0000738	76.58	gold quality
left uterine tube	UBERON:0001303	76.44	gold quality
tibia	UBERON:0000979	76.37	gold quality
right testis	UBERON:0004534	76.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.63

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Long non-coding RNA SDCBP2-AS1 delays the progression of ovarian cancer via microRNA-100-5p-targeted EPDR1. (PMID:34218800)
• SDCBP-AS1 destabilizes beta-catenin by regulating ubiquitination and SUMOylation of hnRNP K to suppress gastric tumorigenicity and metastasis. (PMID:36209503)
• Silencing of long non-coding RNA SDCBP2-AS1/microRNA-656-3p/CRIM1 axis promotes ferroptosis of lung cancer cells. (PMID:37807311)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.