SDE2

Summary

SDE2 (spliceosome associated SDE2, HGNC:26643) is a protein-coding gene on chromosome 1q42.12, encoding Splicing regulator SDE2 (Q6IQ49). Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress. It is a common-essential gene (DepMap: required in 100.0% of cancer cell lines).

Enables damaged DNA binding activity and snoRNA binding activity. Involved in several processes, including cellular response to UV; gene expression; and mitotic G1 DNA damage checkpoint signaling. Located in several cellular components, including Golgi apparatus; cytosol; and nuclear speck.

Source: NCBI Gene 163859 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 67 total
• Cancer dependency (DepMap): dependent in 100.0% of screened cell lines (common-essential)
• MANE Select transcript: NM_152608

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26643
Approved symbol	SDE2
Name	spliceosome associated SDE2
Location	1q42.12
Locus type	gene with protein product
Status	Approved
Aliases	FLJ35382
Ensembl gene	ENSG00000143751
Ensembl biotype	protein_coding
OMIM	620743
Entrez	163859

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000272091, ENST00000921002

RefSeq mRNA: 1 — MANE Select: NM_152608 NM_152608

CCDS: CCDS41473

Canonical transcript exons

ENST00000272091 — 7 exons

Exon	Start	End
ENSE00000961804	225992891	225993002
ENSE00000961805	225992398	225992567
ENSE00001205040	225987896	225988388
ENSE00001205057	225991243	225991363
ENSE00001902148	225982702	225985523
ENSE00001935405	225999193	225999343
ENSE00003689286	225995266	225995383

Expression profiles

Bgee: expression breadth ubiquitous, 258 present calls, max score 97.66.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 22.6362 / max 471.9752, expressed in 1814 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
17738	22.6362	1814

Top tissues by expression

259 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	97.66	gold quality
oocyte	CL:0000023	96.18	gold quality
tibialis anterior	UBERON:0001385	95.50	gold quality
deltoid	UBERON:0001476	94.24	silver quality
lower lobe of lung	UBERON:0008949	93.68	gold quality
epithelial cell of pancreas	CL:0000083	93.64	silver quality
pericardium	UBERON:0002407	93.45	gold quality
thymus	UBERON:0002370	93.18	gold quality
trabecular bone tissue	UBERON:0002483	93.04	gold quality
adult organism	UBERON:0007023	93.04	gold quality
palpebral conjunctiva	UBERON:0001812	92.94	gold quality
upper leg skin	UBERON:0004262	92.62	gold quality
skin of hip	UBERON:0001554	92.16	gold quality
ileal mucosa	UBERON:0000331	92.15	gold quality
sperm	CL:0000019	91.87	gold quality
seminal vesicle	UBERON:0000998	91.78	gold quality
parietal pleura	UBERON:0002400	91.19	gold quality
germinal epithelium of ovary	UBERON:0001304	91.05	gold quality
cauda epididymis	UBERON:0004360	90.76	gold quality
bone marrow	UBERON:0002371	90.61	gold quality
cardiac muscle of right atrium	UBERON:0003379	90.53	silver quality
visceral pleura	UBERON:0002401	90.28	gold quality
caput epididymis	UBERON:0004358	90.26	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	90.25	gold quality
vena cava	UBERON:0004087	90.11	gold quality
epithelium of nasopharynx	UBERON:0001951	89.68	gold quality
nasopharynx	UBERON:0001728	89.67	gold quality
biceps brachii	UBERON:0001507	89.60	gold quality
epithelium of mammary gland	UBERON:0003244	89.51	gold quality
cartilage tissue	UBERON:0002418	89.50	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.85
E-MTAB-6386	no	360.91
E-GEOD-70580	no	139.23
E-CURD-112	no	2.39

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

122 targeting SDE2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-3617-3P	99.98	67.86	918
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AQ-5P	99.94	71.34	3426

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 100.0% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 5)

• collectively, this study uncovers a new role for CRL4CDT2 in protecting genomic integrity against replication stress via regulated proteolysis of PCNA-associated SDE2 and provides insights into how an integrated UBL domain within linear polypeptide sequence controls protein stability and function. (PMID:27906959)
• Conditional degradation of SDE2 by the Arg/N-End rule pathway regulates stress response at replication forks. (PMID:30698750)
• SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks. (PMID:33127907)
• SDE2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing. (PMID:34365507)
• Extended DNA-binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks. (PMID:35850305)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	sde2	ENSDARG00000024124
mus_musculus	Sde2	ENSMUSG00000038806
rattus_norvegicus	Sde2	ENSRNOG00000003247
drosophila_melanogaster	CG5986	FBGN0043455
caenorhabditis_elegans		WBGENE00009996

Paralogs (1): SF3A3 (ENSG00000183431)

Protein

Protein identifiers

Splicing regulator SDE2 — Q6IQ49 (reviewed: Q6IQ49)

Alternative names: Replication stress response regulator SDE2

All UniProt accessions (1): Q6IQ49

UniProt curated annotations — full annotation on UniProt →

Function. Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress. SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage. Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3’-splice sites (ss) and high GC content. May recruit CACTIN to the spliceosome. Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor. Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118.

Subunit / interactions. Interacts (via PIP-box) with PCNA; the interaction is direct and prevents ultraviolet light induced monoubiquitination of PCNA. Interacts with FBL/fibrillarin. Interacts with CACTIN. Interacts with SF3B1. Interacts with U2AF1.

Subcellular location. Nucleus. Cytoplasm.

Tissue specificity. Ubiquitously expressed; enriched in brain, lung and liver.

Post-translational modifications. Upon binding to PCNA, the N-terminal UBL (ubiquitin-like) propeptide is cleaved at Gly-77 by an unidentified deubiquitinating enzyme; the resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner. Both SDE2-UBL and the mature SDE2 are polyubiquitinated.

Domain organisation. The PIP-box (PCNA interacting peptide) motif mediates both the interaction with PCNA and cleavage of the SDE2 precursor by a deubiquitinating enzyme. The SAP domain is necessary for specific binding to DNA. The propeptide displays a ubiquitin-like fold.

Similarity. Belongs to the SDE2 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q6IQ49-1	1	yes
Q6IQ49-2	2
Q6IQ49-3	3

RefSeq proteins (1): NP_689821* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR025086	SDE2/SF3A3_SAP	Domain
IPR051421	RNA_Proc_DNA_Dmg_Regulator	Family
IPR053821	Sde2_Ubi	Domain
IPR053822	SDE2-like_dom	Domain

Pfam: PF13297, PF22781, PF22782

UniProt features (29 total): modified residue 5, helix 4, mutagenesis site 3, splice variant 2, sequence conflict 2, turn 2, region of interest 2, compositionally biased region 2, propeptide 1, chain 1, sequence variant 1, domain 1, coiled-coil region 1, short sequence motif 1, site 1

Structure

Experimental structures (PDB)

5 structures.

PDB	Method	Resolution (Å)
8C6J	ELECTRON MICROSCOPY	2.8
6QDV	ELECTRON MICROSCOPY	3.3
9FMD	ELECTRON MICROSCOPY	3.3
8RO2	ELECTRON MICROSCOPY	3.5
7N99	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6IQ49-F1	65.59	0.21

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 77–78 (cleavage)

Post-translational modifications (5): 266, 274, 278, 319, 326

Mutagenesis-validated functional residues (3):

Position	Phenotype
47–48	no binding to pcna; no cleavage at gly-77.
76–77	no cleavage at gly-77.
78	no effect on cleavage at gly-77.

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-72163	mRNA Splicing - Major Pathway
R-HSA-72172	mRNA Splicing
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA
R-HSA-8953854	Metabolism of RNA

MSigDB gene sets: 212 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_UP, GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_DN, GSE45365_NK_CELL_VS_BCELL_UP, GOBP_RIBOSOME_BIOGENESIS, GOBP_CELLULAR_RESPONSE_TO_UV, GOBP_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS, GOBP_CELL_CYCLE_PHASE_TRANSITION, MAZ_Q6, GOBP_PROTEIN_MATURATION, GOBP_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS, GOBP_NEGATIVE_REGULATION_OF_CELL_CYCLE, REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA, GOBP_REGULATION_OF_CELL_CYCLE, GOBP_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION, GOBP_CELL_CYCLE_G1_S_PHASE_TRANSITION

GO Biological Process (11): endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000479), DNA replication (GO:0006260), protein processing (GO:0016485), protein ubiquitination (GO:0016567), mitotic G1 DNA damage checkpoint signaling (GO:0031571), cellular response to UV (GO:0034644), mRNA cis splicing, via spliceosome (GO:0045292), cell division (GO:0051301), mRNA processing (GO:0006397), RNA splicing (GO:0008380), ribosome biogenesis (GO:0042254)

GO Molecular Function (5): damaged DNA binding (GO:0003684), snoRNA binding (GO:0030515), DNA binding (GO:0003677), RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (8): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), mitochondrion (GO:0005739), Golgi apparatus (GO:0005794), cytosol (GO:0005829), plasma membrane (GO:0005886), nuclear speck (GO:0016607)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
mRNA Splicing	1
Processing of Capped Intron-Containing Pre-mRNA	1
Metabolism of RNA	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membrane-bounded organelle	3
cellular anatomical structure	3
cytoplasm	3
RNA processing	2
nucleic acid binding	2
rRNA processing	1
DNA metabolic process	1
DNA biosynthetic process	1
proteolysis	1
protein maturation	1
protein modification by small protein conjugation	1
mitotic G1 phase	1
mitotic DNA damage checkpoint signaling	1
mitotic G1/S transition checkpoint signaling	1
response to UV	1
cellular response to light stimulus	1
mRNA splicing, via spliceosome	1
cellular process	1
mRNA metabolic process	1
ribonucleoprotein complex biogenesis	1
DNA binding	1
RNA binding	1
binding	1
nuclear lumen	1
intracellular anatomical structure	1
endomembrane system	1
membrane	1
cell periphery	1
nuclear ribonucleoprotein granule	1

Protein interactions and networks

STRING

804 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SDE2	CDC5L	Q99459	667
SDE2	PRKRIP1	Q9H875	595
SDE2	CACTIN	Q8WUQ7	591
SDE2	FAM32A	Q9Y421	575
SDE2	SPRTN	Q9H040	508
SDE2	SLU7	O95391	487
SDE2	YJU2	Q9BW85	474
SDE2	SPEG	Q15772	471
SDE2	GART	P22102	469
SDE2	CRNKL1	Q9BZJ0	464
SDE2	GNL3L	Q9NVN8	461
SDE2	OR1M1	Q8NGA1	455
SDE2	RTF2	Q9BY42	452
SDE2	CENPU	Q71F23	451
SDE2	UBXN7	O94888	450

IntAct

12 interactions, top by confidence:

A	B	Type	Score
MED4	MED19	psi-mi:“MI:0914”(association)	0.900
SDE2	HSPBAP1	psi-mi:“MI:0915”(physical association)	0.500
SLX4	SMAP	psi-mi:“MI:0914”(association)	0.350
SDE2	HOXB6	psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
H2BC10	SMCHD1	psi-mi:“MI:2364”(proximity)	0.270
GPKOW	ESYT2	psi-mi:“MI:2364”(proximity)	0.270
HNRNPC	SBNO1	psi-mi:“MI:2364”(proximity)	0.270
SF3B4	MED19	psi-mi:“MI:2364”(proximity)	0.270
SUPV3L1	BLTP3B	psi-mi:“MI:2364”(proximity)	0.270
HNRNPA1	CNOT1	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (43): SDE2 (Proximity Label-MS), SDE2 (Affinity Capture-MS), SDE2 (Affinity Capture-MS), SDE2 (Affinity Capture-MS), SDE2 (Affinity Capture-MS), SDE2 (Affinity Capture-MS), SDE2 (Affinity Capture-MS), SDE2 (Reconstituted Complex), DTL (Affinity Capture-Western), SDE2 (Affinity Capture-MS), SDE2 (Affinity Capture-RNA), SDE2 (Affinity Capture-MS), HSPBAP1 (Affinity Capture-MS), HOXA5 (Affinity Capture-MS), HOXB6 (Affinity Capture-MS)

ESM2 similar proteins: A0A1L8ENT6, A2BGP7, A2CJ06, B1H1W9, F6RRD7, O00124, O55036, P54274, Q1LV50, Q1LWH4, Q1T7B8, Q28HU3, Q3KNJ2, Q3U1D0, Q3US16, Q4KLN8, Q4V832, Q5I0E6, Q5I2W8, Q5NVA9, Q5RA37, Q5RET9, Q5XI46, Q5ZIN2, Q6AYI4, Q6DRL4, Q6IQ49, Q6IRN0, Q6NV18, Q6P1H6, Q7Z2Z1, Q7Z4M0, Q8BJW7, Q8BKT3, Q8BMG1, Q8BMI4, Q8BQ33, Q8IXW5, Q8K1J5, Q8VC34

Diamond homologs: O14113, Q07G43, Q5BJN8, Q5RET9, Q6IQ49, Q6NRI5, Q7T293, Q8K1J5, O46106, O59706, Q12874, Q9D554, Q9FG01, P19736

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
DTL	“down-regulates quantity by destabilization”	SDE2	binding
Cullin4-RBX1-DDB1	“down-regulates quantity by destabilization”	SDE2	polyubiquitination

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 18 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Dengue Virus-Host Interactions	5	19.0×	4e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

67 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	58
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1067 predictions. Top by Δscore:

Variant	Effect	Δscore
1:225985304:A:AC	donor_gain	1.0000
1:225985313:T:TA	donor_gain	1.0000
1:225985314:C:A	donor_gain	1.0000
1:225987890:A:AC	donor_gain	1.0000
1:225987891:C:CC	donor_gain	1.0000
1:225987891:CTTA:C	donor_gain	1.0000
1:225987892:TTA:T	donor_loss	1.0000
1:225987894:A:AC	donor_gain	1.0000
1:225987894:ACTG:A	donor_gain	1.0000
1:225987895:C:CT	donor_gain	1.0000
1:225987895:CT:C	donor_gain	1.0000
1:225987895:CTG:C	donor_gain	1.0000
1:225987895:CTGC:C	donor_gain	1.0000
1:225987895:CTGCG:C	donor_gain	1.0000
1:225987915:T:A	donor_gain	1.0000
1:225991238:CTTA:C	donor_loss	1.0000
1:225991239:TTAC:T	donor_loss	1.0000
1:225991240:TACCA:T	donor_loss	1.0000
1:225991241:A:AC	donor_gain	1.0000
1:225991241:AC:A	donor_gain	1.0000
1:225991241:ACCA:A	donor_loss	1.0000
1:225991242:C:CT	donor_gain	1.0000
1:225991242:CC:C	donor_gain	1.0000
1:225991242:CCA:C	donor_gain	1.0000
1:225991242:CCAG:C	donor_gain	1.0000
1:225991242:CCAGA:C	donor_gain	1.0000
1:225991359:CATAC:C	acceptor_gain	1.0000
1:225991361:TAC:T	acceptor_gain	1.0000
1:225991362:AC:A	acceptor_gain	1.0000
1:225991363:CC:C	acceptor_gain	1.0000

AlphaMissense

2956 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:225992915:A:G	L109P	0.999
1:225992917:T:A	R108S	0.999
1:225992917:T:G	R108S	0.999
1:225992918:C:G	R108T	0.999
1:225992920:C:A	R107S	0.999
1:225992920:C:G	R107S	0.999
1:225992921:C:G	R107T	0.999
1:225992924:C:T	G106E	0.999
1:225992930:A:G	L104P	0.999
1:225992933:T:G	D103A	0.999
1:225992936:C:G	R102P	0.999
1:225992987:A:T	L85H	0.999
1:225992998:A:C	F81L	0.999
1:225992998:A:T	F81L	0.999
1:225993000:A:G	F81L	0.999
1:225992912:C:G	R110P	0.998
1:225992919:T:C	R108G	0.998
1:225992921:C:A	R107M	0.998
1:225992930:A:T	L104H	0.998
1:225992932:A:C	D103E	0.998
1:225992932:A:T	D103E	0.998
1:225992933:T:A	D103V	0.998
1:225992933:T:C	D103G	0.998
1:225992934:C:G	D103H	0.998
1:225992987:A:G	L85P	0.998
1:225992996:C:T	G82E	0.998
1:225992555:C:A	W121C	0.997
1:225992555:C:G	W121C	0.997
1:225992913:G:T	R110S	0.997
1:225992924:C:A	G106V	0.997

dbSNP variants (sampled 300 via entrez): RS1000195235 (1:225994095 T>G), RS1000204923 (1:225993788 G>A,C,T), RS1000458350 (1:225999654 A>G), RS1000514442 (1:225988983 G>A,C), RS1000519694 (1:225995502 T>G), RS1000815645 (1:225990332 T>C), RS1000846951 (1:225990023 C>T), RS1000976718 (1:225983471 T>C), RS1000982584 (1:225995203 T>C), RS1001037236 (1:225984585 T>G), RS1001087761 (1:225990105 C>A), RS1001101170 (1:225982974 A>G), RS1001140285 (1:225996589 C>T), RS1001183427 (1:225985597 C>T), RS1001422384 (1:225984236 A>G)

Disease associations

OMIM: gene MIM:620743 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

46 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cyclosporine	increases expression	3
sodium arsenite	increases abundance, increases expression	2
Arsenic	affects expression, increases abundance, increases expression	2
Tobacco Smoke Pollution	increases expression	2
aristolochic acid I	increases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
FR900359	increases phosphorylation	1
ginger extract	decreases expression, decreases reaction, increases abundance	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression, decreases reaction, increases abundance	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
cobaltous chloride	increases expression	1
butyraldehyde	increases expression	1
zinc chromate	increases abundance, increases expression	1
gossypol acetic acid	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
chromium hexavalent ion	increases abundance, increases expression	1
pentabromodiphenyl ether	increases expression	1
dimethylarsinous acid	increases expression	1
abrine	increases expression	1
elesclomol	increases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	increases expression	1
bisphenol S	increases methylation	1
jinfukang	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Leflunomide	increases expression	1
Acetaminophen	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Air Pollutants, Occupational	increases expression	1
Benzo(a)pyrene	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.