SEC22B

Summary

SEC22B (SEC22 homolog B, vesicle trafficking protein, HGNC:10700) is a protein-coding gene on chromosome 1p12, encoding Vesicle-trafficking protein SEC22b (O75396). SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. It is a common-essential gene (DepMap: required in 97.3% of cancer cell lines).

The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins.

Source: NCBI Gene 9554 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 97.3% of screened cell lines (common-essential)
• MANE Select transcript: NM_004892

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10700
Approved symbol	SEC22B
Name	SEC22 homolog B, vesicle trafficking protein
Location	1p12
Locus type	gene with protein product
Status	Approved
Aliases	ERS-24
Ensembl gene	ENSG00000265808
Ensembl biotype	protein_coding
OMIM	604029
Entrez	9554

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 protein_coding

ENST00000578049, ENST00000618538, ENST00000875746, ENST00000932119, ENST00000943846

RefSeq mRNA: 1 — MANE Select: NM_004892 NM_004892

CCDS: CCDS83523

Canonical transcript exons

ENST00000578049 — 5 exons

Exon	Start	End
ENSE00002687444	120163210	120163370
ENSE00002708696	120168840	120168949
ENSE00002722905	120160384	120160530
ENSE00002727263	120176307	120176520
ENSE00002732617	120150898	120157192

Expression profiles

Bgee: expression breadth ubiquitous, 204 present calls, max score 93.49.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 128.2116 / max 1469.1791, expressed in 1827 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
14106	112.8231	1827
14105	7.0924	1680
14104	4.6620	1581
14103	3.2605	1503
14102	0.3736	173

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	93.49	gold quality
body of pancreas	UBERON:0001150	91.86	gold quality
islet of Langerhans	UBERON:0000006	91.64	gold quality
stromal cell of endometrium	CL:0002255	91.47	gold quality
adenohypophysis	UBERON:0002196	91.23	gold quality
colonic epithelium	UBERON:0000397	90.98	gold quality
pancreas	UBERON:0001264	90.28	gold quality
rectum	UBERON:0001052	90.06	gold quality
adrenal tissue	UBERON:0018303	90.04	gold quality
monocyte	CL:0000576	89.79	gold quality
left adrenal gland	UBERON:0001234	89.76	gold quality
leukocyte	CL:0000738	89.64	gold quality
descending thoracic aorta	UBERON:0002345	89.59	gold quality
smooth muscle tissue	UBERON:0001135	89.55	gold quality
left adrenal gland cortex	UBERON:0035825	89.42	gold quality
right adrenal gland	UBERON:0001233	89.32	gold quality
thoracic aorta	UBERON:0001515	89.12	gold quality
ascending aorta	UBERON:0001496	89.09	gold quality
right adrenal gland cortex	UBERON:0035827	89.06	gold quality
endocervix	UBERON:0000458	89.02	gold quality
right coronary artery	UBERON:0001625	88.96	gold quality
pituitary gland	UBERON:0000007	88.83	gold quality
bone marrow cell	CL:0002092	88.78	gold quality
right lobe of liver	UBERON:0001114	88.72	gold quality
vermiform appendix	UBERON:0001154	88.70	gold quality
left coronary artery	UBERON:0001626	88.69	gold quality
tibial artery	UBERON:0007610	88.54	gold quality
aorta	UBERON:0000947	88.53	gold quality
popliteal artery	UBERON:0002250	88.53	gold quality
right lung	UBERON:0002167	88.40	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-GEOD-86618	no	916.83
E-MTAB-7303	no	452.51
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

135 targeting SEC22B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AR-5P	99.94	71.28	3515
HSA-MIR-548AS-5P	99.94	71.22	3482
HSA-MIR-548AU-5P	99.94	71.24	3488
HSA-MIR-548AY-5P	99.94	71.23	3502
HSA-MIR-548B-5P	99.94	71.23	3502
HSA-MIR-548BB-5P	99.94	71.27	3509

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 97.3% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 7)

• DrrA activation of the Rab1 GTPase on plasma membrane-derived organelles stimulated the tethering of endoplasmic reticulum-derived vesicles, resulting in vesicle fusion through the pairing of Sec22b with the plasma membrane syntaxin proteins. (PMID:22264512)
• Suggest that close apposition of the ER and plasma membrane mediated by Sec22b and plasma membrane syntaxins generates a non-fusogenic SNARE bridge contributing to plasma membrane expansion, probably through non-vesicular lipid transfer. (PMID:24705552)
• the target gene SEC22B regulated by miRNA-206 may play a key role in the progression and development of AD. (PMID:26082458)
• The endoplasmic reticulum protein SEC22B interacts with NBEAL2 and is required for megakaryocyte alpha-granule biogenesis. (PMID:32384141)
• The function of SEC22B and its role in human diseases. (PMID:32748571)
• Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B(+) vesicle pathway in liver cancer. (PMID:36044553)
• SEC22B inhibition attenuates colorectal cancer aggressiveness and autophagic flux under unfavorable environment. (PMID:37148741)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	sec22ba	ENSDARG00000030108
danio_rerio	sec22bb	ENSDARG00000100435
mus_musculus	Sec22b	ENSMUSG00000027879
rattus_norvegicus	Sec22b	ENSRNOG00000018673
drosophila_melanogaster	Sec22	FBGN0260855
caenorhabditis_elegans		WBGENE00018853

Paralogs (10): VAMP3 (ENSG00000049245), SEC22C (ENSG00000093183), YKT6 (ENSG00000106636), VAMP4 (ENSG00000117533), VAMP8 (ENSG00000118640), SEC22A (ENSG00000121542), VAMP7 (ENSG00000124333), VAMP1 (ENSG00000139190), VAMP5 (ENSG00000168899), VAMP2 (ENSG00000220205)

Protein

Protein identifiers

Vesicle-trafficking protein SEC22b — O75396 (reviewed: O75396)

Alternative names: ER-Golgi SNARE of 24 kDa, SEC22 vesicle-trafficking protein homolog B, SEC22 vesicle-trafficking protein-like 1

All UniProt accessions (2): O75396, A0A087X1A9

UniProt curated annotations — full annotation on UniProt →

Function. SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.

Subunit / interactions. Interacts with STX17. Component of two distinct SNARE complexes consisting of STX5, GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L, BNIP1/SEC20L and SEC22B. YKT6 can probably replace SEC22B in either complex. Interacts with the COPII Sec23/24 complex composed of SEC23A and SEC24A; recruits SEC22B into COPII-coated vesicles to allow its transport from the endoplasmic reticulum to the Golgi. Interacts with BET1.

Subcellular location. Endoplasmic reticulum membrane. Endoplasmic reticulum-Golgi intermediate compartment membrane. Golgi apparatus. cis-Golgi network membrane. trans-Golgi network membrane. Melanosome.

Similarity. Belongs to the synaptobrevin family.

RefSeq proteins (1): NP_004883* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001388	Synaptobrevin-like	Family
IPR010908	Longin_dom	Domain
IPR011012	Longin-like_dom_sf	Homologous_superfamily
IPR042855	V_SNARE_CC	Domain
IPR044565	Sec22	Family

Pfam: PF00957, PF13774

UniProt features (30 total): modified residue 7, strand 7, turn 5, helix 5, domain 2, initiator methionine 1, chain 1, topological domain 1, transmembrane region 1

Structure

Experimental structures (PDB)

9 structures.

PDB	Method	Resolution (Å)
2NUT	X-RAY DIFFRACTION	2.3
9UVG	X-RAY DIFFRACTION	2.54
9UVE	X-RAY DIFFRACTION	2.6
3EGD	X-RAY DIFFRACTION	2.7
2NUP	X-RAY DIFFRACTION	2.8
9UVD	X-RAY DIFFRACTION	2.98
9UVF	X-RAY DIFFRACTION	3.15
3EGX	X-RAY DIFFRACTION	3.3
8HR0	X-RAY DIFFRACTION	3.34

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O75396-F1	83.66	0.44

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (7): 168, 174, 177, 38, 137, 140, 164

Function

Pathways and Gene Ontology

Reactome pathways

17 pathways

ID	Pathway
R-HSA-1236974	ER-Phagosome pathway
R-HSA-204005	COPII-mediated vesicle transport
R-HSA-5694530	Cargo concentration in the ER
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-1236975	Antigen processing-Cross presentation
R-HSA-1280218	Adaptive Immune System
R-HSA-168256	Immune System
R-HSA-199977	ER to Golgi Anterograde Transport
R-HSA-199991	Membrane Trafficking
R-HSA-392499	Metabolism of proteins
R-HSA-446203	Asparagine N-linked glycosylation
R-HSA-5653656	Vesicle-mediated transport
R-HSA-597592	Post-translational protein modification
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-8856688	Golgi-to-ER retrograde transport
R-HSA-948021	Transport to the Golgi and subsequent modification
R-HSA-983169	Class I MHC mediated antigen processing & presentation

MSigDB gene sets: 253 (showing top): GOBP_REGULATION_OF_AUTOPHAGY, GOBP_VACUOLE_ORGANIZATION, REACTOME_ADAPTIVE_IMMUNE_SYSTEM, REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION, GOCC_VACUOLAR_MEMBRANE, GOBP_VESICLE_ORGANIZATION, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, GOBP_MEMBRANE_FUSION, GOBP_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_REGULATION_OF_VACUOLE_ORGANIZATION, REACTOME_MEMBRANE_TRAFFICKING, MODULE_16, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS

GO Biological Process (7): endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888), retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum (GO:0006890), protein transport (GO:0015031), positive regulation of protein catabolic process (GO:0045732), negative regulation of autophagosome assembly (GO:1902902), vesicle-mediated transport (GO:0016192), membrane fusion (GO:0061025)

GO Molecular Function (2): SNAP receptor activity (GO:0005484), protein binding (GO:0005515)

GO Cellular Component (13): Golgi membrane (GO:0000139), endoplasmic reticulum membrane (GO:0005789), endoplasmic reticulum-Golgi intermediate compartment (GO:0005793), ER to Golgi transport vesicle membrane (GO:0012507), transport vesicle (GO:0030133), phagocytic vesicle membrane (GO:0030670), endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116), melanosome (GO:0042470), cytoplasm (GO:0005737), endoplasmic reticulum (GO:0005783), Golgi apparatus (GO:0005794), endomembrane system (GO:0012505), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-13 pathways:

Category	Pathways
ER to Golgi Anterograde Transport	2
Membrane Trafficking	2
Antigen processing-Cross presentation	1
Golgi-to-ER retrograde transport	1
Class I MHC mediated antigen processing & presentation	1
Immune System	1
Transport to the Golgi and subsequent modification	1
Vesicle-mediated transport	1
Post-translational protein modification	1
Metabolism of proteins	1
Intra-Golgi and retrograde Golgi-to-ER traffic	1
Asparagine N-linked glycosylation	1
Adaptive Immune System	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	4
intracellular membrane-bounded organelle	3
endomembrane system	3
cellular anatomical structure	3
Golgi vesicle transport	2
transport	2
bounding membrane of organelle	2
intercellular transport	1
intracellular transport	1
intracellular protein localization	1
establishment of protein localization	1
positive regulation of catabolic process	1
protein catabolic process	1
regulation of protein catabolic process	1
positive regulation of protein metabolic process	1
autophagosome assembly	1
negative regulation of macroautophagy	1
negative regulation of organelle assembly	1
regulation of autophagosome assembly	1
cellular process	1
membrane organization	1
protein-macromolecule adaptor activity	1
membrane fusion	1
fusogenic activity	1
binding	1
Golgi apparatus	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
COPII-coated ER to Golgi transport vesicle	1
transport vesicle membrane	1
coated vesicle membrane	1
cytoplasmic vesicle	1
endocytic vesicle membrane	1
phagocytic vesicle	1
endoplasmic reticulum-Golgi intermediate compartment	1
pigment granule	1
intracellular anatomical structure	1
vacuole	1
plasma membrane	1

Protein interactions and networks

STRING

1898 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SEC22B	GOSR2	O14653	999
SEC22B	STX5	Q13190	997
SEC22B	BET1	O15155	996
SEC22B	STX4	Q12846	990
SEC22B	STX18	Q9P2W9	977
SEC22B	GOSR1	O95249	961
SEC22B	YKT6	O15498	953
SEC22B	SCFD1	Q8WVM8	948
SEC22B	SNAP23	O00161	944
SEC22B	TRIM16	O95361	937
SEC22B	STX3	Q13277	918
SEC22B	USE1	Q9NZ43	908
SEC22B	TRAPPC2	P0DI81	899
SEC22B	VTI1B	Q9UEU0	882
SEC22B	VAMP7	P51809	863

IntAct

344 interactions, top by confidence:

A	B	Type	Score
STX18	SEC22B	psi-mi:“MI:0915”(physical association)	0.820
STX18	NBAS	psi-mi:“MI:0914”(association)	0.810
SEC22B	STX4	psi-mi:“MI:0915”(physical association)	0.680
SEC22B	MFSD5	psi-mi:“MI:0915”(physical association)	0.670
SEC22B	CD79A	psi-mi:“MI:0915”(physical association)	0.560
SEC22B	HSD17B13	psi-mi:“MI:0915”(physical association)	0.560
SEC22B	LHFPL5	psi-mi:“MI:0915”(physical association)	0.560
SEC22B	JAGN1	psi-mi:“MI:0915”(physical association)	0.560
SEC22B	GJA8	psi-mi:“MI:0915”(physical association)	0.560
SEC22B	STX2	psi-mi:“MI:0915”(physical association)	0.560
SEC22B	STX1A	psi-mi:“MI:0915”(physical association)	0.560
SEC22B	MFF	psi-mi:“MI:0915”(physical association)	0.560
SEC22B	CREB3L1	psi-mi:“MI:0915”(physical association)	0.560
SEC22B	HSD17B11	psi-mi:“MI:0915”(physical association)	0.560
SEC22B	DPM3	psi-mi:“MI:0915”(physical association)	0.560
	SEC22B	psi-mi:“MI:0915”(physical association)	0.560
SEC22B	IFNGR2	psi-mi:“MI:0915”(physical association)	0.560
SEC22B	TM4SF19	psi-mi:“MI:0915”(physical association)	0.560
SEC22B	MMGT1	psi-mi:“MI:0915”(physical association)	0.560
SEC22B	GJB5	psi-mi:“MI:0915”(physical association)	0.560
SEC22B	RELL2	psi-mi:“MI:0915”(physical association)	0.560
SEC22B	ERGIC3	psi-mi:“MI:0915”(physical association)	0.560
SEC22B	GPX8	psi-mi:“MI:0915”(physical association)	0.560
SEC22B	TMEM167B	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (537): SEC22B (Affinity Capture-MS), SEC22B (Affinity Capture-MS), SEC22B (Affinity Capture-MS), SEC22B (Affinity Capture-MS), SEC22B (Affinity Capture-MS), SEC22B (Affinity Capture-MS), SEC22B (Affinity Capture-MS), STX5 (Two-hybrid), STX1A (Two-hybrid), SEC22B (Proximity Label-MS), SEC22B (Proximity Label-MS), SEC22B (Proximity Label-MS), SEC22B (Proximity Label-MS), SEC22B (Two-hybrid), SEC22B (Affinity Capture-MS)

ESM2 similar proteins: A8WVD0, O08547, O08595, O15498, O16000, O60073, O74824, O75396, P22214, P36015, P47192, P48612, Q16932, Q24547, Q32N70, Q3T000, Q4KM74, Q58DV0, Q5EGY4, Q5RAI9, Q5RCE3, Q5TX47, Q5XIP1, Q5ZJW4, Q5ZK01, Q6BSL0, Q6C537, Q6C880, Q6CJA0, Q6CSA2, Q6DDU7, Q6FW27, Q6FWT0, Q6P7L4, Q6P816, Q74ZD2, Q757A4, Q7SXP0, Q7ZUN8, Q7ZV15

Diamond homologs: O08547, O08595, O75396, P22214, Q4KM74, Q4R866, Q5RAI9, Q5ZJW4, Q642F4, Q6C880, Q6CJA0, Q6FWT0, Q6P7L4, Q74ZD2, Q7SXP0, Q7ZV15, Q8BH47, Q8BXT9, Q94AU2, Q96IW7, Q9BRL7, Q9Y7L0, O70404, Q3T0Y8, Q5REQ5, Q9BV40, Q9WUF4, Q2YDJ2, O60073, P36015, Q6FW27, Q3T000

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
“CHEVI complex”	“up-regulates activity”	SEC22B	relocalization

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 127 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Membrane Trafficking	10	5.6×	3e-03
Vesicle-mediated transport	10	5.3×	3e-03

GO biological processes:

GO term	Partners	Fold	FDR
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	5	16.7×	3e-03
endoplasmic reticulum to Golgi vesicle-mediated transport	8	10.8×	5e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

1398 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1048141 (1:120156120 T>G), RS1048143 (1:120156112 G>C), RS10737761 (1:120150479 C>A,T), RS10797289 (1:120153694 G>A,C), RS10923956 (1:120150540 T>G), RS111256146 (1:120178255 C>A), RS111388320 (1:120178175 T>A), RS111469374 (1:120151841 T>A,C), RS111497322 (1:120178080 C>A,T), RS112272410 (1:120177218 A>G,T), RS112398854 (1:120177741 C>T), RS112898568 (1:120152130 C>A), RS112972311 (1:120177313 G>T), RS113015484 (1:120177093 C>G), RS113190980 (1:120150635 G>A,C,T)

Disease associations

OMIM: gene MIM:604029 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST007743_35	Iris color (L* coordinate)	4.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0009764	eye colour measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4295679 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 3 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.48	Kd	3321	nM	CHEMBL5653589
5.48	ED50	3321	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 5 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149362: Binding affinity to human SEC22B incubated for 45 mins by Kinobead based pull down assay	kd	3.3213	uM

CTD chemical–gene interactions

44 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects cotreatment, increases abundance, increases expression, decreases expression	4
bisphenol F	increases expression, affects cotreatment	2
bisphenol A	increases expression	2
Arsenic	affects cotreatment, increases abundance, increases expression, decreases expression	2
Cyclosporine	increases expression, increases methylation	2
Cadmium Chloride	increases abundance, increases expression	2
aristolochic acid I	decreases expression	1
FR900359	increases phosphorylation	1
dicrotophos	decreases expression	1
methylmercuric chloride	decreases expression	1
sodium arsenate	decreases expression	1
decabromobiphenyl ether	increases expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
1-UFT protocol	decreases response to substance	1
pinosylvin	increases expression	1
perfluorooctane sulfonic acid	increases expression	1
K 7174	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, affects cotreatment	1
bisphenol B	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	increases expression	1
pentabrominated diphenyl ether 100	increases expression	1
LDN 193189	increases expression, affects cotreatment	1
bisphenol AF	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Cadmium	increases abundance, increases expression	1
Caffeine	decreases phosphorylation	1
Dexamethasone	affects cotreatment, increases expression	1
Diethylstilbestrol	increases expression	1

ChEMBL screening assays

2 unique, capped per target: 2 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4119052	Binding	Binding affinity to SEC22B in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay	Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors. — Bioorg Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.