SEC23IP

Summary

SEC23IP (SEC23 interacting protein, HGNC:17018) is a protein-coding gene on chromosome 10q26.11-q26.12, encoding SEC23-interacting protein (Q9Y6Y8). Plays a role in the organization of endoplasmic reticulum exit sites.

This gene encodes a member of the phosphatidic acid preferring-phospholipase A1 family. The encoded protein is localized to endoplasmic reticulum exit sites and plays a critical role in ER-Golgi transport as part of the multimeric coat protein II complex. An orthologous gene in frogs is required for normal neural crest cell development, suggesting that this gene may play a role in Waardenburg syndrome neural crest defects. Alternatively spliced transcript variants have been observed for this gene.

Source: NCBI Gene 11196 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 171 total — 1 likely-pathogenic
• Druggable target: yes
• MANE Select transcript: NM_007190

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17018
Approved symbol	SEC23IP
Name	SEC23 interacting protein
Location	10q26.11-q26.12
Locus type	gene with protein product
Status	Approved
Aliases	p125, iPLA1beta, iPLA1β, p125A
Ensembl gene	ENSG00000107651
Ensembl biotype	protein_coding
OMIM	617852
Entrez	11196

Gene structure

Transcript identifiers

Ensembl transcripts: 25 — 21 protein_coding, 4 protein_coding_CDS_not_defined

ENST00000369075, ENST00000442952, ENST00000446561, ENST00000462222, ENST00000470478, ENST00000475542, ENST00000483890, ENST00000705471, ENST00000875157, ENST00000875158, ENST00000875159, ENST00000875160, ENST00000875161, ENST00000875162, ENST00000875163, ENST00000923023, ENST00000923024, ENST00000923025, ENST00000923026, ENST00000923027, ENST00000923028, ENST00000923029, ENST00000923030, ENST00000970232, ENST00000970233

RefSeq mRNA: 2 — MANE Select: NM_007190 NM_001411070, NM_007190

CCDS: CCDS7618, CCDS91362

Canonical transcript exons

ENST00000369075 — 19 exons

Exon	Start	End
ENSE00000511982	119912044	119912164
ENSE00000726413	119920889	119920984
ENSE00000726417	119926036	119926227
ENSE00000726423	119929607	119929762
ENSE00000726429	119930329	119930431
ENSE00000726508	119909041	119909130
ENSE00000987866	119902799	119903009
ENSE00000987867	119904084	119904277
ENSE00000987868	119914730	119914819
ENSE00000987870	119917836	119918044
ENSE00000987871	119918393	119918511
ENSE00001002555	119933686	119933787
ENSE00001226973	119898427	119898959
ENSE00001307651	119919444	119919596
ENSE00003514349	119915748	119915889
ENSE00003606659	119932133	119932318
ENSE00003993586	119892730	119892945
ENSE00003993587	119933005	119933167
ENSE00003993588	119940586	119944657

Expression profiles

Bgee: expression breadth ubiquitous, 284 present calls, max score 95.28.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 45.3129 / max 217.6176, expressed in 1818 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
107355	44.0693	1818
107354	0.7364	404
107352	0.2593	100
107353	0.2480	98

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	95.28	gold quality
stromal cell of endometrium	CL:0002255	94.46	gold quality
adrenal tissue	UBERON:0018303	92.83	gold quality
secondary oocyte	CL:0000655	92.19	gold quality
calcaneal tendon	UBERON:0003701	91.76	gold quality
islet of Langerhans	UBERON:0000006	91.00	gold quality
monocyte	CL:0000576	89.95	gold quality
mononuclear cell	CL:0000842	89.71	gold quality
leukocyte	CL:0000738	89.49	gold quality
smooth muscle tissue	UBERON:0001135	89.28	gold quality
mucosa of sigmoid colon	UBERON:0004993	89.27	gold quality
oocyte	CL:0000023	89.18	gold quality
cartilage tissue	UBERON:0002418	89.08	gold quality
ventricular zone	UBERON:0003053	89.08	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.95	gold quality
tonsil	UBERON:0002372	88.66	gold quality
tibia	UBERON:0000979	88.31	gold quality
rectum	UBERON:0001052	88.28	gold quality
stomach	UBERON:0000945	88.27	gold quality
gall bladder	UBERON:0002110	88.15	gold quality
body of stomach	UBERON:0001161	88.03	gold quality
pancreas	UBERON:0001264	88.00	gold quality
bone marrow cell	CL:0002092	87.61	gold quality
vermiform appendix	UBERON:0001154	87.61	gold quality
corpus epididymis	UBERON:0004359	87.32	gold quality
body of pancreas	UBERON:0001150	86.75	gold quality
tibial artery	UBERON:0007610	86.63	gold quality
popliteal artery	UBERON:0002250	86.62	gold quality
colonic mucosa	UBERON:0000317	86.61	gold quality
muscle of leg	UBERON:0001383	86.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• p125 is a mammalian-specific component of ER exit sites and participates in the organization of this compartment (PMID:15623529)
• Xenopus sec23ip is required for normal neural crest cell development, suggesting a role for the human ortholog in Waardenburg syndrome neural crest defects. (PMID:20308572)
• The results suggest that p125A is part of the Sec13/Sec31A subcomplex and facilitates ER export in mammalian cells. (PMID:20679433)
• A basic cluster and a hydrophobic interface in the DDHD and SAM domains, respectively, are required for p125A-mediated functional endoplasmic reticulum exit site assembly. (PMID:24522181)
• Sec23IP recruits VPS13B/COH1 to ER exit site-Golgi interface for tubular ERGIC formation. (PMID:39352497)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	sec23ip	ENSDARG00000061413
mus_musculus	Sec23ip	ENSMUSG00000055319
rattus_norvegicus	Sec23ip	ENSRNOG00000020411
drosophila_melanogaster	PAPLA1	FBGN0031990

Paralogs (2): DDHD2 (ENSG00000085788), DDHD1 (ENSG00000100523)

Protein

Protein identifiers

SEC23-interacting protein — Q9Y6Y8 (reviewed: Q9Y6Y8)

Alternative names: p125

All UniProt accessions (4): Q9Y6Y8, A0A994J542, H7C0V8, H7C4C4

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P).

Subunit / interactions. Interacts with SEC23A.

Subcellular location. Cytoplasmic vesicle. COPII-coated vesicle membrane. Endoplasmic reticulum.

Tissue specificity. Ubiquitously expressed with stronger levels detected in heart, liver and skeletal muscle.

Similarity. Belongs to the PA-PLA1 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9Y6Y8-1	1	yes
Q9Y6Y8-2	2

RefSeq proteins (2): NP_001397999, NP_009121* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001660	SAM	Domain
IPR004170	WWE_dom	Domain
IPR004177	DDHD_dom	Domain
IPR013761	SAM/pointed_sf	Homologous_superfamily
IPR037603	SEC23IP_SAM	Domain
IPR057825	WWE_SEC23-DDH2	Domain
IPR058055	PA-PLA1	Family

Pfam: PF00536, PF02825, PF02862, PF23464

UniProt features (15 total): region of interest 3, compositionally biased region 3, domain 2, modified residue 2, splice variant 2, chain 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y6Y8-F1	65.95	0.29

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 926, 737

Function

Pathways and Gene Ontology

Reactome pathways

8 pathways

ID	Pathway
R-HSA-204005	COPII-mediated vesicle transport
R-HSA-199977	ER to Golgi Anterograde Transport
R-HSA-199991	Membrane Trafficking
R-HSA-392499	Metabolism of proteins
R-HSA-446203	Asparagine N-linked glycosylation
R-HSA-5653656	Vesicle-mediated transport
R-HSA-597592	Post-translational protein modification
R-HSA-948021	Transport to the Golgi and subsequent modification

MSigDB gene sets: 183 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_UP, ELVIDGE_HYPOXIA_DN, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, TGCGCANK_UNKNOWN, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, BROWNE_HCMV_INFECTION_16HR_UP, GOBP_VESICLE_MEDIATED_TRANSPORT, RIZKI_TUMOR_INVASIVENESS_3D_DN, GOBP_MALE_GAMETE_GENERATION, REACTOME_MEMBRANE_TRAFFICKING, MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP, OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP, GOBP_ENDOPLASMIC_RETICULUM_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT, GOCC_COATED_VESICLE, GOBP_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM

GO Biological Process (4): intracellular protein transport (GO:0006886), endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888), Golgi organization (GO:0007030), endomembrane system organization (GO:0010256)

GO Molecular Function (4): RNA binding (GO:0003723), glycerophospholipase activity (GO:0004620), metal ion binding (GO:0046872), protein binding (GO:0005515)

GO Cellular Component (9): cytoplasm (GO:0005737), endoplasmic reticulum (GO:0005783), endoplasmic reticulum-Golgi intermediate compartment (GO:0005793), Golgi apparatus (GO:0005794), cytosol (GO:0005829), ER to Golgi transport vesicle membrane (GO:0012507), COPII-coated ER to Golgi transport vesicle (GO:0030134), membrane (GO:0016020), cytoplasmic vesicle (GO:0031410)

Reactome top-level categories

Rollup of top-7 pathways:

Category	Pathways
ER to Golgi Anterograde Transport	1
Membrane Trafficking	1
Transport to the Golgi and subsequent modification	1
Vesicle-mediated transport	1
Post-translational protein modification	1
Metabolism of proteins	1
Asparagine N-linked glycosylation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	6
cellular anatomical structure	3
intracellular membrane-bounded organelle	3
intracellular transport	2
endomembrane system	2
intracellular protein localization	1
protein transport	1
intercellular transport	1
Golgi vesicle transport	1
organelle organization	1
endomembrane system organization	1
cellular component organization	1
nucleic acid binding	1
phospholipase activity	1
cation binding	1
binding	1
intracellular anatomical structure	1
COPII-coated ER to Golgi transport vesicle	1
transport vesicle membrane	1
coated vesicle membrane	1
coated vesicle	1
intracellular vesicle	1

Protein interactions and networks

STRING

1960 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SEC23IP	SEC24B	O95487	707
SEC23IP	SEC24A	O95486	607
SEC23IP	SEC23A	Q15436	585
SEC23IP	SEC13	P55735	548
SEC23IP	COPB1	P53618	530
SEC23IP	ZNF668	Q96K58	529
SEC23IP	ARCN1	P48444	527
SEC23IP	SEC16A	O15027	506
SEC23IP	SCFD1	Q8WVM8	494
SEC23IP	SEC31A	O94979	491
SEC23IP	WWOX	Q9NZC7	479
SEC23IP	COPB2	P35606	458
SEC23IP	H7C0V5	H7C0V5	453
SEC23IP	NT5DC1	Q5TFE4	451
SEC23IP	SEC22B	O75396	446

IntAct

105 interactions, top by confidence:

A	B	Type	Score
SEC23B	SEC24D	psi-mi:“MI:0914”(association)	0.920
PDCD6	SEC31A	psi-mi:“MI:0403”(colocalization)	0.740
PDCD6	SEC31A	psi-mi:“MI:0914”(association)	0.740
SEC31A	SEC13	psi-mi:“MI:0914”(association)	0.730
SSC5D	SEC23IP	psi-mi:“MI:0915”(physical association)	0.720
SEC23IP	SSC5D	psi-mi:“MI:0915”(physical association)	0.720
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
SEC23A	SEC23IP	psi-mi:“MI:0915”(physical association)	0.670
TRIM32	SEC23IP	psi-mi:“MI:0915”(physical association)	0.660
SEC13	SEC16A	psi-mi:“MI:0914”(association)	0.640
PDCD6	SEC23IP	psi-mi:“MI:0403”(colocalization)	0.580
IFT25	SEC23IP	psi-mi:“MI:0915”(physical association)	0.560
SEC23IP	IFT25	psi-mi:“MI:0915”(physical association)	0.560
YIF1A	SEC23IP	psi-mi:“MI:0915”(physical association)	0.560
SLC31A1	C2orf72	psi-mi:“MI:0914”(association)	0.530
SEC23B	SEC16A	psi-mi:“MI:0914”(association)	0.530
DDHD2	CHI3L1	psi-mi:“MI:0914”(association)	0.530
SEC31A	NOP14	psi-mi:“MI:0914”(association)	0.530
ANKRD22	ESYT2	psi-mi:“MI:0914”(association)	0.530
TRIM32	TRPC4AP	psi-mi:“MI:0914”(association)	0.510
NRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.480
DNAJC16	SEC23IP	psi-mi:“MI:0915”(physical association)	0.400
	AGPS	psi-mi:“MI:0915”(physical association)	0.400
	TK2	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (312): HSPB11 (Two-hybrid), SSC5D (Two-hybrid), SEC23IP (Affinity Capture-MS), SEC23IP (Affinity Capture-MS), SEC23IP (Affinity Capture-MS), HSPA4 (Co-fractionation), NCBP1 (Co-fractionation), SEC23IP (Affinity Capture-MS), SEC23IP (Proximity Label-MS), SEC23IP (Proximity Label-MS), SEC23IP (Proximity Label-MS), SEC23IP (Proximity Label-MS), SEC23IP (Proximity Label-MS), SEC23IP (Affinity Capture-MS), SEC23IP (Affinity Capture-MS)

ESM2 similar proteins: A3KMI0, A3KQS4, A5PF44, A6QP16, A8E7C5, B1H2Q2, F4HZF0, O15226, O96838, P34550, Q09874, Q29FC1, Q2KI23, Q2KJ22, Q3SWY8, Q3T9Z9, Q3V0G7, Q4R4A2, Q5BJQ2, Q5R7G8, Q5U2S3, Q5VVW2, Q5XHY7, Q61502, Q6NZC7, Q6P158, Q6P5D3, Q6PDI6, Q6PGC1, Q75E61, Q76LS9, Q7M760, Q7TSI3, Q7XI08, Q7Z478, Q8C437, Q8GY87, Q8H106, Q8N5J2, Q8NBR6

Diamond homologs: O94830, Q495M9, Q6NZC7, Q80T11, Q80Y98, Q80YA3, Q8K3X6, Q8N8V4, Q9Y6Y8, Q12204, Q6ZPQ6, Q9BZ72, O14593, Q3KP44, Q8BLD6, Q9Z205, O00562, O35954, P43125, Q3UHE1, Q5U2N3, Q9BZ71

SIGNOR signaling

5 interactions.

A	Effect	B	Mechanism
SEC23IP	“down-regulates quantity”	“phosphatidic acid”	“chemical modification”
SEC23IP	“up-regulates quantity”	“long-chain fatty acid anion”	“chemical modification”
SEC23IP	“up-regulates quantity”	“1-acyl-sn-glycerol 3-phosphate”	“chemical modification”
SEC23IP	“up-regulates activity”	SEC23B	binding
SEC23IP	“up-regulates activity”	SEC23A	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 114 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
COPII-mediated vesicle transport	8	17.2×	1e-05
ER to Golgi Anterograde Transport	7	12.2×	2e-04
Transport to the Golgi and subsequent modification	7	9.5×	9e-04
Asparagine N-linked glycosylation	8	6.3×	3e-03
Vesicle-mediated transport	13	6.0×	6e-05
Membrane Trafficking	12	5.8×	1e-04

GO biological processes:

GO term	Partners	Fold	FDR
COPII-coated vesicle cargo loading	5	51.6×	2e-05
endoplasmic reticulum to Golgi vesicle-mediated transport	8	11.3×	2e-04
cell surface receptor protein tyrosine kinase signaling pathway	6	10.9×	5e-03
positive regulation of MAPK cascade	8	6.7×	5e-03
cilium assembly	8	6.1×	7e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

171 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	122
Likely benign	12
Benign	13

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
148437	GRCh38/hg38 10q25.2-26.12(chr10:112701186-120970617)x3	Likely pathogenic

SpliceAI

3274 predictions. Top by Δscore:

Variant	Effect	Δscore
10:119892943:G:GT	donor_gain	1.0000
10:119904082:A:AG	acceptor_gain	1.0000
10:119904083:G:GA	acceptor_gain	1.0000
10:119909035:TTATA:T	acceptor_loss	1.0000
10:119909036:TATA:T	acceptor_loss	1.0000
10:119909037:ATAGG:A	acceptor_loss	1.0000
10:119909038:TAG:T	acceptor_loss	1.0000
10:119912035:A:AG	acceptor_gain	1.0000
10:119912035:ATCTT:A	acceptor_gain	1.0000
10:119912036:T:G	acceptor_gain	1.0000
10:119914815:GTGTG:G	donor_gain	1.0000
10:119915746:A:AG	acceptor_gain	1.0000
10:119915747:G:GG	acceptor_gain	1.0000
10:119915816:A:T	donor_gain	1.0000
10:119915819:G:GG	donor_gain	1.0000
10:119918015:G:GT	donor_gain	1.0000
10:119918015:G:T	donor_gain	1.0000
10:119918042:TAGGT:T	donor_loss	1.0000
10:119918045:G:GA	donor_loss	1.0000
10:119918390:T:G	acceptor_gain	1.0000
10:119918390:TAGGT:T	acceptor_loss	1.0000
10:119918391:A:AG	acceptor_gain	1.0000
10:119918391:A:AT	acceptor_loss	1.0000
10:119918392:G:GG	acceptor_gain	1.0000
10:119918392:GGTT:G	acceptor_gain	1.0000
10:119918508:GCAG:G	donor_gain	1.0000
10:119918511:GGT:G	donor_loss	1.0000
10:119918512:G:GC	donor_loss	1.0000
10:119918512:G:GG	donor_gain	1.0000
10:119919440:A:AG	acceptor_gain	1.0000

AlphaMissense

6561 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:119904209:T:A	W345R	1.000
10:119904209:T:C	W345R	1.000
10:119904246:C:A	P357H	1.000
10:119904273:T:C	L366P	1.000
10:119909074:T:A	W379R	1.000
10:119909074:T:C	W379R	1.000
10:119909114:T:A	V392D	1.000
10:119912051:T:A	V400D	1.000
10:119912128:C:A	R426S	1.000
10:119932136:T:C	L859S	1.000
10:119902919:T:A	W273R	0.999
10:119902919:T:C	W273R	0.999
10:119902955:T:A	W285R	0.999
10:119902955:T:C	W285R	0.999
10:119904205:T:G	C343W	0.999
10:119904211:G:C	W345C	0.999
10:119904211:G:T	W345C	0.999
10:119904246:C:G	P357R	0.999
10:119904248:T:G	Y358D	0.999
10:119909047:T:G	Y370D	0.999
10:119909076:G:C	W379C	0.999
10:119909076:G:T	W379C	0.999
10:119909111:T:A	I391N	0.999
10:119909119:C:G	H394D	0.999
10:119909121:C:A	H394Q	0.999
10:119909121:C:G	H394Q	0.999
10:119912056:T:C	F402L	0.999
10:119912057:T:C	F402S	0.999
10:119912058:C:A	F402L	0.999
10:119912058:C:G	F402L	0.999

dbSNP variants (sampled 300 via entrez): RS1000126009 (10:119911250 T>A,C), RS1000126570 (10:119898665 A>G,T), RS1000136264 (10:119906065 C>T), RS1000157043 (10:119910987 CCTT>C), RS1000192398 (10:119923042 T>A), RS1000284914 (10:119929206 T>C), RS1000387083 (10:119916556 T>C), RS1000401225 (10:119928878 G>A), RS1000436244 (10:119935628 A>G), RS1000490376 (10:119909592 A>G), RS1000627815 (10:119922764 A>C,G), RS1000655154 (10:119916481 A>G), RS1000684975 (10:119916234 C>G,T), RS1000903971 (10:119939894 C>T), RS1000991560 (10:119921907 T>C)

Disease associations

OMIM: gene MIM:617852 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST002541_80	Menarche (age at onset)	3.000000e-10
GCST003134_13	Cerebrospinal fluid clusterin levels	5.000000e-06
GCST010242_107	HDL cholesterol levels	2.000000e-08
GCST90000025_181	Appendicular lean mass	1.000000e-10
GCST90002396_497	Mean reticulocyte volume	2.000000e-11
GCST90002397_554	Mean spheric corpuscular volume	6.000000e-11

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0004703	age at menarche
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:0004980	appendicular lean mass
EFO:0010701	mean reticulocyte volume

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066475 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.12	Kd	75.3	nM	CHEMBL5653589
7.12	ED50	75.3	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149365: Binding affinity to human SEC23IP incubated for 45 mins by Kinobead based pull down assay	kd	0.0753	uM

CTD chemical–gene interactions

40 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases expression	2
sodium arsenite	affects cotreatment, increases abundance, increases expression	2
FR900359	decreases phosphorylation	1
testosterone enanthate	affects expression	1
triphenyl phosphate	affects expression	1
pyrogallol 1,3-dimethyl ether	affects cotreatment, affects localization, increases expression	1
methylparaben	increases expression	1
perfluorooctanoic acid	decreases expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
K 7174	increases expression	1
ICG 001	decreases expression	1
bisphenol S	increases expression	1
jinfukang	decreases expression	1
bisphenol AF	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Acetaminophen	decreases expression	1
Air Pollutants, Occupational	decreases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Caffeine	decreases phosphorylation	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Doxorubicin	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Ethyl Methanesulfonate	decreases expression	1
Formaldehyde	decreases expression	1
Furaldehyde	affects cotreatment, affects localization, decreases expression	1
Hydrogen Peroxide	affects expression	1
Ivermectin	decreases expression	1
Manganese	affects cotreatment, increases abundance, increases expression	1
Nickel	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652407	Binding	Binding affinity to human SEC23IP incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TK41	HAP1 SEC23IP (-) 1	Cancer cell line	Male
CVCL_TK42	HAP1 SEC23IP (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.