SEC24B-AS1

Summary

SEC24B-AS1 (SEC24B antisense RNA 1, HGNC:44003) is a long non-coding RNA gene on chromosome 4q25.

This lncRNA contains a single Alu element which, along with 1/2-sbsRNA3, appears to target the 3’ UTR Alu element in MTAP. Downregulation of the RNA appears to up-regulate the target.

Source: NCBI Gene 100533182 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44003
Approved symbol	SEC24B-AS1
Name	SEC24B antisense RNA 1
Location	4q25
Locus type	RNA, long non-coding
Status	Approved
Aliases	1/2-SBSRNA4
Ensembl gene	ENSG00000247950
Ensembl biotype	lncRNA
Entrez	100533182
RNAcentral	URS000075B00A — lncRNA, 984 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 56 — 56 lncRNA

ENST00000499359, ENST00000499713, ENST00000505895, ENST00000510971, ENST00000654972, ENST00000657290, ENST00000659270, ENST00000667746, ENST00000670376, ENST00000689777, ENST00000690454, ENST00000702378, ENST00000844644, ENST00000844650, ENST00000844652, ENST00000844654, ENST00000844658, ENST00000844661, ENST00000844682, ENST00000844683, ENST00000844684, ENST00000844685, ENST00000844686, ENST00000844687, ENST00000844688, ENST00000844689, ENST00000844690, ENST00000844692, ENST00000844693, ENST00000844696, ENST00000844698, ENST00000844699, ENST00000844701, ENST00000844703, ENST00000844705, ENST00000844706, ENST00000844707, ENST00000844708, ENST00000844709, ENST00000844710, ENST00000844711, ENST00000844712, ENST00000844713, ENST00000844714, ENST00000844715, ENST00000844716, ENST00000844717, ENST00000844718, ENST00000844719, ENST00000844720, ENST00000844721, ENST00000844722, ENST00000844723, ENST00000844724, ENST00000844725, ENST00000844726

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000499359 — 3 exons

Exon	Start	End
ENSE00001959710	109431692	109431746
ENSE00001971287	109433734	109433817
ENSE00001991205	109429963	109430780

Expression profiles

Bgee: expression breadth ubiquitous, 168 present calls, max score 85.78.

FANTOM5 (CAGE): breadth broad, TPM avg 0.7533 / max 25.0981, expressed in 425 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
53598	0.7533	425

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.78	gold quality
corpus epididymis	UBERON:0004359	81.63	gold quality
buccal mucosa cell	CL:0002336	79.22	gold quality
right uterine tube	UBERON:0001302	77.81	gold quality
bone marrow cell	CL:0002092	75.71	gold quality
right lobe of thyroid gland	UBERON:0001119	74.44	gold quality
left lobe of thyroid gland	UBERON:0001120	73.96	gold quality
thyroid gland	UBERON:0002046	73.44	gold quality
calcaneal tendon	UBERON:0003701	72.34	gold quality
right ovary	UBERON:0002118	72.17	gold quality
left ovary	UBERON:0002119	72.11	gold quality
right hemisphere of cerebellum	UBERON:0014890	71.53	gold quality
cerebellar hemisphere	UBERON:0002245	71.16	gold quality
cortical plate	UBERON:0005343	71.00	gold quality
cerebellar cortex	UBERON:0002129	70.99	gold quality
metanephros cortex	UBERON:0010533	70.84	gold quality
adenohypophysis	UBERON:0002196	70.37	gold quality
endocervix	UBERON:0000458	69.76	gold quality
body of uterus	UBERON:0009853	69.56	gold quality
ovary	UBERON:0000992	69.54	gold quality
tibial nerve	UBERON:0001323	69.32	gold quality
caput epididymis	UBERON:0004358	69.31	gold quality
cerebellum	UBERON:0002037	69.30	gold quality
pituitary gland	UBERON:0000007	69.04	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	68.97	gold quality
right coronary artery	UBERON:0001625	68.71	gold quality
smooth muscle tissue	UBERON:0001135	68.55	gold quality
ectocervix	UBERON:0012249	68.51	gold quality
rectum	UBERON:0001052	68.39	gold quality
colonic epithelium	UBERON:0000397	68.24	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.17

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.