SEC31B

Summary

SEC31B (SEC31 homolog B, COPII component, HGNC:23197) is a protein-coding gene on chromosome 10q24.31, encoding Protein transport protein Sec31B (Q9NQW1). As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum.

This gene encodes a protein of unknown function. The protein has moderate similarity to rat VAP1 protein which is an endosomal membrane-associated protein, containing a putative Ca2+/calmodulin-dependent kinase II phosphorylation site.

Source: NCBI Gene 25956 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 214 total
• MANE Select transcript: NM_015490

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23197
Approved symbol	SEC31B
Name	SEC31 homolog B, COPII component
Location	10q24.31
Locus type	gene with protein product
Status	Approved
Aliases	SEC31B-1, DKFZP434M183
Ensembl gene	ENSG00000075826
Ensembl biotype	protein_coding
OMIM	610258
Entrez	25956

Gene structure

Transcript identifiers

Ensembl transcripts: 21 — 9 protein_coding, 5 nonsense_mediated_decay, 5 retained_intron, 2 protein_coding_CDS_not_defined

ENST00000370345, ENST00000462434, ENST00000469546, ENST00000469824, ENST00000479697, ENST00000480905, ENST00000482456, ENST00000484848, ENST00000485800, ENST00000490567, ENST00000492667, ENST00000494350, ENST00000498298, ENST00000883193, ENST00000883194, ENST00000955332, ENST00000955333, ENST00000955334, ENST00000955335, ENST00000955336, ENST00000955337

RefSeq mRNA: 1 — MANE Select: NM_015490 NM_015490

CCDS: CCDS7495

Canonical transcript exons

ENST00000370345 — 26 exons

Exon	Start	End
ENSE00001818448	100519782	100519861
ENSE00001822116	100486647	100487795
ENSE00003461888	100516096	100516219
ENSE00003468404	100498705	100498804
ENSE00003473355	100497135	100497280
ENSE00003475356	100497667	100497793
ENSE00003484453	100499160	100499258
ENSE00003486339	100490008	100490322
ENSE00003495877	100490706	100490883
ENSE00003497222	100509007	100509102
ENSE00003503770	100509316	100509511
ENSE00003515223	100488027	100488098
ENSE00003530384	100495385	100495546
ENSE00003539239	100489703	100489761
ENSE00003554884	100498029	100498207
ENSE00003565353	100507908	100508051
ENSE00003582771	100506040	100506201
ENSE00003594424	100488858	100488974
ENSE00003618690	100489252	100489398
ENSE00003625559	100499524	100499598
ENSE00003648471	100507425	100507567
ENSE00003658946	100506321	100506420
ENSE00003664857	100502254	100502484
ENSE00003671710	100505361	100505495
ENSE00003680641	100496258	100496431
ENSE00003680947	100516874	100516997

Expression profiles

Bgee: expression breadth ubiquitous, 191 present calls, max score 95.26.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4477 / max 23.9330, expressed in 177 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
111061	0.3011	138
111055	0.0586	20
111057	0.0576	21
111058	0.0172	14
111056	0.0131	7

Top tissues by expression

275 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	95.26	gold quality
cerebellar hemisphere	UBERON:0002245	94.54	gold quality
cerebellar cortex	UBERON:0002129	94.34	gold quality
cerebellum	UBERON:0002037	91.52	gold quality
granulocyte	CL:0000094	91.25	gold quality
apex of heart	UBERON:0002098	91.24	gold quality
adenohypophysis	UBERON:0002196	90.58	gold quality
right frontal lobe	UBERON:0002810	90.27	gold quality
mucosa of stomach	UBERON:0001199	90.14	gold quality
pituitary gland	UBERON:0000007	89.53	gold quality
small intestine Peyer’s patch	UBERON:0003454	88.37	gold quality
transverse colon	UBERON:0001157	88.16	gold quality
muscle layer of sigmoid colon	UBERON:0035805	87.99	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	87.81	gold quality
mucosa of transverse colon	UBERON:0004991	87.68	gold quality
left testis	UBERON:0004533	87.67	gold quality
lower esophagus muscularis layer	UBERON:0035833	87.61	gold quality
lower esophagus	UBERON:0013473	87.59	gold quality
tibial nerve	UBERON:0001323	87.57	gold quality
right testis	UBERON:0004534	87.55	gold quality
spleen	UBERON:0002106	87.22	gold quality
right ovary	UBERON:0002118	86.75	gold quality
type B pancreatic cell	CL:0000169	86.51	gold quality
olfactory bulb	UBERON:0002264	86.08	gold quality
left ovary	UBERON:0002119	86.01	gold quality
sural nerve	UBERON:0015488	85.99	gold quality
body of uterus	UBERON:0009853	85.96	gold quality
hindlimb stylopod muscle	UBERON:0004252	85.84	gold quality
right lobe of liver	UBERON:0001114	85.74	gold quality
right uterine tube	UBERON:0001302	85.62	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	5.14
E-GEOD-83139	no	3.06

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

76 targeting SEC31B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-767-5P	99.95	70.85	993
HSA-MIR-4493	99.90	66.48	977
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-137-3P	99.87	74.74	2401
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-3121-3P	99.82	71.96	3630

Literature-anchored findings (GeneRIF, showing 1)

• The SEC31B protein is an orthologue of Saccharomyces cerevisiae Sec31p, a component of the COPII vesicle coat that mediates vesicular traffic from the endoplasmic reticulum. (PMID:16495487)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	sec31b	ENSDARG00000002916
mus_musculus	Sec31b	ENSMUSG00000051984
rattus_norvegicus	Sec31b	ENSRNOG00000025781
drosophila_melanogaster	Sec31	FBGN0033339
caenorhabditis_elegans		WBGENE00011338

Paralogs (1): SEC31A (ENSG00000138674)

Protein

Protein identifiers

Protein transport protein Sec31B — Q9NQW1 (reviewed: Q9NQW1)

Alternative names: SEC31-like protein 2, SEC31-related protein B, SEC31B-1

All UniProt accessions (3): Q9NQW1, E9PKR7, F6TTE0

UniProt curated annotations — full annotation on UniProt →

Function. As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum.

Subunit / interactions. COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13. Interacts with SEC31A.

Subcellular location. Cytoplasm. Cytoplasmic vesicle. COPII-coated vesicle membrane. Endoplasmic reticulum membrane.

Tissue specificity. Ubiquitously expressed at low levels with specific expression in thymus and testis. Expressed in testis by Sertoli cells, Leydig cells and spermatogonia and in cerebellum more prominently by Purkinje and granular cells (at protein level).

Post-translational modifications. Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Similarity. Belongs to the WD repeat SEC31 family.

Isoforms (5)

UniProt ID	Names	Canonical?
Q9NQW1-1	1, SEC31B-F	yes
Q9NQW1-2	2
Q9NQW1-3	3
Q9NQW1-4	4, SEC31B-t
Q9NQW1-5	5

RefSeq proteins (1): NP_056305* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR019775	WD40_repeat_CS	Conserved_site
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily
IPR040251	SEC31-like	Family

Pfam: PF00400

UniProt features (28 total): sequence variant 9, repeat 8, splice variant 7, chain 1, compositionally biased region 1, sequence conflict 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NQW1-F1	70.08	0.22

Function

Pathways and Gene Ontology

Reactome pathways

8 pathways

ID	Pathway
R-HSA-204005	COPII-mediated vesicle transport
R-HSA-199977	ER to Golgi Anterograde Transport
R-HSA-199991	Membrane Trafficking
R-HSA-392499	Metabolism of proteins
R-HSA-446203	Asparagine N-linked glycosylation
R-HSA-5653656	Vesicle-mediated transport
R-HSA-597592	Post-translational protein modification
R-HSA-948021	Transport to the Golgi and subsequent modification

MSigDB gene sets: 152 (showing top): GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, GOBP_VESICLE_ORGANIZATION, GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT, GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, GOBP_VESICLE_MEDIATED_TRANSPORT, REACTOME_MEMBRANE_TRAFFICKING, GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT, GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT, CCANNAGRKGGC_UNKNOWN, GOBP_ENDOPLASMIC_RETICULUM_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT, MYOD_01, GOBP_REGULATION_OF_CELLULAR_LOCALIZATION, GOCC_COATED_VESICLE, GOBP_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT

GO Biological Process (5): endoplasmic reticulum organization (GO:0007029), protein transport (GO:0015031), COPII-coated vesicle cargo loading (GO:0090110), endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888), vesicle-mediated transport (GO:0016192)

GO Molecular Function (2): structural molecule activity (GO:0005198), protein binding (GO:0005515)

GO Cellular Component (9): endoplasmic reticulum membrane (GO:0005789), vesicle coat (GO:0030120), COPII vesicle coat (GO:0030127), endoplasmic reticulum exit site (GO:0070971), cytoplasm (GO:0005737), endoplasmic reticulum (GO:0005783), ER to Golgi transport vesicle membrane (GO:0012507), membrane (GO:0016020), cytoplasmic vesicle (GO:0031410)

Reactome top-level categories

Rollup of top-7 pathways:

Category	Pathways
ER to Golgi Anterograde Transport	1
Membrane Trafficking	1
Transport to the Golgi and subsequent modification	1
Vesicle-mediated transport	1
Post-translational protein modification	1
Metabolism of proteins	1
Asparagine N-linked glycosylation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	3
cellular anatomical structure	3
transport	2
intracellular transport	2
coated vesicle membrane	2
organelle organization	1
endomembrane system organization	1
intracellular protein localization	1
establishment of protein localization	1
vesicle cargo loading	1
COPII-coated vesicle budding	1
intercellular transport	1
Golgi vesicle transport	1
cellular process	1
molecular_function	1
binding	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
membrane coat	1
ER to Golgi transport vesicle membrane	1
vesicle coat	1
endoplasmic reticulum	1
intracellular anatomical structure	1
endomembrane system	1
intracellular membrane-bounded organelle	1
COPII-coated ER to Golgi transport vesicle	1
transport vesicle membrane	1
intracellular vesicle	1

Protein interactions and networks

STRING

948 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SEC31B	SEC13	P55735	918
SEC31B	SEC24B	O95487	743
SEC31B	SEC24D	O94855	673
SEC31B	SEC23B	Q15437	607
SEC31B	SEC24A	O95486	585
SEC31B	SEC16A	O15027	559
SEC31B	SEC24C	P53992	523
SEC31B	SAR1A	Q9NR31	494
SEC31B	PREB	Q9HCU5	477
SEC31B	SAR1B	Q9Y6B6	471
SEC31B	SEC31A	O94979	455
SEC31B	COPB1	P53618	414
SEC31B	COPB2	P35606	414
SEC31B	USO1	O60763	401
SEC31B	STPG4	Q8N801	400

IntAct

11 interactions, top by confidence:

A	B	Type	Score
YBX1	HNRNPR	psi-mi:“MI:0915”(physical association)	0.770
SF3A2	SEC31B	psi-mi:“MI:0915”(physical association)	0.400
DND1	RPSA2	psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
MYC	PDZD2	psi-mi:“MI:0914”(association)	0.350
	KIF2A	psi-mi:“MI:0914”(association)	0.350
SEC31B	TCP1	psi-mi:“MI:0914”(association)	0.350
SNW1		psi-mi:“MI:0914”(association)	0.350
RUNX1	SEC31B	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (37): SEC31B (Affinity Capture-MS), CCT7 (Affinity Capture-MS), CCT3 (Affinity Capture-MS), CCT6B (Affinity Capture-MS), CCT6A (Affinity Capture-MS), CCT2 (Affinity Capture-MS), CCT4 (Affinity Capture-MS), TCP1 (Affinity Capture-MS), SEC31B (Co-fractionation), SEC31B (Affinity Capture-MS), CCT7 (Affinity Capture-MS), CCT6B (Affinity Capture-MS), CCT2 (Affinity Capture-MS), CCT6A (Affinity Capture-MS), TCP1 (Affinity Capture-MS)

ESM2 similar proteins: A0A2R8QPS5, A0A571BF63, A0A8M9QN10, A1A535, A1A5P5, A2BID5, A4D1P6, A9JRI0, B2RYI0, D3YVL2, F1QNV4, P97874, Q05B30, Q0WV90, Q15291, Q1LUT1, Q1LXR6, Q27GK7, Q2HJE1, Q32PH0, Q3TZ89, Q3U0M1, Q3UMY5, Q4V9P9, Q5NBT9, Q5PQS3, Q5R5R2, Q5R6T6, Q5ZLL7, Q6AI08, Q6DTM3, Q6PA97, Q6TEN6, Q7TMQ7, Q7Z3E5, Q7ZVL2, Q84JM4, Q8BL99, Q8CFJ9, Q8N957

Diamond homologs: A1C6X5, A1DHK2, A2QBZ0, F4ICD9, O94979, Q0CYG9, Q0ULF5, Q2GVT8, Q2UF60, Q3TZ89, Q3UPL0, Q4P2B6, Q4X0M4, Q55CT5, Q5AZM3, Q5F3X8, Q5R4F4, Q5S580, Q7SYD5, Q873A1, Q8L611, Q9NQW1, Q9Z2Q1, A3GFK8, A4RD35, A5DB75, A5DTX3, O13637, Q1DX43, Q5AAU3, Q5RHI5, Q6BRR2, Q6C414, Q9R1K5, Q9SU78, Q9UM11, A6ZN74, B3LIS9, C7GV13, C8ZHH9

SIGNOR signaling

4 interactions.

A	Effect	B	Mechanism
SEC31B	“form complex”	“COPII vesicle”	binding
KLHL12	“up-regulates activity”	SEC31B	binding
“Cullin 3-RBX1-Skp1”	“up-regulates activity”	SEC31B	monoubiquitination

Disease & clinical

Clinical variants and AI predictions

ClinVar

214 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	175
Likely benign	17
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

4063 predictions. Top by Δscore:

Variant	Effect	Δscore
10:100488025:A:AC	donor_gain	1.0000
10:100488025:ACTGT:A	donor_gain	1.0000
10:100488026:C:CC	donor_gain	1.0000
10:100488026:CTGT:C	donor_gain	1.0000
10:100488026:CTGTC:C	donor_gain	1.0000
10:100488099:C:CC	acceptor_gain	1.0000
10:100488854:TTA:T	donor_loss	1.0000
10:100488855:TA:T	donor_loss	1.0000
10:100488856:A:AC	donor_gain	1.0000
10:100488856:AC:A	donor_loss	1.0000
10:100488857:C:CC	donor_gain	1.0000
10:100488857:CT:C	donor_gain	1.0000
10:100488857:CTA:C	donor_gain	1.0000
10:100488857:CTAA:C	donor_gain	1.0000
10:100488857:CTAAG:C	donor_gain	1.0000
10:100488975:CTG:C	acceptor_gain	1.0000
10:100488976:TG:T	acceptor_gain	1.0000
10:100488978:C:CC	acceptor_gain	1.0000
10:100489698:TTGAC:T	donor_loss	1.0000
10:100489699:TGACC:T	donor_loss	1.0000
10:100489700:GACCT:G	donor_loss	1.0000
10:100489702:C:CT	donor_loss	1.0000
10:100496253:CTTA:C	donor_loss	1.0000
10:100496254:TTA:T	donor_loss	1.0000
10:100496255:TACCT:T	donor_loss	1.0000
10:100496256:A:AT	donor_loss	1.0000
10:100496257:C:A	donor_loss	1.0000
10:100496429:GTCC:G	acceptor_loss	1.0000
10:100496430:TCCTG:T	acceptor_loss	1.0000
10:100496432:C:CC	acceptor_gain	1.0000

AlphaMissense

7648 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:100502482:A:C	F394L	0.972
10:100502482:A:T	F394L	0.972
10:100502484:A:G	F394L	0.972
10:100505364:A:C	F392L	0.965
10:100505364:A:T	F392L	0.965
10:100505366:A:G	F392L	0.965
10:100509057:A:G	W149R	0.963
10:100509057:A:T	W149R	0.963
10:100516165:A:T	I45K	0.961
10:100509495:A:G	W74R	0.954
10:100509495:A:T	W74R	0.954
10:100496289:G:T	A760D	0.952
10:100495521:C:G	R779P	0.950
10:100487667:G:C	F1163L	0.948
10:100487667:G:T	F1163L	0.948
10:100487669:A:G	F1163L	0.948
10:100509344:A:T	V124D	0.946
10:100497730:A:G	W643R	0.941
10:100497730:A:T	W643R	0.941
10:100509089:G:T	A138D	0.940
10:100516165:A:C	I45R	0.940
10:100502471:A:G	L398P	0.936
10:100502268:A:G	W466R	0.935
10:100502268:A:T	W466R	0.935
10:100497265:C:G	R669P	0.932
10:100497728:C:A	W643C	0.929
10:100497728:C:G	W643C	0.929
10:100502260:G:C	F468L	0.928
10:100502260:G:T	F468L	0.928
10:100502262:A:G	F468L	0.928

dbSNP variants (sampled 300 via entrez): RS1000017998 (10:100495123 G>A,C), RS1000088032 (10:100493648 TC>T), RS1000095580 (10:100489125 G>A,C), RS1000161061 (10:100488490 T>C), RS1000240469 (10:100515760 A>G), RS1000292564 (10:100508608 C>A,G,T), RS1000299461 (10:100488767 G>A,T), RS1000405951 (10:100502000 T>C), RS1000534964 (10:100507163 G>T), RS1000758371 (10:100500368 A>G,T), RS1000940729 (10:100514774 C>A), RS1001026005 (10:100513903 G>A), RS1001093881 (10:100520558 C>A,G,T), RS1001123153 (10:100508318 A>G), RS1001209662 (10:100495827 C>T)

Disease associations

OMIM: gene MIM:610258 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST001841_4	Palmitoleic acid (16:1n-7) levels	6.000000e-09
GCST010703_13	Brain morphology (MOSTest)	1.000000e-09

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases expression, increases methylation	2
Cisplatin	decreases expression, affects cotreatment, increases expression	2
Tobacco Smoke Pollution	decreases expression	2
aristolochic acid I	increases expression	1
methylmercuric chloride	decreases expression	1
alpha-pinene	affects cotreatment, decreases expression, increases abundance	1
tris(2-butoxyethyl) phosphate	affects expression	1
beta-lapachone	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	affects expression	1
butyraldehyde	decreases expression	1
methacrylaldehyde	affects cotreatment, decreases expression, increases abundance	1
perfluorooctane sulfonic acid	increases expression	1
CGP 52608	affects binding, increases reaction	1
abrine	increases expression	1
jinfukang	affects cotreatment, increases expression	1
Acrolein	affects cotreatment, decreases expression, increases abundance	1
Air Pollutants	increases abundance, affects cotreatment, decreases expression	1
Diethylhexyl Phthalate	decreases expression	1
Doxorubicin	decreases expression	1
Fluorouracil	affects reaction, decreases expression	1
Methotrexate	increases expression	1
Ozone	affects cotreatment, decreases expression, increases abundance	1
Polychlorinated Biphenyls	affects expression	1
Tetrachlorodibenzodioxin	increases expression	1
Vincristine	decreases expression	1
Aflatoxin B1	decreases expression, increases expression	1
Okadaic Acid	decreases expression	1
Copper Sulfate	decreases expression	1
Volatile Organic Compounds	affects cotreatment, decreases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B5KU	HAP1 SEC31B (-) 2	Cancer cell line	Male
CVCL_XS55	HAP1 SEC31B (-) 1	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.