SELENOV

Summary

SELENOV (selenoprotein V, HGNC:30399) is a protein-coding gene on chromosome 19q13.2, encoding Selenoprotein V (P59797). May be involved in a redox-related process.

This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3’ UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is specifically expressed in the testis. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Alternatively spliced transcript variants have been found for this gene.

Source: NCBI Gene 348303 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 69 total
• MANE Select transcript: NM_182704

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30399
Approved symbol	SELENOV
Name	selenoprotein V
Location	19q13.2
Locus type	gene with protein product
Status	Approved
Aliases	SELV
Ensembl gene	ENSG00000186838
Ensembl biotype	protein_coding
OMIM	607919
Entrez	348303

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 1 protein_coding, 1 retained_intron, 1 nonsense_mediated_decay

ENST00000335426, ENST00000597876, ENST00000600586

RefSeq mRNA: 2 — MANE Select: NM_182704 NM_001350809, NM_182704

CCDS: CCDS54266

Canonical transcript exons

ENST00000335426 — 6 exons

Exon	Start	End
ENSE00001339575	39518903	39518977
ENSE00002052574	39518608	39518632
ENSE00003502858	39519071	39519170
ENSE00003668851	39518740	39518793
ENSE00003978235	39520146	39520675
ENSE00003978236	39515139	39516021

Expression profiles

Bgee: expression breadth broad, 60 present calls, max score 79.25.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1483 / max 18.9456, expressed in 92 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
175789	0.1215	82
175788	0.0268	3

Top tissues by expression

100 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	79.25	gold quality
right testis	UBERON:0004534	78.14	gold quality
testis	UBERON:0000473	78.13	gold quality
left lobe of thyroid gland	UBERON:0001120	72.99	gold quality
thyroid gland	UBERON:0002046	72.96	gold quality
right lobe of thyroid gland	UBERON:0001119	72.66	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	70.83	gold quality
mucosa of stomach	UBERON:0001199	50.67	gold quality
temporal lobe	UBERON:0001871	49.44	gold quality
anterior cingulate cortex	UBERON:0009835	49.42	gold quality
amygdala	UBERON:0001876	49.34	gold quality
nucleus accumbens	UBERON:0001882	47.95	gold quality
calcaneal tendon	UBERON:0003701	47.59	silver quality
hypothalamus	UBERON:0001898	47.29	gold quality
superior frontal gyrus	UBERON:0002661	46.73	gold quality
Ammon’s horn	UBERON:0001954	46.32	gold quality
putamen	UBERON:0001874	46.04	gold quality
left ovary	UBERON:0002119	45.80	gold quality
colonic epithelium	UBERON:0000397	45.57	gold quality
cerebral cortex	UBERON:0000956	45.37	gold quality
prefrontal cortex	UBERON:0000451	45.21	gold quality
frontal cortex	UBERON:0001870	45.01	gold quality
ovary	UBERON:0000992	44.88	gold quality
pituitary gland	UBERON:0000007	44.17	gold quality
right frontal lobe	UBERON:0002810	44.05	gold quality
brain	UBERON:0000955	43.97	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	43.84	gold quality
right ovary	UBERON:0002118	43.26	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	42.94	gold quality
primary visual cortex	UBERON:0002436	42.92	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.12

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

16 targeting SELENOV, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-6887-3P	99.66	67.83	1778
HSA-MIR-6837-5P	99.25	65.47	1632
HSA-MIR-4685-5P	99.25	65.99	1563
HSA-MIR-4279	99.19	66.70	2437
HSA-MIR-4426	99.17	66.74	1949
HSA-MIR-4662B	98.33	66.37	1163
HSA-MIR-4647	98.30	66.41	1139
HSA-MIR-3652	97.71	65.43	1890
HSA-MIR-192-3P	97.52	67.66	1001
HSA-MIR-4430	97.47	65.61	1813
HSA-MIR-600	97.07	66.73	1259
HSA-MIR-7161-3P	96.79	68.79	798
HSA-MIR-617	96.79	65.96	738
HSA-MIR-4522	95.76	66.23	742
HSA-MIR-492	94.02	64.46	413

Literature-anchored findings (GeneRIF, showing 1)

• The SS concentrations that lead to a decrease in the viability of human prostate adenocarcinoma cells (line Du-145) have been selected, and the effect of sodium selenite on the expression of mRNA of the SELV, SELW, and TGR selenocysteine proteins in these cells has been analyzed. (PMID:29989584)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Selenov	ENSMUSG00000046750
rattus_norvegicus	Selenov	ENSRNOG00000051208

Paralogs (2): MIEN1 (ENSG00000141741), SELENOW (ENSG00000178980)

Protein

Protein identifiers

Selenoprotein V — P59797 (reviewed: P59797)

All UniProt accessions (2): M0QZN9, P59797

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in a redox-related process.

Tissue specificity. Testis specific.

Post-translational modifications. Truncated SELENOV proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(APPBP2) complex, which recognizes the glycine (Gly) at the C-terminus of truncated SELENOV proteins.

Similarity. Belongs to the SelWTH family.

RefSeq proteins (2): NP_001337738, NP_874363* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011893	Selenoprotein_Rdx-typ	Family
IPR036249	Thioredoxin-like_sf	Homologous_superfamily
IPR051441	SelW_related	Family

Pfam: PF10262

UniProt features (7 total): region of interest 2, chain 1, compositionally biased region 1, non-standard amino acid 1, cross-link 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

No AlphaFold model available for P59797 — AlphaFold DB does not currently provide models for proteins above ~3000 aa.

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 270–273

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 37 (showing top): CAGGTCC_MIR492, KUUSELO_PANCREATIC_CANCER_19Q13_AMPLIFICATION, MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED, MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3, MIKKELSEN_MEF_HCP_WITH_H3K27ME3, ZNF282_TARGET_GENES, ZNF664_TARGET_GENES, MIR4426, MIR7161_3P, MIR4647_MIR4662B, GSE15733_BM_VS_SPLEEN_MEMORY_CD4_TCELL_UP, GSE17721_CTRL_VS_POLYIC_6H_BMDC_DN, WP_SELENIUM_MICRONUTRIENT_NETWORK, DESCARTES_MAIN_FETAL_METANEPHRIC_CELLS, DESCARTES_FETAL_PANCREAS_DUCTAL_CELLS

GO Biological Process (1): response to selenium ion (GO:0010269)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (1): cytosol (GO:0005829)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
response to chemical	1
binding	1
cytoplasm	1
cellular anatomical structure	1

Protein interactions and networks

STRING

362 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SELENOV	SELENOT	P62341	873
SELENOV	SELENOK	Q9Y6D0	854
SELENOV	SELENOH	Q8IZQ5	852
SELENOV	SELENOO	Q9BVL4	831
SELENOV	SELENOS	Q9BQE4	804
SELENOV	SELENOF	O60613	799
SELENOV	SELENOI	Q9C0D9	796
SELENOV	SEPHS2	Q99611	789
SELENOV	SELENON	Q9NZV5	776
SELENOV	SELENOM	Q8WWX9	775
SELENOV	SECISBP2	Q96T21	762
SELENOV	MSRB1	Q9NZV6	738
SELENOV	TXNRD3	Q86VQ6	730
SELENOV	SELENOP	P49908	669
SELENOV	TXNRD1	Q16881	624

IntAct

34 interactions, top by confidence:

A	B	Type	Score
SELENOV	ZMYND19	psi-mi:“MI:0915”(physical association)	0.720
ZMYND19	SELENOV	psi-mi:“MI:0915”(physical association)	0.720
SELENOV	PRR20C	psi-mi:“MI:0915”(physical association)	0.560
GOLGA2	SELENOV	psi-mi:“MI:0915”(physical association)	0.560
SELENOV	ZMIZ2	psi-mi:“MI:0915”(physical association)	0.560
SELENOV	APPBP2	psi-mi:“MI:0915”(physical association)	0.560
PRR20C	SELENOV	psi-mi:“MI:0915”(physical association)	0.560
ZMIZ2	SELENOV	psi-mi:“MI:0915”(physical association)	0.560
APPBP2	SELENOV	psi-mi:“MI:0915”(physical association)	0.560
SELENOV	GOLGA2	psi-mi:“MI:0915”(physical association)	0.560
HSF2BP	SELENOV	psi-mi:“MI:0915”(physical association)	0.560
SELENOV	EFHC1	psi-mi:“MI:0915”(physical association)	0.560
SELENOV	PIN1	psi-mi:“MI:0915”(physical association)	0.560
SELENOV	NTAQ1	psi-mi:“MI:0915”(physical association)	0.560
SELENOV	QRICH1	psi-mi:“MI:0915”(physical association)	0.560
ZMYND19	SELENOV	psi-mi:“MI:0915”(physical association)	0.000
HSF2BP	SELENOV	psi-mi:“MI:0915”(physical association)	0.000
EFHC1	SELENOV	psi-mi:“MI:0915”(physical association)	0.000
PIN1	SELENOV	psi-mi:“MI:0915”(physical association)	0.000
NTAQ1	SELENOV	psi-mi:“MI:0915”(physical association)	0.000
QRICH1	SELENOV	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (14): SELV (Two-hybrid), SELV (Two-hybrid), SELV (Two-hybrid), SELV (Two-hybrid), SELV (Two-hybrid), SELV (Two-hybrid), SELV (Two-hybrid), SELV (Two-hybrid), SELV (Two-hybrid), SELV (Two-hybrid), QRICH1 (Two-hybrid), SELV (Two-hybrid), SELV (Two-hybrid), SELV (Affinity Capture-Western)

ESM2 similar proteins: A0A0J9YWL9, A0A0J9YY54, A0A0U1RQI7, A0A494C071, A6NNC1, A6QL64, B3KS81, D3YZV8, E2RYF7, E9Q6E9, F1LWT0, F8W0I5, O60732, P0C8Z4, P0DKJ7, P0DKJ8, P0DKL2, P0DPF3, P18751, P20930, P43537, P53353, P59797, P62521, Q01456, Q08AG5, Q12816, Q3BBV2, Q5H9R4, Q5HY64, Q5JPF3, Q6P902, Q6ZQX7, Q86T75, Q86VE3, Q86VQ3, Q8BGJ3, Q8N307, Q8N7U7, Q8N7X1

Diamond homologs: D0EYG3, O19097, P59797, P63300, P63301, P63302, P63303, Q148C8, Q568W0, Q5NVB2, Q95KL4, Q9BRT3, Q9CQ86, Q9STZ2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

69 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	62
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

827 predictions. Top by Δscore:

Variant	Effect	Δscore
19:39516019:CTGG:C	donor_loss	1.0000
19:39516020:TGGTG:T	donor_loss	1.0000
19:39516021:GGTG:G	donor_loss	1.0000
19:39516022:G:C	donor_loss	1.0000
19:39516022:G:GG	donor_gain	1.0000
19:39518738:A:AG	acceptor_gain	1.0000
19:39518739:G:GG	acceptor_gain	1.0000
19:39519062:T:TA	acceptor_gain	1.0000
19:39516023:T:A	donor_loss	0.9900
19:39518579:A:AG	acceptor_gain	0.9900
19:39518580:A:G	acceptor_gain	0.9900
19:39518592:T:A	acceptor_gain	0.9900
19:39518598:T:TA	acceptor_gain	0.9900
19:39518606:A:AG	acceptor_gain	0.9900
19:39518607:G:GG	acceptor_gain	0.9900
19:39518607:GT:G	acceptor_gain	0.9900
19:39518739:GT:G	acceptor_gain	0.9900
19:39518739:GTA:G	acceptor_gain	0.9900
19:39518739:GTAC:G	acceptor_gain	0.9900
19:39518794:G:GG	donor_gain	0.9900
19:39518988:G:GG	donor_gain	0.9900
19:39519006:G:T	donor_gain	0.9900
19:39519064:T:TA	acceptor_gain	0.9900
19:39519069:AGAG:A	acceptor_gain	0.9900
19:39519069:AGAGG:A	acceptor_gain	0.9900
19:39519070:GAGG:G	acceptor_gain	0.9900
19:39519070:GAGGG:G	acceptor_gain	0.9900
19:39516017:TACTG:T	donor_gain	0.9800
19:39516020:TG:T	donor_gain	0.9800
19:39516021:GG:G	donor_gain	0.9800

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000046545 (19:39519590 C>T), RS1000967317 (19:39516575 T>C), RS1000997495 (19:39515627 C>G,T), RS1001375560 (19:39520531 A>G), RS1001445444 (19:39515110 TCG>T), RS1001560716 (19:39518036 G>A), RS1001851542 (19:39513506 C>A), RS1002536506 (19:39513689 C>T), RS1002854153 (19:39516059 A>T), RS1002971551 (19:39518954 G>A,C), RS1003917037 (19:39518922 A>C), RS1004089935 (19:39513431 T>C), RS1004351057 (19:39518585 C>G,T), RS1005614396 (19:39520206 G>A), RS1005816991 (19:39514393 G>A,C)

Disease associations

OMIM: gene MIM:607919 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	affects cotreatment, decreases expression	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1
Valproic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.