SEMA4B

Summary

SEMA4B (semaphorin 4B, HGNC:10730) is a protein-coding gene on chromosome 15q26.1, encoding Semaphorin-4B (Q9NPR2). Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.

Predicted to enable chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Predicted to be involved in several processes, including axon guidance; neural crest cell migration; and semaphorin-plexin signaling pathway. Predicted to be located in membrane and synapse. Predicted to be active in glutamatergic synapse and postsynaptic density membrane.

Source: NCBI Gene 10509 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 166 total
• MANE Select transcript: NM_198925

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10730
Approved symbol	SEMA4B
Name	semaphorin 4B
Location	15q26.1
Locus type	gene with protein product
Status	Approved
Aliases	SemC, KIAA1745, MGC131831
Ensembl gene	ENSG00000185033
Ensembl biotype	protein_coding
OMIM	617029
Entrez	10509

Gene structure

Transcript identifiers

Ensembl transcripts: 28 — 17 protein_coding, 7 retained_intron, 2 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay

ENST00000332496, ENST00000411539, ENST00000558051, ENST00000558065, ENST00000558848, ENST00000558895, ENST00000558975, ENST00000559074, ENST00000559247, ENST00000559300, ENST00000559322, ENST00000559792, ENST00000559983, ENST00000560003, ENST00000560089, ENST00000560263, ENST00000560993, ENST00000561085, ENST00000561252, ENST00000561321, ENST00000864015, ENST00000864016, ENST00000864017, ENST00000864018, ENST00000864019, ENST00000928644, ENST00000928645, ENST00000947039

RefSeq mRNA: 8 — MANE Select: NM_198925 NM_001324029, NM_001324030, NM_001324031, NM_001324032, NM_001324034, NM_001393916, NM_020210, NM_198925

CCDS: CCDS45347

Canonical transcript exons

ENST00000411539 — 14 exons

Exon	Start	End
ENSE00001700923	90201330	90201735
ENSE00002546741	90227904	90229660
ENSE00003462154	90220982	90221093
ENSE00003472405	90225661	90225827
ENSE00003476841	90225282	90225397
ENSE00003483536	90224968	90225178
ENSE00003550351	90223838	90223988
ENSE00003561135	90221614	90221765
ENSE00003577538	90223559	90223740
ENSE00003613352	90217767	90217829
ENSE00003635555	90221367	90221480
ENSE00003649008	90227557	90227642
ENSE00003666194	90219793	90219891
ENSE00003729453	90217439	90217602

Expression profiles

Bgee: expression breadth ubiquitous, 212 present calls, max score 98.02.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 26.9921 / max 559.4280, expressed in 1766 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
148414	10.7150	1485
148417	9.0955	1666
148418	6.6964	985
148415	0.4852	180

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ileal mucosa	UBERON:0000331	98.02	gold quality
esophagus mucosa	UBERON:0002469	97.63	gold quality
lower esophagus mucosa	UBERON:0035834	97.39	gold quality
secondary oocyte	CL:0000655	97.08	gold quality
esophagus	UBERON:0001043	95.52	gold quality
muscle layer of sigmoid colon	UBERON:0035805	95.07	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	94.69	gold quality
gingiva	UBERON:0001828	94.34	gold quality
vagina	UBERON:0000996	94.24	gold quality
transverse colon	UBERON:0001157	94.14	gold quality
gingival epithelium	UBERON:0001949	94.12	silver quality
right lobe of thyroid gland	UBERON:0001119	94.03	gold quality
skin of abdomen	UBERON:0001416	94.02	gold quality
left lobe of thyroid gland	UBERON:0001120	93.97	gold quality
skin of leg	UBERON:0001511	93.81	gold quality
mucosa of transverse colon	UBERON:0004991	93.79	gold quality
minor salivary gland	UBERON:0001830	93.72	gold quality
mouth mucosa	UBERON:0003729	93.52	gold quality
left adrenal gland	UBERON:0001234	93.30	gold quality
sural nerve	UBERON:0015488	93.28	gold quality
tibial nerve	UBERON:0001323	93.27	gold quality
small intestine Peyer’s patch	UBERON:0003454	93.27	gold quality
lower esophagus	UBERON:0013473	93.25	gold quality
lower esophagus muscularis layer	UBERON:0035833	93.23	gold quality
oocyte	CL:0000023	93.22	gold quality
colon	UBERON:0001155	93.19	gold quality
thyroid gland	UBERON:0002046	93.13	gold quality
left adrenal gland cortex	UBERON:0035825	93.11	gold quality
large intestine	UBERON:0000059	92.76	gold quality
zone of skin	UBERON:0000014	92.67	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-75688	yes	590.12
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): STAT1

miRNA regulators (miRDB)

71 targeting SEMA4B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-7152-3P	99.97	67.47	849
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-106A-5P	99.90	73.94	2683
HSA-MIR-6499-3P	99.90	66.38	1212
HSA-MIR-17-5P	99.89	73.83	2665
HSA-MIR-345-3P	99.89	70.23	1421
HSA-MIR-106B-5P	99.88	74.72	2795
HSA-MIR-20A-5P	99.88	74.76	2769
HSA-MIR-20B-5P	99.88	74.01	2621
HSA-MIR-519D-3P	99.88	73.97	2607
HSA-MIR-526B-3P	99.88	74.06	2587
HSA-MIR-93-5P	99.88	73.98	2606
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-12119	99.87	68.35	1653
HSA-MIR-548BB-3P	99.86	70.58	4354
HSA-MIR-548AC	99.84	70.77	4351
HSA-MIR-548H-3P	99.84	70.80	4349
HSA-MIR-548Z	99.84	70.80	4349
HSA-MIR-4319	99.76	69.83	2586
HSA-MIR-6745	99.74	65.33	1321

Literature-anchored findings (GeneRIF, showing 5)

• showed that HIF-1alpha recognized a hypoxia-responsive element (HRE) of SEMA4B gene, which is required for HIF-1-repressed SEMA4B expression (PMID:24474252)
• Decrease in SEMA4b levels are associated with metastasis of non-small cell lung cancer. (PMID:25095981)
• SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling pathway, which subsequently inhibited cell growth through the direct nuclear target of FoxO1, p21. (PMID:25746385)
• Semaphorin 4B promotes tumor progression and associates with immune infiltrates in lung adenocarcinoma. (PMID:35676688)
• CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation. (PMID:36115854)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	sema4ba	ENSDARG00000074414
danio_rerio	sema4bb	ENSDARG00000076104
mus_musculus	Sema4b	ENSMUSG00000030539
rattus_norvegicus	Sema4b	ENSRNOG00000025167

Paralogs (19): SEMA3F (ENSG00000001617), SEMA3G (ENSG00000010319), SEMA3B (ENSG00000012171), SEMA3A (ENSG00000075213), SEMA3C (ENSG00000075223), SEMA5B (ENSG00000082684), SEMA6A (ENSG00000092421), SEMA4G (ENSG00000095539), SEMA5A (ENSG00000112902), SEMA4F (ENSG00000135622), SEMA6D (ENSG00000137872), SEMA7A (ENSG00000138623), SEMA6C (ENSG00000143434), SEMA3D (ENSG00000153993), SEMA6B (ENSG00000167680), SEMA4C (ENSG00000168758), SEMA3E (ENSG00000170381), SEMA4D (ENSG00000187764), SEMA4A (ENSG00000196189)

Protein

Protein identifiers

Semaphorin-4B — Q9NPR2 (reviewed: Q9NPR2)

Alternative names: Semaphorin-C

All UniProt accessions (10): Q9NPR2, H0YKV7, H0YLN3, H0YM68, H0YMD6, H0YMR1, H0YMZ3, H0YN49, H0YNC4, H0YNM2

UniProt curated annotations — full annotation on UniProt →

Function. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.

Subcellular location. Membrane.

Similarity. Belongs to the semaphorin family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9NPR2-1	1	yes
Q9NPR2-2	2

RefSeq proteins (8): NP_001310958, NP_001310959, NP_001310960, NP_001310961, NP_001310963, NP_001380845, NP_064595, NP_945119* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001627	Semap_dom	Domain
IPR002165	Plexin_repeat	Repeat
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR016201	PSI	Domain
IPR027231	Semaphorin	Family
IPR036352	Semap_dom_sf	Homologous_superfamily

Pfam: PF01403, PF01437

UniProt features (28 total): glycosylation site 6, disulfide bond 6, modified residue 3, domain 3, topological domain 2, sequence conflict 2, signal peptide 1, chain 1, splice variant 1, sequence variant 1, transmembrane region 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NPR2-F1	82.14	0.64

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 818, 830, 793

Disulfide bonds (6): 120–131, 149–158, 286–399, 310–359, 526–543, 611–656

Glycosylation sites (6): 69, 96, 165, 410, 525, 630

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 238 (showing top): TGCACTT_MIR519C_MIR519B_MIR519A, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, GOBP_NEUROGENESIS, GOBP_AMEBOIDAL_TYPE_CELL_MIGRATION, BILD_HRAS_ONCOGENIC_SIGNATURE, GOBP_TAXIS, RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN, GOBP_MESENCHYMAL_CELL_DIFFERENTIATION, SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1, TGCTGAY_UNKNOWN, MARTIN_VIRAL_GPCR_SIGNALING_UP, NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN, BASAKI_YBX1_TARGETS_DN, GOBP_MESENCHYME_DEVELOPMENT, RFX1_02

GO Biological Process (7): neural crest cell migration (GO:0001755), axon guidance (GO:0007411), positive regulation of cell migration (GO:0030335), negative chemotaxis (GO:0050919), semaphorin-plexin signaling pathway (GO:0071526), nervous system development (GO:0007399), cell differentiation (GO:0030154)

GO Molecular Function (4): semaphorin receptor binding (GO:0030215), neuropilin binding (GO:0038191), chemorepellent activity (GO:0045499), protein binding (GO:0005515)

GO Cellular Component (5): plasma membrane (GO:0005886), postsynaptic density membrane (GO:0098839), glutamatergic synapse (GO:0098978), membrane (GO:0016020), synapse (GO:0045202)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
signaling receptor binding	2
neural crest cell development	1
mesenchymal cell migration	1
axonogenesis	1
neuron projection guidance	1
cell migration	1
regulation of cell migration	1
positive regulation of cell motility	1
chemotaxis	1
cell surface receptor signaling pathway	1
system development	1
cellular developmental process	1
receptor ligand activity	1
negative chemotaxis	1
binding	1
membrane	1
cell periphery	1
postsynaptic density	1
postsynaptic membrane	1
postsynaptic specialization membrane	1
synapse	1
cellular anatomical structure	1
cell junction	1

Protein interactions and networks

STRING

542 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SEMA4B	DCBLD2	Q96PD2	874
SEMA4B	GNAT1	P11488	691
SEMA4B	PLXNB2	O15031	594
SEMA4B	GNAI2	P04899	590
SEMA4B	GTPBP4	Q9BZE4	589
SEMA4B	PLXNA1	Q9UIW2	536
SEMA4B	DLG4	P78352	491
SEMA4B	NRP2	O60462	462
SEMA4B	SNX33	Q8WV41	459
SEMA4B	SNX18	Q96RF0	449
SEMA4B	SYT1	P21579	422
SEMA4B	EZH2	Q15910	414
SEMA4B	NCDN	Q9UBB6	409
SEMA4B	ABAT	P80404	396
SEMA4B	PPAT	Q06203	388

IntAct

33 interactions, top by confidence:

A	B	Type	Score
SEMA4B		psi-mi:“MI:0915”(physical association)	0.660
FBXO2	TMEM131L	psi-mi:“MI:0914”(association)	0.530
C1orf54	EXTL3	psi-mi:“MI:0914”(association)	0.530
TDRD9	SEMA4B	psi-mi:“MI:0915”(physical association)	0.400
SEMA4B		psi-mi:“MI:0915”(physical association)	0.370
	SHTN1	psi-mi:“MI:0914”(association)	0.350
	TMEM223	psi-mi:“MI:0914”(association)	0.350
	FAM171A2	psi-mi:“MI:0914”(association)	0.350
PDCD2	PRMT3	psi-mi:“MI:0914”(association)	0.350
SEMA4A	TMEM192	psi-mi:“MI:0914”(association)	0.350
SEMA4B	NLGN1	psi-mi:“MI:0914”(association)	0.350
TMEM106A	TMEM131L	psi-mi:“MI:0914”(association)	0.350
SFTPC	TMEM131L	psi-mi:“MI:0914”(association)	0.350
BRICD5	TMEM131L	psi-mi:“MI:0914”(association)	0.350
HLA-DQA1	TMEM131L	psi-mi:“MI:0914”(association)	0.350
PTCH1	TMEM131L	psi-mi:“MI:0914”(association)	0.350
NCR3	POTEF	psi-mi:“MI:0914”(association)	0.350
LYPD4	POTEF	psi-mi:“MI:0914”(association)	0.350
DNAJB9	POTEF	psi-mi:“MI:0914”(association)	0.350
CFC1	POTEF	psi-mi:“MI:0914”(association)	0.350
EDN3	POTEF	psi-mi:“MI:0914”(association)	0.350
DPEP2	QSOX1	psi-mi:“MI:0914”(association)	0.350
PDGFRA	QSOX1	psi-mi:“MI:0914”(association)	0.350
ELSPBP1	QSOX1	psi-mi:“MI:0914”(association)	0.350
PRG2	QSOX1	psi-mi:“MI:0914”(association)	0.350
CST9L	QSOX1	psi-mi:“MI:0914”(association)	0.350
SDF2L1	MANBA	psi-mi:“MI:0914”(association)	0.350
LYZL1	MAN2B1	psi-mi:“MI:0914”(association)	0.350
FIBIN	MAN2B1	psi-mi:“MI:0914”(association)	0.350

ESM2 similar proteins: A0JND9, D3YTS9, O19058, O35795, O55026, O75173, P08648, P11117, P17405, P20611, P21217, P24638, P29376, P56433, Q04519, Q0P5F0, Q0V8G3, Q0VD19, Q11128, Q11131, Q32M88, Q4R5N9, Q4R942, Q5MY95, Q5NVF6, Q5RFQ8, Q62994, Q63148, Q6IY74, Q8BH73, Q8HYJ3, Q8HYJ4, Q8HYJ5, Q8HYJ7, Q8HZR3, Q8K1S1, Q8N135, Q923W9, Q9BZG2, Q9H3T2

Diamond homologs: A7MB70, D3ZTD8, O08665, O09126, O15041, O35464, O42236, O42237, O88632, O95025, O95754, P70275, Q13214, Q13275, Q13591, Q14563, Q17330, Q24322, Q24323, Q26473, Q26972, Q4LFA9, Q5EA85, Q5R7F5, Q5RE75, Q60519, Q62177, Q62178, Q62179, Q62181, Q62217, Q63548, Q64151, Q76KF0, Q8BH34, Q8NFY4, Q90607, Q90663, Q90665, Q92854

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

166 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	140
Likely benign	10
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2814 predictions. Top by Δscore:

Variant	Effect	Δscore
15:90217434:CCCA:C	acceptor_loss	1.0000
15:90217435:CCAG:C	acceptor_loss	1.0000
15:90217436:CA:C	acceptor_loss	1.0000
15:90217437:A:AG	acceptor_gain	1.0000
15:90217437:AGGCT:A	acceptor_loss	1.0000
15:90217438:G:A	acceptor_loss	1.0000
15:90217438:G:GA	acceptor_gain	1.0000
15:90217598:AGGAG:A	donor_loss	1.0000
15:90217599:GGAG:G	donor_gain	1.0000
15:90217600:G:GT	donor_gain	1.0000
15:90217600:GAGGT:G	donor_loss	1.0000
15:90217603:GTGA:G	donor_loss	1.0000
15:90217604:T:G	donor_loss	1.0000
15:90217765:A:AG	acceptor_gain	1.0000
15:90217766:G:GG	acceptor_gain	1.0000
15:90219788:CCCA:C	acceptor_loss	1.0000
15:90219789:CCA:C	acceptor_loss	1.0000
15:90219791:A:AG	acceptor_gain	1.0000
15:90219791:AGC:A	acceptor_gain	1.0000
15:90219791:AGCGC:A	acceptor_gain	1.0000
15:90219792:G:A	acceptor_loss	1.0000
15:90219792:G:GT	acceptor_gain	1.0000
15:90219792:GC:G	acceptor_gain	1.0000
15:90219792:GCG:G	acceptor_gain	1.0000
15:90219792:GCGC:G	acceptor_gain	1.0000
15:90219792:GCGCG:G	acceptor_gain	1.0000
15:90219888:CATC:C	donor_gain	1.0000
15:90219889:ATC:A	donor_gain	1.0000
15:90219890:TC:T	donor_gain	1.0000
15:90219890:TCGT:T	donor_loss	1.0000

AlphaMissense

5436 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:90223595:T:A	W300R	0.999
15:90223595:T:C	W300R	0.999
15:90217803:T:A	C120S	0.998
15:90217804:G:C	C120S	0.998
15:90219799:T:A	C131S	0.998
15:90219800:G:C	C131S	0.998
15:90219868:T:C	F154L	0.998
15:90219870:C:A	F154L	0.998
15:90219870:C:G	F154L	0.998
15:90221746:G:C	R281P	0.998
15:90221760:T:A	C286S	0.998
15:90221761:G:C	C286S	0.998
15:90223612:G:C	K305N	0.998
15:90223612:G:T	K305N	0.998
15:90219800:G:A	C131Y	0.997
15:90219801:T:G	C131W	0.997
15:90219807:C:A	N133K	0.997
15:90219807:C:G	N133K	0.997
15:90221400:T:G	F210C	0.997
15:90221623:T:G	F240C	0.997
15:90221752:C:A	A283D	0.997
15:90221761:G:A	C286Y	0.997
15:90223597:G:C	W300C	0.997
15:90223597:G:T	W300C	0.997
15:90217803:T:C	C120R	0.996
15:90217805:C:G	C120W	0.996
15:90219854:G:A	C149Y	0.996
15:90219855:T:G	C149W	0.996
15:90219875:C:A	P156H	0.996
15:90221751:G:C	A283P	0.996

dbSNP variants (sampled 300 via entrez): RS1000082982 (15:90185387 A>C,G,T), RS1000145295 (15:90193314 A>G), RS1000146032 (15:90208981 T>C), RS1000147064 (15:90185109 G>A), RS1000229027 (15:90188767 A>T), RS1000306011 (15:90229326 G>A), RS1000341834 (15:90203930 G>A), RS1000408421 (15:90193694 G>A), RS1000486838 (15:90184677 G>A), RS1000516913 (15:90213349 A>G), RS1000589671 (15:90215482 CTTG>C), RS1000606883 (15:90224441 C>T), RS1000620613 (15:90215713 G>A), RS1000664071 (15:90214337 A>C), RS1000692069 (15:90184326 C>T)

Disease associations

OMIM: gene MIM:617029 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST007096_28	Pulse pressure	4.000000e-08
GCST007234_18	Acne (severe)	6.000000e-15
GCST007234_19	Acne (severe)	7.000000e-08
GCST007713_4	Frontal fibrosing alopecia	8.000000e-10
GCST90011900_119	Serum alkaline phosphatase levels	4.000000e-13
GCST90013406_285	Liver enzyme levels (alkaline phosphatase)	1.000000e-16
GCST90013407_11	Liver enzyme levels (gamma-glutamyl transferase)	7.000000e-12

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0005763	pulse pressure measurement
EFO:0009855	frontal fibrosing alopecia
EFO:0004533	alkaline phosphatase measurement
EFO:0004532	serum gamma-glutamyl transferase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

52 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects splicing, decreases expression, increases expression	3
Air Pollutants	affects expression, increases abundance, decreases expression, increases expression	3
Particulate Matter	increases abundance, increases expression, affects cotreatment, decreases expression	3
Acetaminophen	decreases expression	2
Calcitriol	increases expression	2
triphenyl phosphate	affects expression	1
bisphenol A	increases expression	1
O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	affects expression, affects response to substance	1
tris(2-butoxyethyl) phosphate	affects expression	1
beta-lapachone	increases expression	1
butyraldehyde	decreases expression	1
ferrous chloride	decreases expression	1
beta-methylcholine	affects expression	1
azoxystrobin	decreases expression	1
CGP 52608	affects binding, increases reaction	1
perfluoro-n-nonanoic acid	decreases expression	1
deguelin	decreases expression	1
fenpyroximate	decreases expression	1
4-chloro-N-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide	decreases expression	1
pyrimidifen	decreases expression	1
abrine	decreases expression	1
pyrachlostrobin	decreases expression	1
darinaparsin	decreases expression	1
bisphenol S	decreases methylation	1
jinfukang	increases expression	1
picoxystrobin	decreases expression	1
PCI 5002	affects cotreatment, increases expression	1
Temozolomide	decreases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	affects methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.