SEMA6A-AS2

Summary

SEMA6A-AS2 (SEMA6A antisense RNA 2, HGNC:52754) is a long non-coding RNA gene on chromosome 5q23.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52754
Approved symbol	SEMA6A-AS2
Name	SEMA6A antisense RNA 2
Location	5q23.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000249167
Ensembl biotype	lncRNA
Entrez	105379132
RNAcentral	URS0000BC4452 — lncRNA, 2351 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000508766, ENST00000655160, ENST00000660166, ENST00000660260, ENST00000663913, ENST00000811511

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000508766 — 2 exons

Exon	Start	End
ENSE00002049514	116574482	116574539
ENSE00002066757	116590975	116591398

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 77.34.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0853 / max 6.0031, expressed in 55 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
58080	0.0853	55

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.34	gold quality
colonic epithelium	UBERON:0000397	74.41	gold quality
cortical plate	UBERON:0005343	70.64	gold quality
mucosa of transverse colon	UBERON:0004991	65.92	gold quality
ganglionic eminence	UBERON:0004023	65.69	gold quality
thymus	UBERON:0002370	64.89	silver quality
ventricular zone	UBERON:0003053	64.71	gold quality
bone marrow	UBERON:0002371	64.58	silver quality
quadriceps femoris	UBERON:0001377	64.14	gold quality
adrenal tissue	UBERON:0018303	63.34	gold quality
cerebellar vermis	UBERON:0004720	63.05	gold quality
corpus callosum	UBERON:0002336	62.17	gold quality
skeletal muscle tissue	UBERON:0001134	60.87	gold quality
hindlimb stylopod muscle	UBERON:0004252	60.33	gold quality
placenta	UBERON:0001987	60.15	gold quality
spinal cord	UBERON:0002240	59.19	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	59.16	gold quality
prefrontal cortex	UBERON:0000451	58.38	gold quality
rectum	UBERON:0001052	57.21	gold quality
right adrenal gland cortex	UBERON:0035827	57.01	gold quality
stromal cell of endometrium	CL:0002255	56.77	gold quality
duodenum	UBERON:0002114	56.64	gold quality
primary visual cortex	UBERON:0002436	56.62	gold quality
adrenal gland	UBERON:0002369	56.53	gold quality
right adrenal gland	UBERON:0001233	56.24	gold quality
left adrenal gland	UBERON:0001234	55.42	gold quality
left adrenal gland cortex	UBERON:0035825	55.06	gold quality
frontal cortex	UBERON:0001870	54.93	gold quality
cerebellum	UBERON:0002037	54.63	gold quality
cerebellar cortex	UBERON:0002129	54.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.13

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.