SENCR

Summary

SENCR (smooth muscle and endothelial cell enriched migration/differentiation-associated lncRNA, HGNC:44177) is a long non-coding RNA gene on chromosome 11q24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44177
Approved symbol	SENCR
Name	smooth muscle and endothelial cell enriched migration/differentiation-associated lncRNA
Location	11q24.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000254703
Ensembl biotype	lncRNA
OMIM	615815
Entrez	100507392
RNAcentral	URS000075E93E — lncRNA, 1319 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000526269, ENST00000685905, ENST00000702959, ENST00000763064

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000526269 — 3 exons

Exon	Start	End
ENSE00002150795	128692655	128693391
ENSE00002164999	128695913	128696023
ENSE00002186472	128691672	128692121

Expression profiles

Bgee: expression breadth ubiquitous, 153 present calls, max score 78.40.

FANTOM5 (CAGE): breadth broad, TPM avg 0.6141 / max 26.2662, expressed in 246 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
123113	0.6141	246

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	78.40	gold quality
leukocyte	CL:0000738	78.17	gold quality
granulocyte	CL:0000094	74.66	gold quality
spleen	UBERON:0002106	74.35	gold quality
blood	UBERON:0000178	73.78	gold quality
bone marrow cell	CL:0002092	69.71	silver quality
apex of heart	UBERON:0002098	68.51	gold quality
colonic epithelium	UBERON:0000397	68.44	silver quality
omental fat pad	UBERON:0010414	68.34	gold quality
peritoneum	UBERON:0002358	68.31	gold quality
bone marrow	UBERON:0002371	67.84	gold quality
cartilage tissue	UBERON:0002418	67.78	gold quality
adipose tissue of abdominal region	UBERON:0007808	67.65	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.07	gold quality
tendon of biceps brachii	UBERON:0008188	65.19	gold quality
upper lobe of left lung	UBERON:0008952	64.99	gold quality
sural nerve	UBERON:0015488	64.91	silver quality
upper lobe of lung	UBERON:0008948	64.37	gold quality
trabecular bone tissue	UBERON:0002483	64.35	gold quality
heart left ventricle	UBERON:0002084	63.68	gold quality
cardiac ventricle	UBERON:0002082	63.49	gold quality
right atrium auricular region	UBERON:0006631	63.19	gold quality
cardiac atrium	UBERON:0002081	63.04	gold quality
left uterine tube	UBERON:0001303	62.65	gold quality
mammary duct	UBERON:0001765	62.65	gold quality
adipose tissue	UBERON:0001013	62.62	gold quality
smooth muscle tissue	UBERON:0001135	62.37	gold quality
heart	UBERON:0000948	62.27	gold quality
right lung	UBERON:0002167	62.15	gold quality
tendon	UBERON:0000043	61.99	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• Data showed that SENCR contributes to the regulation of endothelial differentiation from pluripotent cells and controls the angiogenic capacity of human umbilical endothelial cells. (PMID:26898221)
• Long non-coding RNA SENCR alleviates the inhibitory effects of rapamycin on human umbilical vein endothelial cells. (PMID:29845247)
• These findings support SENCR as a flow-responsive lncRNA that promotes EC adherens junction integrity through physical association with CKAP4, thereby stabilizing cell membrane-bound CDH5. (PMID:30584103)
• Preliminary study on the mechanism of long noncoding RNA SENCR regulating the proliferation and migration of vascular smooth muscle cells. (PMID:32401347)
• LncRNA SENCR overexpression attenuated the proliferation, migration and phenotypic switching of vascular smooth muscle cells in aortic dissection via the miR-206/myocardin axis. (PMID:35351345)
• Super enhancer-LncRNA SENCR promoted cisplatin resistance and growth of NSCLC through upregulating FLI1. (PMID:35500152)
• The relationship between preeclampsia risk and SENCR rs555172 gene polymorphism and expression. (PMID:38650152)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.