SEPTIN10

Summary

SEPTIN10 (septin 10, HGNC:14349) is a protein-coding gene on chromosome 2q13, encoding Septin-10 (Q9P0V9). Filament-forming cytoskeletal GTPase.

This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. A pseudogene for this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 151011 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 4 total
• MANE Select transcript: NM_144710

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14349
Approved symbol	SEPTIN10
Name	septin 10
Location	2q13
Locus type	gene with protein product
Status	Approved
Aliases	FLJ11619, Septin-10
Ensembl gene	ENSG00000186522
Ensembl biotype	protein_coding
OMIM	611737
Entrez	151011

Gene structure

Transcript identifiers

Ensembl transcripts: 28 — 24 protein_coding, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000356688, ENST00000397712, ENST00000397714, ENST00000411469, ENST00000415095, ENST00000423520, ENST00000425498, ENST00000437928, ENST00000442746, ENST00000461295, ENST00000468616, ENST00000483047, ENST00000486678, ENST00000493445, ENST00000894640, ENST00000894641, ENST00000894642, ENST00000894643, ENST00000894644, ENST00000894645, ENST00000894646, ENST00000894647, ENST00000934718, ENST00000934719, ENST00000934720, ENST00000948158, ENST00000948159, ENST00000948160

RefSeq mRNA: 21 — MANE Select: NM_144710 NM_001321496, NM_001321498, NM_001321499, NM_001321500, NM_001321501, NM_001321502, NM_001321503, NM_001321504, NM_001321505, NM_001321506, NM_001321507, NM_001321508, NM_001321509, NM_001321510, NM_001321511, NM_001321512, NM_001321513, NM_001321514, NM_001321515, NM_144710, NM_178584

CCDS: CCDS42726, CCDS46383, CCDS82496, CCDS82497

Canonical transcript exons

ENST00000397712 — 11 exons

Exon	Start	End
ENSE00001659459	109553087	109553219
ENSE00002479198	109546050	109546237
ENSE00002481830	109585721	109585838
ENSE00002696538	109613798	109613966
ENSE00003481666	109593051	109593119
ENSE00003504356	109564366	109564534
ENSE00003553427	109574581	109574767
ENSE00003598204	109542799	109544324
ENSE00003607263	109585126	109585321
ENSE00003644271	109565763	109565859
ENSE00003663283	109567815	109567976

Expression profiles

Bgee: expression breadth ubiquitous, 291 present calls, max score 98.80.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 25.8505 / max 271.3708, expressed in 1660 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
30105	14.8721	1589
30108	8.3027	1509
30106	0.7106	452
30107	0.6151	370
30110	0.5357	271
30111	0.4130	228
30109	0.2737	137
30104	0.1275	26

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skin of hip	UBERON:0001554	98.80	gold quality
upper leg skin	UBERON:0004262	98.73	gold quality
oral cavity	UBERON:0000167	98.39	gold quality
upper arm skin	UBERON:0004263	98.37	gold quality
blood vessel layer	UBERON:0004797	98.31	gold quality
germinal epithelium of ovary	UBERON:0001304	98.29	gold quality
penis	UBERON:0000989	98.25	gold quality
choroid plexus epithelium	UBERON:0003911	98.22	gold quality
hair follicle	UBERON:0002073	98.07	gold quality
amniotic fluid	UBERON:0000173	97.91	gold quality
parietal pleura	UBERON:0002400	97.85	gold quality
calcaneal tendon	UBERON:0003701	97.79	gold quality
synovial joint	UBERON:0002217	97.72	gold quality
gingiva	UBERON:0001828	97.62	gold quality
pleura	UBERON:0000977	97.54	gold quality
lower lobe of lung	UBERON:0008949	97.47	gold quality
visceral pleura	UBERON:0002401	97.46	gold quality
esophagus squamous epithelium	UBERON:0006920	97.45	gold quality
mammalian vulva	UBERON:0000997	97.43	gold quality
gingival epithelium	UBERON:0001949	97.41	gold quality
squamous epithelium	UBERON:0006914	97.25	gold quality
urethra	UBERON:0000057	97.17	gold quality
cauda epididymis	UBERON:0004360	97.14	gold quality
urinary bladder	UBERON:0001255	97.04	gold quality
tongue squamous epithelium	UBERON:0006919	97.01	gold quality
cartilage tissue	UBERON:0002418	96.99	gold quality
epithelium of esophagus	UBERON:0001976	96.86	gold quality
saphenous vein	UBERON:0007318	96.86	gold quality
pharyngeal mucosa	UBERON:0000355	96.82	gold quality
mammary duct	UBERON:0001765	96.76	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	12.91
E-CURD-112	no	3.05

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

82 targeting SEPTIN10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-3646	100.00	73.56	5283
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-223-3P	99.99	70.14	1140
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-6835-3P	99.93	70.49	2904
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-4697-3P	99.89	67.09	1123

Literature-anchored findings (GeneRIF, showing 6)

• Cloning and functional characterization of septin 10. (PMID:12711328)
• Lack of SEPT10 transcript is associated with B-cell chronic lymphocytic leukemia (PMID:17657217)
• we found that paclitaxel-resistant tumors had decreased expression of SEPT10. (PMID:22320903)
• miR-124-3p regulates the proliferation and differentiation of retinal progenitor cells through SEPT10. (PMID:36802303)
• Exosomal circCLIP1 regulates PM2.5-induced airway obstruction via targeting SEPT10 in vitro. (PMID:36950992)
• SEPTIN10-mediated crosstalk between cytoskeletal networks controls mechanotransduction and oncogenic YAP/TAZ signaling. (PMID:38242197)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	septin10	ENSDARG00000099236
mus_musculus	Septin10	ENSMUSG00000019917
rattus_norvegicus	Septin10	ENSRNOG00000049507
drosophila_melanogaster	Septin5	FBGN0026361

Paralogs (12): SEPTIN3 (ENSG00000100167), SEPTIN7 (ENSG00000122545), SEPTIN6 (ENSG00000125354), SEPTIN11 (ENSG00000138758), SEPTIN12 (ENSG00000140623), SEPTIN14 (ENSG00000154997), SEPTIN8 (ENSG00000164402), SEPTIN2 (ENSG00000168385), SEPTIN1 (ENSG00000180096), SEPTIN9 (ENSG00000184640), SEPTIN5 (ENSG00000184702), TMEM250 (ENSG00000238227)

Protein

Protein identifiers

Septin-10 — Q9P0V9 (reviewed: Q9P0V9)

All UniProt accessions (11): B5ME97, C9JEQ7, C9JEW2, C9JNR7, E7EW69, E7EX04, Q9P0V9, F5GYV2, F5H1F2, F5H1W3, F8WC85

UniProt curated annotations — full annotation on UniProt →

Function. Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential).

Subunit / interactions. Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with ADGB.

Subcellular location. Cytoplasm. Cytoskeleton. Cell projection. Cilium. Flagellum.

Tissue specificity. Widely expressed. Abundantly expressed in heart and kidney, placenta, skeletal muscles, liver and lung, as well as various tumor cell lines.

Post-translational modifications. Proteolytically cleaved in vitro in a calmodulin-dependent manner.

Similarity. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9P0V9-1	1	yes
Q9P0V9-2	2
Q9P0V9-3	3

RefSeq proteins (21): NP_001308425, NP_001308427, NP_001308428, NP_001308429, NP_001308430, NP_001308431, NP_001308432, NP_001308433, NP_001308434, NP_001308435, NP_001308436, NP_001308437, NP_001308438, NP_001308439, NP_001308440, NP_001308441, NP_001308442, NP_001308443, NP_001308444, NP_653311, NP_848699 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR016491	Septin	Family
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR030379	G_SEPTIN_dom	Domain

Pfam: PF00735

UniProt features (13 total): binding site 5, region of interest 3, splice variant 2, chain 1, domain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9P0V9-F1	81.07	0.51

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (5): 73–80; 128; 209–217; 263; 278

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 211 (showing top): HORIUCHI_WTAP_TARGETS_DN, MYOGENIN_Q6, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GEORGES_CELL_CYCLE_MIR192_TARGETS, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GTGCCTT_MIR506, PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP, ONKEN_UVEAL_MELANOMA_UP, GOBP_CYTOKINESIS, SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN, DAZARD_RESPONSE_TO_UV_SCC_UP, CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN, FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN, BURTON_ADIPOGENESIS_10, PITX2_Q2

GO Biological Process (3): intracellular protein localization (GO:0008104), cytoskeleton-dependent cytokinesis (GO:0061640), cell division (GO:0051301)

GO Molecular Function (5): GTPase activity (GO:0003924), GTP binding (GO:0005525), molecular adaptor activity (GO:0060090), nucleotide binding (GO:0000166), protein binding (GO:0005515)

GO Cellular Component (9): septin ring (GO:0005940), microtubule cytoskeleton (GO:0015630), septin complex (GO:0031105), motile cilium (GO:0031514), cell division site (GO:0032153), cytoplasm (GO:0005737), cytoskeleton (GO:0005856), cilium (GO:0005929), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
binding	2
cytoskeleton	2
cell cortex	2
septin cytoskeleton	2
macromolecule localization	1
cytokinesis	1
cellular process	1
ribonucleoside triphosphate phosphatase activity	1
guanyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
molecular_function	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
protein-containing complex	1
cilium	1
intracellular anatomical structure	1
intracellular membraneless organelle	1
intraciliary transport particle	1
membrane-bounded organelle	1
plasma membrane bounded cell projection	1

Protein interactions and networks

STRING

528 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SEPTIN10	SEPTIN11	Q9NVA2	747
SEPTIN10	SEPTIN4	O43236	687
SEPTIN10	SEPTIN9	Q9UHD8	588
SEPTIN10	SEPTIN7	Q16181	554
SEPTIN10	SEPTIN1	Q8WYJ6	533
SEPTIN10	SEPTIN6	Q14141	477
SEPTIN10	SH3RF3	Q8TEJ3	462
SEPTIN10	SEPTIN2	Q15019	420
SEPTIN10	SEPTIN8	Q92599	409
SEPTIN10	ADAM29	Q9UKF5	400
SEPTIN10	SEPTIN14	Q6ZU15	396
SEPTIN10	CDC42EP2	O14613	388
SEPTIN10	CDC42EP5	Q6NZY7	378
SEPTIN10	LDOC1	O95751	349
SEPTIN10	AKAP17A	Q02040	330

IntAct

64 interactions, top by confidence:

A	B	Type	Score
SEPTIN2	SEPTIN6	psi-mi:“MI:0914”(association)	0.950
SEPTIN6	SEPTIN2	psi-mi:“MI:0914”(association)	0.950
SEPTIN7	SEPTIN6	psi-mi:“MI:0914”(association)	0.850
SEPTIN12	SEPTIN6	psi-mi:“MI:0914”(association)	0.830
SEPTIN3	SEPTIN6	psi-mi:“MI:0914”(association)	0.800
SEPTIN12	SEPTIN4	psi-mi:“MI:0914”(association)	0.730
SEPTIN10	SEPTIN5	psi-mi:“MI:0915”(physical association)	0.670
SEPTIN5	SEPTIN10	psi-mi:“MI:0915”(physical association)	0.670
SEPTIN10	SEPTIN7	psi-mi:“MI:0915”(physical association)	0.670
SEPTIN11	SEPTIN6	psi-mi:“MI:0914”(association)	0.640
RALBP1	JUN	psi-mi:“MI:0914”(association)	0.640
IGF1R	PIK3R2	psi-mi:“MI:2364”(proximity)	0.590
SEPTIN10	SEPTIN7	psi-mi:“MI:0915”(physical association)	0.560
SEPTIN7	SEPTIN10	psi-mi:“MI:0915”(physical association)	0.560
CDC42EP4	SEPTIN6	psi-mi:“MI:0914”(association)	0.530
SEPTIN10	SEPTIN2	psi-mi:“MI:0914”(association)	0.530
SEPTIN7	SEPTIN4	psi-mi:“MI:0914”(association)	0.530
	GNAT3	psi-mi:“MI:0915”(physical association)	0.400
SEPTIN10	LSM8	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (234): SEPT10 (Two-hybrid), SEPT10 (Two-hybrid), SEPT10 (Affinity Capture-MS), SEPT10 (Affinity Capture-MS), SEPT10 (Affinity Capture-MS), SEPT10 (Affinity Capture-MS), SEPT10 (Affinity Capture-MS), CORO1C (Co-fractionation), SEPT10 (Co-fractionation), SEPT10 (Co-fractionation), SEPT10 (Co-fractionation), SEPT10 (Co-fractionation), SEPT10 (Co-fractionation), SEPT10 (Co-fractionation), SEPT10 (Affinity Capture-MS)

ESM2 similar proteins: A0A096MJN4, A2BGU8, A4FUM1, A5D7Q3, A5PJU9, A6QQL3, B0BNF1, B0KWP7, B1H120, B1MTN8, B2KIE9, B3GNI6, B5FW69, O36023, O43236, P28661, P32468, P40797, P42209, P48010, Q08DM7, Q0VC68, Q0VCP4, Q14141, Q2KJB1, Q3SZN0, Q4R4X5, Q4R555, Q4V8G5, Q5EB96, Q5PQK1, Q5R6R7, Q5REG8, Q6AXA6, Q6IRQ5, Q8C1B7, Q8C650, Q8CHH9, Q8IYM1, Q92599

Diamond homologs: A0A096MJN4, A0A3Q0KDV9, A1L0Y5, A2BGU8, A2VE99, A4FUM1, A5D7Q3, A5PJU9, A6QQL3, B0BNF1, B0KWP7, B1H120, B1MTN8, B2KIE9, B3GNI6, B5FW69, G1UB61, O36023, O43236, O55131, O60165, P25342, P28661, P32457, P32458, P32468, P39826, P39827, P40797, P41901, P42207, P42208, P42209, P48008, P48009, P48010, P54359, Q04921, Q08DM7, Q09116

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 60 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
cytoskeleton-dependent cytokinesis	10	151.4×	6e-18
intracellular protein localization	10	19.8×	1e-08

Disease & clinical

Clinical variants and AI predictions

ClinVar

4 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	3
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2565 predictions. Top by Δscore:

Variant	Effect	Δscore
2:109546049:CTT:C	donor_gain	1.0000
2:109564535:C:CC	acceptor_gain	1.0000
2:109567809:GCTCA:G	donor_loss	1.0000
2:109567810:CTCAC:C	donor_loss	1.0000
2:109567811:TCACA:T	donor_loss	1.0000
2:109567812:CACAT:C	donor_loss	1.0000
2:109567813:A:AC	donor_gain	1.0000
2:109567813:A:C	donor_loss	1.0000
2:109567814:C:CA	donor_gain	1.0000
2:109567814:CATT:C	donor_gain	1.0000
2:109567972:TTTAC:T	acceptor_gain	1.0000
2:109567973:TTAC:T	acceptor_gain	1.0000
2:109567974:TACC:T	acceptor_loss	1.0000
2:109567976:CC:C	acceptor_loss	1.0000
2:109567980:T:C	acceptor_gain	1.0000
2:109567980:T:TC	acceptor_gain	1.0000
2:109574569:T:A	donor_gain	1.0000
2:109585121:CATA:C	donor_loss	1.0000
2:109585122:ATAC:A	donor_loss	1.0000
2:109585123:TA:T	donor_loss	1.0000
2:109585125:C:G	donor_loss	1.0000
2:109585125:CCT:C	donor_gain	1.0000
2:109585125:CCTCT:C	donor_gain	1.0000
2:109585198:T:A	donor_gain	1.0000
2:109585322:C:CC	acceptor_gain	1.0000
2:109593049:A:AC	donor_gain	1.0000
2:109593050:C:CC	donor_gain	1.0000
2:109593050:CTAT:C	donor_gain	1.0000
2:109593120:C:CC	acceptor_gain	1.0000
2:109546048:A:AC	donor_gain	0.9900

AlphaMissense

3056 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:109564465:A:G	L310P	0.999
2:109565778:A:G	W282R	0.998
2:109565778:A:T	W282R	0.998
2:109565840:A:T	V261D	0.998
2:109564501:A:G	L298P	0.997
2:109574656:A:C	C175W	0.997
2:109574658:A:G	C175R	0.997
2:109564498:C:G	R299P	0.996
2:109565789:C:G	R278P	0.996
2:109565790:G:T	R278S	0.996
2:109565843:G:T	A260D	0.996
2:109567966:A:T	I204K	0.996
2:109567971:G:C	N202K	0.996
2:109567971:G:T	N202K	0.996
2:109585321:C:T	G73E	0.996
2:109585721:C:A	G73W	0.996
2:109585729:A:G	L70P	0.996
2:109565849:G:T	P258Q	0.995
2:109567954:G:T	A208D	0.995
2:109574670:G:T	R171S	0.995
2:109585294:A:G	L82P	0.995
2:109585721:C:G	G73R	0.995
2:109585721:C:T	G73R	0.995
2:109564426:C:G	R323T	0.994
2:109564489:A:G	L302P	0.994
2:109574591:A:G	L197P	0.994
2:109585177:A:G	L121S	0.994
2:109585321:C:A	G73V	0.994
2:109564515:A:C	C293W	0.993
2:109564517:A:G	C293R	0.993

dbSNP variants (sampled 300 via entrez): RS1000035955 (2:109544151 G>A,C,T), RS1000045476 (2:109571818 A>T), RS1000059540 (2:109572378 C>T), RS1000113076 (2:109596155 C>T), RS1000115271 (2:109612423 G>A,T), RS1000163412 (2:109600776 A>G), RS1000230933 (2:109562607 CTGA>C), RS1000248042 (2:109568806 T>C), RS1000250726 (2:109596369 G>A,C), RS1000338111 (2:109555848 C>T), RS1000355125 (2:109597772 C>T), RS1000362439 (2:109590179 A>C,G), RS1000452028 (2:109562916 T>A), RS1000490362 (2:109574157 C>T), RS1000563086 (2:109613925 G>A,C,T)

Disease associations

OMIM: gene MIM:611737 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST003048_108	Schizophrenia	5.000000e-08
GCST012490_96	Femur bone mineral density x serum urate levels interaction	4.000000e-10

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004531	urate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression, increases methylation	4
trichostatin A	affects cotreatment, decreases expression	2
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	2
Aflatoxin B1	decreases methylation, increases expression, increases methylation	2
aristolochic acid I	decreases expression	1
FR900359	affects phosphorylation	1
2,4,6-tribromophenol	decreases expression	1
bisphenol A	decreases expression	1
decabromobiphenyl ether	decreases expression	1
arsenite	affects binding, decreases reaction	1
sodium arsenite	decreases expression, increases abundance	1
tetrabromobisphenol A	decreases expression	1
ciglitazone	affects binding, increases expression	1
2-palmitoylglycerol	increases expression	1
K 7174	increases expression	1
fenpyroximate	increases expression	1
pyrimidifen	increases expression	1
nutlin 3	affects cotreatment, increases secretion	1
abrine	decreases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
pentabrominated diphenyl ether 100	decreases expression	1
LDN 193189	affects cotreatment, decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	decreases expression, increases abundance	1
Cuprizone	increases expression	1
Dactinomycin	affects cotreatment, increases secretion	1
Ivermectin	decreases expression	1
Potassium Dichromate	increases expression	1
Silicon Dioxide	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.