SERP1

Summary

SERP1 (stress associated endoplasmic reticulum protein 1, HGNC:10759) is a protein-coding gene on chromosome 3q25.1, encoding Stress-associated endoplasmic reticulum protein 1 (Q9Y6X1). Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum.

Predicted to be involved in endoplasmic reticulum unfolded protein response. Predicted to act upstream of or within several processes, including positive regulation of organ growth; positive regulation of peptide hormone secretion; and positive regulation of translation. Located in cytoplasmic microtubule.

Source: NCBI Gene 27230 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 10 total
• MANE Select transcript: NM_014445

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10759
Approved symbol	SERP1
Name	stress associated endoplasmic reticulum protein 1
Location	3q25.1
Locus type	gene with protein product
Status	Approved
Aliases	RAMP4, FLJ43424
Ensembl gene	ENSG00000120742
Ensembl biotype	protein_coding
OMIM	617674
Entrez	27230

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 5 protein_coding, 4 protein_coding_CDS_not_defined

ENST00000239944, ENST00000463647, ENST00000479209, ENST00000484608, ENST00000487153, ENST00000490945, ENST00000491195, ENST00000491660, ENST00000914303

RefSeq mRNA: 1 — MANE Select: NM_014445 NM_014445

CCDS: CCDS3150

Canonical transcript exons

ENST00000239944 — 3 exons

Exon	Start	End
ENSE00001233110	150546052	150546496
ENSE00003891354	150541998	150544498
ENSE00003895983	150545703	150545778

Expression profiles

Bgee: expression breadth ubiquitous, 303 present calls, max score 99.67.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 227.4358 / max 1399.4231, expressed in 1828 samples.

FANTOM5 promoters (13 alternative TSS)

Promoter ID	TPM avg	Samples expressed
45102	104.5855	1823
45100	79.6799	1828
45101	19.4184	1796
45105	6.2322	1510
45096	5.3120	1329
45097	4.6083	1209
45099	4.5156	1352
202975	0.8460	553
45098	0.7943	311
45106	0.5616	342

Top tissues by expression

303 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
parotid gland	UBERON:0001831	99.67	gold quality
corpus epididymis	UBERON:0004359	99.28	gold quality
body of pancreas	UBERON:0001150	99.20	gold quality
caput epididymis	UBERON:0004358	98.96	gold quality
bronchial epithelial cell	CL:0002328	98.73	gold quality
epithelium of bronchus	UBERON:0002031	98.66	gold quality
bronchus	UBERON:0002185	98.65	gold quality
cervix squamous epithelium	UBERON:0006922	98.62	gold quality
amniotic fluid	UBERON:0000173	98.50	gold quality
palpebral conjunctiva	UBERON:0001812	98.50	gold quality
mucosa of paranasal sinus	UBERON:0005030	98.50	gold quality
superficial temporal artery	UBERON:0001614	98.47	gold quality
lower lobe of lung	UBERON:0008949	98.46	gold quality
mononuclear cell	CL:0000842	98.45	gold quality
monocyte	CL:0000576	98.43	gold quality
mucosa of sigmoid colon	UBERON:0004993	98.42	gold quality
leukocyte	CL:0000738	98.39	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	98.35	gold quality
gingival epithelium	UBERON:0001949	98.28	gold quality
epithelium of nasopharynx	UBERON:0001951	98.28	gold quality
germinal epithelium of ovary	UBERON:0001304	98.26	gold quality
nasopharynx	UBERON:0001728	98.26	gold quality
sperm	CL:0000019	98.16	gold quality
pylorus	UBERON:0001166	98.16	gold quality
trachea	UBERON:0003126	98.13	gold quality
decidua	UBERON:0002450	98.11	gold quality
periodontal ligament	UBERON:0008266	98.08	gold quality
colonic mucosa	UBERON:0000317	98.06	gold quality
gingiva	UBERON:0001828	98.01	gold quality
type B pancreatic cell	CL:0000169	97.94	gold quality

Single-cell (SCXA)

Detected in 10 experiment(s), a significant marker in 7.

Experiment	Marker?	Max mean expression
E-HCAD-1	yes	39.38
E-HCAD-11	yes	20.45
E-HCAD-9	yes	14.90
E-HCAD-10	yes	14.16
E-CURD-46	yes	10.93
E-MTAB-10042	yes	7.85
E-MTAB-8060	no	2773.32
E-GEOD-125970	no	16.28
E-HCAD-13	no	3.10
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): ATF6

miRNA regulators (miRDB)

151 targeting SERP1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-196A-5P	100.00	68.16	684
HSA-MIR-196B-5P	100.00	68.16	681
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-218-5P	99.93	72.22	2103
HSA-MIR-1-3P	99.93	72.35	1914
HSA-MIR-206	99.93	72.50	1893
HSA-MIR-6744-5P	99.93	66.82	748
HSA-MIR-145-5P	99.92	71.13	1836
HSA-MIR-5195-3P	99.92	70.92	1877

Literature-anchored findings (GeneRIF, showing 9)

• SFRP1 DNA methylation, accumulates with age in normal-appearing kidney tissues and is associated with increased renal cancer risk. (PMID:22419128)
• SERP1 is a novel cochaperone and regulator of ENaC expression. (PMID:22526458)
• expression of SFRP1 mRNA and protein correlates with the Gleason score, survival rate and response for endocrine therapy of prostate cancer. (PMID:25719802)
• Study demonstrated that SERP1 expression level was significantly upregulated in human pancreatic ductal adenocarcinoma (PDAC) tissues which positively associated with advanced clinical stage and shorter survival time (OS and DFS). Downregulated SERP1 expression promoted PDAC cell apoptosis and inhibited NF-kappaB activation probably by upregulating SRPRB expression. (PMID:28902358)
• This study reveals the important role of SERP1/Ysy6 and Atg8 in endoplasmic reticulum stress response and virulence in Candida albicans. (PMID:29544880)
• SERP1 is an assembly regulator of gamma-secretase in metabolic stress conditions. (PMID:32184288)
• Let-7b-5p is involved in the response of endoplasmic reticulum stress in acute pulmonary embolism through upregulating the expression of stress-associated endoplasmic reticulum protein 1. (PMID:32534478)
• Low expression of endoplasmic reticulum stress-related gene SERP1 is associated with poor prognosis and immune infiltration in skin cutaneous melanoma. (PMID:34613934)
• CircWDR33 alleviates human pulmonary microvascular endothelial cell injury in sepsis-associated acute lung injury by targeting miR-217-5p/SERP1 axis. (PMID:36417821)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	SERP1	ENSDARG00000076223
danio_rerio	serp1	ENSDARG00000099439
mus_musculus	Serp1	ENSMUSG00000027808
rattus_norvegicus	Serp1	ENSRNOG00000011763
drosophila_melanogaster	CG32276	FBGN0047135
caenorhabditis_elegans		WBGENE00010337
caenorhabditis_elegans		WBGENE00020374

Paralogs (1): SERP2 (ENSG00000151778)

Protein

Protein identifiers

Stress-associated endoplasmic reticulum protein 1 — Q9Y6X1 (reviewed: Q9Y6X1)

Alternative names: Ribosome-attached membrane protein 4

All UniProt accessions (3): C9JSB0, C9JUH5, Q9Y6X1

UniProt curated annotations — full annotation on UniProt →

Function. Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins.

Subunit / interactions. Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX.

Subcellular location. Membrane. Endoplasmic reticulum membrane.

Similarity. Belongs to the RAMP4 family.

RefSeq proteins (1): NP_055260* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR010580	ER_stress-assoc	Family

Pfam: PF06624

UniProt features (4 total): chain 1, transmembrane region 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
9N9J	ELECTRON MICROSCOPY	3.2
9YGY	ELECTRON MICROSCOPY	4.1

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y6X1-F1	77.19	0.24

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-381038	XBP1(S) activates chaperone genes
R-HSA-9609523	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
R-HSA-2262752	Cellular responses to stress
R-HSA-381070	IRE1alpha activates chaperones
R-HSA-381119	Unfolded Protein Response (UPR)
R-HSA-8953897	Cellular responses to stimuli
R-HSA-9609507	Protein localization

MSigDB gene sets: 395 (showing top): GSE45365_NK_CELL_VS_CD8_TCELL_UP, MORF_MTA1, AAGCAAT_MIR137, REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR, YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_10, WANG_CLIM2_TARGETS_UP, GOBP_SKELETAL_SYSTEM_DEVELOPMENT, GOBP_REGULATION_OF_DEVELOPMENTAL_GROWTH, GOBP_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS, GOBP_INSULIN_SECRETION, GOBP_GROWTH, GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION, GOBP_PLASMA_MEMBRANE_ORGANIZATION, GOBP_REGULATION_OF_HORMONE_LEVELS, GOBP_HORMONE_TRANSPORT

GO Biological Process (16): skeletal system development (GO:0001501), glucose metabolic process (GO:0006006), plasma membrane organization (GO:0007009), glycoprotein biosynthetic process (GO:0009101), post-embryonic development (GO:0009791), insulin secretion (GO:0030073), endoplasmic reticulum unfolded protein response (GO:0030968), positive regulation of insulin secretion (GO:0032024), protein modification process (GO:0036211), positive regulation of translation (GO:0045727), positive regulation of organ growth (GO:0046622), muscle organ morphogenesis (GO:0048644), positive regulation of growth hormone secretion (GO:0060124), obsolete protein glycosylation (GO:0006486), response to unfolded protein (GO:0006986), protein transport (GO:0015031)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (6): endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), cytosol (GO:0005829), ribosome (GO:0005840), cytoplasmic microtubule (GO:0005881), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
IRE1alpha activates chaperones	1
Protein localization	1
Cellular responses to stimuli	1
Unfolded Protein Response (UPR)	1
Cellular responses to stress	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	3
positive regulation of peptide hormone secretion	2
cellular anatomical structure	2
system development	1
hexose metabolic process	1
endomembrane system organization	1
membrane organization	1
macromolecule biosynthetic process	1
glycoprotein metabolic process	1
carbohydrate derivative biosynthetic process	1
multicellular organism development	1
multicellular organismal process	1
protein secretion	1
peptide hormone secretion	1
cellular response to unfolded protein	1
response to endoplasmic reticulum stress	1
intracellular signal transduction	1
insulin secretion	1
positive regulation of protein secretion	1
regulation of insulin secretion	1
protein metabolic process	1
macromolecule modification	1
translation	1
regulation of translation	1
positive regulation of gene expression	1
positive regulation of protein metabolic process	1
organ growth	1
regulation of organ growth	1
positive regulation of developmental growth	1
positive regulation of multicellular organismal process	1
muscle organ development	1
animal organ morphogenesis	1
growth hormone secretion	1
regulation of growth hormone secretion	1
response to topologically incorrect protein	1
transport	1
intracellular protein localization	1
establishment of protein localization	1
binding	1
endomembrane system	1

Protein interactions and networks

STRING

778 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SERP1	GET1	O00258	528
SERP1	F10	P00742	509
SERP1	SEC61A1	P38378	507
SERP1	C1S	P09871	487
SERP1	GET3	O43681	479
SERP1	EDEM1	Q92611	478
SERP1	DNAJC3	Q13217	478
SERP1	TMED2	Q15363	474
SERP1	DNAJB9	Q9UBS3	447
SERP1	SEC62	Q99442	441
SERP1	CCDC134	Q9H6E4	418
SERP1	DNAJB11	Q9UBS4	418
SERP1	SSR3	Q9UNL2	412
SERP1	GOLM2	Q6P4E1	410
SERP1	SEC61B	P38390	397

IntAct

131 interactions, top by confidence:

A	B	Type	Score
KCNF1	SERP1	psi-mi:“MI:0915”(physical association)	0.600
SERP1	TMEM79	psi-mi:“MI:0915”(physical association)	0.560
TMEM79	SERP1	psi-mi:“MI:0915”(physical association)	0.560
SERP1	FAM210B	psi-mi:“MI:0915”(physical association)	0.560
SERP1	HSD17B13	psi-mi:“MI:0915”(physical association)	0.560
SERP1	AQP6	psi-mi:“MI:0915”(physical association)	0.560
SERP1	LHFPL5	psi-mi:“MI:0915”(physical association)	0.560
SERP1	TMEM14B	psi-mi:“MI:0915”(physical association)	0.560
SERP1	ALG3	psi-mi:“MI:0915”(physical association)	0.560
SERP1	CYBRD1	psi-mi:“MI:0915”(physical association)	0.560
SERP1	BSCL2	psi-mi:“MI:0915”(physical association)	0.560
SERP1	MTIF3	psi-mi:“MI:0915”(physical association)	0.560
STX4	SERP1	psi-mi:“MI:0915”(physical association)	0.560
STX1A	SERP1	psi-mi:“MI:0915”(physical association)	0.560
CD74	SERP1	psi-mi:“MI:0915”(physical association)	0.560
TNFRSF9	SERP1	psi-mi:“MI:0915”(physical association)	0.560
FRMD3	SERP1	psi-mi:“MI:0915”(physical association)	0.560
BIK	SERP1	psi-mi:“MI:0915”(physical association)	0.560
GKN1	SERP1	psi-mi:“MI:0915”(physical association)	0.560
TMEM52B	SERP1	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (86): LOC100355886 (Affinity Capture-MS), BAG6 (Affinity Capture-Western), ASNA1 (Affinity Capture-Western), ASNA1 (Affinity Capture-MS), BAG6 (Affinity Capture-MS), DNAJB1 (Affinity Capture-MS), DNAJB1 (Affinity Capture-Western), HSPA4 (Affinity Capture-MS), HSPA4 (Affinity Capture-Western), HSPA8 (Affinity Capture-MS), HSPA8 (Affinity Capture-Western), SGTA (Affinity Capture-Western), TMEM79 (Two-hybrid), SERP1 (Two-hybrid), SERP1 (PCA)

ESM2 similar proteins: A0A0H2ZNG3, A0A242DI27, A3N0X3, A4ZUD5, A5UE01, A5UHM6, A9MHQ7, B0BPQ7, B3GXV7, C5DQ18, C5DT30, G2TRT3, O60071, P44844, P47301, P52871, P75090, P94520, P96728, Q07541, Q08JR8, Q0I282, Q20687, Q3T073, Q3ZBR1, Q4QMH2, Q54P38, Q553P6, Q5FB24, Q5HJ89, Q5REZ1, Q5UQ15, Q65W23, Q6CLJ7, Q6GCI8, Q6TAW2, Q7NX81, Q7VKZ7, Q87TF6, Q8MN49

Diamond homologs: Q3T073, Q3ZBR1, Q5REZ1, Q6TAW2, Q8N6R1, Q9R2C1, Q9Y6X1, Q9Z1W5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

10 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	5
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1618 predictions. Top by Δscore:

Variant	Effect	Δscore
3:150544499:C:CC	acceptor_gain	1.0000
3:150546045:T:A	donor_gain	1.0000
3:150546046:CCTTA:C	donor_loss	1.0000
3:150546047:CTTAC:C	donor_loss	1.0000
3:150546048:TTACC:T	donor_loss	1.0000
3:150546049:TACCG:T	donor_loss	1.0000
3:150546050:A:AC	donor_gain	1.0000
3:150546050:ACCG:A	donor_loss	1.0000
3:150546051:C:CC	donor_gain	1.0000
3:150546826:GACAG:G	donor_gain	1.0000
3:150546831:G:GG	donor_gain	1.0000
3:150552341:A:AG	acceptor_gain	1.0000
3:150552342:T:G	acceptor_gain	1.0000
3:150552346:A:AG	acceptor_gain	1.0000
3:150552347:C:G	acceptor_gain	1.0000
3:150552354:A:AG	acceptor_gain	1.0000
3:150552354:A:C	acceptor_loss	1.0000
3:150552354:AGTCC:A	acceptor_gain	1.0000
3:150552355:G:GG	acceptor_gain	1.0000
3:150552355:GT:G	acceptor_gain	1.0000
3:150552355:GTC:G	acceptor_gain	1.0000
3:150552355:GTCC:G	acceptor_gain	1.0000
3:150552355:GTCCG:G	acceptor_gain	1.0000
3:150552421:CCAAG:C	donor_loss	1.0000
3:150552422:CAAGG:C	donor_loss	1.0000
3:150552424:AGGTA:A	donor_loss	1.0000
3:150552425:GGTA:G	donor_loss	1.0000
3:150552426:GTATG:G	donor_loss	1.0000
3:150552427:T:G	donor_loss	1.0000
3:150558458:GAAAA:G	donor_gain	1.0000

AlphaMissense

439 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:150545708:C:T	G52D	1.000
3:150545709:C:G	G52R	1.000
3:150546108:C:G	A10P	1.000
3:150545712:A:G	C51R	0.999
3:150545717:A:T	V49D	0.999
3:150545732:G:T	A44D	0.999
3:150546071:C:A	G22V	0.999
3:150546071:C:T	G22D	0.999
3:150546072:C:A	G22C	0.999
3:150546072:C:G	G22R	0.999
3:150546075:G:A	R21C	0.999
3:150546075:G:T	R21S	0.999
3:150546119:C:A	R6M	0.999
3:150545711:C:T	C51Y	0.998
3:150545729:A:T	L45H	0.998
3:150546083:A:T	I18N	0.998
3:150546096:G:C	H14D	0.998
3:150546103:G:C	N11K	0.998
3:150546103:G:T	N11K	0.998
3:150546107:G:T	A10D	0.998
3:150546118:C:A	R6S	0.998
3:150546118:C:G	R6S	0.998
3:150546119:C:G	R6T	0.998
3:150545710:A:C	C51W	0.997
3:150545714:A:T	V50D	0.997
3:150545729:A:G	L45P	0.997
3:150546083:A:C	I18S	0.997
3:150546113:C:G	R8P	0.997
3:150546120:T:A	R6W	0.997
3:150545703:C:G	A54P	0.996

dbSNP variants (sampled 300 via entrez): RS1000413088 (3:150544825 C>A,G), RS1000861731 (3:150542883 A>G), RS1000928135 (3:150546844 A>G), RS1001150410 (3:150543270 T>C), RS1001257435 (3:150547637 T>C), RS1001303814 (3:150547375 G>A,C), RS1002183890 (3:150546510 C>G), RS1002914490 (3:150545222 A>C,G), RS1003335820 (3:150546594 C>A,G,T), RS1003719823 (3:150544887 C>G), RS1004058908 (3:150547537 G>C,T), RS1005338575 (3:150543673 T>G), RS1005363356 (3:150548418 C>G), RS1005408795 (3:150541585 C>A), RS1005414258 (3:150548022 A>G)

Disease associations

OMIM: gene MIM:617674 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST011358_15	Academic attainment (English)	5.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0011015	educational attainment

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

41 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, affects cotreatment, increases abundance, increases expression	4
Cyclosporine	increases expression	4
Air Pollutants	affects expression, increases abundance, decreases expression, increases expression	3
Valproic Acid	decreases methylation, increases expression	3
Cisplatin	decreases expression, increases expression	2
Tobacco Smoke Pollution	increases expression	2
Tunicamycin	increases expression	2
Cadmium Chloride	increases expression, increases abundance	2
Thapsigargin	increases expression	2
Particulate Matter	decreases expression, increases abundance, increases expression	2
methylmercuric chloride	increases expression	1
triphenyl phosphate	affects expression	1
bis(tri-n-butyltin)oxide	affects expression	1
bisphenol A	affects expression	1
trichostatin A	increases expression	1
beta-lapachone	increases expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
celastrol	increases expression	1
perfluorooctane sulfonic acid	increases expression	1
gedunin	increases expression	1
entinostat	increases expression	1
clothianidin	decreases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	increases expression	1
Sunitinib	decreases expression	1
Vorinostat	increases expression	1
Acetaminophen	increases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Cadmium	increases abundance, increases expression	1
Diuron	decreases expression	1
Doxorubicin	decreases expression	1

Cellosaurus cell lines

10 cell lines: 9 embryonic stem cell, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3GU	Abcam HEK293T SERP1 KO	Transformed cell line	Female
CVCL_D1IK	H9 AAVS1-TRE3G-NGN2 CCPG1-/- Keima-RAMP4	Embryonic stem cell	Female
CVCL_D1IM	H9 AAVS1-TRE3G-NGN2 RETREG1-/- Keima-RAMP4	Embryonic stem cell	Female
CVCL_D1IP	H9 AAVS1-TRE3G-NGN2 RETREG3-/- Keima-RAMP4	Embryonic stem cell	Female
CVCL_D1IR	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/- Keima-RAMP4	Embryonic stem cell	Female
CVCL_D1IT	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/- RETREG1-/- Keima-RAMP4	Embryonic stem cell	Female
CVCL_D1IV	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/- RETREG1-/- TEX264-/- Keima-RAMP4	Embryonic stem cell	Female
CVCL_D1IX	H9 AAVS1-TRE3G-NGN2 RETREG3-/- RETREG2-/- RETREG1-/- TEX264-/- CCPG1-/- Keima-RAMP4	Embryonic stem cell	Female
CVCL_D1IZ	H9 AAVS1-TRE3G-NGN2 TEX264-/- Keima-RAMP4	Embryonic stem cell	Female
CVCL_D1J1	H9 AAVS1-TRE3G-NGN2 RETREG2-/- Keima-RAMP4	Embryonic stem cell	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.