SERP2

Summary

SERP2 (stress associated endoplasmic reticulum protein family member 2, HGNC:20607) is a protein-coding gene on chromosome 13q14.11, encoding Stress-associated endoplasmic reticulum protein 2 (Q8N6R1). Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum.

Predicted to be involved in endoplasmic reticulum unfolded protein response. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum.

Source: NCBI Gene 387923 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 4 total
• MANE Select transcript: NM_001010897

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20607
Approved symbol	SERP2
Name	stress associated endoplasmic reticulum protein family member 2
Location	13q14.11
Locus type	gene with protein product
Status	Approved
Aliases	bA269C23.1
Ensembl gene	ENSG00000151778
Ensembl biotype	protein_coding
Entrez	387923

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 3 protein_coding, 2 nonsense_mediated_decay

ENST00000379179, ENST00000474333, ENST00000493476, ENST00000616650, ENST00000885982

RefSeq mRNA: 2 — MANE Select: NM_001010897 NM_001010897, NM_001346980

CCDS: CCDS31965

Canonical transcript exons

ENST00000379179 — 3 exons

Exon	Start	End
ENSE00001001734	44373824	44374109
ENSE00001267320	44379641	44379713
ENSE00001893249	44397272	44397714

Expression profiles

Bgee: expression breadth ubiquitous, 195 present calls, max score 96.67.

FANTOM5 (CAGE): breadth broad, TPM avg 3.8814 / max 103.9184, expressed in 914 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
134941	3.5707	900
134939	0.2048	84
134940	0.1059	50

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
Brodmann (1909) area 9	UBERON:0013540	96.67	gold quality
right frontal lobe	UBERON:0002810	96.32	gold quality
anterior cingulate cortex	UBERON:0009835	96.17	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	96.09	gold quality
endothelial cell	CL:0000115	95.30	silver quality
nucleus accumbens	UBERON:0001882	94.85	gold quality
prefrontal cortex	UBERON:0000451	94.80	gold quality
primary visual cortex	UBERON:0002436	94.79	gold quality
caudate nucleus	UBERON:0001873	94.78	gold quality
Brodmann (1909) area 23	UBERON:0013554	94.60	silver quality
neocortex	UBERON:0001950	94.51	gold quality
frontal cortex	UBERON:0001870	94.37	gold quality
amygdala	UBERON:0001876	94.30	gold quality
cerebral cortex	UBERON:0000956	94.05	gold quality
middle temporal gyrus	UBERON:0002771	93.92	silver quality
putamen	UBERON:0001874	93.71	gold quality
left testis	UBERON:0004533	93.58	gold quality
sperm	CL:0000019	93.57	silver quality
hypothalamus	UBERON:0001898	93.48	gold quality
right testis	UBERON:0004534	93.45	gold quality
superior frontal gyrus	UBERON:0002661	92.74	gold quality
forebrain	UBERON:0001890	92.66	gold quality
Ammon’s horn	UBERON:0001954	92.62	gold quality
temporal lobe	UBERON:0001871	92.09	gold quality
cortical plate	UBERON:0005343	91.98	gold quality
brain	UBERON:0000955	91.87	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	91.80	gold quality
right hemisphere of cerebellum	UBERON:0014890	91.65	gold quality
Brodmann (1909) area 46	UBERON:0006483	91.54	silver quality
postcentral gyrus	UBERON:0002581	91.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

33 targeting SERP2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-605-3P	99.88	69.22	1833
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-11181-3P	99.75	66.38	2205
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-4472	99.56	66.08	1478
HSA-MIR-3616-5P	99.55	67.02	989
HSA-MIR-573	99.55	67.44	955
HSA-MIR-6727-3P	99.49	65.92	1333
HSA-MIR-5584-5P	99.49	68.22	2814
HSA-MIR-5571-5P	99.49	66.99	1764
HSA-MIR-4441	99.49	66.56	3216
HSA-MIR-766-5P	99.47	67.91	2225
HSA-MIR-4722-3P	99.35	65.22	1099
HSA-MIR-3606-5P	99.31	69.67	1168
HSA-MIR-6770-5P	98.97	66.76	1853
HSA-MIR-1843	98.97	66.07	838
HSA-MIR-4802-5P	98.97	66.26	833
HSA-MIR-6894-5P	98.70	63.78	809
HSA-MIR-219B-5P	97.91	65.80	531
HSA-MIR-7154-3P	97.65	65.02	985

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	serp2	ENSDARG00000094003
mus_musculus	Serp2	ENSMUSG00000052584
rattus_norvegicus	Serp2	ENSRNOG00000038228
drosophila_melanogaster	CG32276	FBGN0047135
caenorhabditis_elegans		WBGENE00010337
caenorhabditis_elegans		WBGENE00020374

Paralogs (1): SERP1 (ENSG00000120742)

Protein

Protein identifiers

Stress-associated endoplasmic reticulum protein 2 — Q8N6R1 (reviewed: Q8N6R1)

Alternative names: Ribosome-associated membrane protein RAMP4-2

All UniProt accessions (4): Q8N6R1, A0A087WTA6, F2Z2S5, H7C5W3

UniProt curated annotations — full annotation on UniProt →

Function. Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins.

Subunit / interactions. Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX.

Subcellular location. Membrane. Endoplasmic reticulum membrane.

Similarity. Belongs to the RAMP4 family.

RefSeq proteins (2): NP_001010897, NP_001333909 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR010580	ER_stress-assoc	Family

Pfam: PF06624

UniProt features (2 total): chain 1, transmembrane region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N6R1-F1	80.53	0.28

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 28 (showing top): GOBP_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS, GOBP_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN, IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_UP, GOBP_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN, chr13q14, GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK, GOCC_ORGANELLE_SUBCOMPARTMENT, LI_INDUCED_T_TO_NATURAL_KILLER_UP, BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B, ZSCAN30_TARGET_GENES, MIR548AA_MIR548AP_3P_MIR548T_3P, MIR765, MIR11181_3P, MIR6727_3P, MIR4722_3P

GO Biological Process (2): endoplasmic reticulum unfolded protein response (GO:0030968), response to unfolded protein (GO:0006986)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (3): endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular response to unfolded protein	1
response to endoplasmic reticulum stress	1
intracellular signal transduction	1
response to topologically incorrect protein	1
binding	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
cellular anatomical structure	1

Protein interactions and networks

STRING

382 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SERP2	ANKMY1	Q9P2S6	434
SERP2	SERPINA1	P01009	429
SERP2	ZGRF1	Q86YA3	367
SERP2	DCN	P07585	353
SERP2	KIAA1614	Q5VZ46	349
SERP2	SMIM11	P58511	305
SERP2	C15orf40	Q8WUR7	305
SERP2	EFEMP2	O95967	286
SERP2	PDCD7	Q8N8D1	285
SERP2	FKBP9	O95302	274
SERP2	C6orf120	Q7Z4R8	272
SERP2	GET1	O00258	270
SERP2	VMO1	Q7Z5L0	261
SERP2	PMM2	O15305	253
SERP2	DTWD1	Q8N5C7	252

IntAct

155 interactions, top by confidence:

A	B	Type	Score
KASH5	SERP2	psi-mi:“MI:0915”(physical association)	0.720
SERP2	KASH5	psi-mi:“MI:0915”(physical association)	0.720
SERP2	TIMMDC1	psi-mi:“MI:0915”(physical association)	0.560
SERP2	LYVE1	psi-mi:“MI:0915”(physical association)	0.560
SERP2	PTGES	psi-mi:“MI:0915”(physical association)	0.560
SERP2	TM4SF19	psi-mi:“MI:0915”(physical association)	0.560
SERP2	SCN3B	psi-mi:“MI:0915”(physical association)	0.560
SERP2	RNASEK	psi-mi:“MI:0915”(physical association)	0.560
SERP2	LHFPL5	psi-mi:“MI:0915”(physical association)	0.560
SERP2	FAM210B	psi-mi:“MI:0915”(physical association)	0.560
SERP2	CYB561	psi-mi:“MI:0915”(physical association)	0.560
SERP2	EBP	psi-mi:“MI:0915”(physical association)	0.560
SERP2	TMX2	psi-mi:“MI:0915”(physical association)	0.560
STX1A	SERP2	psi-mi:“MI:0915”(physical association)	0.560
TMED8	SERP2	psi-mi:“MI:0915”(physical association)	0.560
SERP2	GKN1	psi-mi:“MI:0915”(physical association)	0.560
SERP2	SLC38A1	psi-mi:“MI:0915”(physical association)	0.560
	SERP2	psi-mi:“MI:0915”(physical association)	0.560
BIK	SERP2	psi-mi:“MI:0915”(physical association)	0.560
SERP2	TMEM106C	psi-mi:“MI:0915”(physical association)	0.560
OPRM1	SERP2	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (64): SERP2 (Two-hybrid), SERP2 (Two-hybrid), SERP2 (Two-hybrid), SERP2 (Two-hybrid), SERP2 (Two-hybrid), SERP2 (Two-hybrid), SERP2 (Two-hybrid), SERP2 (Two-hybrid), SERP2 (Two-hybrid), SERP2 (Two-hybrid), SERP2 (Two-hybrid), SERP2 (Two-hybrid), SERP2 (Two-hybrid), SERP2 (Two-hybrid), SERP2 (Two-hybrid)

ESM2 similar proteins: A0A0H2ZNG3, A0A242DI27, A3N0X3, A4ZUD5, A5UE01, A5UHM6, A9MHQ7, B0BPQ7, B3GXV7, C5DQ18, C5DT30, G2TRT3, O60071, P44844, P47301, P52871, P75090, P94520, P96728, Q07541, Q08JR8, Q0I282, Q20687, Q3T073, Q3ZBR1, Q4QMH2, Q54P38, Q553P6, Q5FB24, Q5HJ89, Q5REZ1, Q5UQ15, Q65W23, Q6CLJ7, Q6GCI8, Q6TAW2, Q7NX81, Q7VKZ7, Q87TF6, Q8MN49

Diamond homologs: Q3T073, Q3ZBR1, Q5REZ1, Q6TAW2, Q8N6R1, Q9R2C1, Q9Y6X1, Q9Z1W5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

4 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	3
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

699 predictions. Top by Δscore:

Variant	Effect	Δscore
13:44374092:A:T	donor_gain	1.0000
13:44374108:TGGT:T	donor_loss	1.0000
13:44374109:GGTAA:G	donor_loss	1.0000
13:44374110:GTAAG:G	donor_loss	1.0000
13:44374111:T:A	donor_loss	1.0000
13:44374105:CCCTG:C	donor_gain	0.9900
13:44374110:G:GG	donor_gain	0.9900
13:44397271:GCT:G	acceptor_gain	0.9800
13:44374106:CCTG:C	donor_gain	0.9700
13:44374107:CTG:C	donor_gain	0.9600
13:44374108:TG:T	donor_gain	0.9600
13:44374109:GG:G	donor_gain	0.9600
13:44397268:TCA:T	acceptor_loss	0.9600
13:44397269:CAGCT:C	acceptor_loss	0.9600
13:44397270:A:AC	acceptor_loss	0.9600
13:44397270:A:AG	acceptor_gain	0.9600
13:44397271:G:C	acceptor_loss	0.9600
13:44397271:G:GA	acceptor_gain	0.9600
13:44397271:GCTA:G	acceptor_gain	0.9600
13:44397271:GCTAT:G	acceptor_gain	0.9600
13:44397271:GC:G	acceptor_gain	0.9500
13:44374061:G:GT	donor_gain	0.9400
13:44379640:G:C	acceptor_gain	0.9300
13:44379640:GA:G	acceptor_gain	0.9300
13:44397267:TTCAG:T	acceptor_gain	0.9100
13:44397268:TCAG:T	acceptor_gain	0.9100
13:44397269:CAGC:C	acceptor_gain	0.9100
13:44397270:AGCTA:A	acceptor_gain	0.9000
13:44374088:G:GT	donor_gain	0.8900
13:44374727:G:T	donor_gain	0.8900

AlphaMissense

427 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
13:44374087:G:T	R21M	0.999
13:44374090:G:A	G22E	0.999
13:44374090:G:T	G22V	0.999
13:44374053:G:C	A10P	0.998
13:44374089:G:A	G22R	0.998
13:44374089:G:C	G22R	0.998
13:44374089:G:T	G22W	0.998
13:44379693:T:A	V46D	0.998
13:44379707:G:C	G51R	0.998
13:44379708:G:A	G51D	0.998
13:44374088:G:C	R21S	0.997
13:44374088:G:T	R21S	0.997
13:44379684:C:A	A43E	0.997
13:44374054:C:A	A10D	0.996
13:44374078:T:A	I18N	0.996
13:44374087:G:C	R21T	0.996
13:44379704:T:C	C50R	0.996
13:44374058:C:A	N11K	0.995
13:44374058:C:G	N11K	0.995
13:44374086:A:T	R21W	0.995
13:44379699:T:A	V48D	0.995
13:44379705:G:A	C50Y	0.995
13:44374065:C:G	H14D	0.994
13:44374078:T:G	I18S	0.993
13:44379687:T:A	L44Q	0.993
13:44374041:C:T	R6W	0.992
13:44379678:T:C	L41P	0.992
13:44379687:T:C	L44P	0.992
13:44379695:T:C	F47L	0.992
13:44379697:T:A	F47L	0.992

dbSNP variants (sampled 300 via entrez): RS1000154772 (13:44383344 T>C), RS1000286520 (13:44390303 C>G), RS1000344744 (13:44377956 A>G), RS1000484476 (13:44383704 T>A,C), RS1000517203 (13:44390611 A>AT), RS1000567394 (13:44397365 G>A,C), RS1000593766 (13:44392349 CAG>C), RS1000902261 (13:44377901 G>A), RS1000932982 (13:44377547 C>T), RS1001024772 (13:44371796 T>A,C), RS1001300181 (13:44379382 T>C), RS1001648249 (13:44396363 A>C,G), RS1001831304 (13:44390157 G>A), RS1001848498 (13:44384578 C>T), RS1002057337 (13:44376732 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST002248_1	Fasting insulin (dietary factor interaction)	7.000000e-06
GCST002253_6	Homeostasis model assessment of insulin resistance (dietary factor interaction)	5.000000e-06
GCST004858_16	Dupuytren’s disease	2.000000e-10
GCST007692_109	Chronic obstructive pulmonary disease	3.000000e-09

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0008111	diet measurement
EFO:0004501	HOMA-IR
EFO:0004229	Dupuytren Contracture

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases expression, affects expression, decreases methylation, affects cotreatment	3
entinostat	affects cotreatment, decreases expression	2
bisphenol A	decreases expression	1
trichostatin A	decreases expression	1
sodium arsenite	decreases expression	1
potassium chromate(VI)	decreases expression	1
nickel sulfate	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	decreases expression, affects cotreatment	1
MRK 003	decreases expression	1
Air Pollutants, Occupational	affects expression	1
Atrazine	decreases expression	1
Benzo(a)pyrene	decreases methylation	1
Dimethyl Sulfoxide	affects expression	1
Endosulfan	decreases expression	1
Fenfluramine	decreases expression	1
Hydralazine	affects cotreatment, increases expression	1
Methotrexate	increases expression	1
Silicon Dioxide	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Triclosan	decreases expression	1
Asbestos, Serpentine	increases expression	1
Antirheumatic Agents	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.