SERPINA7

Summary

SERPINA7 (serpin family A member 7, HGNC:11583) is a protein-coding gene on chromosome Xq22.3, encoding Thyroxine-binding globulin (P05543). Major thyroid hormone transport protein in serum.

There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3’-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.

Source: NCBI Gene 6906 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 82 total — 6 pathogenic, 1 likely-pathogenic
• Druggable target: yes
• MANE Select transcript: NM_000354

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11583
Approved symbol	SERPINA7
Name	serpin family A member 7
Location	Xq22.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000123561
Ensembl biotype	protein_coding
OMIM	314200
Entrez	6906

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 5 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000327674, ENST00000372563, ENST00000487487, ENST00000907820, ENST00000907821, ENST00000907822

RefSeq mRNA: 1 — MANE Select: NM_000354 NM_000354

CCDS: CCDS14518

Canonical transcript exons

ENST00000372563 — 5 exons

Exon	Start	End
ENSE00000840354	106032435	106033703
ENSE00000840356	106035112	106035385
ENSE00001458102	106036437	106037075
ENSE00001458103	106038698	106038727
ENSE00003660533	106034235	106034382

Expression profiles

Bgee: expression breadth broad, 48 present calls, max score 96.91.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.7864 / max 265.0250, expressed in 28 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
200040	0.7864	28

Top tissues by expression

235 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	96.91	gold quality
right lobe of liver	UBERON:0001114	96.87	gold quality
frontal pole	UBERON:0002795	65.23	silver quality
middle frontal gyrus	UBERON:0002702	64.72	gold quality
endometrium epithelium	UBERON:0004811	59.29	gold quality
oocyte	CL:0000023	55.58	gold quality
thymus	UBERON:0002370	51.59	gold quality
Brodmann (1909) area 10	UBERON:0013541	50.18	gold quality
quadriceps femoris	UBERON:0001377	50.16	gold quality
vastus lateralis	UBERON:0001379	49.49	gold quality
upper leg skin	UBERON:0004262	49.34	gold quality
Brodmann (1909) area 46	UBERON:0006483	49.30	gold quality
blood vessel layer	UBERON:0004797	49.29	gold quality
cerebellar vermis	UBERON:0004720	49.25	gold quality
cervix squamous epithelium	UBERON:0006922	49.20	gold quality
epithelial cell of pancreas	CL:0000083	49.19	gold quality
hair follicle	UBERON:0002073	49.18	gold quality
oviduct epithelium	UBERON:0004804	49.12	gold quality
olfactory bulb	UBERON:0002264	48.92	gold quality
choroid plexus epithelium	UBERON:0003911	48.89	gold quality
myocardium	UBERON:0002349	48.87	gold quality
type B pancreatic cell	CL:0000169	48.83	gold quality
cardiac muscle of right atrium	UBERON:0003379	48.55	gold quality
CA1 field of hippocampus	UBERON:0003881	48.50	gold quality
pancreatic ductal cell	CL:0002079	48.44	silver quality
left ventricle myocardium	UBERON:0006566	48.24	gold quality
orbitofrontal cortex	UBERON:0004167	48.20	gold quality
deltoid	UBERON:0001476	48.09	gold quality
upper arm skin	UBERON:0004263	48.06	gold quality
cervix epithelium	UBERON:0004801	48.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.28

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): HNF1A, HNF1B, TCF3

miRNA regulators (miRDB)

25 targeting SERPINA7, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-656-3P	100.00	72.15	2788
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-202-5P	99.78	67.65	991
HSA-MIR-6719-3P	99.29	67.78	1387
HSA-MIR-4705	99.10	69.10	1091
HSA-MIR-219A-1-3P	98.91	67.87	639
HSA-MIR-3194-3P	98.83	66.22	1167
HSA-MIR-1261	98.62	68.10	896
HSA-MIR-4662A-5P	98.48	67.18	1007
HSA-MIR-3130-5P	98.14	66.00	711
HSA-MIR-4769-3P	97.95	68.17	1002
HSA-MIR-6817-5P	97.95	67.86	1026
HSA-MIR-4482-5P	97.53	65.68	598
HSA-MIR-2278	97.30	66.19	1130
HSA-MIR-6892-5P	97.27	68.60	847
HSA-MIR-5194	96.77	63.91	1021
HSA-MIR-6738-5P	96.33	63.61	815
HSA-MIR-6734-5P	95.70	65.56	950
HSA-MIR-1914-3P	95.07	63.37	762
HSA-MIR-6767-3P	93.99	66.01	204

Literature-anchored findings (GeneRIF, showing 18)

• an intragenic A/G polymorphism (125 bp upstream from exon 2) was identified. complete TBG deficiency was homozygous for the polymorphic TBG allele. (PMID:11889160)
• Two novel variants in the thyroxine-binding globulin gene behind the diagnosis of TBG deficiency. homozygous. One involved codon 23 (TCA–>TAA) and the other, codon 223. (PMID:11916615)
• Loop variants of the serpin thyroxine-binding globulin: implications for hormone release upon limited proteolysis. (PMID:11931635)
• guanine deletion at position 1711, codon 201 (Asp) in exon 2 (GAC –> AC) led to a frame shift and premature termination at codon 206, causing a short TBG protein of 205 amino acids (AA) compared to 395 AA of the normal TBG. (PMID:17887925)
• new serpina7 gene variant in three members of the same family results in the replacement of the normal asparagine 233 by isoleucine and, subsequently, in disruption of a glycosylation site (PMID:19415532)
• Freshly isolated TBG-Chicago exists in loop expelled conformation. At 37C, the protein readily converts to a more stable loop inserted conformation with enhanced heat stability. (PMID:20429632)
• Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins. (PMID:21325280)
• the TBG promoter has a role in sustaining transgene expression in liver-specific pattern (PMID:22820390)
• TBG allosteric regulation is entropy driven. The presence of multiple S states may allow more efficient T4 release due to protease activity. (PMID:23458682)
• mutation in a liver-specific enhancer region of the TBG gene caused inherited TBG deficiency. To our knowledge, the present study is the first report of an inherited endocrine disorder caused by a mutation in an enhancer region. (PMID:25361180)
• THBG is a potential plasma biomarker for COPD. (PMID:28579773)
• A new SERPINA7 variant associated with thyroxine-binding globulin deficiency in three siblings. (PMID:29733970)
• Partial thyroxine-binding globulin deficiency in a family with coding region mutations in the TBG gene. (PMID:32266677)
• Compound hemizygous variants in SERPINA7 gene cause thyroxine-binding globulin deficiency. (PMID:33554479)
• The decrease of T3 / T4 is not hypothyroidism - a new mutation of Serpina7 gene results in partial thyroglobulin deficiency. (PMID:34481533)
• Identification of a novel mutation in thyroxine-binding globulin (TBG) gene associated with TBG-deficiency and its effect on the thyroid function. (PMID:34761328)
• Identification of Mutations in the Thyroxine-Binding Globulin (TBG) Gene in Patients with TBG Deficiency in Korea. (PMID:36475360)
• The first exon (exon 0) is a short noncoding sequence located 1.62 kilobase pairs (kbp) upstream from exon 1. HNF-1 site (located 65 bp upstream of the TSS) is required for the hepatocyte specific expression of the hTBG gene. (PMID:8232304)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Serpina7	ENSMUSG00000031271
rattus_norvegicus	Serpina7	ENSRNOG00000011081

Paralogs (36): SERPINB1 (ENSG00000021355), SERPINB3 (ENSG00000057149), SERPIND1 (ENSG00000099937), SERPINA4 (ENSG00000100665), SERPINE1 (ENSG00000106366), SERPINI2 (ENSG00000114204), SERPINC1 (ENSG00000117601), SERPINB6 (ENSG00000124570), SERPINF1 (ENSG00000132386), AGT (ENSG00000135744), SERPINE2 (ENSG00000135919), SERPINA10 (ENSG00000140093), SERPING1 (ENSG00000149131), SERPINH1 (ENSG00000149257), SERPINI1 (ENSG00000163536), SERPINA12 (ENSG00000165953), SERPINB7 (ENSG00000166396), SERPINB8 (ENSG00000166401), SERPINB12 (ENSG00000166634), SERPINF2 (ENSG00000167711), SERPINA9 (ENSG00000170054), SERPINA6 (ENSG00000170099), SERPINB9 (ENSG00000170542), SERPINA11 (ENSG00000186910), SERPINA5 (ENSG00000188488), SERPINA3 (ENSG00000196136), SERPINA1 (ENSG00000197249), SERPINB2 (ENSG00000197632), SERPINB13 (ENSG00000197641), SERPINB11 (ENSG00000206072), SERPINB4 (ENSG00000206073), SERPINB5 (ENSG00000206075), HMSD (ENSG00000221887), SERPINB10 (ENSG00000242550), SERPINE3 (ENSG00000253309), SERPINA2 (ENSG00000258597)

Protein

Protein identifiers

Thyroxine-binding globulin — P05543 (reviewed: P05543)

Alternative names: Serpin A7, T4-binding globulin

All UniProt accessions (1): P05543

UniProt curated annotations — full annotation on UniProt →

Function. Major thyroid hormone transport protein in serum.

Subcellular location. Secreted.

Tissue specificity. Expressed by the liver and secreted in plasma.

Polymorphism. Genetic variants in SERPINA7 influence the serum levels of thyroxine-binding globulin and define the thyroxine-binding globulin quantitative trait locus (TBGQTL) [MIM:300932]. Individuals with low or high serum levels of thyroxine-binding globulin show, respectively, reduced or elevated protein-bound iodine but are euthyroid and do not manifest major metabolic alterations. Two qualitative TBG variants occur in particular populations. TBG-A is found in 40% of Australian aborigines, it has reduced affinity for thyroxine and triiodothyroxine and increased susceptibility to inactivation by heat or acid. TBG-S (’s’ for slow shift on isoelectic focusing) is found in blacks, Eskimos, Melanesians, Polynesians and Indonesians, but not in Caucasians; TBG-S is slightly more thermolabile.

Similarity. Belongs to the serpin family.

RefSeq proteins (1): NP_000345* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000215	Serpin_fam	Family
IPR023795	Serpin_CS	Conserved_site
IPR023796	Serpin_dom	Domain
IPR036186	Serpin_sf	Homologous_superfamily
IPR042178	Serpin_sf_1	Homologous_superfamily
IPR042185	Serpin_sf_2	Homologous_superfamily

Pfam: PF00079

UniProt features (52 total): strand 15, helix 11, sequence variant 9, turn 5, glycosylation site 5, sequence conflict 3, binding site 2, signal peptide 1, chain 1

Structure

Experimental structures (PDB)

9 structures.

PDB	Method	Resolution (Å)
2XN6	X-RAY DIFFRACTION	1.29
2XN7	X-RAY DIFFRACTION	1.43
2RIV	X-RAY DIFFRACTION	1.5
4X30	X-RAY DIFFRACTION	1.55
4YIA	X-RAY DIFFRACTION	1.58
2XN5	X-RAY DIFFRACTION	1.7
2RIW	X-RAY DIFFRACTION	2.04
2XN3	X-RAY DIFFRACTION	2.09
2CEO	X-RAY DIFFRACTION	2.8

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P05543-F1	87.48	0.74

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (2): 293; 398

Glycosylation sites (5): 36, 99, 116, 165, 253

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 66 (showing top): GOBP_REGULATION_OF_HORMONE_LEVELS, GOBP_HORMONE_TRANSPORT, HNF1_Q6, CEBP_Q2, HSIAO_LIVER_SPECIFIC_GENES, HNF1_C, HNF1_01, TTTNNANAGCYR_UNKNOWN, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, CHIANG_LIVER_CANCER_SUBCLASS_INTERFERON_UP, MODULE_112, GOMF_PEPTIDASE_REGULATOR_ACTIVITY, GOMF_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY, GOMF_ENZYME_INHIBITOR_ACTIVITY, GOMF_ENZYME_REGULATOR_ACTIVITY

GO Biological Process (1): thyroid hormone transport (GO:0070327)

GO Molecular Function (1): serine-type endopeptidase inhibitor activity (GO:0004867)

GO Cellular Component (3): extracellular region (GO:0005576), obsolete extracellular space (GO:0005615), extracellular exosome (GO:0070062)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
hormone transport	1
serine-type endopeptidase activity	1
endopeptidase inhibitor activity	1
cellular anatomical structure	1
extracellular vesicle	1

Protein interactions and networks

STRING

1056 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SERPINA7	TTR	P02766	976
SERPINA7	ALB	P02768	848
SERPINA7	SHBG	P04278	753
SERPINA7	TRH	P20396	748
SERPINA7	TG	P01266	670
SERPINA7	DIO2	Q92813	668
SERPINA7	TSPAN4	O14817	643
SERPINA7	DIO1	P49895	630
SERPINA7	THRB	P10828	592
SERPINA7	DIO3	P55073	590
SERPINA7	GC	P02774	585
SERPINA7	TSHR	P16473	578
SERPINA7	SLC16A2	P36021	571
SERPINA7	ARSB	P15848	506
SERPINA7	AFP	P02771	504

IntAct

4 interactions, top by confidence:

A	B	Type	Score
RIPK4	VWA8	psi-mi:“MI:0914”(association)	0.350
SERPINA7	RTL8C	psi-mi:“MI:0914”(association)	0.350
SERPINA7	ERF	psi-mi:“MI:0914”(association)	0.350

BioGRID (15): MIA3 (Affinity Capture-MS), FAM127A (Affinity Capture-MS), DHFRL1 (Affinity Capture-MS), ERF (Affinity Capture-MS), DHFRL1 (Affinity Capture-MS), FAM127A (Affinity Capture-MS), MIA3 (Affinity Capture-MS), SERPINA7 (Affinity Capture-MS), SERPINA7 (Affinity Capture-MS), ERF (Affinity Capture-MS), DHFRL1 (Affinity Capture-MS), MIA3 (Affinity Capture-MS), SERPINA7 (Affinity Capture-MS), SERPINA7 (Proximity Label-MS), SERPINA7 (Affinity Capture-MS)

ESM2 similar proteins: A2I7M9, A2I7N0, A2I7N1, A2I7N2, A2I7N3, A6QPQ2, B2D1U1, E1BF81, O54762, P01011, P05154, P05543, P05544, P05545, P07759, P08185, P09006, P20848, P22323, P22324, P22325, P23775, P26595, P29621, P29622, P31211, P35577, P49920, P50451, P61640, P61939, Q00896, Q00897, Q00898, Q03734, Q3ZEJ6, Q5I2A0, Q5R536, Q5R9E3, Q5RCR2

Diamond homologs: A2I7M9, A2I7N0, A2I7N1, A2I7N2, A2I7N3, A6QPQ2, B2D1U1, E1BF81, O00394, O54757, O54758, O54759, O54760, O54761, O54762, O54763, O75830, P01009, P01010, P01011, P05154, P05543, P05544, P05545, P05619, P07758, P07759, P08185, P09005, P09006, P12725, P17475, P20848, P22323, P22324, P22325, P22599, P23035, P23775, P26595

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

82 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	6
Likely pathogenic	1
Uncertain significance	41
Likely benign	8
Benign	4

Top pathogenic / likely-pathogenic (7)

Variant ID	HGVS	Classification
1323575	NM_000354.6(SERPINA7):c.804_805del (p.Phe269fs)	Pathogenic
4075315	NM_000354.6(SERPINA7):c.1117_1118delinsCAG (p.Ser373fs)	Pathogenic
816377	GRCh37/hg19 Xq22.3(chrX:104728884-105652106)x0	Pathogenic
9786	NM_000354.5(SERPINA7):c.571G>A (p.Asp191Asn)	Pathogenic
9790	NM_000354.5(SERPINA7):c.347T>A (p.Ile116Asn)	Pathogenic
9792	NM_000354.5(SERPINA7):c.986A>T (p.Tyr329Phe)	Pathogenic
9791	NM_000354.6(SERPINA7):c.1114del (p.Leu372fs)	Likely pathogenic

SpliceAI

488 predictions. Top by Δscore:

Variant	Effect	Δscore
X:106034233:A:AC	donor_gain	1.0000
X:106034234:C:CC	donor_gain	1.0000
X:106034378:CCCAT:C	acceptor_gain	1.0000
X:106034379:CCAT:C	acceptor_gain	1.0000
X:106034379:CCATC:C	acceptor_gain	1.0000
X:106034380:CAT:C	acceptor_gain	1.0000
X:106034380:CATC:C	acceptor_gain	1.0000
X:106035110:ACC:A	donor_gain	1.0000
X:106035111:CCC:C	donor_gain	1.0000
X:106035137:T:TA	donor_gain	1.0000
X:106035381:CTGGG:C	acceptor_gain	1.0000
X:106035382:TGGG:T	acceptor_gain	1.0000
X:106035383:GGG:G	acceptor_gain	1.0000
X:106035384:GG:G	acceptor_gain	1.0000
X:106035385:GC:G	acceptor_loss	1.0000
X:106035386:C:CA	acceptor_loss	1.0000
X:106035386:C:CC	acceptor_gain	1.0000
X:106035387:T:C	acceptor_gain	1.0000
X:106035387:T:TC	acceptor_gain	1.0000
X:106035392:A:AC	acceptor_gain	1.0000
X:106035392:A:C	acceptor_gain	1.0000
X:106036431:TCTTA:T	donor_loss	1.0000
X:106036432:CTTAC:C	donor_loss	1.0000
X:106036433:TTA:T	donor_loss	1.0000
X:106036434:TA:T	donor_loss	1.0000
X:106036436:C:CT	donor_loss	1.0000
X:106034227:CAACT:C	donor_loss	0.9900
X:106034228:AACTT:A	donor_loss	0.9900
X:106034229:ACT:A	donor_loss	0.9900
X:106034230:CT:C	donor_loss	0.9900

AlphaMissense

2757 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:106035333:G:C	F225L	0.975
X:106035333:G:T	F225L	0.975
X:106035335:A:G	F225L	0.975
X:106035241:A:T	V256D	0.972
X:106033575:G:C	F391L	0.970
X:106033575:G:T	F391L	0.970
X:106033577:A:G	F391L	0.970
X:106035366:A:C	F214L	0.970
X:106035366:A:T	F214L	0.970
X:106035368:A:G	F214L	0.970
X:106035199:A:T	V270D	0.969
X:106035134:A:G	W292R	0.967
X:106035134:A:T	W292R	0.967
X:106035380:A:G	W210R	0.966
X:106035380:A:T	W210R	0.966
X:106035378:C:A	W210C	0.962
X:106035378:C:G	W210C	0.962
X:106035238:A:G	L257P	0.959
X:106036654:G:C	F135L	0.955
X:106036654:G:T	F135L	0.955
X:106036656:A:G	F135L	0.955
X:106036843:G:C	S72R	0.950
X:106036843:G:T	S72R	0.950
X:106036845:T:G	S72R	0.950
X:106034365:A:T	V305D	0.949
X:106035246:G:C	C254W	0.942
X:106035248:A:G	C254R	0.941
X:106035132:C:A	W292C	0.939
X:106035132:C:G	W292C	0.939
X:106036621:G:C	F146L	0.939

dbSNP variants (sampled 300 via entrez): RS1000131785 (X:106032353 A>G), RS1000461401 (X:106032884 T>G), RS1001010671 (X:106034742 G>A), RS1001087007 (X:106034593 T>C), RS1001629182 (X:106035600 G>A), RS1001933253 (X:106039938 G>A), RS1002017651 (X:106035282 T>G), RS1002608899 (X:106035439 C>T), RS1002614055 (X:106033577 A>G), RS1003076038 (X:106033925 C>T), RS1003458620 (X:106039896 G>A), RS1003586440 (X:106038371 C>T), RS1004811736 (X:106035243 T>C), RS1005816464 (X:106033516 T>C), RS1006428158 (X:106035863 C>T)

Disease associations

OMIM: gene MIM:314200 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST009391_1040	Metabolite levels	6.000000e-14
GCST009391_1042	Metabolite levels	6.000000e-11
GCST009391_1654	Metabolite levels	4.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0010469	carnitine measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL3843 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

71 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects expression, affects binding, decreases reaction, decreases methylation	4
Benzo(a)pyrene	decreases expression, increases expression	4
Tetrachlorodibenzodioxin	decreases expression	4
Thyroxine	affects binding, decreases reaction	4
Cyclosporine	decreases expression	4
sodium arsenite	decreases expression, increases expression	2
perfluorooctane sulfonic acid	decreases expression	2
Acetaminophen	affects cotreatment, decreases expression	2
Triiodothyronine	affects binding	2
Aflatoxin B1	affects expression, decreases methylation	2
dicrotophos	decreases expression	1
decabromobiphenyl ether	decreases expression, increases abundance	1
tris(2-butoxyethyl) phosphate	affects expression	1
norgestimate	affects cotreatment, increases expression	1
tetrabromobisphenol A	affects binding, decreases reaction	1
beta-hexachlorocyclohexane	decreases expression	1
2,2’,3’,4,4’,5-hexachlorobiphenyl	decreases expression	1
3,5-dichlorobiphenyl	affects binding, decreases reaction	1
benazol P	affects expression	1
tetrachlorodian	affects binding, decreases reaction	1
gallium arsenide	increases expression	1
2,3,3’,4,4’-pentachlorobiphenyl	decreases expression	1
2,3’,4,4’,5-pentachlorobiphenyl	decreases expression	1
1,2-bis(2,4,6-tribromophenoxy)ethane	increases abundance, increases expression	1
3,5-dibromo-2-(2,4-dibromophenoxy)phenol	affects binding	1
pentabromodiphenyl ether	affects binding	1
perfluoro-n-nonanoic acid	decreases expression	1
entinostat	decreases expression	1
2,2’,4,4’,5-brominated diphenyl ether	increases abundance, increases expression	1
2,2’,3,4,4’,5’,6-heptabromodiphenyl ether	decreases expression, increases abundance	1

ChEMBL screening assays

4 unique, capped per target: 3 binding, 1 admet

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL3285084	Binding	Binding affinity to thyroxine binding globulin (unknown origin) relative to T4	Thyroxine analogues. 23. Quantitative structure-activity correlation studies of in vivo and in vitro thyromimetic activities. — J Med Chem
CHEMBL3862358	ADMET	Displacement of [125I]-T4 from TBG in human plasma after 1 hr by PAGE analysis	A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition. — Eur J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.