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SERPINB10

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Summary

SERPINB10 (serpin family B member 10, HGNC:8942) is a protein-coding gene on chromosome 18q21.3, encoding Serpin B10 (P48595). Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF.

This gene is a member of the serpin peptidase inhibitor, clade B family and is found in a cluster of other similar genes on chromosome 18. The protein encoded by this gene appears to help control the regulation of protease functions during hematopoiesis. Variations in this gene may increase the risk of prostate cancer.

Source: NCBI Gene 5273 — RefSeq curated summary.

At a glance

  • GWAS associations: 4
  • Clinical variants (ClinVar): 59 total
  • Druggable target: yes — 1 molecules with ChEMBL bioactivity
  • MANE Select transcript: NM_005024

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:8942
Approved symbolSERPINB10
Nameserpin family B member 10
Location18q21.3
Locus typegene with protein product
StatusApproved
Ensembl geneENSG00000242550
Ensembl biotypeprotein_coding
OMIM602058
Entrez5273

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000238508

RefSeq mRNA: 1 — MANE Select: NM_005024 NM_005024

CCDS: CCDS11990

Canonical transcript exons

ENST00000238508 — 8 exons

ExonStartEnd
ENSE000006702806393304863933203
ENSE000008074256393483863936111
ENSE000011026546391796563918102
ENSE000011026566391978863919905
ENSE000011026616391745663917521
ENSE000011026626393004563930187
ENSE000015311226390795863908040
ENSE000034935636391550263915678

Expression profiles

Bgee: expression breadth broad, 88 present calls, max score 90.45.

FANTOM5 (CAGE): breadth broad, TPM avg 1.9117 / max 203.7974, expressed in 239 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter IDTPM avgSamples expressed
1706611.2650128
1706600.306461
1706320.210385
1706330.103657
2085840.02636

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
bone marrowUBERON:000237190.45gold quality
bone marrow cellCL:000209287.91gold quality
type B pancreatic cellCL:000016984.34gold quality
olfactory bulbUBERON:000226484.00gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047378.64silver quality
monocyteCL:000057675.42gold quality
mononuclear cellCL:000084275.34gold quality
leukocyteCL:000073874.46gold quality
trabecular bone tissueUBERON:000248371.78gold quality
diaphragmUBERON:000110368.78gold quality
hair follicleUBERON:000207366.15gold quality
cardiac muscle of right atriumUBERON:000337965.50gold quality
left ventricle myocardiumUBERON:000656665.44gold quality
upper arm skinUBERON:000426363.89gold quality
epithelium of bronchusUBERON:000203163.00silver quality
olfactory segment of nasal mucosaUBERON:000538662.42gold quality
bronchusUBERON:000218562.35silver quality
stromal cell of endometriumCL:000225561.52gold quality
bloodUBERON:000017861.30gold quality
bronchial epithelial cellCL:000232860.05gold quality
mucosa of urinary bladderUBERON:000125959.65gold quality
nasal cavity epitheliumUBERON:000538459.27silver quality
tibialis anteriorUBERON:000138559.11silver quality
ileal mucosaUBERON:000033158.95silver quality
quadriceps femorisUBERON:000137758.59gold quality
myocardiumUBERON:000234958.53gold quality
vastus lateralisUBERON:000137958.43gold quality
thymusUBERON:000237058.11gold quality
cervix epitheliumUBERON:000480157.82gold quality
epithelium of nasopharynxUBERON:000195156.86gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

ExperimentMarker?Max mean expression
E-MTAB-9067yes15.31
E-MTAB-9801yes6.47
E-ANND-3yes3.38

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

49 targeting SERPINB10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-340-5P100.0072.504437
HSA-MIR-3646100.0073.565283
HSA-MIR-569699.9872.364487
HSA-MIR-806899.9873.852376
HSA-MIR-590-3P99.9674.346478
HSA-MIR-391099.9571.132227
HSA-MIR-23A-3P99.9574.243163
HSA-MIR-23B-3P99.9574.243163
HSA-MIR-23C99.9573.923192
HSA-MIR-335-3P99.9373.364958
HSA-MIR-218-5P99.9372.222103
HSA-MIR-124-3P99.8973.743043
HSA-MIR-153-5P99.8973.866317
HSA-MIR-5582-3P99.8672.484221
HSA-MIR-579-3P99.8671.663628
HSA-MIR-664B-3P99.8471.653590
HSA-MIR-6505-5P99.7369.251595
HSA-MIR-4699-3P99.7170.153142
HSA-MIR-472999.6972.184233
HSA-MIR-58699.6570.402051
HSA-MIR-715099.6266.801322
HSA-MIR-317199.4969.06776
HSA-MIR-5571-5P99.4966.991764
HSA-MIR-653-5P99.4667.351300
HSA-MIR-508-5P99.4164.251248
HSA-MIR-3678-3P99.3167.101432
HSA-MIR-504-3P99.3067.181745
HSA-MIR-580-5P99.2870.941776
HSA-MIR-520E-5P99.2768.901513
HSA-MIR-442699.1766.741949

Literature-anchored findings (GeneRIF, showing 6)

  • Bomapin is a redox-sensitive nuclear serpin that augments proliferation or apoptosis of leukaemia cells, depending on growth factors availability. (PMID:20433722)
  • DGCR2, GPR44 and SerpinB10, found in beta cells, were negative in all other cell types within pancreas and exposed epitopes at the cell surface (PMID:22465717)
  • Epithelial SERPINB10 contributes to allergic airway eosinophilic inflammation, at least in part, by regulating the expression of periostin and CCL26. (PMID:30382768)
  • SerpinB10, a Serine Protease Inhibitor, Is Implicated in UV-Induced Cellular Response. (PMID:34445206)
  • Increased SERPINB10 Expression in Induced Sputum Was Associated with Airway Type 2 Inflammation in Asthma. (PMID:35526531)
  • Increased Expression of SERPINB10 Associated with Postoperative Recurrence in Chronic Rhinosinusitis with Nasal Polyps. (PMID:36398030)

Cross-species orthologs

2 orthologs

OrganismSymbolGene ID
mus_musculusSerpinb10ENSMUSG00000092572
rattus_norvegicusSerpinb10ENSRNOG00000002417

Paralogs (36): SERPINB1 (ENSG00000021355), SERPINB3 (ENSG00000057149), SERPIND1 (ENSG00000099937), SERPINA4 (ENSG00000100665), SERPINE1 (ENSG00000106366), SERPINI2 (ENSG00000114204), SERPINC1 (ENSG00000117601), SERPINA7 (ENSG00000123561), SERPINB6 (ENSG00000124570), SERPINF1 (ENSG00000132386), AGT (ENSG00000135744), SERPINE2 (ENSG00000135919), SERPINA10 (ENSG00000140093), SERPING1 (ENSG00000149131), SERPINH1 (ENSG00000149257), SERPINI1 (ENSG00000163536), SERPINA12 (ENSG00000165953), SERPINB7 (ENSG00000166396), SERPINB8 (ENSG00000166401), SERPINB12 (ENSG00000166634), SERPINF2 (ENSG00000167711), SERPINA9 (ENSG00000170054), SERPINA6 (ENSG00000170099), SERPINB9 (ENSG00000170542), SERPINA11 (ENSG00000186910), SERPINA5 (ENSG00000188488), SERPINA3 (ENSG00000196136), SERPINA1 (ENSG00000197249), SERPINB2 (ENSG00000197632), SERPINB13 (ENSG00000197641), SERPINB11 (ENSG00000206072), SERPINB4 (ENSG00000206073), SERPINB5 (ENSG00000206075), HMSD (ENSG00000221887), SERPINE3 (ENSG00000253309), SERPINA2 (ENSG00000258597)

Protein

Protein identifiers

Serpin B10 — P48595 (reviewed: P48595)

Alternative names: Bomapin, Peptidase inhibitor 10

All UniProt accessions (1): P48595

UniProt curated annotations — full annotation on UniProt →

Function. Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus.

Subcellular location. Nucleus. Cytoplasm.

Tissue specificity. Expressed specifically in myeloid cells and the bone marrow.

Similarity. Belongs to the serpin family. Ov-serpin subfamily.

RefSeq proteins (1): NP_005015* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR000215Serpin_famFamily
IPR023795Serpin_CSConserved_site
IPR023796Serpin_domDomain
IPR036186Serpin_sfHomologous_superfamily
IPR042178Serpin_sf_1Homologous_superfamily
IPR042185Serpin_sf_2Homologous_superfamily

Pfam: PF00079

UniProt features (13 total): sequence variant 7, mutagenesis site 2, chain 1, short sequence motif 1, site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-P48595-F188.990.75

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 362–363 (reactive bond)

Disulfide bonds (1): 68–395

Mutagenesis-validated functional residues (2):

PositionPhenotype
74–77abolishes nuclear localization.
395no effect on cell proliferation.

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

IDPathway
R-HSA-6798695Neutrophil degranulation
R-HSA-168249Innate Immune System
R-HSA-168256Immune System

MSigDB gene sets: 80 (showing top): REACTOME_INNATE_IMMUNE_SYSTEM, GOCC_SECRETORY_GRANULE, BROWNE_HCMV_INFECTION_48HR_DN, chr18q22, TGGAAA_NFAT_Q4_01, GOCC_SECRETORY_VESICLE, GOCC_SECRETORY_GRANULE_MEMBRANE, GOMF_PEPTIDASE_REGULATOR_ACTIVITY, GOMF_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY, GOMF_ENZYME_INHIBITOR_ACTIVITY, GOMF_ENZYME_REGULATOR_ACTIVITY, CHYLA_CBFA2T3_TARGETS_UP, WANG_MLL_TARGETS, RAO_BOUND_BY_SALL4_ISOFORM_A, GOCC_TERTIARY_GRANULE

GO Biological Process (0):

GO Molecular Function (2): serine-type endopeptidase inhibitor activity (GO:0004867), peptidase inhibitor activity (GO:0030414)

GO Cellular Component (8): obsolete extracellular space (GO:0005615), nucleoplasm (GO:0005654), cytosol (GO:0005829), plasma membrane (GO:0005886), secretory granule membrane (GO:0030667), ficolin-1-rich granule membrane (GO:0101003), nucleus (GO:0005634), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-2 pathways:

CategoryPathways
Innate Immune System1
Immune System1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
cellular anatomical structure3
serine-type endopeptidase activity1
endopeptidase inhibitor activity1
enzyme inhibitor activity1
peptidase activity1
peptidase regulator activity1
nuclear lumen1
cytoplasm1
membrane1
cell periphery1
secretory granule1
cytoplasmic vesicle membrane1
bounding membrane of organelle1
secretory granule membrane1
tertiary granule1
ficolin-1-rich granule1
intracellular membrane-bounded organelle1
intracellular anatomical structure1

Protein interactions and networks

STRING

706 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
SERPINB10LYG2Q86SG7511
SERPINB10BPIFB1Q8TDL5472
SERPINB10SERPINB4P48594423
SERPINB10SLC14A1Q13336404
SERPINB10UPK1BO75841400
SERPINB10IVNS1ABPQ9Y6Y0400
SERPINB10FBF1Q8TES7391
SERPINB10CRISP3P54108388
SERPINB10AGO2Q9UKV8383
SERPINB10CLIP2Q9UDT6382
SERPINB10SLC4A1P02730375
SERPINB10OAS1P00973371
SERPINB10PI15O43692370
SERPINB10SULT4A1Q9BR01368
SERPINB10CSTAP01040359

IntAct

4 interactions, top by confidence:

ABTypeScore
SERPINB10SRPK1psi-mi:“MI:0217”(phosphorylation reaction)0.440
CFTRSERPINB10psi-mi:“MI:0915”(physical association)0.370
KLK10IGLL5psi-mi:“MI:0914”(association)0.350

BioGRID (3): SERPINB10 (Affinity Capture-MS), SERPINB10 (PCA), SERPINB10 (Biochemical Activity)

ESM2 similar proteins: A0A090BX51, A2I7M9, A2I7N0, A2I7N2, A5PJK0, A9RA96, B0CMB0, B1MTB7, B1MTC3, B2KI30, B3RFC3, B4USX2, E2RVI8, O08800, O73790, O73860, O75635, P01012, P01013, P01014, P05120, P05544, P09006, P12388, P19104, P29508, P29524, P36952, P48594, P48595, P70124, P70458, P70564, Q03044, Q52L45, Q5I0S8, Q5M8J5, Q5SV42, Q6GLQ1, Q6V115

Diamond homologs: A0A090BX51, A0A0K8RCY5, A0A0K8RJ89, A0A0K8RJV9, A5PJK0, A9RA96, B0CMB0, B1MTB7, B1MTC3, B2KI30, B3RFC3, B4USX2, E2RVI8, O02739, O08800, O35684, O54757, O54758, O54759, O54760, O73790, O73860, O75635, O75830, P01008, P01011, P01012, P01014, P05120, P05619, P12388, P17475, P19104, P22323, P22325, P22922, P23035, P29508, P29524, P30740

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

59 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance54
Likely benign4
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

748 predictions. Top by Δscore:

VariantEffectΔscore
18:63915498:TTA:Tacceptor_loss1.0000
18:63915500:A:ACacceptor_loss1.0000
18:63915500:A:AGacceptor_gain1.0000
18:63915500:AG:Aacceptor_gain1.0000
18:63915501:G:GTacceptor_gain1.0000
18:63915501:GG:Gacceptor_gain1.0000
18:63915501:GGT:Gacceptor_gain1.0000
18:63915501:GGTTT:Gacceptor_gain1.0000
18:63917515:G:GTdonor_gain1.0000
18:63917516:A:Tdonor_gain1.0000
18:63917960:TAAAG:Tacceptor_loss1.0000
18:63917961:AAAG:Aacceptor_gain1.0000
18:63917962:AAGGA:Aacceptor_loss1.0000
18:63917963:A:AGacceptor_gain1.0000
18:63917963:AGG:Aacceptor_loss1.0000
18:63917964:G:Aacceptor_gain1.0000
18:63917964:G:GGacceptor_gain1.0000
18:63918098:ACAAT:Adonor_gain1.0000
18:63918099:CAAT:Cdonor_gain1.0000
18:63918100:AAT:Adonor_gain1.0000
18:63918101:AT:Adonor_gain1.0000
18:63918102:TGTA:Tdonor_loss1.0000
18:63918103:G:GGdonor_gain1.0000
18:63918103:GT:Gdonor_loss1.0000
18:63918104:T:TCdonor_loss1.0000
18:63918105:AAGT:Adonor_loss1.0000
18:63919902:GAGG:Gdonor_gain1.0000
18:63919904:GG:Gdonor_gain1.0000
18:63919904:GGGTA:Gdonor_loss1.0000
18:63919905:GG:Gdonor_gain1.0000

AlphaMissense

2675 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
18:63930173:T:CF207L0.987
18:63930175:T:AF207L0.987
18:63930175:T:GF207L0.987
18:63934991:T:CF315L0.981
18:63934993:C:AF315L0.981
18:63934993:C:GF315L0.981
18:63930143:T:CF197L0.978
18:63930145:C:AF197L0.978
18:63930145:C:GF197L0.978
18:63930174:T:CF207S0.976
18:63934874:T:AW276R0.974
18:63934874:T:CW276R0.974
18:63930131:T:AW193R0.973
18:63930131:T:CW193R0.973
18:63935174:T:CF376L0.972
18:63935176:C:AF376L0.972
18:63935176:C:GF376L0.972
18:63915610:A:CS34R0.969
18:63915612:C:AS34R0.969
18:63915612:C:GS34R0.969
18:63933130:T:CL239P0.966
18:63934920:T:CL291P0.963
18:63930133:G:CW193C0.962
18:63930133:G:TW193C0.962
18:63930174:T:GF207C0.961
18:63934923:C:AP292H0.957
18:63930144:T:CF197S0.953
18:63933163:T:CL250P0.951
18:63933169:T:AI252K0.948
18:63915646:G:CA46P0.946

dbSNP variants (sampled 300 via entrez): RS1000102140 (18:63912632 T>A,C), RS1000225277 (18:63927643 G>T), RS1000310770 (18:63907532 G>A,C), RS1000353850 (18:63932494 A>G,T), RS1000406137 (18:63932857 T>C), RS1000575432 (18:63927302 G>A), RS1000618414 (18:63927444 G>C), RS1000652863 (18:63916843 A>C), RS1000789083 (18:63917291 T>C), RS1000908646 (18:63932766 C>T), RS1000960448 (18:63906669 T>C), RS1001215690 (18:63915929 G>T), RS1001224998 (18:63926206 G>T), RS1001232403 (18:63930362 G>C), RS1001386887 (18:63918503 T>C)

Disease associations

OMIM: gene MIM:602058 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

StudyTraitp-value
GCST008891_21Cognitive performance (processing speed)8.000000e-06
GCST008916_98Asthma2.000000e-09
GCST009391_75Metabolite levels5.000000e-06
GCST011739_11Cutaneous leishmaniasis2.000000e-06

EFO canonical traits (2, from GWAS)

EFO IDTrait name
EFO:0004363information processing speed
EFO:0009767glycine measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5725094 (SINGLE PROTEIN)

Molecules with ChEMBL bioactivity

1 molecules (phase ≥1), by development phase (incl. off-target/promiscuous compounds). Patent mentions across the top 20 by phase: 1,538 (via chembl_molecule»patent_compound — counts attach to the compound, not the gene–compound relationship, so off-target/promiscuous molecules can dominate).

MoleculeNamePhasePatents
CHEMBL1232461MOLIBRESIB21,538

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

1 potent at pChembl≥5 of 1 total, top 1 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChemblTypeValueUnitMolecule
6.68IC50210nMMOLIBRESIB

PubChem BioAssay actives

1 with measured affinity, of 6 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

CompoundAssayTypeValueUnit
2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide2178887: Inhibition of SERPINB10 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisic500.2100uM

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

ChemicalActions (top 5)PubMed papers
Formaldehydeincreases expression2
Tobacco Smoke Pollutiondecreases expression2
bisphenol Aaffects cotreatment, increases methylation1
2-methyl-4-isothiazolin-3-oneincreases expression1
perfluorooctanoic acidincreases expression1
tamibarotenedecreases expression1
perfluorohexanesulfonic acidincreases expression1
theaflavin-3,3’-digallateaffects expression1
Fulvestrantaffects cotreatment, increases methylation1
Air Pollutantsaffects expression, increases abundance1
Benzo(a)pyrenedecreases expression1
Cisplatindecreases expression1
Demecolcineincreases expression1
Ethyl Methanesulfonateincreases expression1
Methyl Methanesulfonateincreases expression1
Ozoneaffects expression, increases abundance1
Tetrachlorodibenzodioxinincreases expression1
Tretinoindecreases expression1
Vincristineincreases expression1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxideincreases expression1

ChEMBL screening assays

6 unique, capped per target: 6 binding

Representative assays (with source publication via chembl_document):

Assay IDTypeDescriptionSource paper
CHEMBL5697617BindingInhibition of SERPINB10 (unknown origin) assessed as fold change at 10 uM incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisInhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. — Nature

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

  • Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): cutaneous leishmaniasis

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 79

This page pulls from 79 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_assaychembl_documentchembl_moleculechembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpatent_compoundpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot