SERPINB11

Summary

SERPINB11 (serpin family B member 11, HGNC:14221) is a protein-coding gene on chromosome 18q21.33, encoding Serpin B11 (Q96P15). Has no serine protease inhibitory activity, probably due to variants in the scaffold impairing conformational change.

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in cytoplasm. Predicted to be active in extracellular space.

Source: NCBI Gene 89778 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 75 total
• MANE Select transcript: NM_001370475

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14221
Approved symbol	SERPINB11
Name	serpin family B member 11
Location	18q21.33
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000206072
Ensembl biotype	protein_coding
OMIM	615682
Entrez	89778

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 5 protein_coding, 2 retained_intron, 1 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000382749, ENST00000467649, ENST00000489748, ENST00000536691, ENST00000544088, ENST00000610304, ENST00000613567, ENST00000623262, ENST00000624518

RefSeq mRNA: 5 — MANE Select: NM_001370475 NM_001291278, NM_001291279, NM_001370475, NM_001426565, NM_080475

CCDS: CCDS77196

Canonical transcript exons

ENST00000544088 — 8 exons

Exon	Start	End
ENSE00001671532	63722995	63723893
ENSE00001876718	63702960	63703006
ENSE00003547448	63712565	63712693
ENSE00003573795	63720013	63720155
ENSE00003615507	63711335	63711394
ENSE00003688433	63710179	63710361
ENSE00003723941	63716035	63716152
ENSE00003749737	63720831	63720986

Expression profiles

Bgee: expression breadth broad, 100 present calls, max score 93.50.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2148 / max 130.6386, expressed in 26 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
170592	0.2148	26

Top tissues by expression

207 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	93.50	gold quality
lower esophagus mucosa	UBERON:0035834	90.40	gold quality
palpebral conjunctiva	UBERON:0001812	90.29	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.07	gold quality
bronchial epithelial cell	CL:0002328	88.58	gold quality
bronchus	UBERON:0002185	87.61	gold quality
oral cavity	UBERON:0000167	86.36	gold quality
mucosa of paranasal sinus	UBERON:0005030	85.75	gold quality
esophagus mucosa	UBERON:0002469	84.51	gold quality
epithelium of nasopharynx	UBERON:0001951	81.62	gold quality
nasal cavity mucosa	UBERON:0001826	78.21	gold quality
prostate gland	UBERON:0002367	77.84	gold quality
nasal cavity epithelium	UBERON:0005384	74.97	gold quality
trachea	UBERON:0003126	74.26	gold quality
urethra	UBERON:0000057	72.08	gold quality
vagina	UBERON:0000996	71.19	gold quality
pharyngeal mucosa	UBERON:0000355	71.11	gold quality
esophagus squamous epithelium	UBERON:0006920	70.87	gold quality
gingiva	UBERON:0001828	70.86	gold quality
gingival epithelium	UBERON:0001949	63.33	gold quality
tonsil	UBERON:0002372	62.22	gold quality
amniotic fluid	UBERON:0000173	60.43	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	60.14	gold quality
esophagus	UBERON:0001043	59.24	gold quality
body of tongue	UBERON:0011876	58.49	silver quality
tongue	UBERON:0001723	56.30	gold quality
superior surface of tongue	UBERON:0007371	56.08	gold quality
decidua	UBERON:0002450	55.87	silver quality
mouth mucosa	UBERON:0003729	54.20	gold quality
urinary bladder	UBERON:0001255	54.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.03

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

25 targeting SERPINB11, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-4503	99.85	71.45	1869
HSA-MIR-544A	99.84	68.66	1965
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-6733-5P	99.74	67.94	2759
HSA-MIR-5580-3P	99.70	69.41	2052
HSA-MIR-4649-3P	99.56	66.90	1783
HSA-MIR-3153	99.55	67.59	2337
HSA-MIR-6882-5P	99.35	71.13	1206
HSA-MIR-3678-3P	99.31	67.10	1432
HSA-MIR-1273H-3P	99.29	67.55	980
HSA-MIR-140-3P	99.04	67.69	1324
HSA-MIR-6830-5P	99.01	68.73	1884
HSA-MIR-1207-3P	98.99	66.22	1532
HSA-MIR-1294	98.91	69.26	1030
HSA-MIR-9986	98.91	69.28	1024
HSA-MIR-6818-3P	98.56	68.23	1307
HSA-MIR-7158-3P	98.46	66.45	728
HSA-MIR-6516-5P	98.42	70.19	1551
HSA-MIR-6792-5P	98.39	68.16	1330
HSA-MIR-188-5P	97.89	67.01	756
HSA-MIR-6866-3P	97.38	66.94	748
HSA-MIR-758-5P	93.99	64.46	534

Literature-anchored findings (GeneRIF, showing 3)

• SERPINB11 is a new noninhibitory intracellular serpin (PMID:17562709)
• SERPINB11 has a role in ovarian endometrioid carcinoma in chickens and human (PMID:22289513)
• SERPINB11 is a gene under selection on standing variation, with roles in host-pathogen interactions (PMID:22393410)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Serpinb11	ENSMUSG00000026327
rattus_norvegicus	Serpinb11	ENSRNOG00000002583

Paralogs (36): SERPINB1 (ENSG00000021355), SERPINB3 (ENSG00000057149), SERPIND1 (ENSG00000099937), SERPINA4 (ENSG00000100665), SERPINE1 (ENSG00000106366), SERPINI2 (ENSG00000114204), SERPINC1 (ENSG00000117601), SERPINA7 (ENSG00000123561), SERPINB6 (ENSG00000124570), SERPINF1 (ENSG00000132386), AGT (ENSG00000135744), SERPINE2 (ENSG00000135919), SERPINA10 (ENSG00000140093), SERPING1 (ENSG00000149131), SERPINH1 (ENSG00000149257), SERPINI1 (ENSG00000163536), SERPINA12 (ENSG00000165953), SERPINB7 (ENSG00000166396), SERPINB8 (ENSG00000166401), SERPINB12 (ENSG00000166634), SERPINF2 (ENSG00000167711), SERPINA9 (ENSG00000170054), SERPINA6 (ENSG00000170099), SERPINB9 (ENSG00000170542), SERPINA11 (ENSG00000186910), SERPINA5 (ENSG00000188488), SERPINA3 (ENSG00000196136), SERPINA1 (ENSG00000197249), SERPINB2 (ENSG00000197632), SERPINB13 (ENSG00000197641), SERPINB4 (ENSG00000206073), SERPINB5 (ENSG00000206075), HMSD (ENSG00000221887), SERPINB10 (ENSG00000242550), SERPINE3 (ENSG00000253309), SERPINA2 (ENSG00000258597)

Protein

Protein identifiers

Serpin B11 — Q96P15 (reviewed: Q96P15)

All UniProt accessions (6): Q96P15, A0A087WWJ8, A0A096LP68, A0A096LPD5, F5GWT8, F5GYW9

UniProt curated annotations — full annotation on UniProt →

Function. Has no serine protease inhibitory activity, probably due to variants in the scaffold impairing conformational change.

Subcellular location. Cytoplasm.

Tissue specificity. Detected in a restricted number of tissues, including lung, placenta, prostate, and tonsil.

Polymorphism. Different combinations of variants define alleles SERPINB11a, SERPINB11b, SERPINB11c, SERPINB11d, SERPINB11e, SERPINB11f and SERPINB11g. Variants in the scaffold leading to either a stop codon instead of a Glu at position 90, an Arg instead of the well conserved Trp at position 188, or a Pro instead of Ser at position 303 lead to the loss of inhibitory activity. The sequence shown in this entry matches the translation of the reference genome assembly (GRCh38/hg38).

Similarity. Belongs to the serpin family. Ov-serpin subfamily.

Isoforms (3)

UniProt ID	Names	Canonical?
Q96P15-1	1	yes
Q96P15-2	2
Q96P15-3	3

RefSeq proteins (5): NP_001278207, NP_001278208, NP_001357404, NP_001413494, NP_536723 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000215	Serpin_fam	Family
IPR023795	Serpin_CS	Conserved_site
IPR023796	Serpin_dom	Domain
IPR036186	Serpin_sf	Homologous_superfamily
IPR042178	Serpin_sf_1	Homologous_superfamily
IPR042185	Serpin_sf_2	Homologous_superfamily

Pfam: PF00079

UniProt features (27 total): sequence variant 15, sequence conflict 7, splice variant 2, chain 1, region of interest 1, site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96P15-F1	90.17	0.79

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 357–358 (reactive bond)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 41 (showing top): ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP, TAATTA_CHX10_01, GOMF_PEPTIDASE_REGULATOR_ACTIVITY, GOMF_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY, GOMF_ENZYME_INHIBITOR_ACTIVITY, GOMF_ENZYME_REGULATOR_ACTIVITY, DODD_NASOPHARYNGEAL_CARCINOMA_DN, chr18q21, MCBRYAN_PUBERTAL_BREAST_4_5WK_UP, MCBRYAN_PUBERTAL_BREAST_6_7WK_DN, GOMF_ENDOPEPTIDASE_REGULATOR_ACTIVITY, GSE13522_CTRL_VS_T_CRUZI_Y_STRAIN_INF_SKIN_IFNG_KO_DN, HMGA1_TARGET_GENES, MIR6882_5P, MIR6792_5P

GO Biological Process (0):

GO Molecular Function (2): serine-type endopeptidase inhibitor activity (GO:0004867), peptidase inhibitor activity (GO:0030414)

GO Cellular Component (2): obsolete extracellular space (GO:0005615), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
serine-type endopeptidase activity	1
endopeptidase inhibitor activity	1
enzyme inhibitor activity	1
peptidase activity	1
peptidase regulator activity	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

596 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SERPINB11	KLK14	Q9P0G3	480
SERPINB11	ZNF799	Q96GE5	477
SERPINB11	ZC2HC1C	Q53FD0	432
SERPINB11	NFASC	O94856	401
SERPINB11	KLK6	Q92876	397
SERPINB11	LCE2C	Q5TA81	396
SERPINB11	LCE2D	Q5TA82	392
SERPINB11	TCHHL1	Q5QJ38	387
SERPINB11	S100A2	P29034	384
SERPINB11	SPRR4	Q96PI1	383
SERPINB11	S100A12	P80511	381
SERPINB11	ING1	Q9UK53	375
SERPINB11	CPLX4	Q7Z7G2	372
SERPINB11	KRT77	Q7Z794	369
SERPINB11	ENKD1	Q9H0I2	368

IntAct

3 interactions, top by confidence:

A	B	Type	Score
SERPINB11	CPE	psi-mi:“MI:0914”(association)	0.350
GPC3	PXDNL	psi-mi:“MI:0914”(association)	0.350

BioGRID (18): HSPA5 (Affinity Capture-MS), TUBA1A (Affinity Capture-MS), CBWD3 (Affinity Capture-MS), ITPA (Affinity Capture-MS), LMF1 (Affinity Capture-MS), CPE (Affinity Capture-MS), DNLZ (Affinity Capture-MS), CBWD3 (Affinity Capture-MS), CPE (Affinity Capture-MS), DNLZ (Affinity Capture-MS), ITPA (Affinity Capture-MS), TUBA4A (Affinity Capture-MS), SIL1 (Affinity Capture-MS), WDTC1 (Affinity Capture-MS), DNLZ (Affinity Capture-MS)

ESM2 similar proteins: A0A090BX51, A0A0K8RCY5, A0A0K8RJ89, A0A0K8RJV9, A0A7H0DNF9, B3RFC3, E2RVI8, O73860, O75635, P01008, P01012, P01014, P05120, P07092, P07093, P07385, P0DSW3, P12388, P13909, P14754, P15059, P19104, P20961, P22777, P22922, P42926, P50449, P68565, P68566, P79335, P80034, Q06B72, Q06B74, Q06B75, Q07235, Q27085, Q27086, Q5MGH0, Q5R5A3, Q6J201

Diamond homologs: A0A090BX51, A0A0K8RCY5, A0A0K8RJ89, A0A0K8RJV9, A5PJK0, A9RA96, B0CMB0, B1MTB7, B1MTC3, B2KI30, B3RFC3, B4USX2, E2RVI8, O02739, O08800, O35684, O54757, O54758, O54759, O54760, O73790, O73860, O75635, O75830, P01008, P01011, P01012, P01014, P05120, P05619, P12388, P17475, P19104, P22323, P22325, P22922, P23035, P29508, P29524, P30740

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

75 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	69
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1917 predictions. Top by Δscore:

Variant	Effect	Δscore
18:63656057:TCAAG:T	acceptor_gain	1.0000
18:63656058:CAAG:C	acceptor_gain	1.0000
18:63656058:CAAGC:C	acceptor_gain	1.0000
18:63656059:AAG:A	acceptor_gain	1.0000
18:63656059:AAGC:A	acceptor_gain	1.0000
18:63656060:AG:A	acceptor_gain	1.0000
18:63656060:AGCT:A	acceptor_gain	1.0000
18:63656061:GC:G	acceptor_loss	1.0000
18:63656061:GCTA:G	acceptor_gain	1.0000
18:63656062:C:A	acceptor_gain	1.0000
18:63656062:C:CC	acceptor_gain	1.0000
18:63656062:CT:C	acceptor_loss	1.0000
18:63656063:T:A	acceptor_gain	1.0000
18:63656064:A:AC	acceptor_gain	1.0000
18:63656064:A:C	acceptor_gain	1.0000
18:63656067:CAAA:C	acceptor_gain	1.0000
18:63656070:A:AC	acceptor_gain	1.0000
18:63656070:A:C	acceptor_gain	1.0000
18:63656825:TCTTA:T	donor_loss	1.0000
18:63656826:CTTA:C	donor_loss	1.0000
18:63656827:TTACC:T	donor_loss	1.0000
18:63656828:TA:T	donor_loss	1.0000
18:63656830:C:CT	donor_loss	1.0000
18:63656830:CCTT:C	donor_gain	1.0000
18:63656927:C:CT	acceptor_gain	1.0000
18:63656928:A:T	acceptor_gain	1.0000
18:63656935:C:CT	acceptor_gain	1.0000
18:63656985:TT:T	acceptor_gain	1.0000
18:63657017:C:CT	acceptor_gain	1.0000
18:63657018:A:T	acceptor_gain	1.0000

AlphaMissense

2611 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000038489 (18:63714781 G>A), RS1000085482 (18:63714539 A>C), RS1000287802 (18:63709835 G>A), RS1000392665 (18:63704256 A>G), RS1000427959 (18:63721968 A>G), RS1000445223 (18:63703886 C>T), RS1000975865 (18:63718767 C>T), RS1001086144 (18:63713683 A>G), RS1001576756 (18:63717376 T>C), RS1001614352 (18:63702284 CAGA>C), RS1001851770 (18:63701094 G>A), RS1001984029 (18:63707366 A>C), RS1002093296 (18:63712428 A>G,T), RS1002261742 (18:63717706 GATAA>G), RS1002346426 (18:63700893 G>A)

Disease associations

OMIM: gene MIM:615682 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST007994_21	Asthma (age of onset)	5.000000e-08
GCST007995_7	Asthma (childhood onset)	3.000000e-16

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, decreases methylation	1
butyraldehyde	decreases expression	1
CGP 52608	affects binding, increases reaction	1
(+)-JQ1 compound	increases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Allergens	decreases expression	1
Benzo(a)pyrene	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.