SETD4-AS1

Summary

SETD4-AS1 (SETD4 antisense RNA 1, HGNC:40104) is a long non-coding RNA gene on chromosome 21q22.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40104
Approved symbol	SETD4-AS1
Name	SETD4 antisense RNA 1
Location	21q22.12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000236677
Ensembl biotype	lncRNA
Entrez	105369295
RNAcentral	URS00026A20A2 — lncRNA, 542 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000436303, ENST00000849287

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000436303 — 3 exons

Exon	Start	End
ENSE00001650043	36064217	36064408
ENSE00001711920	36060432	36060621
ENSE00001788299	36063506	36063569

Expression profiles

Bgee: expression breadth broad, 99 present calls, max score 64.51.

FANTOM5 (CAGE): breadth broad, TPM avg 0.4705 / max 27.0833, expressed in 220 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
209305	0.4705	220

Top tissues by expression

99 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hindlimb stylopod muscle	UBERON:0004252	64.51	gold quality
bone marrow	UBERON:0002371	60.40	gold quality
lymph node	UBERON:0000029	59.09	gold quality
gall bladder	UBERON:0002110	58.18	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	57.45	gold quality
calcaneal tendon	UBERON:0003701	56.58	gold quality
blood	UBERON:0000178	56.24	gold quality
prefrontal cortex	UBERON:0000451	56.07	gold quality
vermiform appendix	UBERON:0001154	54.86	gold quality
placenta	UBERON:0001987	54.79	gold quality
superior frontal gyrus	UBERON:0002661	54.58	gold quality
cortex of kidney	UBERON:0001225	54.15	gold quality
liver	UBERON:0002107	53.82	gold quality
monocyte	CL:0000576	53.28	gold quality
islet of Langerhans	UBERON:0000006	53.07	gold quality
muscle of leg	UBERON:0001383	52.43	gold quality
right lobe of liver	UBERON:0001114	50.73	gold quality
gastrocnemius	UBERON:0001388	50.45	gold quality
primary visual cortex	UBERON:0002436	49.93	gold quality
kidney	UBERON:0002113	49.53	gold quality
corpus callosum	UBERON:0002336	49.48	gold quality
endocervix	UBERON:0000458	48.90	gold quality
adult mammalian kidney	UBERON:0000082	47.91	gold quality
heart left ventricle	UBERON:0002084	47.80	gold quality
heart	UBERON:0000948	47.00	gold quality
cerebellar cortex	UBERON:0002129	46.85	silver quality
tibial artery	UBERON:0007610	46.83	gold quality
popliteal artery	UBERON:0002250	46.80	gold quality
cerebellar hemisphere	UBERON:0002245	46.41	silver quality
right hemisphere of cerebellum	UBERON:0014890	46.41	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.46

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.