SFTA1P

Summary

SFTA1P (surfactant associated 1, lncRNA, HGNC:18383) is a long non-coding RNA gene on chromosome 10p14.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18383
Approved symbol	SFTA1P
Name	surfactant associated 1, lncRNA
Location	10p14
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000225383
Ensembl biotype	lncRNA
Entrez	207107
RNAcentral	URS0001A2145B — lncRNA, 2459 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 17 lncRNA

ENST00000415590, ENST00000434919, ENST00000446372, ENST00000602763, ENST00000634899, ENST00000652890, ENST00000653216, ENST00000656654, ENST00000660024, ENST00000663743, ENST00000665724, ENST00000667544, ENST00000739709, ENST00000739710, ENST00000739711, ENST00000739712, ENST00000739713

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000415590 — 4 exons

Exon	Start	End
ENSE00001726837	10792372	10792525
ENSE00001737614	10786645	10786755
ENSE00003440395	10784437	10784669
ENSE00004075153	10794877	10794980

Expression profiles

Bgee: expression breadth ubiquitous, 161 present calls, max score 97.74.

FANTOM5 (CAGE): breadth broad, TPM avg 2.0743 / max 213.2823, expressed in 361 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
108234	1.1822	252
108235	0.4413	161
108232	0.1863	65
108233	0.1362	55
108230	0.0635	19
108231	0.0262	12
108236	0.0257	11
108229	0.0129	3

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lung	UBERON:0002167	97.74	gold quality
upper lobe of left lung	UBERON:0008952	95.88	gold quality
upper lobe of lung	UBERON:0008948	95.11	gold quality
lung	UBERON:0002048	90.37	gold quality
lower lobe of lung	UBERON:0008949	84.58	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.78	gold quality
colonic epithelium	UBERON:0000397	76.63	gold quality
rectum	UBERON:0001052	74.22	gold quality
putamen	UBERON:0001874	73.16	gold quality
caudate nucleus	UBERON:0001873	73.14	gold quality
mucosa of transverse colon	UBERON:0004991	72.53	gold quality
kidney epithelium	UBERON:0004819	72.18	gold quality
amygdala	UBERON:0001876	70.80	gold quality
anterior cingulate cortex	UBERON:0009835	70.75	gold quality
visceral pleura	UBERON:0002401	70.47	gold quality
epithelial cell of pancreas	CL:0000083	69.93	gold quality
omental fat pad	UBERON:0010414	69.41	gold quality
peritoneum	UBERON:0002358	69.38	gold quality
tendon of biceps brachii	UBERON:0008188	69.19	gold quality
adipose tissue of abdominal region	UBERON:0007808	69.06	gold quality
parotid gland	UBERON:0001831	68.06	gold quality
right frontal lobe	UBERON:0002810	67.89	gold quality
small intestine	UBERON:0002108	67.87	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.87	gold quality
small intestine Peyer’s patch	UBERON:0003454	67.68	gold quality
adult organism	UBERON:0007023	67.57	gold quality
right atrium auricular region	UBERON:0006631	67.54	gold quality
transverse colon	UBERON:0001157	67.38	gold quality
substantia nigra	UBERON:0002038	67.36	gold quality
cardiac atrium	UBERON:0002081	67.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Findings demonstrate that pseudogene-derived long noncoding RNA SFTA1P exerts the tumor suppressor functions in human lung adenocarcinoma. (PMID:28231733)
• work suggests that the pseudogene-derived lncRNA SFTA1P functions as a tumor suppressor in GC and thus may act as a potential diagnostic and therapeutic target of gastric cancer. (PMID:29523596)
• Expression of long non-coding RNA SFTA1P and its function in non-small cell lung cancer. (PMID:32825934)
• LncRNA SFTA1P promotes cervical cancer progression by interaction with PTBP1 to facilitate TPM4 mRNA degradation. (PMID:36344495)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.