SFXN4

Summary

SFXN4 (sideroflexin 4, HGNC:16088) is a protein-coding gene on chromosome 10q26.11, encoding Sideroflexin-4 (Q6P4A7). Mitochondrial amino-acid transporter.

This gene encodes a member of the sideroflexin family. The encoded protein is a transmembrane protein of the inner mitochondrial membrane, and is required for mitochondrial respiratory homeostasis and erythropoiesis. Mutations in this gene are associated with mitochondriopathy and macrocytic anemia. Alternatively spliced transcript variants have been found in this gene.

Source: NCBI Gene 119559 — RefSeq curated summary.

At a glance

• Gene–disease (curated): mitochondrial disease (Definitive, ClinGen) — +1 more curated relationship
• GWAS associations: 3
• Clinical variants (ClinVar): 208 total — 6 pathogenic, 5 likely-pathogenic
• Phenotypes (HPO): 20
• MANE Select transcript: NM_213649

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16088
Approved symbol	SFXN4
Name	sideroflexin 4
Location	10q26.11
Locus type	gene with protein product
Status	Approved
Aliases	SLC56A4
Ensembl gene	ENSG00000183605
Ensembl biotype	protein_coding
OMIM	615564
Entrez	119559

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 4 protein_coding, 4 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000355697, ENST00000369131, ENST00000419372, ENST00000461438, ENST00000462913, ENST00000466218, ENST00000484960, ENST00000490417, ENST00000955059

RefSeq mRNA: 1 — MANE Select: NM_213649 NM_213649

CCDS: CCDS7610

Canonical transcript exons

ENST00000355697 — 14 exons

Exon	Start	End
ENSE00001381725	119165537	119165714
ENSE00003465290	119158009	119158062
ENSE00003518084	119160915	119160969
ENSE00003527894	119146236	119146353
ENSE00003540082	119147775	119147860
ENSE00003557921	119161055	119161081
ENSE00003576053	119157871	119157927
ENSE00003581833	119164131	119164196
ENSE00003582633	119156678	119156756
ENSE00003611443	119162340	119162414
ENSE00003614459	119140767	119141319
ENSE00003620095	119159728	119159753
ENSE00003691536	119157668	119157733
ENSE00003691862	119155062	119155177

Expression profiles

Bgee: expression breadth ubiquitous, 254 present calls, max score 96.99.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.9300 / max 85.0433, expressed in 1775 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
111677	9.7320	1754
111676	2.1752	970
111675	0.0228	13

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	96.99	gold quality
adrenal tissue	UBERON:0018303	95.43	gold quality
tibialis anterior	UBERON:0001385	95.14	gold quality
right adrenal gland cortex	UBERON:0035827	94.96	gold quality
body of pancreas	UBERON:0001150	94.68	gold quality
right adrenal gland	UBERON:0001233	94.42	gold quality
hindlimb stylopod muscle	UBERON:0004252	94.35	gold quality
mucosa of transverse colon	UBERON:0004991	94.30	gold quality
right uterine tube	UBERON:0001302	93.95	gold quality
gastrocnemius	UBERON:0001388	93.72	gold quality
left adrenal gland	UBERON:0001234	93.60	gold quality
deltoid	UBERON:0001476	93.55	gold quality
heart left ventricle	UBERON:0002084	93.49	gold quality
left adrenal gland cortex	UBERON:0035825	93.49	gold quality
muscle of leg	UBERON:0001383	93.44	gold quality
cardiac ventricle	UBERON:0002082	93.17	gold quality
sperm	CL:0000019	93.12	gold quality
adrenal gland	UBERON:0002369	93.12	gold quality
rectum	UBERON:0001052	93.05	gold quality
adrenal cortex	UBERON:0001235	92.89	gold quality
right lobe of liver	UBERON:0001114	92.69	gold quality
right lobe of thyroid gland	UBERON:0001119	92.69	gold quality
right atrium auricular region	UBERON:0006631	92.51	gold quality
left lobe of thyroid gland	UBERON:0001120	92.44	gold quality
pancreas	UBERON:0001264	92.17	gold quality
left ventricle myocardium	UBERON:0006566	92.00	gold quality
thyroid gland	UBERON:0002046	91.96	gold quality
cardiac atrium	UBERON:0002081	91.89	gold quality
skeletal muscle tissue	UBERON:0001134	91.82	gold quality
transverse colon	UBERON:0001157	91.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.71

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

14 targeting SFXN4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-8062	99.88	68.43	995
HSA-MIR-498-5P	99.76	69.64	1807
HSA-MIR-4524A-3P	99.72	66.85	2406
HSA-MIR-520F-5P	99.34	70.40	1632
HSA-MIR-4254	99.11	65.15	1315
HSA-MIR-661	99.09	65.94	2062
HSA-MIR-6771-3P	98.20	66.53	971
HSA-MIR-4797-3P	97.48	67.14	989
HSA-MIR-6849-3P	97.25	64.57	1371
HSA-MIR-3194-5P	96.80	64.90	1027
HSA-MIR-1292-5P	96.74	62.14	238

Literature-anchored findings (GeneRIF, showing 6)

• we isolated a cDNA encoding a novel sideroflexin protein (SFXN4), which showed 59% identity and 71% similarity to mouse sideroflexin4. (PMID:14756423)
• Our findings establish mutations in SFXN4 as a cause of mitochondriopathy and macrocytic anemia. (PMID:24119684)
• Prenatal onset of mitochondrial disease is associated with sideroflexin 4 deficiency. (PMID:31059822)
• Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes. (PMID:31873120)
• Sideroflexin 4 is a complex I assembly factor that interacts with the MCIA complex and is required for the assembly of the ND2 module. (PMID:35333655)
• Comprehensive Analysis of Sideroflexin 4 in Hepatocellular Carcinoma by Bioinformatics and Experiments. (PMID:37786439)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	sfxn4	ENSDARG00000069832
mus_musculus	Sfxn4	ENSMUSG00000063698
rattus_norvegicus	Sfxn4	ENSRNOG00000036572

Paralogs (4): SFXN3 (ENSG00000107819), SFXN5 (ENSG00000144040), SFXN2 (ENSG00000156398), SFXN1 (ENSG00000164466)

Protein

Protein identifiers

Sideroflexin-4 — Q6P4A7 (reviewed: Q6P4A7)

Alternative names: Breast cancer resistance marker 1

All UniProt accessions (3): B1AMV7, B1AMV8, Q6P4A7

UniProt curated annotations — full annotation on UniProt →

Function. Mitochondrial amino-acid transporter. Does not act as a serine transporter: not able to mediate transport of serine into mitochondria.

Subcellular location. Mitochondrion inner membrane.

Disease relevance. Combined oxidative phosphorylation deficiency 18 (COXPD18) [MIM:615578] An autosomal recessive disorder of mitochondrial dysfunction characterized by intrauterine growth retardation, hypotonia, visual impairment, speech delay, and lactic acidosis associated with decreased mitochondrial respiratory chain activity. Affected patients may also show hematologic abnormalities, mainly macrocytic anemia. The disease is caused by variants affecting the gene represented in this entry.

Similarity. Belongs to the sideroflexin family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q6P4A7-1	1	yes
Q6P4A7-2	2
Q6P4A7-3	3

RefSeq proteins (1): NP_998814* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004686	Mtc	Family

Pfam: PF03820

UniProt features (12 total): transmembrane region 5, splice variant 3, modified residue 2, initiator methionine 1, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6P4A7-F1	85.33	0.57

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 2, 197

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-6799198	Complex I biogenesis
R-HSA-1428517	Aerobic respiration and respiratory electron transport
R-HSA-1430728	Metabolism
R-HSA-611105	Respiratory electron transport

MSigDB gene sets: 139 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_BRAIN_TUMORAL_MACROPHAGE_DN, WWTAAGGC_UNKNOWN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GOBP_MITOCHONDRIAL_TRANSPORT, CEBPB_01, GOBP_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT, WEI_MYCN_TARGETS_WITH_E_BOX, SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1, GOBP_AMINO_ACID_TRANSPORT, GOCC_MITOCHONDRIAL_ENVELOPE, IVANOVA_HEMATOPOIESIS_INTERMEDIATE_PROGENITOR, GOBP_TRANSMEMBRANE_TRANSPORT, GOCC_ORGANELLE_INNER_MEMBRANE, VECCHI_GASTRIC_CANCER_EARLY_UP, GOMF_TRANSPORTER_ACTIVITY

GO Biological Process (5): amino acid transport (GO:0006865), mitochondrial transmembrane transport (GO:1990542), monoatomic ion transport (GO:0006811), monoatomic ion transmembrane transport (GO:0034220), transmembrane transport (GO:0055085)

GO Molecular Function (2): monoatomic ion transmembrane transporter activity (GO:0015075), transmembrane transporter activity (GO:0022857)

GO Cellular Component (5): nucleoplasm (GO:0005654), mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), membrane (GO:0016020), mitochondrial membrane (GO:0031966)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Respiratory electron transport	1
Metabolism	1
Aerobic respiration and respiratory electron transport	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	3
transmembrane transport	3
cellular anatomical structure	2
mitochondrial transport	1
monoatomic ion transport	1
cellular process	1
transmembrane transporter activity	1
monoatomic ion transmembrane transport	1
transporter activity	1
nuclear lumen	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
mitochondrion	1
mitochondrial envelope	1
organelle membrane	1

Protein interactions and networks

STRING

904 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SFXN4	PRADC1	Q9BSG0	568
SFXN4	PRSS37	A4D1T9	492
SFXN4	CCDC18	Q5T9S5	471
SFXN4	COL24A1	Q17RW2	438
SFXN4	FECH	P22830	423
SFXN4	PSME4	Q14997	421
SFXN4	GLRX5	Q86SX6	420
SFXN4	GNAL	P38405	418
SFXN4	EBF2	Q9HAK2	416
SFXN4	ZNF490	Q9ULM2	413
SFXN4	CSDE1	O75534	413
SFXN4	NRN1	Q9NPD7	413
SFXN4	MAPK8IP3	Q9UPT6	410
SFXN4	NANOS2	P60321	406
SFXN4	NEGR1	Q7Z3B1	405

IntAct

61 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
IFT27	IFT56	psi-mi:“MI:0914”(association)	0.690
TNFSF8	LGALS8	psi-mi:“MI:0914”(association)	0.530
APLNR	SLC33A1	psi-mi:“MI:0914”(association)	0.530
COX15	SLC25A3	psi-mi:“MI:0914”(association)	0.530
TUBA1A	TUBAL3	psi-mi:“MI:0914”(association)	0.420
FLT4	ILVBL	psi-mi:“MI:0914”(association)	0.420
RIPK4	VWA8	psi-mi:“MI:0914”(association)	0.350
PB2	ESYT2	psi-mi:“MI:0914”(association)	0.350
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
LRRK2		psi-mi:“MI:0914”(association)	0.350
NMES1	NDUFS8	psi-mi:“MI:0914”(association)	0.350
COQ9	NDUFS8	psi-mi:“MI:0914”(association)	0.350
NDUFA4	NUDT19	psi-mi:“MI:0914”(association)	0.350
NDUFA4	NDUFS8	psi-mi:“MI:0914”(association)	0.350
MAIP1	COQ9	psi-mi:“MI:0914”(association)	0.350
COQ9	ACOT7	psi-mi:“MI:0914”(association)	0.350
BABAM1	PYCR3	psi-mi:“MI:0914”(association)	0.350
P		psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
SLC16A11	ESYT2	psi-mi:“MI:0914”(association)	0.350
MAPK4	ILVBL	psi-mi:“MI:0914”(association)	0.350

BioGRID (118): SFXN4 (Affinity Capture-RNA), SFXN4 (Affinity Capture-RNA), SFXN4 (Affinity Capture-MS), SFXN4 (Affinity Capture-MS), SFXN4 (Affinity Capture-MS), SFXN4 (Affinity Capture-MS), SFXN4 (Affinity Capture-MS), SFXN4 (Affinity Capture-MS), SFXN4 (Affinity Capture-MS), SFXN4 (Affinity Capture-MS), SFXN4 (Affinity Capture-MS), SFXN4 (Affinity Capture-MS), SFXN4 (Affinity Capture-MS), SFXN4 (Affinity Capture-MS), SFXN4 (Affinity Capture-MS)

ESM2 similar proteins: A5A761, A6QP55, A8E7G5, B2LU20, B3M6C8, B4H6M2, B4HKS2, B4J252, B4LE89, B4QNU8, B6IJ52, O13793, P00425, P25710, P38857, P53311, P81928, Q09201, Q12029, Q16FT5, Q2LZH7, Q32L86, Q3T0M2, Q54NQ9, Q5E9M8, Q5EA43, Q5FC79, Q5HZA9, Q5RD16, Q63965, Q6BKZ1, Q6CFW6, Q6CXR8, Q6FJJ0, Q6P4A7, Q759E9, Q91V61, Q925N1, Q925N2, Q95QD1

Diamond homologs: A8E7G5, Q3T0M2, Q54NQ9, Q6P4A7, Q8CFD0, Q8TD22, Q925N0, Q925N1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

208 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	6
Likely pathogenic	5
Uncertain significance	38
Likely benign	66
Benign	59

Top pathogenic / likely-pathogenic (11)

Variant ID	HGVS	Classification
1323582	NM_213649.2(SFXN4):c.368T>A (p.Leu123Ter)	Pathogenic
2175492	NM_213649.2(SFXN4):c.668del (p.Lys223fs)	Pathogenic
488593	NM_213649.2(SFXN4):c.414+1G>A	Pathogenic
638327	NM_213649.2(SFXN4):c.940C>T (p.Gln314Ter)	Pathogenic
92098	NM_213649.2(SFXN4):c.233del (p.Pro78fs)	Pathogenic
92099	NM_213649.2(SFXN4):c.739dup (p.Arg247fs)	Pathogenic
2076813	NM_213649.2(SFXN4):c.819-1G>C	Likely pathogenic
2182106	NM_213649.2(SFXN4):c.818+2T>A	Likely pathogenic
2427788	NC_000010.10:g.(?120905748)(120905865_?)dup	Likely pathogenic
3381959	NM_213649.2(SFXN4):c.823C>T (p.Gln275Ter)	Likely pathogenic
3767158	NM_213649.2(SFXN4):c.361-2A>T	Likely pathogenic

SpliceAI

1839 predictions. Top by Δscore:

Variant	Effect	Δscore
10:119155056:TCTTA:T	donor_loss	1.0000
10:119155057:CTTAC:C	donor_loss	1.0000
10:119155058:TTAC:T	donor_loss	1.0000
10:119155059:TAC:T	donor_loss	1.0000
10:119155060:ACC:A	donor_loss	1.0000
10:119155061:C:CG	donor_loss	1.0000
10:119156668:T:TA	donor_gain	1.0000
10:119156673:CTCA:C	donor_loss	1.0000
10:119156674:TCA:T	donor_loss	1.0000
10:119156675:CACC:C	donor_loss	1.0000
10:119156676:ACC:A	donor_loss	1.0000
10:119156752:ATTAC:A	acceptor_gain	1.0000
10:119156753:TTAC:T	acceptor_gain	1.0000
10:119156754:TAC:T	acceptor_gain	1.0000
10:119156755:AC:A	acceptor_gain	1.0000
10:119156756:CC:C	acceptor_gain	1.0000
10:119156757:C:CC	acceptor_gain	1.0000
10:119157617:T:TA	donor_gain	1.0000
10:119157666:A:AC	donor_gain	1.0000
10:119157666:ACT:A	donor_gain	1.0000
10:119157667:C:CG	donor_gain	1.0000
10:119157667:CT:C	donor_gain	1.0000
10:119157667:CTC:C	donor_gain	1.0000
10:119157869:A:AC	donor_gain	1.0000
10:119157870:C:CA	donor_gain	1.0000
10:119157870:CGTAA:C	donor_gain	1.0000
10:119157874:A:C	donor_gain	1.0000
10:119160911:TCA:T	donor_loss	1.0000
10:119160912:CAC:C	donor_loss	1.0000
10:119160914:C:CA	donor_loss	1.0000

AlphaMissense

2190 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:119146257:A:C	S305R	0.989
10:119146257:A:T	S305R	0.989
10:119146259:T:G	S305R	0.989
10:119155072:G:T	A241D	0.980
10:119155114:A:T	V227D	0.980
10:119155070:C:A	G242W	0.979
10:119157898:G:C	F148L	0.972
10:119157898:G:T	F148L	0.972
10:119157900:A:G	F148L	0.972
10:119164172:A:G	W46R	0.968
10:119164172:A:T	W46R	0.968
10:119155144:C:G	R217P	0.966
10:119161058:A:C	S92R	0.965
10:119161058:A:T	S92R	0.965
10:119161060:T:G	S92R	0.965
10:119155081:G:A	S238F	0.959
10:119155167:A:C	S209R	0.959
10:119155167:A:T	S209R	0.959
10:119155169:T:G	S209R	0.959
10:119141251:T:A	R335S	0.957
10:119141251:T:G	R335S	0.957
10:119155082:A:G	S238P	0.953
10:119160923:C:G	R109P	0.951
10:119141250:C:A	G336W	0.946
10:119141259:A:C	Y333D	0.941
10:119147834:T:A	R253S	0.941
10:119147834:T:G	R253S	0.941
10:119146251:A:C	F307L	0.939
10:119146251:A:T	F307L	0.939
10:119146253:A:G	F307L	0.939

dbSNP variants (sampled 300 via entrez): RS1000105689 (10:119141702 C>T), RS1000170489 (10:119158446 C>T), RS1000300559 (10:119146981 A>C), RS1000412845 (10:119165183 C>A,G,T), RS1000461166 (10:119157382 G>A), RS1000492032 (10:119156993 G>A), RS1000539777 (10:119141545 C>A,G), RS1000777530 (10:119152438 C>G), RS1000798706 (10:119165974 G>C), RS1000955792 (10:119153357 C>T), RS1001026942 (10:119163275 G>A,T), RS1001029439 (10:119153077 C>T), RS1001214233 (10:119150802 A>T), RS1001239714 (10:119152569 C>T), RS1001301939 (10:119141800 G>A)

Disease associations

OMIM: gene MIM:615564 | disease phenotypes: MIM:615578

GenCC curated gene-disease

Disease	Classification	Inheritance
growth and developmental delay-hypotonia-vision impairment-lactic acidosis syndrome	Strong	Autosomal recessive

ClinGen Gene-Disease Validity (1)

Expert-panel classifications — Definitive > Strong > Moderate > Limited > Disputed > Refuted.

Disease	Classification	Inheritance
mitochondrial disease	Definitive	AR

Mondo (1): growth and developmental delay-hypotonia-vision impairment-lactic acidosis syndrome (MONDO:0014261)

Orphanet (1): Growth and developmental delay-hypotonia-vision impairment-lactic acidosis syndrome (Orphanet:391348)

HPO phenotypes

20 total (20 of 20 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0000505	Visual impairment
HP:0000750	Delayed speech and language development
HP:0001252	Hypotonia
HP:0001256	Mild intellectual disability
HP:0001310	Dysmetria
HP:0001337	Tremor
HP:0001511	Intrauterine growth retardation
HP:0001562	Oligohydramnios
HP:0001972	Macrocytic anemia
HP:0002151	Increased circulating lactate concentration
HP:0003128	Lactic acidosis
HP:0003202	Skeletal muscle atrophy
HP:0003577	Congenital onset
HP:0004821	Hypersegmentation of neutrophil nuclei
HP:0009046	Difficulty running
HP:0010862	Delayed fine motor development
HP:0011923	Decreased activity of mitochondrial complex I
HP:0012120	Methylmalonic aciduria
HP:0040014	Increased mitochondrial number

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST004860_17	Alcoholic chronic pancreatitis	6.000000e-06
GCST011176_5	Stroke	1.000000e-07
GCST90020029_302	Waist circumference adjusted for body mass index	2.000000e-08

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007789	BMI-adjusted waist circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

2 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs2275112	EIF3A, SFXN4		0.00	0
rs11198804	EIF3A, SFXN4		0.00	0

CTD chemical–gene interactions

46 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
(+)-JQ1 compound	decreases expression	5
Acetaminophen	decreases expression	4
Valproic Acid	decreases expression, increases expression, increases methylation, affects expression	4
sodium arsenite	decreases expression, affects cotreatment, increases abundance, increases expression	2
Hydrogen Peroxide	affects expression, decreases expression	2
Plant Extracts	affects cotreatment, increases expression, decreases expression	2
Cadmium Chloride	decreases expression, increases abundance, increases expression	2
Particulate Matter	increases expression, affects cotreatment, decreases expression, increases abundance	2
aristolochic acid I	decreases expression	1
methylmercuric chloride	decreases expression	1
cobaltous chloride	decreases expression	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
caffeic acid	decreases expression, increases reaction	1
isobutyl alcohol	increases abundance, affects cotreatment, decreases expression	1
4-methoxycinnamate methyl ester	decreases expression, increases reaction	1
perfluoro-n-nonanoic acid	increases expression	1
ICG 001	increases expression	1
14-deoxy-11,12-didehydroandrographolide	decreases expression	1
bisphenol S	affects expression	1
NSC 689534	affects binding, decreases expression	1
3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Air Pollutants	increases abundance, increases expression	1
Arsenic	increases expression, affects cotreatment, increases abundance	1
Atrazine	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Cadmium	increases expression, increases abundance	1
Caffeine	increases phosphorylation	1
Carbamazepine	affects expression	1
Copper	affects binding, decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4HE	HCT116-SFXN4-KO-c34	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.