SGMS1-AS1

Summary

SGMS1-AS1 (SGMS1 antisense RNA 1, HGNC:49683) is a long non-coding RNA gene on chromosome 10q11.23.

Predicted to act upstream of or within positive regulation of myelination and regulation of gene expression.

Source: NCBI Gene 104355295 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49683
Approved symbol	SGMS1-AS1
Name	SGMS1 antisense RNA 1
Location	10q11.23
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000226200
Ensembl biotype	lncRNA
Entrez	104355295
RNAcentral	URS00007E4E8F — lncRNA, 2585 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 lncRNA

ENST00000443374, ENST00000609579, ENST00000653493, ENST00000795195, ENST00000795196, ENST00000795197, ENST00000795198, ENST00000795199, ENST00000795200, ENST00000795201, ENST00000795202, ENST00000795203, ENST00000795204, ENST00000795205

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000443374 — 4 exons

Exon	Start	End
ENSE00001655131	50629031	50629178
ENSE00003702535	50629577	50641451
ENSE00003702551	50626670	50626805
ENSE00003709759	50624943	50625191

Expression profiles

Bgee: expression breadth ubiquitous, 182 present calls, max score 86.13.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 1.8077 / max 27.0525, expressed in 1039 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
104911	1.8077	1039

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	86.13	gold quality
endothelial cell	CL:0000115	74.81	gold quality
ileal mucosa	UBERON:0000331	72.37	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	71.59	gold quality
oviduct epithelium	UBERON:0004804	71.03	gold quality
pigmented layer of retina	UBERON:0001782	70.81	gold quality
bone marrow cell	CL:0002092	70.57	silver quality
right adrenal gland cortex	UBERON:0035827	69.79	gold quality
adrenal tissue	UBERON:0018303	68.90	gold quality
gingival epithelium	UBERON:0001949	68.33	gold quality
left adrenal gland cortex	UBERON:0035825	68.04	gold quality
colonic epithelium	UBERON:0000397	68.03	silver quality
right adrenal gland	UBERON:0001233	67.76	gold quality
epithelial cell of pancreas	CL:0000083	67.65	silver quality
left adrenal gland	UBERON:0001234	67.62	gold quality
adrenal cortex	UBERON:0001235	67.50	gold quality
adrenal gland	UBERON:0002369	67.22	gold quality
leukocyte	CL:0000738	66.53	gold quality
monocyte	CL:0000576	66.25	gold quality
calcaneal tendon	UBERON:0003701	66.20	gold quality
kidney epithelium	UBERON:0004819	66.18	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	66.14	gold quality
parotid gland	UBERON:0001831	65.74	gold quality
islet of Langerhans	UBERON:0000006	65.62	gold quality
fallopian tube	UBERON:0003889	65.21	gold quality
gingiva	UBERON:0001828	65.15	gold quality
liver	UBERON:0002107	65.14	gold quality
stromal cell of endometrium	CL:0002255	65.09	gold quality
tibialis anterior	UBERON:0001385	64.93	silver quality
palpebral conjunctiva	UBERON:0001812	64.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	6.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LncRNA SGMS1-AS1 regulates lung adenocarcinoma cell proliferation, migration, invasion, and EMT progression via miR-106a-5p/MYLI9 axis. (PMID:34061466)
• SGMS1-AS1/MicroRNA-106a-5p/CPT2 Axis as a Novel Target for Regulating Lactate Metabolism in Colon Cancer. (PMID:37926998)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.