SGO1-AS1

Summary

SGO1-AS1 (SGO1 antisense RNA 1, HGNC:41081) is a long non-coding RNA gene on chromosome 3p24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41081
Approved symbol	SGO1-AS1
Name	SGO1 antisense RNA 1
Location	3p24.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000231304
Ensembl biotype	lncRNA
Entrez	100874028
RNAcentral	URS0000558545 — lncRNA, 499 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 30 — 30 lncRNA

ENST00000441442, ENST00000448208, ENST00000455626, ENST00000634618, ENST00000634837, ENST00000635369, ENST00000736217, ENST00000736218, ENST00000736219, ENST00000736220, ENST00000736221, ENST00000736222, ENST00000736223, ENST00000736224, ENST00000736225, ENST00000736226, ENST00000736227, ENST00000736228, ENST00000754069, ENST00000826894, ENST00000826895, ENST00000826896, ENST00000826897, ENST00000826898, ENST00000826899, ENST00000826900, ENST00000826901, ENST00000826902, ENST00000826903, ENST00000837212

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000441442 — 4 exons

Exon	Start	End
ENSE00001701431	20174286	20174525
ENSE00001703267	20174735	20174818
ENSE00001706215	20185975	20186115
ENSE00001724070	20177217	20177250

Expression profiles

Bgee: expression breadth ubiquitous, 131 present calls, max score 82.50.

FANTOM5 (CAGE): breadth broad, TPM avg 1.1747 / max 108.4932, expressed in 261 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
35676	0.4835	148
35675	0.3799	119
35674	0.2721	84
35673	0.0393	8

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.50	gold quality
bone marrow cell	CL:0002092	71.09	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	69.78	gold quality
granulocyte	CL:0000094	67.74	gold quality
islet of Langerhans	UBERON:0000006	67.12	gold quality
ganglionic eminence	UBERON:0004023	67.00	gold quality
ventricular zone	UBERON:0003053	66.27	gold quality
lower esophagus mucosa	UBERON:0035834	66.09	gold quality
blood	UBERON:0000178	65.32	gold quality
sural nerve	UBERON:0015488	63.26	silver quality
testis	UBERON:0000473	63.11	gold quality
colonic epithelium	UBERON:0000397	63.03	silver quality
bone marrow	UBERON:0002371	62.28	gold quality
right testis	UBERON:0004534	62.13	gold quality
left testis	UBERON:0004533	61.43	gold quality
leukocyte	CL:0000738	61.34	gold quality
monocyte	CL:0000576	61.08	gold quality
stromal cell of endometrium	CL:0002255	59.62	gold quality
tonsil	UBERON:0002372	58.47	gold quality
hindlimb stylopod muscle	UBERON:0004252	58.10	gold quality
lymph node	UBERON:0000029	57.88	gold quality
pancreas	UBERON:0001264	57.77	gold quality
liver	UBERON:0002107	57.06	gold quality
muscle of leg	UBERON:0001383	56.28	gold quality
gastrocnemius	UBERON:0001388	56.14	gold quality
skeletal muscle tissue	UBERON:0001134	55.97	gold quality
calcaneal tendon	UBERON:0003701	55.21	gold quality
cortex of kidney	UBERON:0001225	54.80	gold quality
vermiform appendix	UBERON:0001154	54.71	gold quality
right lobe of liver	UBERON:0001114	54.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.89

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long noncoding RNA SGO1-AS1 inactivates TGFbeta signaling by facilitating TGFB1/2 mRNA decay and inhibits gastric carcinoma metastasis. (PMID:34706749)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.