SH3BP4

Summary

SH3BP4 (SH3 domain binding protein 4, HGNC:10826) is a protein-coding gene on chromosome 2q37.2, encoding SH3 domain-binding protein 4 (Q9P0V3). May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis.

This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor.

Source: NCBI Gene 23677 — RefSeq curated summary.

At a glance

• GWAS associations: 12
• Clinical variants (ClinVar): 169 total
• MANE Select transcript: NM_014521

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10826
Approved symbol	SH3BP4
Name	SH3 domain binding protein 4
Location	2q37.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000130147
Ensembl biotype	protein_coding
OMIM	605611
Entrez	23677

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 11 protein_coding, 4 protein_coding_CDS_not_defined

ENST00000344528, ENST00000392011, ENST00000409212, ENST00000416021, ENST00000444916, ENST00000446904, ENST00000454947, ENST00000462602, ENST00000484097, ENST00000489601, ENST00000493436, ENST00000875805, ENST00000875806, ENST00000924838, ENST00000961226

RefSeq mRNA: 6 — MANE Select: NM_014521 NM_001371302, NM_001371303, NM_001371304, NM_001371305, NM_001371306, NM_014521

CCDS: CCDS2513

Canonical transcript exons

ENST00000392011 — 6 exons

Exon	Start	End
ENSE00001030217	235034871	235035120
ENSE00001030218	234995303	234995376
ENSE00001132676	235052562	235052750
ENSE00001132679	235040888	235043247
ENSE00001510416	235053592	235055714
ENSE00001828184	234952017	234952170

Expression profiles

Bgee: expression breadth ubiquitous, 274 present calls, max score 99.60.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 25.1629 / max 172.4797, expressed in 1541 samples.

FANTOM5 promoters (17 alternative TSS)

Promoter ID	TPM avg	Samples expressed
26167	13.5688	1491
26168	6.3857	1350
26166	2.9862	1339
26182	0.4743	279
26180	0.3840	151
26183	0.3631	168
26173	0.2354	141
26169	0.2137	90
26179	0.1149	51
26171	0.0814	27

Top tissues by expression

285 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
parotid gland	UBERON:0001831	99.60	gold quality
trachea	UBERON:0003126	96.45	gold quality
mucosa of paranasal sinus	UBERON:0005030	96.13	gold quality
renal medulla	UBERON:0000362	96.12	gold quality
germinal epithelium of ovary	UBERON:0001304	96.07	gold quality
nasal cavity epithelium	UBERON:0005384	95.99	gold quality
caput epididymis	UBERON:0004358	95.52	gold quality
saliva-secreting gland	UBERON:0001044	94.90	gold quality
nasal cavity mucosa	UBERON:0001826	94.81	gold quality
choroid plexus epithelium	UBERON:0003911	94.69	gold quality
tibia	UBERON:0000979	94.47	gold quality
epithelium of mammary gland	UBERON:0003244	94.22	gold quality
mammary duct	UBERON:0001765	94.17	gold quality
minor salivary gland	UBERON:0001830	93.89	gold quality
bronchial epithelial cell	CL:0002328	93.87	gold quality
bronchus	UBERON:0002185	93.76	gold quality
epithelium of bronchus	UBERON:0002031	93.73	gold quality
stromal cell of endometrium	CL:0002255	93.64	gold quality
corpus epididymis	UBERON:0004359	93.55	gold quality
pylorus	UBERON:0001166	93.51	gold quality
inferior vagus X ganglion	UBERON:0005363	93.43	gold quality
parietal pleura	UBERON:0002400	93.32	gold quality
mouth mucosa	UBERON:0003729	93.19	gold quality
endothelial cell	CL:0000115	93.16	silver quality
inferior olivary complex	UBERON:0002127	93.10	gold quality
cardia of stomach	UBERON:0001162	93.08	gold quality
gingival epithelium	UBERON:0001949	92.91	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	92.89	gold quality
body of pancreas	UBERON:0001150	92.59	gold quality
metanephric glomerulus	UBERON:0004736	92.57	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-93593	yes	8.41
E-ANND-3	yes	7.79
E-GEOD-81383	no	303.84

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• Results show that TTP (SH3BP4), a SH3-containing protein, specifically regulates the internalization of the transferrin receptor (TfR). (PMID:16325581)
• SH3BP4 is a negative regulator of the Rag GTPase complex and amino acid-dependent mTORC1 signaling. (PMID:22575674)
• SH3BP4 has been identified as a novel pigmentation gene. The SH3BP4 is a direct target of miR-125b. The SH3BP4 is transcriptionally regulated by MITF as its direct target. (PMID:28819321)
• A SNP in the 3’UTR of SH3BP4 (rs56161233) that overlaps predicted miR-100-binding sites and is predicted to disrupt several miRNA-mRNA interactions was associated with overall survival of laryngeal cancer. (PMID:29880533)
• The data uncover the tumor-suppressive role of SH3BP4 that functions as a negative feedback regulator of Wnt signaling through modulating beta-catenin’s subcellular localization. (PMID:30811977)
• SH3BP4 promotes neuropilin-1 and alpha5-integrin endocytosis and is inhibited by Akt. (PMID:33761321)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	sh3bp4a	ENSDARG00000020000
danio_rerio	sh3bp4	ENSDARG00000030104
mus_musculus	Sh3bp4	ENSMUSG00000036206
rattus_norvegicus	Sh3bp4	ENSRNOG00000019316

Paralogs (1): MACC1 (ENSG00000183742)

Protein

Protein identifiers

SH3 domain-binding protein 4 — Q9P0V3 (reviewed: Q9P0V3)

Alternative names: EH-binding protein 10, Transferrin receptor-trafficking protein

All UniProt accessions (5): Q9P0V3, C9JED2, C9JF25, C9JRG1, C9JWW6

UniProt curated annotations — full annotation on UniProt →

Function. May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.

Subunit / interactions. Homodimer or homooligomer. Interacts with DNM2, EPS15, clathrin, the adapter protein complex 2/AP-2 and TFRC. Interacts with the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; the interaction is most probably direct, preferentially occurs with their inactive GDP-bound form and is negatively regulated by amino acids. (Microbial infection) Interacts with molluscum contagiosum virus protein MC159L; this interaction is important for the suppression of autophagy.

Subcellular location. Membrane. Clathrin-coated pit. Cytoplasmic vesicle. Clathrin-coated vesicle. Nucleus.

Tissue specificity. Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level).

Post-translational modifications. Phosphorylated upon EGF stimulation. Phosphorylation prevents interaction with DNM2.

Domain organisation. The SH3 domain mediates localization to the clathrin-coated pits and vesicles. The SH3 domain mediates interaction with DNM2 and the cytoplasmic part of TFRC with a lower affinity. The SH3 domain also mediates interaction with RRAGB, RRAGC and is required for the negative regulation of mTORC1.

Miscellaneous. Overexpression or depletion of SH3BP4 result in a specific decrease of the transferrin receptor endocytosis that can be rescued by DNM2 overexpression. Dubious isoform produced through aberrant splice sites.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9P0V3-1	1	yes
Q9P0V3-2	2

RefSeq proteins (6): NP_001358231, NP_001358232, NP_001358233, NP_001358234, NP_001358235, NP_055336* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000906	ZU5_dom	Domain
IPR001452	SH3_domain	Domain
IPR035456	SH3BP4_SH3	Domain
IPR036028	SH3-like_dom_sf	Homologous_superfamily
IPR056181	SH3BP4_C	Domain
IPR056182	UPA_SH3BP4	Domain
IPR056183	DEATH_SH3BP4	Domain

Pfam: PF00018, PF00791, PF07653, PF23637, PF23640, PF24094

UniProt features (15 total): modified residue 6, domain 3, sequence variant 2, chain 1, splice variant 1, mutagenesis site 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9P0V3-F1	70.15	0.29

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (6): 131, 246, 251, 279, 296, 637

Mutagenesis-validated functional residues (1):

Position	Phenotype
92	loss of function. loss of targeting to the clathrin-coated pits and vesicles. loss of interaction with dnm2, rragb and r

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-9639288	Amino acids regulate mTORC1
R-HSA-2262752	Cellular responses to stress
R-HSA-8953897	Cellular responses to stimuli
R-HSA-9711097	Cellular response to starvation

MSigDB gene sets: 224 (showing top): GCACCTT_MIR18A_MIR18B, VERHAAK_AML_WITH_NPM1_MUTATED_DN, GOBP_REGULATION_OF_AUTOPHAGY, GOBP_RESPONSE_TO_ACID_CHEMICAL, GOBP_NEGATIVE_REGULATION_OF_CELL_GROWTH, GOBP_NEGATIVE_REGULATION_OF_HYDROLASE_ACTIVITY, GEORGES_CELL_CYCLE_MIR192_TARGETS, GOBP_GROWTH, GOBP_REGULATION_OF_GTPASE_ACTIVITY, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, GOBP_VESICLE_MEDIATED_TRANSPORT, GOMF_GTPASE_BINDING, GOBP_CELLULAR_RESPONSE_TO_ACID_CHEMICAL, CTATGCA_MIR153, GOBP_PROTEIN_LOCALIZATION_TO_LYSOSOME

GO Biological Process (9): endocytosis (GO:0006897), negative regulation of cell population proliferation (GO:0008285), positive regulation of autophagy (GO:0010508), negative regulation of cell growth (GO:0030308), negative regulation of TOR signaling (GO:0032007), negative regulation of GTPase activity (GO:0034260), regulation of catalytic activity (GO:0050790), protein localization to lysosome (GO:0061462), cellular response to amino acid stimulus (GO:0071230)

GO Molecular Function (4): GDP-dissociation inhibitor activity (GO:0005092), small GTPase binding (GO:0031267), identical protein binding (GO:0042802), protein binding (GO:0005515)

GO Cellular Component (7): nucleus (GO:0005634), cytoplasm (GO:0005737), clathrin-coated pit (GO:0005905), clathrin-coated vesicle (GO:0030136), extracellular exosome (GO:0070062), membrane (GO:0016020), cytoplasmic vesicle (GO:0031410)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Cellular response to starvation	1
Cellular responses to stimuli	1
Cellular responses to stress	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
negative regulation of cellular process	2
cellular anatomical structure	2
vesicle budding from membrane	1
membrane invagination	1
vesicle-mediated transport	1
import into cell	1
cell population proliferation	1
regulation of cell population proliferation	1
autophagy	1
positive regulation of catabolic process	1
regulation of autophagy	1
regulation of cell growth	1
cell growth	1
negative regulation of growth	1
TOR signaling	1
regulation of TOR signaling	1
negative regulation of intracellular signal transduction	1
GTPase activity	1
regulation of GTPase activity	1
negative regulation of biological process	1
negative regulation of hydrolase activity	1
catalytic activity	1
regulation of molecular function	1
protein localization to vacuole	1
response to amino acid	1
cellular response to acid chemical	1
GDP binding	1
GTPase regulator activity	1
GTPase binding	1
protein binding	1
binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
endomembrane system	1
membrane	1
coated vesicle	1
extracellular vesicle	1
cytoplasm	1
intracellular vesicle	1

Protein interactions and networks

STRING

896 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SH3BP4	EPS15	P42566	799
SH3BP4	RRAGB	Q5VZM2	794
SH3BP4	NUMB	P49757	726
SH3BP4	NUMBL	Q9Y6R0	725
SH3BP4	EFNA5	P52803	724
SH3BP4	SRC	P12931	562
SH3BP4	STON2	Q8WXE9	522
SH3BP4	PDRG1	Q9NUG6	495
SH3BP4	TMEM82	A0PJX8	492
SH3BP4	SYNJ1	O43426	480
SH3BP4	RAB11FIP2	Q7L804	477
SH3BP4	RRAGC	Q9HB90	472
SH3BP4	SPATA3	Q8NHX4	459
SH3BP4	SYNJ2	O15056	455
SH3BP4	MYOF	Q9NZM1	451

IntAct

152 interactions, top by confidence:

A	B	Type	Score
SH3BP4	YWHAG	psi-mi:“MI:0915”(physical association)	0.910
SH3BP4	GIPC1	psi-mi:“MI:0914”(association)	0.740
GIPC1	SH3BP4	psi-mi:“MI:0915”(physical association)	0.740
ARHGEF12	GIPC1	psi-mi:“MI:0914”(association)	0.720
ARHGEF12	GIPC1	psi-mi:“MI:2364”(proximity)	0.720
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
SH3BP4	TFRC	psi-mi:“MI:0915”(physical association)	0.670
TFRC	SH3BP4	psi-mi:“MI:0915”(physical association)	0.670
SH3BP4	TFRC	psi-mi:“MI:0407”(direct interaction)	0.670
YWHAZ	SH3BP4	psi-mi:“MI:0915”(physical association)	0.650
CETN1	SFI1	psi-mi:“MI:0914”(association)	0.640
YWHAG	BLTP3B	psi-mi:“MI:2364”(proximity)	0.640
YWHAH	PLEKHG3	psi-mi:“MI:0914”(association)	0.610
EPS15	SH3BP4	psi-mi:“MI:0407”(direct interaction)	0.610
YWHAB	BLTP3B	psi-mi:“MI:2364”(proximity)	0.610
EPS15	SH3BP4	psi-mi:“MI:0915”(physical association)	0.610
SH3BP4	Dnm2	psi-mi:“MI:0915”(physical association)	0.610
Dnm2	SH3BP4	psi-mi:“MI:0407”(direct interaction)	0.610
SH3BP4	Dnm2	psi-mi:“MI:0407”(direct interaction)	0.610
YWHAH	BLTP3B	psi-mi:“MI:2364”(proximity)	0.570
YWHAG	SHTN1	psi-mi:“MI:0914”(association)	0.560

BioGRID (199): SH3BP4 (Affinity Capture-MS), SH3BP4 (Affinity Capture-MS), SH3BP4 (Affinity Capture-MS), SH3BP4 (Affinity Capture-MS), SH3BP4 (Affinity Capture-MS), SH3BP4 (Affinity Capture-MS), SH3BP4 (Affinity Capture-MS), SH3BP4 (Affinity Capture-MS), SH3BP4 (Affinity Capture-MS), SH3BP4 (Affinity Capture-MS), SH3BP4 (Affinity Capture-MS), SH3BP4 (Affinity Capture-MS), SH3BP4 (Affinity Capture-MS), SH3BP4 (Affinity Capture-MS), SH3BP4 (Affinity Capture-MS)

ESM2 similar proteins: A0A0R4I9Y1, A0A0R4IBK5, A2ARZ3, A5WUT8, A6NKT7, A7S7F2, E9Q3L2, E9Q555, F1QB81, F5H4B4, H2QII6, O08662, O14715, O15050, O43310, P0DJD0, P0DJD1, P13864, P42356, P49792, Q06190, Q0V9S3, Q0VF22, Q16533, Q1LVQ2, Q24K09, Q2T9I9, Q4R6W9, Q4V847, Q5U228, Q63HN8, Q65Z40, Q6NU22, Q6NU51, Q7TPV2, Q7Z3J3, Q80TA9, Q811D2, Q86Y13, Q921I6

Diamond homologs: A0JNB0, A1A5H8, A1DFN5, A1Y2K1, P00523, P00524, P00525, P00526, P05480, P06241, P09324, P12931, P13115, P13116, P13406, P14084, P14085, P15054, P17713, P25020, P27447, P34109, P39688, P63185, Q05876, Q1JPZ3, Q1LVQ2, Q5RBY8, Q5U228, Q62844, Q6EWH2, Q6NU22, Q6NU51, Q6ZN28, Q8AXQ3, Q921I6, Q9JJS5, Q9P0V3, Q9V9J3, Q9WUD9

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
SH3BP4	down-regulates	TFRC	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 113 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Activation of BAD and translocation to mitochondria	7	76.1×	3e-10
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	7	67.2×	5e-10
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	7	67.2×	5e-10
Activation of BH3-only proteins	7	49.6×	4e-09
RHO GTPases activate PKNs	7	31.7×	1e-07
Intrinsic Pathway for Apoptosis	7	29.3×	2e-07
FOXO-mediated transcription	5	24.0×	4e-05
SARS-CoV-1-host interactions	7	17.6×	5e-06

GO biological processes:

GO term	Partners	Fold	FDR
protein targeting	7	27.0×	4e-06
intracellular protein localization	9	9.9×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

169 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	133
Likely benign	15
Benign	7

Top pathogenic / likely-pathogenic (0)

SpliceAI

2095 predictions. Top by Δscore:

Variant	Effect	Δscore
2:234952172:T:G	donor_loss	1.0000
2:234995297:TTGCA:T	acceptor_loss	1.0000
2:234995298:TGCAG:T	acceptor_loss	1.0000
2:234995300:CA:C	acceptor_loss	1.0000
2:234995301:A:AG	acceptor_gain	1.0000
2:234995301:AGC:A	acceptor_gain	1.0000
2:234995302:G:GA	acceptor_gain	1.0000
2:234995302:GC:G	acceptor_gain	1.0000
2:234995302:GCG:G	acceptor_gain	1.0000
2:234995302:GCGT:G	acceptor_gain	1.0000
2:234995372:ACCAG:A	donor_loss	1.0000
2:234995374:CAGG:C	donor_loss	1.0000
2:234995376:GG:G	donor_loss	1.0000
2:234995377:GTA:G	donor_loss	1.0000
2:234995378:T:G	donor_loss	1.0000
2:235035121:G:GA	donor_loss	1.0000
2:235035122:T:G	donor_loss	1.0000
2:235040884:A:AG	acceptor_gain	1.0000
2:235040884:ACAGT:A	acceptor_gain	1.0000
2:235040885:C:G	acceptor_gain	1.0000
2:235040886:A:AG	acceptor_gain	1.0000
2:235040887:G:GT	acceptor_gain	1.0000
2:235040887:GT:G	acceptor_gain	1.0000
2:235052557:T:TA	acceptor_gain	1.0000
2:235052559:CA:C	acceptor_loss	1.0000
2:235052560:A:AG	acceptor_gain	1.0000
2:235052560:A:C	acceptor_loss	1.0000
2:235052560:AG:A	acceptor_gain	1.0000
2:235052561:G:GC	acceptor_gain	1.0000
2:235052561:GG:G	acceptor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000006154 (2:234990634 G>A), RS1000024534 (2:235038662 A>C,G), RS1000028771 (2:235002698 C>A,G), RS1000137896 (2:234987031 CA>C), RS1000140993 (2:235033315 C>A,T), RS1000158187 (2:234950935 G>A), RS1000160649 (2:235037472 T>G), RS1000181309 (2:235019975 C>T), RS1000190450 (2:234992646 C>T), RS1000245581 (2:235007396 C>T), RS1000256296 (2:234972042 C>T), RS1000287194 (2:235028009 C>A,T), RS1000375946 (2:235038213 T>A), RS1000399065 (2:234967923 T>C), RS1000406494 (2:234987970 A>G)

Disease associations

OMIM: gene MIM:605611 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

12 associations (top):

Study	Trait	p-value
GCST001066_25	Dialysis-related mortality	9.000000e-06
GCST001442_12	Orofacial clefts	7.000000e-07
GCST004227_9	Obstetric antiphospholipid syndrome	9.000000e-06
GCST005993_2	Mean corpuscular hemoglobin	3.000000e-08
GCST006011_23	Mean corpuscular volume	5.000000e-09
GCST006427_30	Depression in smokers	2.000000e-06
GCST011742_12	Triglyceride levels in HIV infection	2.000000e-07
GCST012308_9	Schizophrenia	3.000000e-07
GCST012309_9	Schizophrenia	2.000000e-07
GCST012311_19	Schizophrenia x sex interaction	3.000000e-06
GCST90002400_348	Plateletcrit	3.000000e-12
GCST90002402_294	Platelet count	7.000000e-14

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0004527	mean corpuscular hemoglobin
EFO:0004530	triglyceride measurement
EFO:0008343	sex interaction measurement
EFO:0007985	platelet crit
EFO:0004309	platelet count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

50 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases methylation, increases expression	4
Benzo(a)pyrene	affects methylation, increases expression	3
Tobacco Smoke Pollution	affects expression, decreases expression, increases expression	3
Silver	increases expression	2
Aflatoxin B1	increases expression, increases methylation	2
3,19-(2-bromobenzylidene)andrographolide	decreases response to substance, increases expression	1
FR900359	affects phosphorylation	1
dicrotophos	increases expression	1
methylmercuric chloride	increases expression	1
alpha-pinene	affects cotreatment, decreases expression, increases abundance	1
bisphenol A	affects cotreatment, increases methylation	1
beta-lapachone	increases expression	1
afimoxifene	decreases expression, decreases reaction	1
sodium arsenite	increases expression	1
cobaltous chloride	increases expression	1
benzo(e)pyrene	increases methylation	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, decreases expression	1
coumarin	decreases phosphorylation	1
methacrylaldehyde	increases abundance, affects cotreatment, decreases expression	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	affects binding, increases reaction	1
Resveratrol	affects cotreatment, decreases expression	1
Temozolomide	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Leflunomide	increases expression	1
Acetaminophen	increases expression	1
Acrolein	affects cotreatment, decreases expression, increases abundance	1
Air Pollutants	affects cotreatment, decreases expression, increases abundance	1
Atrazine	decreases expression	1
Cadmium	increases abundance, decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D9RJ	Ubigene HEK293 SH3BP4 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.