SH3BP5-AS1

Summary

SH3BP5-AS1 (SH3BP5 antisense RNA 1, HGNC:44501) is a long non-coding RNA gene on chromosome 3p25.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44501
Approved symbol	SH3BP5-AS1
Name	SH3BP5 antisense RNA 1
Location	3p25.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224660
Ensembl biotype	lncRNA
Entrez	100505696
RNAcentral	URS000075EBEB — lncRNA, 5592 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000413977, ENST00000420195, ENST00000436602, ENST00000655760, ENST00000659956, ENST00000668440

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000413977 — 3 exons

Exon	Start	End
ENSE00001662726	15258546	15260582
ENSE00001790738	15257226	15257606
ENSE00003887138	15264296	15264515

Expression profiles

Bgee: expression breadth ubiquitous, 213 present calls, max score 93.36.

Top tissues by expression

235 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	93.36	gold quality
right uterine tube	UBERON:0001302	93.17	gold quality
right ovary	UBERON:0002118	92.32	gold quality
right lobe of thyroid gland	UBERON:0001119	92.03	gold quality
left lobe of thyroid gland	UBERON:0001120	91.93	gold quality
left ovary	UBERON:0002119	91.59	gold quality
left uterine tube	UBERON:0001303	91.33	gold quality
thyroid gland	UBERON:0002046	90.76	gold quality
adenohypophysis	UBERON:0002196	90.39	gold quality
right hemisphere of cerebellum	UBERON:0014890	90.00	gold quality
cerebellar hemisphere	UBERON:0002245	89.91	gold quality
endocervix	UBERON:0000458	89.82	gold quality
cerebellar cortex	UBERON:0002129	89.77	gold quality
right adrenal gland cortex	UBERON:0035827	89.55	gold quality
mucosa of stomach	UBERON:0001199	89.38	gold quality
pituitary gland	UBERON:0000007	89.33	gold quality
left adrenal gland cortex	UBERON:0035825	89.19	gold quality
body of uterus	UBERON:0009853	89.09	gold quality
right adrenal gland	UBERON:0001233	88.97	gold quality
gastrocnemius	UBERON:0001388	88.73	gold quality
adrenal cortex	UBERON:0001235	88.58	gold quality
cerebellum	UBERON:0002037	88.36	gold quality
left adrenal gland	UBERON:0001234	88.21	gold quality
cardiac muscle of right atrium	UBERON:0003379	88.05	gold quality
tibial nerve	UBERON:0001323	88.00	gold quality
adrenal gland	UBERON:0002369	87.88	gold quality
left ventricle myocardium	UBERON:0006566	87.67	gold quality
muscle of leg	UBERON:0001383	87.50	gold quality
ectocervix	UBERON:0012249	87.37	gold quality
small intestine Peyer’s patch	UBERON:0003454	87.35	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	15.14
E-ANND-3	yes	9.02

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA SH3BP5-AS1 promotes hepatocellular carcinoma progression by sponging miR-6838-5p and activation of PTPN4. (PMID:38761175)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.