SH3PXD2A-AS1

Summary

SH3PXD2A-AS1 (SH3PXD2A antisense RNA 1, HGNC:45242) is a long non-coding RNA gene on chromosome 10q24.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:45242
Approved symbol	SH3PXD2A-AS1
Name	SH3PXD2A antisense RNA 1
Location	10q24.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000280693
Ensembl biotype	lncRNA
Entrez	100505839
RNAcentral	URS000075EA37 — lncRNA, 2023 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000625265, ENST00000627886

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000625265 — 3 exons

Exon	Start	End
ENSE00003761487	103746793	103747096
ENSE00003769533	103753844	103754466
ENSE00003769552	103749782	103749920

Expression profiles

Bgee: expression breadth ubiquitous, 137 present calls, max score 95.80.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1789 / max 25.3357, expressed in 65 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
106838	0.1419	50
106837	0.0370	14

Top tissues by expression

215 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	95.80	gold quality
esophagus mucosa	UBERON:0002469	85.87	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.15	gold quality
lower esophagus mucosa	UBERON:0035834	80.27	gold quality
esophagus squamous epithelium	UBERON:0006920	77.41	gold quality
sural nerve	UBERON:0015488	75.09	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.96	silver quality
vagina	UBERON:0000996	74.23	gold quality
oral cavity	UBERON:0000167	73.97	gold quality
esophagus	UBERON:0001043	73.36	gold quality
buccal mucosa cell	CL:0002336	72.74	gold quality
mammalian vulva	UBERON:0000997	72.29	gold quality
skin of abdomen	UBERON:0001416	70.92	gold quality
colonic epithelium	UBERON:0000397	70.00	gold quality
amniotic fluid	UBERON:0000173	69.97	gold quality
penis	UBERON:0000989	69.89	gold quality
zone of skin	UBERON:0000014	68.11	gold quality
skin of leg	UBERON:0001511	67.77	gold quality
gingiva	UBERON:0001828	66.33	gold quality
ectocervix	UBERON:0012249	65.45	gold quality
gingival epithelium	UBERON:0001949	64.76	silver quality
prefrontal cortex	UBERON:0000451	64.24	gold quality
pharyngeal mucosa	UBERON:0000355	63.43	gold quality
upper leg skin	UBERON:0004262	63.43	silver quality
palpebral conjunctiva	UBERON:0001812	62.61	gold quality
tonsil	UBERON:0002372	61.57	gold quality
cortical plate	UBERON:0005343	59.52	gold quality
ganglionic eminence	UBERON:0004023	58.02	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	57.86	gold quality
uterine cervix	UBERON:0000002	57.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• SH3PXD2A-AS1 was significantly upregulated in Colorectal cancer (CRC) tissues and cell lines, and overexpression of SH3PXD2A-AS1 was correlated with tumor size, TNM stage, and lymph node metastasis in patients with CRC. (PMID:29734178)
• Results found that LncRNA-CTS is expressed at high levels in cervical carcinoma (CC) tissues and associated with poor outcome. These results implied that lncRNA-CTS might be useful as a novel marker of CC progression. Also, LncRNA-CTS enhances TGF-beta1-induced cell migration, invasion and EMT through mir-505 sponging. (PMID:31499118)
• Association of lncRNA SH3PXD2A-AS1 with preeclampsia and its function in invasion and migration of placental trophoblast cells. (PMID:32719429)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.