SHANK2-AS1

Summary

SHANK2-AS1 (SHANK2 antisense RNA 1, HGNC:40014) is a long non-coding RNA gene on chromosome 11q13.4.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40014
Approved symbol	SHANK2-AS1
Name	SHANK2 antisense RNA 1
Location	11q13.4
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000226627
Ensembl biotype	lncRNA
Entrez	100874198
RNAcentral	URS00001C3516 — lncRNA, 2252 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000429268, ENST00000429561, ENST00000663650, ENST00000715742, ENST00000749009, ENST00000797230

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000429268 — 3 exons

Exon	Start	End
ENSE00001606641	70647341	70647562
ENSE00004027775	70646088	70646298
ENSE00004183671	70631642	70631930

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 78.77.

Top tissues by expression

78 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.77	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.94	silver quality
bone marrow cell	CL:0002092	71.32	silver quality
tonsil	UBERON:0002372	69.85	gold quality
liver	UBERON:0002107	64.62	silver quality
colonic epithelium	UBERON:0000397	63.72	silver quality
thoracic mammary gland	UBERON:0005200	61.17	silver quality
prostate gland	UBERON:0002367	58.37	silver quality
ganglionic eminence	UBERON:0004023	56.66	silver quality
prefrontal cortex	UBERON:0000451	55.76	gold quality
lung	UBERON:0002048	55.12	silver quality
kidney	UBERON:0002113	54.70	silver quality
superior frontal gyrus	UBERON:0002661	53.99	gold quality
right hemisphere of cerebellum	UBERON:0014890	53.50	gold quality
primary visual cortex	UBERON:0002436	52.82	gold quality
frontal cortex	UBERON:0001870	52.38	gold quality
testis	UBERON:0000473	51.55	gold quality
monocyte	CL:0000576	51.48	silver quality
right testis	UBERON:0004534	50.71	gold quality
left testis	UBERON:0004533	50.34	gold quality
cerebellar hemisphere	UBERON:0002245	49.94	gold quality
cortex of kidney	UBERON:0001225	49.91	silver quality
myometrium	UBERON:0001296	49.84	silver quality
cerebral cortex	UBERON:0000956	49.25	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	48.74	gold quality
heart	UBERON:0000948	48.40	silver quality
Brodmann (1909) area 9	UBERON:0013540	48.16	gold quality
multicellular organism	UBERON:0000468	47.78	gold quality
right frontal lobe	UBERON:0002810	47.57	gold quality
blood	UBERON:0000178	47.12	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.28

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.