SHPK

Summary

SHPK (sedoheptulokinase, HGNC:1492) is a protein-coding gene on chromosome 17p13.2, encoding Sedoheptulokinase (Q9UHJ6). Acts as a modulator of macrophage activation through control of glucose metabolism.

The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements.

Source: NCBI Gene 23729 — RefSeq curated summary.

At a glance

• Gene–disease (curated): isolated sedoheptulokinase deficiency (Moderate, GenCC)
• Clinical variants (ClinVar): 219 total
• Phenotypes (HPO): 30
• MANE Select transcript: NM_013276

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1492
Approved symbol	SHPK
Name	sedoheptulokinase
Location	17p13.2
Locus type	gene with protein product
Status	Approved
Aliases	SHK
Ensembl gene	ENSG00000197417
Ensembl biotype	protein_coding
OMIM	605060
Entrez	23729

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000225519

RefSeq mRNA: 1 — MANE Select: NM_013276 NM_013276

CCDS: CCDS11030

Canonical transcript exons

ENST00000225519 — 7 exons

Exon	Start	End
ENSE00001196861	3608240	3610972
ENSE00001196867	3636052	3636250
ENSE00003532999	3624048	3624231
ENSE00003572285	3623339	3623491
ENSE00003577256	3630205	3630346
ENSE00003591891	3621237	3621412
ENSE00003629913	3615337	3615537

Expression profiles

Bgee: expression breadth ubiquitous, 191 present calls, max score 84.95.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.2473 / max 114.5880, expressed in 1756 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
163854	5.3387	1671
163855	3.9086	1536

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	84.95	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.57	gold quality
liver	UBERON:0002107	81.98	gold quality
tongue squamous epithelium	UBERON:0006919	81.70	gold quality
left adrenal gland cortex	UBERON:0035825	80.44	gold quality
left adrenal gland	UBERON:0001234	80.35	gold quality
right adrenal gland	UBERON:0001233	80.29	gold quality
right adrenal gland cortex	UBERON:0035827	80.21	gold quality
adrenal cortex	UBERON:0001235	79.65	gold quality
ventricular zone	UBERON:0003053	79.48	gold quality
body of pancreas	UBERON:0001150	79.26	gold quality
adrenal gland	UBERON:0002369	79.17	gold quality
body of stomach	UBERON:0001161	78.80	gold quality
skin of leg	UBERON:0001511	78.77	gold quality
hair follicle	UBERON:0002073	78.68	gold quality
ganglionic eminence	UBERON:0004023	78.50	gold quality
esophagus mucosa	UBERON:0002469	78.41	gold quality
ectocervix	UBERON:0012249	78.19	gold quality
adult mammalian kidney	UBERON:0000082	78.13	gold quality
adrenal tissue	UBERON:0018303	78.04	gold quality
mucosa of transverse colon	UBERON:0004991	78.00	gold quality
jejunal mucosa	UBERON:0000399	77.99	silver quality
metanephros cortex	UBERON:0010533	77.98	gold quality
mucosa of stomach	UBERON:0001199	77.97	gold quality
stromal cell of endometrium	CL:0002255	77.88	gold quality
pancreas	UBERON:0001264	77.85	gold quality
endothelial cell	CL:0000115	77.82	silver quality
right uterine tube	UBERON:0001302	77.82	gold quality
cerebellar vermis	UBERON:0004720	77.80	gold quality
duodenum	UBERON:0002114	77.63	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.25
E-MTAB-6142	no	141.17

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

66 targeting SHPK, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-3162-3P	100.00	65.37	363
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-3605-5P	99.96	67.12	932
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-1-3P	99.93	72.35	1914
HSA-MIR-206	99.93	72.50	1893
HSA-MIR-613	99.91	71.50	1710
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-12119	99.87	68.35	1653
HSA-MIR-7978	99.86	66.90	856
HSA-MIR-6817-3P	99.79	68.35	2126
HSA-MIR-1299	99.77	71.24	2389
HSA-MIR-1255A	99.74	68.09	744
HSA-MIR-1255B-5P	99.74	68.16	741
HSA-MIR-5584-5P	99.49	68.22	2814
HSA-MIR-6513-5P	99.43	67.81	1071
HSA-MIR-519D-5P	99.41	69.30	2057
HSA-MIR-4318	99.38	66.94	1505
HSA-MIR-532-3P	99.34	65.76	1195
HSA-MIR-128-1-5P	99.33	60.46	332
HSA-MIR-128-2-5P	99.33	60.83	311

Literature-anchored findings (GeneRIF, showing 2)

• the CARKL-encoded protein, sedoheptulokinase (SHK), is responsible for the reaction: sedoheptulose + ATP –> sedoheptulose-7-phosphate + ADP, and deletion of CARKL causes urinary accumulation of sedoheptulose and erythritol (PMID:18186520)
• CARKL-dependent metabolic reprogramming is required for proper M1- and M2-like macrophage polarization (PMID:22682222)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	shpk	ENSDARG00000002355
mus_musculus	Shpk	ENSMUSG00000005951
rattus_norvegicus	Shpk	ENSRNOG00000019458

Paralogs (6): XYLB (ENSG00000093217), FGGY (ENSG00000172456), GK5 (ENSG00000175066), GK2 (ENSG00000196475), GK (ENSG00000198814), GK3 (ENSG00000229894)

Protein

Protein identifiers

Sedoheptulokinase — Q9UHJ6 (reviewed: Q9UHJ6)

Alternative names: Carbohydrate kinase-like protein

All UniProt accessions (1): Q9UHJ6

UniProt curated annotations — full annotation on UniProt →

Function. Acts as a modulator of macrophage activation through control of glucose metabolism.

Subcellular location. Cytoplasm.

Tissue specificity. Strongly expressed in liver, kidney and pancreas. Expressed at lower levels in placenta and heart. Very weakly expressed in lung and brain.

Disease relevance. Sedoheptulokinase deficiency (SHPKD) [MIM:617213] An autosomal recessive metabolic disease characterized by increased urinary erythritol and sedoheptulose. Neonatal cholestasis, hypoglycemia, anemia, congenital arthrogryposis multiplex, multiple contractures and dysmorphisms have been reported in SHPKD patients, but the relationship of these features to the SHPKD is unclear. The disease is caused by variants affecting the gene represented in this entry.

Induction. Down-regulated by LPS.

Similarity. Belongs to the FGGY kinase family.

RefSeq proteins (1): NP_037408* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR018484	FGGY_N	Domain
IPR043129	ATPase_NBD	Homologous_superfamily

Pfam: PF00370

Enzyme classification (BRENDA):

• EC 2.7.1.14 — sedoheptulokinase (BRENDA: 4 organisms, 5 substrates, 5 inhibitors, 1 Km, 1 kcat entries)

Substrate kinetics (BRENDA)

1 substrates with measured Km, best-characterized 1. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
SEDOHEPTULOSE	0.19	1

Catalyzed reactions (Rhea), 1 shown:

• sedoheptulose + ATP = D-sedoheptulose 7-phosphate + ADP + H(+) (RHEA:23844)

UniProt features (4 total): sequence variant 3, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UHJ6-F1	94.25	0.88

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-71336	Pentose phosphate pathway
R-HSA-1430728	Metabolism
R-HSA-71387	Metabolism of carbohydrates and carbohydrate derivatives

MSigDB gene sets: 176 (showing top): GOBP_REGULATION_OF_CELL_ACTIVATION, GOBP_INFLAMMATORY_RESPONSE, GOBP_RESPONSE_TO_INTERLEUKIN_4, GOBP_RESPONSE_TO_PEPTIDE, GOBP_CELLULAR_RESPONSE_TO_LIPID, GOBP_NADPPLUS_METABOLIC_PROCESS, GOBP_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS, GOBP_REGULATION_OF_MACROPHAGE_ACTIVATION, GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GOBP_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS, GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS, GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY, GOBP_MYELOID_LEUKOCYTE_ACTIVATION

GO Biological Process (9): carbohydrate metabolic process (GO:0005975), pentose-phosphate shunt (GO:0006098), pentose-phosphate shunt, non-oxidative branch (GO:0009052), phosphorylation (GO:0016310), cellular response to interleukin-13 (GO:0035963), regulation of macrophage activation (GO:0043030), regulation of inflammatory response (GO:0050727), cellular response to lipopolysaccharide (GO:0071222), cellular response to interleukin-4 (GO:0071353)

GO Molecular Function (6): ATP binding (GO:0005524), sedoheptulokinase activity (GO:0050277), nucleotide binding (GO:0000166), protein binding (GO:0005515), kinase activity (GO:0016301), transferase activity (GO:0016740)

GO Cellular Component (2): cytoplasm (GO:0005737), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Metabolism of carbohydrates and carbohydrate derivatives	1
Metabolism	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular response to cytokine stimulus	2
cellular anatomical structure	2
primary metabolic process	1
NADPH regeneration	1
pentose-phosphate shunt, oxidative branch	1
pentose-phosphate shunt, non-oxidative branch	1
glucose 6-phosphate metabolic process	1
D-ribulose-phosphate 3-epimerase activity	1
ribose-5-phosphate isomerase activity	1
transaldolase activity	1
transketolase activity	1
generation of precursor metabolites and energy	1
pentose-phosphate shunt	1
glyceraldehyde-3-phosphate metabolic process	1
phosphate-containing compound metabolic process	1
response to interleukin-13	1
regulation of leukocyte activation	1
macrophage activation	1
inflammatory response	1
regulation of defense response	1
regulation of response to external stimulus	1
response to lipopolysaccharide	1
cellular response to molecule of bacterial origin	1
cellular response to lipid	1
cellular response to oxygen-containing compound	1
response to interleukin-4	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
kinase activity	1
phosphotransferase activity, alcohol group as acceptor	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
binding	1
transferase activity, transferring phosphorus-containing groups	1
catalytic activity	1
intracellular anatomical structure	1
cytoplasm	1

Protein interactions and networks

STRING

2077 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SHPK	CTNS	O60931	976
SHPK	KCNA3	P22001	952
SHPK	FGGY	Q96C11	878
SHPK	KCNA1	Q09470	792
SHPK	KCNN4	O15554	726
SHPK	KCNA6	P17658	716
SHPK	KCNA2	P16389	600
SHPK	KCNC2	Q96PR1	577
SHPK	KCNC4	Q03721	557
SHPK	SPATA22	Q8NHS9	506
SHPK	ASPA	P45381	487
SHPK	SYK	P43405	439
SHPK	TRPV1	Q8NER1	433
SHPK	HARBI1	Q96MB7	433
SHPK	KCNA7	Q96RP8	432

IntAct

25 interactions, top by confidence:

A	B	Type	Score
THYN1	SHPK	psi-mi:“MI:0915”(physical association)	0.590
SHPK	TRAF3	psi-mi:“MI:0915”(physical association)	0.560
NR2F2	GC	psi-mi:“MI:0914”(association)	0.530
HYCC1	GC	psi-mi:“MI:0914”(association)	0.530
TCF25	BCKDHB	psi-mi:“MI:0914”(association)	0.530
RAB6B	RAB6A	psi-mi:“MI:0914”(association)	0.530
FAM219A	OBSL1	psi-mi:“MI:0914”(association)	0.530
BTBD9	SHPK	psi-mi:“MI:0915”(physical association)	0.400
PSMF1	SHPK	psi-mi:“MI:0915”(physical association)	0.400
MDM2	SHPK	psi-mi:“MI:0915”(physical association)	0.370
GATD1		psi-mi:“MI:0914”(association)	0.350
TCF25	AMD1	psi-mi:“MI:0914”(association)	0.350
LINC01587	UBA6	psi-mi:“MI:0914”(association)	0.350
MCOLN2	POTEF	psi-mi:“MI:0914”(association)	0.350
GATD1	MYO9A	psi-mi:“MI:0914”(association)	0.350
LRRC8E	TBC1D4	psi-mi:“MI:0914”(association)	0.350
FAM219A	NBN	psi-mi:“MI:0914”(association)	0.350
SHPK	LRP4	psi-mi:“MI:0914”(association)	0.350
NFATC1	OBSL1	psi-mi:“MI:0914”(association)	0.350
PAAT	HIP1	psi-mi:“MI:0914”(association)	0.350
TCF25	BCKDHA	psi-mi:“MI:0914”(association)	0.350

BioGRID (38): SHPK (Affinity Capture-MS), SHPK (Affinity Capture-MS), SHPK (Affinity Capture-MS), SHPK (Affinity Capture-MS), TRAF3 (Affinity Capture-MS), SHPK (Affinity Capture-MS), SHPK (Affinity Capture-MS), SHPK (Affinity Capture-MS), SHPK (Affinity Capture-MS), SHPK (Affinity Capture-MS), SHPK (Affinity Capture-MS), SHPK (Affinity Capture-RNA), SHPK (Affinity Capture-RNA), LRP4 (Affinity Capture-MS), SHPK (Affinity Capture-MS)

ESM2 similar proteins: A0JPE9, A2AJL3, A2VD33, O46504, O75191, P12276, P12785, P13439, P17256, P19096, P31754, Q08D86, Q0IH28, Q0VFE7, Q3MIF4, Q3SYZ6, Q3TNA1, Q4V831, Q4V9P6, Q503J2, Q566S6, Q5M7T9, Q5R979, Q5RFE6, Q5U5V2, Q5XH07, Q5XIG6, Q5ZMJ4, Q64FG0, Q68FH4, Q6DCD1, Q6DH69, Q6GMR7, Q6GP95, Q6NUM9, Q6NUW9, Q6ZS86, Q71SP7, Q7TSQ8, Q80SY6

Diamond homologs: Q9D5J6, Q9UHJ6

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
SHPK	“down-regulates quantity”	sedoheptulose	“chemical modification”
SHPK	“up-regulates quantity”	“sedoheptulose 7-phosphate”	phosphorylation

Disease & clinical

Clinical variants and AI predictions

ClinVar

219 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	128
Likely benign	70
Benign	9

Top pathogenic / likely-pathogenic (0)

SpliceAI

1511 predictions. Top by Δscore:

Variant	Effect	Δscore
17:3610973:C:CC	acceptor_gain	1.0000
17:3615538:C:CC	acceptor_gain	1.0000
17:3623333:ACTC:A	donor_loss	1.0000
17:3623335:TCAC:T	donor_loss	1.0000
17:3623336:CA:C	donor_loss	1.0000
17:3623337:A:AC	donor_gain	1.0000
17:3623337:ACGT:A	donor_gain	1.0000
17:3623338:C:CT	donor_gain	1.0000
17:3623338:CG:C	donor_gain	1.0000
17:3623338:CGT:C	donor_gain	1.0000
17:3623338:CGTC:C	donor_gain	1.0000
17:3623338:CGTCT:C	donor_gain	1.0000
17:3623487:CTGGG:C	acceptor_gain	1.0000
17:3623488:TGGG:T	acceptor_gain	1.0000
17:3623492:C:CC	acceptor_gain	1.0000
17:3623500:C:CT	acceptor_gain	1.0000
17:3623501:A:AC	acceptor_gain	1.0000
17:3623501:A:C	acceptor_gain	1.0000
17:3623505:C:CT	acceptor_gain	1.0000
17:3623505:C:T	acceptor_gain	1.0000
17:3623506:A:T	acceptor_gain	1.0000
17:3636047:CTCA:C	donor_loss	1.0000
17:3636048:TCAC:T	donor_loss	1.0000
17:3636049:CAC:C	donor_loss	1.0000
17:3636049:CACCT:C	donor_loss	1.0000
17:3636050:A:AC	donor_gain	1.0000
17:3636050:A:C	donor_loss	1.0000
17:3636051:C:CA	donor_loss	1.0000
17:3636051:C:CC	donor_gain	1.0000
17:3636051:C:G	donor_loss	1.0000

AlphaMissense

3088 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:3615394:C:A	G323W	0.996
17:3615524:G:C	S279R	0.996
17:3615524:G:T	S279R	0.996
17:3615526:T:G	S279R	0.996
17:3615393:C:T	G323E	0.995
17:3615525:C:A	S279I	0.995
17:3610790:A:G	C403R	0.994
17:3615352:A:G	W337R	0.992
17:3615352:A:T	W337R	0.992
17:3621284:T:A	D259V	0.992
17:3623352:A:G	W212R	0.992
17:3623352:A:T	W212R	0.992
17:3623382:A:G	W202R	0.992
17:3623382:A:T	W202R	0.992
17:3610796:C:G	A401P	0.991
17:3624163:A:G	W127R	0.991
17:3624163:A:T	W127R	0.991
17:3615395:G:C	N322K	0.990
17:3615395:G:T	N322K	0.990
17:3610686:A:C	N437K	0.989
17:3610686:A:T	N437K	0.989
17:3615393:C:A	G323V	0.989
17:3615519:G:C	S281W	0.989
17:3615530:G:C	N277K	0.989
17:3615530:G:T	N277K	0.989
17:3621284:T:G	D259A	0.989
17:3610705:C:T	G431E	0.988
17:3623383:G:C	S201R	0.988
17:3623383:G:T	S201R	0.988
17:3623385:T:G	S201R	0.988

dbSNP variants (sampled 300 via entrez): RS1000003826 (17:3615989 G>A), RS1000155941 (17:3638234 T>G), RS1000167461 (17:3632186 A>C,G), RS1000241774 (17:3621873 G>A,T), RS1000597128 (17:3634153 C>T), RS1000718405 (17:3625317 G>A), RS1000819477 (17:3630648 C>T), RS1001005127 (17:3614986 A>G), RS1001051095 (17:3634397 C>A), RS1001270573 (17:3631977 T>C), RS1001302488 (17:3613977 G>A), RS1001310885 (17:3633874 T>A), RS1001343177 (17:3620102 G>T), RS1001549344 (17:3634415 C>G,T), RS1001718523 (17:3609632 T>C)

Disease associations

OMIM: gene MIM:605060 | disease phenotypes: MIM:617213

GenCC curated gene-disease

Disease	Classification	Inheritance
isolated sedoheptulokinase deficiency	Moderate	Autosomal recessive

Mondo (1): isolated sedoheptulokinase deficiency (MONDO:0014969)

Orphanet (1): Isolated sedoheptulokinase deficiency (Orphanet:440713)

HPO phenotypes

30 total (30 of 30 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0000023	Inguinal hernia
HP:0000083	Renal insufficiency
HP:0000091	Abnormal renal tubule morphology
HP:0000239	Large fontanelles
HP:0000256	Macrocephaly
HP:0000348	High forehead
HP:0000586	Shallow orbits
HP:0000601	Hypotelorism
HP:0001371	Flexion contracture
HP:0001385	Hip dysplasia
HP:0001396	Cholestasis
HP:0001409	Portal hypertension
HP:0001540	Diastasis recti
HP:0001623	Breech presentation
HP:0001903	Anemia
HP:0002119	Ventriculomegaly
HP:0002570	Steatorrhea
HP:0002611	Cholestatic liver disease
HP:0002804	Arthrogryposis multiplex congenita
HP:0004322	Short stature
HP:0004840	Hypochromic microcytic anemia
HP:0008850	Severe postnatal growth retardation
HP:0011400	Abnormal CNS myelination
HP:0011998	Postprandial hyperglycemia
HP:0012115	Hepatitis
HP:0012157	Subcortical cerebral atrophy
HP:0012768	Neonatal asphyxia
HP:0025157	Increased urinary sedoheptulose
HP:0100886	Abnormality of globe location

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, decreases methylation, decreases expression	2
sodium arsenite	decreases expression	2
deoxynivalenol	decreases expression	1
decabromobiphenyl ether	increases expression	1
arsenite	affects binding, decreases reaction	1
tetrabromobisphenol A	increases expression	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
abrine	decreases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	decreases expression	1
pentabrominated diphenyl ether 100	increases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Leflunomide	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Benzo(a)pyrene	decreases expression	1
Dimethyl Sulfoxide	increases expression	1
Hydrogen Peroxide	affects expression	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	affects expression	1
Valproic Acid	decreases expression	1
Aflatoxin B1	increases methylation	1
Lithium Chloride	increases expression	1
Copper Sulfate	decreases expression	1
Acrylamide	decreases expression	1
Particulate Matter	decreases expression, increases abundance	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3H0	Abcam HEK293T SHPK KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.