SILC1

Summary

SILC1 (sciatic injury induced lincRNA upregulator of SOX11, HGNC:26403) is a long non-coding RNA gene on chromosome 2p25.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26403
Approved symbol	SILC1
Name	sciatic injury induced lincRNA upregulator of SOX11
Location	2p25.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ30594, LOC150622
Ensembl gene	ENSG00000232044
Ensembl biotype	lncRNA
Entrez	150622
RNAcentral	URS000075E952 — lncRNA, 11868 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 64 — 63 lncRNA, 1 TEC

ENST00000391666, ENST00000431182, ENST00000431188, ENST00000444416, ENST00000450794, ENST00000456327, ENST00000625018, ENST00000654025, ENST00000654655, ENST00000654672, ENST00000654857, ENST00000658702, ENST00000659164, ENST00000659985, ENST00000660066, ENST00000660326, ENST00000661262, ENST00000663243, ENST00000663649, ENST00000664097, ENST00000664766, ENST00000665307, ENST00000665790, ENST00000666985, ENST00000667433, ENST00000668005, ENST00000668795, ENST00000669751, ENST00000669975, ENST00000670048, ENST00000670583, ENST00000670820, ENST00000670914, ENST00000670925, ENST00000687697, ENST00000690744, ENST00000747556, ENST00000747557, ENST00000747558, ENST00000747559, ENST00000747560, ENST00000747561, ENST00000747562, ENST00000747563, ENST00000747564, ENST00000747565, ENST00000747566, ENST00000747567, ENST00000747568, ENST00000747569, ENST00000747570, ENST00000747571, ENST00000747572, ENST00000747573, ENST00000747574, ENST00000747575, ENST00000747576, ENST00000747577, ENST00000747578, ENST00000747579, ENST00000747580, ENST00000747581, ENST00000747582, ENST00000747583

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000391666 — 1 exons

Exon	Start	End
ENSE00001509442	5970973	5974241

Expression profiles

Bgee: expression breadth ubiquitous, 158 present calls, max score 97.11.

FANTOM5 (CAGE): breadth broad, TPM avg 3.6272 / max 379.9191, expressed in 204 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
18672	3.0389	181
18671	0.2837	115
18670	0.1759	87
18674	0.1287	37

Top tissues by expression

227 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
inferior vagus X ganglion	UBERON:0005363	97.11	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	96.90	gold quality
substantia nigra pars reticulata	UBERON:0001966	96.56	gold quality
spinal cord	UBERON:0002240	96.43	gold quality
lateral nuclear group of thalamus	UBERON:0002736	96.39	gold quality
substantia nigra pars compacta	UBERON:0001965	96.36	gold quality
lateral globus pallidus	UBERON:0002476	96.22	gold quality
subthalamic nucleus	UBERON:0001906	96.14	gold quality
dorsal plus ventral thalamus	UBERON:0001897	95.46	gold quality
globus pallidus	UBERON:0001875	94.91	gold quality
medial globus pallidus	UBERON:0002477	94.53	gold quality
corpus callosum	UBERON:0002336	94.44	gold quality
putamen	UBERON:0001874	94.31	gold quality
substantia nigra	UBERON:0002038	94.26	gold quality
midbrain	UBERON:0001891	94.23	gold quality
germinal epithelium of ovary	UBERON:0001304	94.17	gold quality
hypothalamus	UBERON:0001898	94.17	gold quality
pigmented layer of retina	UBERON:0001782	93.87	gold quality
ventral tegmental area	UBERON:0002691	93.68	gold quality
caudate nucleus	UBERON:0001873	93.20	gold quality
ganglionic eminence	UBERON:0004023	93.20	gold quality
medulla oblongata	UBERON:0001896	93.01	gold quality
Ammon’s horn	UBERON:0001954	92.73	gold quality
superior vestibular nucleus	UBERON:0007227	92.64	gold quality
amygdala	UBERON:0001876	91.92	gold quality
Brodmann (1909) area 46	UBERON:0006483	91.82	gold quality
nucleus accumbens	UBERON:0001882	91.56	gold quality
pons	UBERON:0000988	91.34	gold quality
endothelial cell	CL:0000115	90.94	gold quality
entorhinal cortex	UBERON:0002728	90.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.