SIMALR

Summary

SIMALR (suppressor of inflammatory macrophage apoptosis lncRNA, HGNC:53554) is a long non-coding RNA gene on chromosome 6q23.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53554
Approved symbol	SIMALR
Name	suppressor of inflammatory macrophage apoptosis lncRNA
Location	6q23.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000226004
Ensembl biotype	lncRNA
Entrez	105378020
RNAcentral	URS0000BC4578 — lncRNA, 575 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000417932, ENST00000689325, ENST00000752847, ENST00000752848, ENST00000752849, ENST00000752850, ENST00000752851, ENST00000752852, ENST00000752853

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000417932 — 4 exons

Exon	Start	End
ENSE00001716122	137945669	137945802
ENSE00004099387	137950904	137950983
ENSE00004099393	137957562	137957702
ENSE00004099395	137942340	137943517

Expression profiles

Bgee: expression breadth broad, 86 present calls, max score 79.84.

Top tissues by expression

86 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	79.84	gold quality
leukocyte	CL:0000738	78.84	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	69.14	gold quality
lymph node	UBERON:0000029	66.31	gold quality
granulocyte	CL:0000094	64.21	gold quality
urinary bladder	UBERON:0001255	61.76	gold quality
vermiform appendix	UBERON:0001154	61.44	gold quality
myometrium	UBERON:0001296	60.81	gold quality
duodenum	UBERON:0002114	60.22	gold quality
smooth muscle tissue	UBERON:0001135	59.01	gold quality
cortex of kidney	UBERON:0001225	56.68	gold quality
bone marrow	UBERON:0002371	55.88	gold quality
blood	UBERON:0000178	55.32	gold quality
placenta	UBERON:0001987	54.09	gold quality
gall bladder	UBERON:0002110	53.55	gold quality
islet of Langerhans	UBERON:0000006	53.44	gold quality
ovary	UBERON:0000992	52.44	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	50.62	gold quality
endometrium	UBERON:0001295	50.07	silver quality
liver	UBERON:0002107	49.28	gold quality
tonsil	UBERON:0002372	47.83	gold quality
lung	UBERON:0002048	47.82	gold quality
spleen	UBERON:0002106	47.66	gold quality
Brodmann (1909) area 9	UBERON:0013540	47.60	gold quality
adenohypophysis	UBERON:0002196	47.58	gold quality
multicellular organism	UBERON:0000468	46.65	gold quality
rectum	UBERON:0001052	45.81	gold quality
right adrenal gland cortex	UBERON:0035827	45.15	gold quality
heart	UBERON:0000948	45.01	gold quality
right lobe of liver	UBERON:0001114	44.90	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.14

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Ac4C modification of lncRNA SIMALR promotes nasopharyngeal carcinoma progression through activating eEF1A2 to facilitate ITGB4/ITGA6 translation. (PMID:39154122)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.