SIRLNT

Summary

SIRLNT (SIRT1 regulating lncRNA tumor promoter, HGNC:53902) is a long non-coding RNA gene on chromosome 8p11.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53902
Approved symbol	SIRLNT
Name	SIRT1 regulating lncRNA tumor promoter
Location	8p11.21
Locus type	RNA, long non-coding
Status	Approved
Aliases	lncRNA-PRLB
Ensembl gene	ENSG00000253802
Ensembl biotype	lncRNA
Entrez	112543493
RNAcentral	URS000016D1BD — lncRNA, 663 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 19 lncRNA

ENST00000521030, ENST00000521363, ENST00000522486, ENST00000654202, ENST00000669842, ENST00000800127, ENST00000800128, ENST00000800129, ENST00000800130, ENST00000800131, ENST00000800132, ENST00000800133, ENST00000800134, ENST00000800135, ENST00000800136, ENST00000800137, ENST00000800138, ENST00000800139, ENST00000800140

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000521030 — 3 exons

Exon	Start	End
ENSE00002093533	40333874	40333953
ENSE00004189327	40333162	40333669
ENSE00004189339	40343278	40343475

Expression profiles

Bgee: expression breadth broad, 57 present calls, max score 87.40.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1663 / max 83.8657, expressed in 34 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
92799	0.0799	22
92797	0.0646	16
92798	0.0218	9

Top tissues by expression

57 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.40	silver quality
kidney	UBERON:0002113	69.07	gold quality
cortex of kidney	UBERON:0001225	69.03	gold quality
adult mammalian kidney	UBERON:0000082	68.54	gold quality
metanephros cortex	UBERON:0010533	66.62	gold quality
monocyte	CL:0000576	59.27	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	56.60	gold quality
testis	UBERON:0000473	56.22	gold quality
right testis	UBERON:0004534	55.68	gold quality
left testis	UBERON:0004533	55.67	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	55.31	gold quality
liver	UBERON:0002107	55.22	gold quality
multicellular organism	UBERON:0000468	51.59	gold quality
spleen	UBERON:0002106	51.38	gold quality
gastrocnemius	UBERON:0001388	51.31	gold quality
prefrontal cortex	UBERON:0000451	50.35	gold quality
superior frontal gyrus	UBERON:0002661	50.17	gold quality
left coronary artery	UBERON:0001626	49.63	gold quality
blood	UBERON:0000178	49.57	gold quality
thyroid gland	UBERON:0002046	49.30	gold quality
placenta	UBERON:0001987	45.85	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	45.42	gold quality
heart left ventricle	UBERON:0002084	45.20	gold quality
Brodmann (1909) area 9	UBERON:0013540	44.90	gold quality
cerebellar hemisphere	UBERON:0002245	44.85	silver quality
heart	UBERON:0000948	44.18	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	44.18	silver quality
hypothalamus	UBERON:0001898	44.07	gold quality
intestine	UBERON:0000160	43.86	gold quality
skin of abdomen	UBERON:0001416	43.33	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.41

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• A novel long non-coding RNA-PRLB acts as a tumor promoter through regulating miR-4766-5p/SIRT1 axis in breast cancer. (PMID:29752439)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.