SIRPB1

Summary

SIRPB1 (signal regulatory protein beta 1, HGNC:15928) is a protein-coding gene on chromosome 20p13, encoding Signal-regulatory protein beta-1 (O00241). Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 10326 — RefSeq curated summary.

At a glance

• GWAS associations: 11
• Clinical variants (ClinVar): 82 total
• MANE Select transcript: NM_006065

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15928
Approved symbol	SIRPB1
Name	signal regulatory protein beta 1
Location	20p13
Locus type	gene with protein product
Status	Approved
Aliases	SIRP-BETA-1, CD172b, SIRB1
Ensembl gene	ENSG00000101307
Ensembl biotype	protein_coding
OMIM	603889
Entrez	10326

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 17 protein_coding, 2 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000262929, ENST00000279477, ENST00000381596, ENST00000381603, ENST00000381605, ENST00000562014, ENST00000563840, ENST00000565076, ENST00000565087, ENST00000565230, ENST00000565775, ENST00000566055, ENST00000568365, ENST00000569387, ENST00000569629, ENST00000876186, ENST00000876187, ENST00000969009, ENST00000969010, ENST00000969011

RefSeq mRNA: 5 — MANE Select: NM_006065 NM_001083910, NM_001135844, NM_001329157, NM_001330639, NM_006065

CCDS: CCDS13019, CCDS42850, CCDS46571, CCDS82591

Canonical transcript exons

ENST00000381605 — 6 exons

Exon	Start	End
ENSE00001165691	1566153	1566267
ENSE00001603289	1571720	1572037
ENSE00001792474	1570805	1571137
ENSE00001958710	1561385	1565497
ENSE00003573334	1578338	1578694
ENSE00003899766	1619869	1620009

Expression profiles

Bgee: expression breadth ubiquitous, 173 present calls, max score 97.71.

FANTOM5 (CAGE): breadth broad, TPM avg 13.9686 / max 2498.3457, expressed in 436 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
186041	10.9682	361
186038	2.2259	175
186040	0.6545	177
186039	0.1199	50

Top tissues by expression

286 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	97.71	gold quality
mononuclear cell	CL:0000842	96.82	gold quality
leukocyte	CL:0000738	96.78	gold quality
granulocyte	CL:0000094	94.21	gold quality
blood	UBERON:0000178	93.72	gold quality
right lung	UBERON:0002167	88.92	gold quality
spleen	UBERON:0002106	85.78	gold quality
bone marrow	UBERON:0002371	85.36	gold quality
bone marrow cell	CL:0002092	84.82	gold quality
vermiform appendix	UBERON:0001154	83.75	gold quality
gall bladder	UBERON:0002110	83.21	gold quality
tongue squamous epithelium	UBERON:0006919	82.20	gold quality
caecum	UBERON:0001153	81.71	gold quality
diaphragm	UBERON:0001103	80.19	gold quality
lymph node	UBERON:0000029	79.84	gold quality
upper lobe of left lung	UBERON:0008952	79.19	gold quality
buccal mucosa cell	CL:0002336	78.43	gold quality
upper lobe of lung	UBERON:0008948	78.18	gold quality
sperm	CL:0000019	77.28	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.83	gold quality
male germ cell	CL:0000015	76.56	gold quality
mucosa of paranasal sinus	UBERON:0005030	73.85	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	73.14	gold quality
gingival epithelium	UBERON:0001949	72.80	gold quality
olfactory bulb	UBERON:0002264	71.39	gold quality
CA1 field of hippocampus	UBERON:0003881	71.39	gold quality
prefrontal cortex	UBERON:0000451	71.29	gold quality
left ventricle myocardium	UBERON:0006566	71.23	gold quality
hair follicle	UBERON:0002073	70.69	gold quality
cardiac muscle of right atrium	UBERON:0003379	69.86	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-MTAB-6678	yes	25.55
E-ANND-3	yes	12.33
E-MTAB-9801	yes	6.45

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

69 targeting SIRPB1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3689D	100.00	66.14	1181
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-4425	100.00	67.59	1049
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-7162-3P	99.89	68.16	1682
HSA-MIR-4271	99.88	68.32	2244
HSA-MIR-3934-3P	99.76	65.51	1351
HSA-MIR-4446-5P	99.72	69.19	2544
HSA-MIR-4755-5P	99.71	70.34	2716
HSA-MIR-5006-3P	99.71	70.26	2728
HSA-MIR-4530	99.69	66.47	1509
HSA-MIR-1827	99.63	68.57	3265
HSA-MIR-3616-5P	99.55	67.02	989
HSA-MIR-573	99.55	67.44	955

Literature-anchored findings (GeneRIF, showing 9)

• SIRP beta 1 is a disulfide-linked homodimer in leukocytes that regulates neutrophil transepithelial migration (PMID:16081415)
• This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia. (PMID:19034380)
• Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. (PMID:19165527)
• SIRPbeta1 is a novel IFN-induced microglial receptor that supports clearance of neural debris and Abeta aggregates by stimulating phagocytosis. (PMID:19893026)
• A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. (PMID:22360420)
• SIRPB1 copy-number polymorphism was significantly associated with impulsive-disinhibited personality scores in a dose-dependent manner. (PMID:25039969)
• Deletions in Genes Participating in Innate Immune Response Modify the Clinical Course of Andes Orthohantavirus Infection. (PMID:31349540)
• An Insertion Within SIRPbeta1 Shows a Dual Effect Over Alzheimer’s Disease Cognitive Decline Altering the Microglial Response. (PMID:38427484)
• SIRPB1 regulates inflammatory factor expression in the glioma microenvironment via SYK: functional and bioinformatics insights. (PMID:38594692)

Cross-species orthologs

9 orthologs

Organism	Symbol	Gene ID
mus_musculus	Sirpa	ENSMUSG00000037902
mus_musculus	Sirpb1c	ENSMUSG00000074677
mus_musculus	Gm5150	ENSMUSG00000078780
mus_musculus	Sirpd	ENSMUSG00000078783
mus_musculus	Sirpb1b	ENSMUSG00000095028
mus_musculus	Sirpb1a	ENSMUSG00000095788
rattus_norvegicus	Sirpa	ENSRNOG00000004763
rattus_norvegicus	LOC100909964	ENSRNOG00000043478
rattus_norvegicus	AABR07008876.1	ENSRNOG00000053292

Paralogs (4): SIRPG (ENSG00000089012), SIRPD (ENSG00000125900), SIRPB2 (ENSG00000196209), SIRPA (ENSG00000198053)

Protein

Protein identifiers

Signal-regulatory protein beta-1 — O00241 (reviewed: O00241, Q5TFQ8)

Alternative names: CD172 antigen-like family member B

All UniProt accessions (9): O00241, Q5TFQ8, H3BQ21, H3BRP9, H3BSK5, H3BTT9, H3BU43, H3BUW0, H9KV29

UniProt curated annotations — full annotation on UniProt →

Function. Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Also participates in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP.

Subunit / interactions. Homodimer; disulfide-linked. Interacts with TYROBP. This interaction results in the recruitment of SYK.

Subcellular location. Cell membrane.

Tissue specificity. Detected in monocytes and dendritic cells.

Post-translational modifications. N-glycosylated.

Isoforms (3)

UniProt ID	Names	Canonical?
O00241-1	1	yes
O00241-2	2
Q5TFQ8-1	3

RefSeq proteins (5): NP_001077379, NP_001129316, NP_001316086, NP_001317568, NP_006056* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003597	Ig_C1-set	Domain
IPR003599	Ig_sub	Domain
IPR007110	Ig-like_dom	Domain
IPR013106	Ig_V-set	Domain
IPR013783	Ig-like_fold	Homologous_superfamily
IPR036179	Ig-like_dom_sf	Homologous_superfamily
IPR051755	Ig-like_CS_Receptor	Family

Pfam: PF07654, PF07686

UniProt features (65 total): strand 24, glycosylation site 6, disulfide bond 6, sequence variant 6, domain 6, topological domain 4, signal peptide 2, chain 2, sequence conflict 2, helix 2, transmembrane region 2, splice variant 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
2JJU	X-RAY DIFFRACTION	1.19
2JJV	X-RAY DIFFRACTION	1.8
2D9C	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O00241-F1	84.76	0.66
AF-Q5TFQ8-F1	85.61	0.67

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

O00241 (canonical)

Disulfide bonds (3): 54–120, 169–227, 320

Glycosylation sites (3): 291, 244, 269

Q5TFQ8

Disulfide bonds (3): 54–120, 169–227, 272–330

Glycosylation sites (3): 244, 291, 318

Function

Pathways and Gene Ontology

Reactome pathways

6 pathways

ID	Pathway
R-HSA-2172127	DAP12 interactions
R-HSA-391160	Signal regulatory protein family interactions
R-HSA-6798695	Neutrophil degranulation
R-HSA-1500931	Cell-Cell communication
R-HSA-168249	Innate Immune System
R-HSA-168256	Immune System

MSigDB gene sets: 158 (showing top): GSE45365_NK_CELL_VS_CD11B_DC_DN, GOBP_REGULATION_OF_CELL_ACTIVATION, REACTOME_INNATE_IMMUNE_SYSTEM, GOBP_POSITIVE_REGULATION_OF_ENDOCYTOSIS, GOCC_SECRETORY_GRANULE, GOCC_CELL_SURFACE, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT, GOBP_POSITIVE_REGULATION_OF_CELL_ADHESION, GCM_PRKCG, GOBP_CELL_CELL_ADHESION, GCM_RING1, GCM_FCGR2B, OUELLET_CULTURED_OVARIAN_CANCER_INVASIVE_VS_LMP_DN, GOBP_POSITIVE_REGULATION_OF_CELL_ACTIVATION

GO Biological Process (4): signal transduction (GO:0007165), cell surface receptor signaling pathway (GO:0007166), positive regulation of phagocytosis (GO:0050766), positive regulation of T cell activation (GO:0050870)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (4): plasma membrane (GO:0005886), cell surface (GO:0009986), secretory granule membrane (GO:0030667), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Innate Immune System	2
Cell-Cell communication	1
Immune System	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
signal transduction	1
phagocytosis	1
positive regulation of endocytosis	1
regulation of phagocytosis	1
T cell activation	1
regulation of T cell activation	1
positive regulation of lymphocyte activation	1
positive regulation of leukocyte cell-cell adhesion	1
binding	1
membrane	1
cell periphery	1
secretory granule	1
cytoplasmic vesicle membrane	1
bounding membrane of organelle	1

Protein interactions and networks

STRING

1123 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SIRPB1	TYROBP	O43914	990
SIRPB1	CD47	Q08722	905
SIRPB1	FCER1G	P30273	732
SIRPB1	PTPN11	Q06124	707
SIRPB1	TREM2	Q9NZC2	690
SIRPB1	OSCAR	Q8IYS5	581
SIRPB1	TREM1	Q9NP99	508
SIRPB1	CD200R1	Q8TD46	463
SIRPB1	CLEC5A	Q9NY25	446
SIRPB1	TMEM86B	Q8N661	411
SIRPB1	SIRPA	P78324	407
SIRPB1	ZNF654	Q8IZM8	397
SIRPB1	TMEM265	A0A087WTH1	390
SIRPB1	PTGR3	Q8N4Q0	389
SIRPB1	IGLL1	P15814	381

IntAct

10 interactions, top by confidence:

A	B	Type	Score
TYROBP	SIRPB1	psi-mi:“MI:0915”(physical association)	0.520
SIRPB1	TYROBP	psi-mi:“MI:0915”(physical association)	0.520
SIRPB1	CD47	psi-mi:“MI:0407”(direct interaction)	0.440
SIRPB1	Syk	psi-mi:“MI:0915”(physical association)	0.400
SIRPB1	PTPRF	psi-mi:“MI:0915”(physical association)	0.400
ATG16L1	ESYT2	psi-mi:“MI:0914”(association)	0.350
SIRPA	SIRPB1	psi-mi:“MI:0914”(association)	0.350

BioGRID (15): SIRPB1 (Two-hybrid), SIRPB1 (Two-hybrid), RBPMS (Two-hybrid), SIRPB1 (Two-hybrid), APOC1 (Two-hybrid), BPIFA1 (Two-hybrid), SIRPB1 (Affinity Capture-MS), TYROBP (Affinity Capture-Western), SIRPB1 (Affinity Capture-Western), TYROBP (Affinity Capture-Western), SYK (Affinity Capture-Western), SIRPB1 (Affinity Capture-MS), SIRPB1 (Affinity Capture-MS), SIRPB1 (Cross-Linking-MS (XL-MS)), SIRPA (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A0A0R4IGV4, A0A8M2B818, A0JM41, A2VD98, B0CLX4, B6ZK77, D3YX43, F1LW30, O00241, O18906, O54901, O88775, O95256, P00545, P04218, P0C673, P10522, P13369, P17948, P21995, P27931, P35916, P35917, P35969, P37301, P42071, P42703, P53767, Q08DK1, Q15762, Q58EG3, Q5DX21, Q5FWR8, Q5R412, Q5U2P2, Q5VJ70, Q6GMZ9, Q6PCB8, Q6X936, Q7TSN7

Diamond homologs: O00241, O46631, P01691, P01844, P01845, P01847, P01915, P04230, P04231, P18211, P18468, P18469, P18470, P20040, P78324, P97710, P97797, Q5JXA9, Q5TFQ8, Q9H106, Q9P1W8, Q9PWR4, P55899, Q29980, A0A5B9, A0M8Q6, B9A064, O42197, P01834, P01835, P01836, P01837, P01838, P01839, P01840, P01841, P01843, P01846, P01850, P01854

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

82 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	57
Likely benign	10
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

2166 predictions. Top by Δscore:

Variant	Effect	Δscore
20:1598820:A:AC	donor_gain	1.0000
20:1598821:C:CC	donor_gain	1.0000
20:1598821:CAGT:C	donor_gain	1.0000
20:1611356:CCA:C	donor_gain	1.0000
20:1611356:CCACG:C	donor_gain	1.0000
20:1578329:TGTAC:T	donor_loss	0.9900
20:1578330:GTACT:G	donor_loss	0.9900
20:1578331:TACT:T	donor_loss	0.9900
20:1578332:AC:A	donor_loss	0.9900
20:1578333:CT:C	donor_loss	0.9900
20:1578334:TCACC:T	donor_loss	0.9900
20:1578335:CACCG:C	donor_loss	0.9900
20:1578337:C:CT	donor_loss	0.9900
20:1578337:CCGCG:C	donor_gain	0.9900
20:1598821:CA:C	donor_gain	0.9900
20:1611348:TGTAC:T	donor_loss	0.9900
20:1611349:GTACT:G	donor_loss	0.9900
20:1611350:TACT:T	donor_loss	0.9900
20:1611351:AC:A	donor_loss	0.9900
20:1611352:CT:C	donor_loss	0.9900
20:1611353:TCACC:T	donor_loss	0.9900
20:1611354:CACCA:C	donor_loss	0.9900
20:1611355:A:AC	donor_gain	0.9900
20:1611355:A:AG	donor_loss	0.9900
20:1611356:C:CC	donor_gain	0.9900
20:1611711:CCC:C	acceptor_gain	0.9900
20:1611712:CC:C	acceptor_gain	0.9900
20:1611712:CCC:C	acceptor_gain	0.9900
20:1611713:CC:C	acceptor_gain	0.9900
20:1611713:CCT:C	acceptor_loss	0.9900

AlphaMissense

2572 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
20:1571949:G:C	F174L	0.979
20:1571949:G:T	F174L	0.979
20:1571951:A:G	F174L	0.979
20:1578570:C:A	W67C	0.976
20:1578570:C:G	W67C	0.976
20:1578572:A:G	W67R	0.972
20:1578572:A:T	W67R	0.972
20:1578412:C:G	C120S	0.970
20:1578413:A:T	C120S	0.970
20:1571058:G:C	F277L	0.969
20:1571058:G:T	F277L	0.969
20:1571060:A:G	F277L	0.969
20:1571924:A:G	W183R	0.969
20:1571924:A:T	W183R	0.969
20:1578610:C:G	C54S	0.969
20:1578611:A:T	C54S	0.969
20:1578419:A:C	Y118D	0.965
20:1578411:A:C	C120W	0.957
20:1578412:C:T	C120Y	0.954
20:1578402:G:C	F123L	0.953
20:1578402:G:T	F123L	0.953
20:1578404:A:G	F123L	0.953
20:1578413:A:G	C120R	0.953
20:1571074:C:G	C272S	0.949
20:1571075:A:T	C272S	0.949
20:1578611:A:G	C54R	0.946
20:1571033:A:G	W286R	0.945
20:1571033:A:T	W286R	0.945
20:1571922:C:A	W183C	0.944
20:1571922:C:G	W183C	0.944

dbSNP variants (sampled 300 via entrez): RS1000311208 (20:1618283 T>C), RS1000372415 (20:1617448 C>A), RS1000479513 (20:1571663 A>G), RS1000592171 (20:1567076 T>A), RS1000743664 (20:1617198 C>T), RS1000907907 (20:1586637 C>G), RS1000930883 (20:1562111 C>T), RS1000987890 (20:1608425 C>T), RS1001007838 (20:1562453 C>A,G), RS1001158200 (20:1573109 C>T), RS1001170886 (20:1594861 T>G), RS1001236876 (20:1585304 A>G), RS1001290780 (20:1608702 G>A), RS1001339778 (20:1563812 T>A,C), RS1001515090 (20:1562614 T>C)

Disease associations

OMIM: gene MIM:603889 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

11 associations (top):

Study	Trait	p-value
GCST004599_203	Mean platelet volume	3.000000e-41
GCST006585_87	Blood protein levels	5.000000e-226
GCST009391_950	Metabolite levels	3.000000e-06
GCST011096_27	Systemic lupus erythematosus	3.000000e-08
GCST90002389_412	Lymphocyte percentage of white cells	9.000000e-10
GCST90002393_676	Monocyte count	4.000000e-17
GCST90002395_582	Mean platelet volume	3.000000e-100
GCST90002398_95	Neutrophil count	1.000000e-10
GCST90002400_103	Plateletcrit	5.000000e-30
GCST90002401_303	Platelet distribution width	9.000000e-21
GCST90002407_637	White blood cell count	6.000000e-10

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0010403	triacylglycerol 48:0 measurement
EFO:0007993	lymphocyte percentage of leukocytes
EFO:0005091	monocyte count
EFO:0004833	neutrophil count
EFO:0007985	platelet crit
EFO:0007984	platelet component distribution width

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Estradiol	affects cotreatment, decreases expression, increases expression	2
triphenyl phosphate	affects expression	1
arsenite	affects binding, decreases reaction	1
mono-(2-ethylhexyl)phthalate	decreases expression	1
zinc chromate	increases abundance, increases expression	1
benzo(e)pyrene	decreases methylation	1
di-n-butylphosphoric acid	affects expression	1
chromium hexavalent ion	increases abundance, increases expression	1
clothianidin	increases expression	1
NSC 689534	increases expression	1
Rosiglitazone	increases expression	1
Zoledronic Acid	increases expression	1
Norethindrone Acetate	affects cotreatment, increases expression	1
Allergens	decreases expression	1
Azacitidine	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Bucladesine	affects cotreatment, decreases expression	1
Doxorubicin	decreases expression	1
Formaldehyde	decreases expression	1
Methapyrilene	decreases methylation	1
Methotrexate	increases expression	1
Methyl Methanesulfonate	decreases expression	1
Nickel	increases expression	1
Smoke	increases expression	1
Testosterone	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	increases expression	1
Triclosan	decreases expression	1
Vincristine	decreases expression	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.