SIX3-AS1

Summary

SIX3-AS1 (SIX3 antisense RNA 1, HGNC:40532) is a long non-coding RNA gene on chromosome 2p21.

Predicted to be involved in regulation of gene expression.

Source: NCBI Gene 100506108 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40532
Approved symbol	SIX3-AS1
Name	SIX3 antisense RNA 1
Location	2p21
Locus type	RNA, long non-coding
Status	Approved
Aliases	SIX3OS
Ensembl gene	ENSG00000236502
Ensembl biotype	lncRNA
Entrez	100506108
RNAcentral	URS000075E4F4 — lncRNA, 1000 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000419364, ENST00000456467, ENST00000693240, ENST00000760560, ENST00000760561, ENST00000760562, ENST00000760563

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000419364 — 2 exons

Exon	Start	End
ENSE00004114277	44941710	44942068
ENSE00004114279	44940130	44940833

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 97.38.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3970 / max 33.9393, expressed in 143 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
28157	0.1667	95
28155	0.1456	76
28154	0.0562	39
28156	0.0286	11

Top tissues by expression

191 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	97.38	gold quality
nucleus accumbens	UBERON:0001882	88.02	gold quality
caudate nucleus	UBERON:0001873	87.05	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	86.18	gold quality
medial globus pallidus	UBERON:0002477	84.63	gold quality
putamen	UBERON:0001874	84.23	gold quality
adenohypophysis	UBERON:0002196	82.39	gold quality
pigmented layer of retina	UBERON:0001782	82.26	gold quality
globus pallidus	UBERON:0001875	80.99	silver quality
pituitary gland	UBERON:0000007	80.24	gold quality
islet of Langerhans	UBERON:0000006	79.65	gold quality
nasal cavity mucosa	UBERON:0001826	75.87	gold quality
hypothalamus	UBERON:0001898	72.98	gold quality
amygdala	UBERON:0001876	72.35	gold quality
pancreatic ductal cell	CL:0002079	68.91	silver quality
mucosa of paranasal sinus	UBERON:0005030	67.22	silver quality
epithelial cell of pancreas	CL:0000083	67.08	gold quality
ganglionic eminence	UBERON:0004023	66.91	gold quality
myocardium	UBERON:0002349	66.39	gold quality
lateral globus pallidus	UBERON:0002476	66.24	silver quality
left ventricle myocardium	UBERON:0006566	65.49	gold quality
forebrain	UBERON:0001890	65.42	gold quality
cardiac muscle of right atrium	UBERON:0003379	65.18	gold quality
pancreas	UBERON:0001264	64.30	gold quality
brain	UBERON:0000955	62.93	gold quality
ventricular zone	UBERON:0003053	62.26	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.09	gold quality
right frontal lobe	UBERON:0002810	60.17	gold quality
temporal lobe	UBERON:0001871	59.39	gold quality
prefrontal cortex	UBERON:0000451	58.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.