SIX5

Summary

SIX5 (SIX homeobox 5, HGNC:10891) is a protein-coding gene on chromosome 19q13.32, encoding Homeobox protein SIX5 (Q8N196). Transcription factor that is thought to be involved in regulation of organogenesis.

The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a cause of branchiootorenal syndrome type 2.

Source: NCBI Gene 147912 — RefSeq curated summary.

At a glance

• Gene–disease (curated): branchiootorenal syndrome 2 (Definitive, GenCC) — +1 more curated relationship
• GWAS associations: 1
• Clinical variants (ClinVar): 305 total
• Phenotypes (HPO): 41
• MANE Select transcript: NM_175875

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10891
Approved symbol	SIX5
Name	SIX homeobox 5
Location	19q13.32
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000177045
Ensembl biotype	protein_coding
OMIM	600963
Entrez	147912

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000317578, ENST00000560160, ENST00000560168

RefSeq mRNA: 1 — MANE Select: NM_175875 NM_175875

CCDS: CCDS12673

Canonical transcript exons

ENST00000317578 — 3 exons

Exon	Start	End
ENSE00001257225	45764785	45766111
ENSE00001352650	45766350	45767155
ENSE00001352655	45768042	45769252

Expression profiles

Bgee: expression breadth ubiquitous, 205 present calls, max score 94.33.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.2232 / max 185.4348, expressed in 1553 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
181566	5.2030	1408
181565	2.0489	1110
181563	1.9713	1099

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cardiac muscle of right atrium	UBERON:0003379	94.33	gold quality
right uterine tube	UBERON:0001302	91.28	gold quality
right ovary	UBERON:0002118	90.96	gold quality
left ventricle myocardium	UBERON:0006566	90.86	silver quality
left ovary	UBERON:0002119	90.54	gold quality
parotid gland	UBERON:0001831	90.21	gold quality
endocervix	UBERON:0000458	89.89	gold quality
right coronary artery	UBERON:0001625	89.81	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	89.33	gold quality
left uterine tube	UBERON:0001303	89.28	gold quality
lower esophagus muscularis layer	UBERON:0035833	89.27	gold quality
body of uterus	UBERON:0009853	89.26	gold quality
lower esophagus	UBERON:0013473	89.24	gold quality
body of pancreas	UBERON:0001150	88.93	gold quality
descending thoracic aorta	UBERON:0002345	88.87	gold quality
popliteal artery	UBERON:0002250	88.75	gold quality
tibial artery	UBERON:0007610	88.71	gold quality
mucosa of stomach	UBERON:0001199	88.57	gold quality
muscle layer of sigmoid colon	UBERON:0035805	88.37	gold quality
aorta	UBERON:0000947	88.23	gold quality
left coronary artery	UBERON:0001626	87.74	gold quality
thoracic aorta	UBERON:0001515	87.69	gold quality
ascending aorta	UBERON:0001496	87.57	gold quality
coronary artery	UBERON:0001621	87.46	gold quality
ectocervix	UBERON:0012249	87.07	gold quality
right lobe of thyroid gland	UBERON:0001119	86.85	gold quality
fundus of stomach	UBERON:0001160	86.32	gold quality
body of stomach	UBERON:0001161	86.27	gold quality
ovary	UBERON:0000992	86.16	gold quality
right adrenal gland	UBERON:0001233	86.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.03

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
IGFBP5	Unknown

Upstream regulators (CollecTRI, top): CTCF

miRNA regulators (miRDB)

52 targeting SIX5, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-3065-3P	99.87	70.25	1407
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-8067	99.86	69.59	2260
HSA-MIR-383-3P	99.85	65.84	1359
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-5004-5P	99.68	66.63	1294
HSA-MIR-651-5P	99.64	68.49	1104
HSA-MIR-7150	99.62	66.80	1322
HSA-MIR-6132	99.60	65.83	1554
HSA-MIR-6836-5P	99.60	65.62	1538
HSA-MIR-1207-5P	99.49	69.11	2983
HSA-MIR-4441	99.49	66.56	3216
HSA-MIR-3612	99.45	66.02	1333
HSA-MIR-650	99.45	65.77	1309
HSA-MIR-4291	99.20	68.88	2969

Literature-anchored findings (GeneRIF, showing 6)

• Transcription factor SIX5 is mutated in patients with branchio-oto-renal syndrome. (PMID:17357085)
• Study reports a screening of 140 patients from 124 families with Branchio-oto-renal and identified 36 EYA1 mutations in 42 unrelated patients, 2 mutations, and 1 change of unknown significance in SIX1 in 3 unrelated patients, but no mutation in SIX5. (PMID:21280147)
• In East Asian populations, a SIX1 mutation has been reported in a Japanese family with branchio-oto (BO) syndrome,yet SIX5 mutations have never been reported. (PMID:22447252)
• Three causative genes for BOR syndrome have been reported thus far: EYA1, SIX1, and SIX5, but the causative genes for approximately half of all BOR patients remain unknown.[review] (PMID:24730701)
• the higher expressions of SIX1-5 were associated with the greater possibility of the tumorigenesis in lung neoplasms (PMID:27821176)
• Phenotype-genotype correlation in patients with typical and atypical branchio-oto-renal syndrome. (PMID:35046468)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	six4a	ENSDARG00000004695
danio_rerio	six4b	ENSDARG00000031983
danio_rerio	six5	ENSDARG00000068406
mus_musculus	Six5	ENSMUSG00000040841
rattus_norvegicus	Six5	ENSRNOG00000060146
drosophila_melanogaster	Optix	FBGN0025360
caenorhabditis_elegans		WBGENE00000453

Paralogs (6): SIX4 (ENSG00000100625), SIX1 (ENSG00000126778), SIX3 (ENSG00000138083), SIX2 (ENSG00000170577), SIX6 (ENSG00000184302), ANHX (ENSG00000227059)

Protein

Protein identifiers

Homeobox protein SIX5 — Q8N196 (reviewed: Q8N196)

Alternative names: DM locus-associated homeodomain protein, Sine oculis homeobox homolog 5

All UniProt accessions (3): Q8N196, H0YLF6, H0YLK1

UniProt curated annotations — full annotation on UniProt →

Function. Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5’-GGTGTCAG-3’ motif present in the ARE regulatory element of ATP1A1. Binds a 5’-TCA[AG][AG]TTNC-3’ motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter. Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3.

Subunit / interactions. Probably binds DNA dimer. Interacts with EYA3, and probably EYA1 and EYA2.

Subcellular location. Cytoplasm. Nucleus.

Tissue specificity. Expressed in adult but not in fetal eyes. Found in corneal epithelium and endothelium, lens epithelium, ciliary body epithelia, cellular layers of the retina and the sclera.

Disease relevance. Branchiootorenal syndrome 2 (BOR2) [MIM:610896] A syndrome characterized by branchial cleft fistulas or cysts, sensorineural and/or conductive hearing loss, pre-auricular pits, structural defects of the outer, middle or inner ear, and renal malformations. The disease is caused by variants affecting the gene represented in this entry.

Similarity. Belongs to the SIX/Sine oculis homeobox family.

RefSeq proteins (1): NP_787071* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001356	HD	Domain
IPR009057	Homeodomain-like_sf	Homologous_superfamily
IPR017970	Homeobox_CS	Conserved_site
IPR031701	SIX1_SD	Domain

Pfam: PF00046, PF16878

UniProt features (18 total): sequence variant 7, compositionally biased region 5, region of interest 4, chain 1, DNA-binding region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N196-F1	53.21	0.18

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 222 (showing top): CREL_01, MYAATNNNNNNNGGC_UNKNOWN, AP4_Q6, GOBP_MALE_GAMETE_GENERATION, GOBP_MUSCLE_CELL_PROLIFERATION, CAGCTG_AP4_Q5, NFKB_C, E2F_Q3, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_DN, BILD_E2F3_ONCOGENIC_SIGNATURE, HEN1_01, HFH3_01, GOBP_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM, AACTTT_UNKNOWN, GOBP_STRIATED_MUSCLE_CELL_PROLIFERATION

GO Biological Process (10): lens development in camera-type eye (GO:0002088), regulation of transcription by RNA polymerase II (GO:0006357), spermatid development (GO:0007286), negative regulation of DNA-templated transcription (GO:0045892), Leydig cell proliferation (GO:0160024), negative regulation of skeletal muscle satellite cell proliferation (GO:1902723), regulation of DNA-templated transcription (GO:0006355), cell population proliferation (GO:0008283), negative regulation of cell population proliferation (GO:0008285), positive regulation of transcription by RNA polymerase II (GO:0045944)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228), DNA binding (GO:0003677), protein binding (GO:0005515), sequence-specific DNA binding (GO:0043565)

GO Cellular Component (7): chromatin (GO:0000785), nucleus (GO:0005634), nucleoplasm (GO:0005654), transcription regulator complex (GO:0005667), Golgi apparatus (GO:0005794), cytosol (GO:0005829), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
RNA polymerase II transcription regulatory region sequence-specific DNA binding	3
regulation of DNA-templated transcription	2
transcription by RNA polymerase II	2
DNA-templated transcription	2
cell population proliferation	2
regulation of transcription by RNA polymerase II	2
intracellular membrane-bounded organelle	2
cytoplasm	2
camera-type eye development	1
anatomical structure development	1
germ cell development	1
spermatid differentiation	1
negative regulation of RNA biosynthetic process	1
skeletal muscle satellite cell proliferation	1
regulation of skeletal muscle satellite cell proliferation	1
negative regulation of skeletal muscle cell proliferation	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cellular process	1
regulation of cell population proliferation	1
negative regulation of cellular process	1
positive regulation of DNA-templated transcription	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription activator activity	1
positive regulation of transcription by RNA polymerase II	1
nucleic acid binding	1
binding	1
DNA binding	1
chromosome	1
nuclear lumen	1
protein-containing complex	1
endomembrane system	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1100 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SIX5	ZNF143	P52747	908
SIX5	EYA1	Q99502	893
SIX5	DMWD	Q09019	855
SIX5	CTCF	P49711	839
SIX5	DMPK	Q09013	832
SIX5	MBNL1	Q9NR56	751
SIX5	CLCN1	P35523	695
SIX5	CELF1	Q92879	668
SIX5	INHA	P05111	654
SIX5	ATP2A1	O14983	640
SIX5	MXI1	P50539	622
SIX5	RAD21	O60216	619
SIX5	ZZZ3	Q8IYH5	614
SIX5	CTCFL	Q8NI51	608
SIX5	INHBB	P09529	603

IntAct

22 interactions, top by confidence:

A	B	Type	Score
ATXN1	SIX5	psi-mi:“MI:0915”(physical association)	0.510
SIX5	Eya1	psi-mi:“MI:0915”(physical association)	0.370
SIX5		psi-mi:“MI:0915”(physical association)	0.370
FOXB1	DDX39A	psi-mi:“MI:0914”(association)	0.350
FOXL1	DDX39A	psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
PTGES3	SBNO1	psi-mi:“MI:0914”(association)	0.350
PRKY	METTL15	psi-mi:“MI:0914”(association)	0.350
CCT8L2	DVL2	psi-mi:“MI:0914”(association)	0.350
SIX5	PPM1G	psi-mi:“MI:0914”(association)	0.350
SRF	ZNF292	psi-mi:“MI:2364”(proximity)	0.270
FEV	TAF4	psi-mi:“MI:2364”(proximity)	0.270
FHIP1B	MED19	psi-mi:“MI:2364”(proximity)	0.270
GPKOW	ESYT2	psi-mi:“MI:2364”(proximity)	0.270
QKI	SMCHD1	psi-mi:“MI:2364”(proximity)	0.270
	SIX5	psi-mi:“MI:0915”(physical association)	0.000
hemC	SIX5	psi-mi:“MI:0915”(physical association)	0.000
degQ	SIX5	psi-mi:“MI:0915”(physical association)	0.000
ATXN1	SIX5	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (36): SIX5 (Affinity Capture-MS), SIX5 (Affinity Capture-MS), EYA3 (Affinity Capture-Western), C18orf25 (Affinity Capture-MS), EYA3 (Affinity Capture-MS), RFWD2 (Affinity Capture-MS), GMNN (Affinity Capture-MS), PPM1G (Affinity Capture-MS), DET1 (Affinity Capture-MS), EYA1 (Affinity Capture-MS), FHL2 (Affinity Capture-MS), MTMR4 (Affinity Capture-MS), SIX5 (Affinity Capture-MS), SIRT1 (Affinity Capture-MS), STK40 (Affinity Capture-MS)

ESM2 similar proteins: A0A8I6AGW3, A2A9A2, A2AEV7, A6NEQ2, A6NMB9, A8MYZ6, E9PZZ1, J3QK54, O02755, O02756, O14813, O35392, O35767, O60548, O70220, P05554, P17676, P23813, P42582, P47902, P49715, P49716, P52952, P53566, Q02779, Q03484, Q13461, Q14526, Q3U0S6, Q60843, Q63250, Q63HR2, Q6BEB4, Q6ZQN5, Q70KY4, Q8IU81, Q8IY67, Q8N196, Q90850, Q96HB5

Diamond homologs: A1YER0, A2D5H2, A6NDR6, A8K0S8, A8WL06, B3DM47, B4F6V6, O00470, O04134, O04135, O14770, O17894, O22299, O35317, O35984, O42406, O46339, O65034, O73916, O80416, O93307, O95343, O95475, P10842, P24345, P40424, P40425, P40426, P40427, P41778, P41779, P41817, P46608, P46609, P46639, P46640, P48731, P53147, P56661, P56662

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

305 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	172
Likely benign	83
Benign	13

Top pathogenic / likely-pathogenic (0)

SpliceAI

612 predictions. Top by Δscore:

Variant	Effect	Δscore
19:45766107:GTTTC:G	acceptor_gain	0.9900
19:45766108:TTTC:T	acceptor_gain	0.9900
19:45766109:TTC:T	acceptor_gain	0.9900
19:45766111:CCTGT:C	acceptor_loss	0.9900
19:45766112:C:CA	acceptor_loss	0.9900
19:45766112:C:CC	acceptor_gain	0.9900
19:45766113:T:A	acceptor_loss	0.9900
19:45766700:T:TA	donor_gain	0.9900
19:45767152:CTCG:C	acceptor_gain	0.9900
19:45766110:TC:T	acceptor_gain	0.9800
19:45766111:CC:C	acceptor_gain	0.9800
19:45767154:CG:C	acceptor_gain	0.9800
19:45767156:C:CC	acceptor_gain	0.9800
19:45768036:CCTCA:C	donor_loss	0.9800
19:45768037:CTCAC:C	donor_loss	0.9800
19:45768038:TCACC:T	donor_loss	0.9800
19:45768039:CACC:C	donor_loss	0.9800
19:45768040:A:T	donor_loss	0.9800
19:45768041:C:G	donor_loss	0.9800
19:45768041:CCT:C	donor_gain	0.9800
19:45766599:C:CT	donor_gain	0.9700
19:45767885:AGTC:A	donor_gain	0.9700
19:45769067:C:CA	donor_gain	0.9700
19:45766906:G:A	donor_gain	0.9600
19:45767153:TCG:T	acceptor_gain	0.9600
19:45767154:C:CT	acceptor_gain	0.9600
19:45767885:AGTCC:A	donor_gain	0.9600
19:45768940:C:CA	donor_gain	0.9500
19:45768941:C:A	donor_gain	0.9500
19:45769131:AGGG:A	donor_gain	0.9500

AlphaMissense

4607 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:45768092:G:C	N251K	1.000
19:45768092:G:T	N251K	1.000
19:45768093:T:A	N251I	1.000
19:45768093:T:G	N251T	1.000
19:45768094:T:C	N251D	1.000
19:45768095:C:A	K250N	1.000
19:45768095:C:G	K250N	1.000
19:45768096:T:A	K250M	1.000
19:45768096:T:G	K250T	1.000
19:45768097:T:C	K250E	1.000
19:45768097:T:G	K250Q	1.000
19:45768098:G:C	F249L	1.000
19:45768098:G:T	F249L	1.000
19:45768099:A:C	F249C	1.000
19:45768099:A:G	F249S	1.000
19:45768100:A:C	F249V	1.000
19:45768100:A:G	F249L	1.000
19:45768100:A:T	F249I	1.000
19:45768101:C:A	W248C	1.000
19:45768101:C:G	W248C	1.000
19:45768102:C:G	W248S	1.000
19:45768103:A:G	W248R	1.000
19:45768103:A:T	W248R	1.000
19:45768104:G:C	N247K	1.000
19:45768104:G:T	N247K	1.000
19:45768106:T:C	N247D	1.000
19:45768111:A:T	V245D	1.000
19:45768113:C:A	Q244H	1.000
19:45768113:C:G	Q244H	1.000
19:45768126:A:G	L240P	1.000

dbSNP variants (sampled 300 via entrez): RS1000009757 (19:45769001 C>G,T), RS1000529688 (19:45770517 G>A), RS1000937485 (19:45770863 C>T), RS1001089151 (19:45767213 G>A), RS1001187469 (19:45764362 T>C), RS1001410910 (19:45769669 G>C), RS1001479405 (19:45770982 G>A), RS1001837963 (19:45769888 T>C,G), RS1002188276 (19:45765307 A>AG), RS1002691514 (19:45765397 G>A,T), RS1002991633 (19:45769400 T>G), RS1003578568 (19:45770063 A>G), RS1003803184 (19:45769256 C>A,G,T), RS1003871860 (19:45770541 C>A,G,T), RS1003924058 (19:45770652 G>A,C)

Disease associations

OMIM: gene MIM:600963 | disease phenotypes: MIM:610896

GenCC curated gene-disease

Disease	Classification	Inheritance
branchiootorenal syndrome 2	Definitive	Autosomal dominant
branchio-oto-renal syndrome	Supportive	Autosomal dominant

ClinGen Gene-Disease Validity (1)

Expert-panel classifications — Definitive > Strong > Moderate > Limited > Disputed > Refuted.

Disease	Classification	Inheritance
branchio-oto-renal syndrome	Disputed	AD

Mondo (2): branchiootorenal syndrome 2 (MONDO:0012575), branchio-oto-renal syndrome (MONDO:0007029)

Orphanet (1): BOR syndrome (Orphanet:107)

HPO phenotypes

41 total (30 of 41 shown, HPO-id order):

HPO	Term
HP:0000003	Multicystic kidney dysplasia
HP:0000006	Autosomal dominant inheritance
HP:0000074	Ureteropelvic junction obstruction
HP:0000076	Vesicoureteral reflux
HP:0000083	Renal insufficiency
HP:0000110	Renal dysplasia
HP:0000126	Hydronephrosis
HP:0000175	Cleft palate
HP:0000278	Retrognathia
HP:0000324	Facial asymmetry
HP:0000356	Abnormality of the outer ear
HP:0000359	Abnormality of the inner ear
HP:0000365	Hearing impairment
HP:0000370	Abnormality of the middle ear
HP:0000377	Abnormal pinna morphology
HP:0000384	Preauricular skin tag
HP:0000394	Lop ear
HP:0000402	Stenosis of the external auditory canal
HP:0000405	Conductive hearing impairment
HP:0000407	Sensorineural hearing impairment
HP:0000410	Mixed hearing impairment
HP:0000413	Atresia of the external auditory canal
HP:0004452	Abnormality of the middle ear ossicles
HP:0004467	Preauricular pit
HP:0007925	Lacrimal duct aplasia
HP:0008551	Microtia
HP:0008586	Hypoplasia of the cochlea
HP:0008678	Renal hypoplasia/aplasia
HP:0009794	Branchial anomaly
HP:0009796	Branchial cyst

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST007612_3	Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy)	1.000000e-08

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D019280	Branchio-Oto-Renal Syndrome	C16.131.077.208; C16.131.260.090; C16.320.180.090

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

35 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression	5
mercuric bromide	decreases expression, affects cotreatment	2
Air Pollutants	decreases expression, increases abundance, increases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Particulate Matter	decreases expression, increases abundance, increases expression	2
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
2,4,5,2’,4’,5’-hexachlorobiphenyl	decreases expression	1
beta-lapachone	decreases expression, increases expression	1
butyraldehyde	decreases expression	1
3,4,5,3’,4’-pentachlorobiphenyl	decreases expression	1
perfluorooctanoic acid	decreases expression	1
ferrous chloride	decreases expression	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
ICG 001	increases expression	1
abrine	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Cadmium	decreases expression	1
Doxorubicin	decreases expression	1
Estradiol	affects expression	1
Niclosamide	increases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Smoke	decreases expression	1
Thimerosal	decreases expression	1

Cellosaurus cell lines

5 cell lines: 3 embryonic stem cell, 1 transformed cell line, 1 finite cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A6F1	SEES3-1V human SIX5, clone1	Embryonic stem cell	Male
CVCL_A6F2	SEES3-1V human SIX5, clone2	Embryonic stem cell	Male
CVCL_A6F3	SEES3-1V human SIX5, clone3	Embryonic stem cell	Male
CVCL_RT81	GM26595	Transformed cell line	Male
CVCL_RT82	GM26596	Finite cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.