SLC10A5

Summary

SLC10A5 (solute carrier family 10 member 5, HGNC:22981) is a protein-coding gene on chromosome 8q21.13, encoding Sodium/bile acid cotransporter 5 (Q5PT55).

Predicted to enable bile acid:sodium symporter activity. Predicted to be involved in bile acid and bile salt transport. Predicted to be located in membrane.

Source: NCBI Gene 347051 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 69 total
• MANE Select transcript: NM_001010893

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:22981
Approved symbol	SLC10A5
Name	solute carrier family 10 member 5
Location	8q21.13
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000253598
Ensembl biotype	protein_coding
OMIM	618582
Entrez	347051

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000518568

RefSeq mRNA: 1 — MANE Select: NM_001010893 NM_001010893

CCDS: CCDS34915

Canonical transcript exons

ENST00000518568 — 1 exons

Exon	Start	End
ENSE00002098482	81693631	81695058

Expression profiles

Bgee: expression breadth ubiquitous, 123 present calls, max score 93.05.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3310 / max 53.2665, expressed in 62 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
93771	0.2814	55
93772	0.0496	16

Top tissues by expression

130 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	93.05	gold quality
liver	UBERON:0002107	74.20	gold quality
rectum	UBERON:0001052	73.13	gold quality
duodenum	UBERON:0002114	71.44	gold quality
right lobe of liver	UBERON:0001114	69.38	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	68.42	gold quality
cerebellar cortex	UBERON:0002129	67.52	gold quality
cerebellar hemisphere	UBERON:0002245	67.47	gold quality
cerebellum	UBERON:0002037	67.42	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.03	gold quality
gall bladder	UBERON:0002110	64.22	gold quality
islet of Langerhans	UBERON:0000006	62.11	gold quality
primary visual cortex	UBERON:0002436	62.06	gold quality
transverse colon	UBERON:0001157	61.65	gold quality
nucleus accumbens	UBERON:0001882	61.42	gold quality
cortical plate	UBERON:0005343	61.30	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.14	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	60.91	gold quality
hypothalamus	UBERON:0001898	60.21	gold quality
right frontal lobe	UBERON:0002810	59.91	gold quality
brain	UBERON:0000955	59.46	gold quality
adenohypophysis	UBERON:0002196	59.32	gold quality
frontal cortex	UBERON:0001870	59.26	gold quality
small intestine	UBERON:0002108	59.12	gold quality
cerebral cortex	UBERON:0000956	58.96	gold quality
prefrontal cortex	UBERON:0000451	58.93	gold quality
pancreas	UBERON:0001264	58.61	gold quality
putamen	UBERON:0001874	58.60	gold quality
intestine	UBERON:0000160	58.25	gold quality
anterior cingulate cortex	UBERON:0009835	58.25	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.58

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Molecular cloning and characterization of SLC10A5 as an orphan carrier with yet non-identified substrates. (PMID:17632081)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Slc10a5	ENSMUSG00000058921
rattus_norvegicus	Slc10a5	ENSRNOG00000067758
drosophila_melanogaster	CG11655	FBGN0030638
drosophila_melanogaster	CG9903	FBGN0030756
caenorhabditis_elegans		WBGENE00044650

Paralogs (5): SLC10A1 (ENSG00000100652), SLC10A2 (ENSG00000125255), SLC10A3 (ENSG00000126903), SLC10A4 (ENSG00000145248), SLC10A6 (ENSG00000145283)

Protein

Protein identifiers

Sodium/bile acid cotransporter 5 — Q5PT55 (reviewed: Q5PT55)

Alternative names: Na(+)/bile acid cotransporter 5, Solute carrier family 10 member 5

All UniProt accessions (1): Q5PT55

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Similarity. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.

RefSeq proteins (1): NP_001010893* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002657	BilAc:Na_symport/Acr3	Family
IPR004710	Bilac:Na_transpt	Family
IPR038770	Na+/solute_symporter_sf	Homologous_superfamily
IPR057103	NTCP5_P3_N	Domain

Pfam: PF01758, PF24690

UniProt features (25 total): topological domain 10, transmembrane region 9, glycosylation site 3, signal peptide 1, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5PT55-F1	79.89	0.33

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (3): 56, 85, 99

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 34 (showing top): GOBP_MONOATOMIC_CATION_TRANSPORT, GOBP_ORGANIC_ACID_TRANSPORT, GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT, GOBP_ORGANIC_ANION_TRANSPORT, GOBP_BILE_ACID_AND_BILE_SALT_TRANSPORT, NIKOLSKY_BREAST_CANCER_8Q12_Q22_AMPLICON, GOBP_MONOCARBOXYLIC_ACID_TRANSPORT, GOBP_LIPID_LOCALIZATION, GOBP_TRANSMEMBRANE_TRANSPORT, GOBP_SODIUM_ION_TRANSPORT, GOMF_LIPID_TRANSPORTER_ACTIVITY, GOMF_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOMF_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOMF_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY

GO Biological Process (4): bile acid and bile salt transport (GO:0015721), monoatomic ion transport (GO:0006811), sodium ion transport (GO:0006814), transmembrane transport (GO:0055085)

GO Molecular Function (2): bile acid:sodium symporter activity (GO:0008508), symporter activity (GO:0015293)

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	2
lipid transport	1
monocarboxylic acid transport	1
organic hydroxy compound transport	1
metal ion transport	1
cellular process	1
organic acid:sodium symporter activity	1
bile acid transmembrane transporter activity	1
secondary active monocarboxylate transmembrane transporter activity	1
secondary active transmembrane transporter activity	1
cellular anatomical structure	1

Protein interactions and networks

STRING

552 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC10A5	SLC10A7	Q0GE19	794
SLC10A5	ZFAND1	Q8TCF1	486
SLC10A5	TMEM253	P0C7T8	475
SLC10A5	ANKRD13C-DT	Q9XRX5	430
SLC10A5	SLC35E4	Q6ICL7	421
SLC10A5	TMEM50A	O95807	404
SLC10A5	NOXRED1	Q6NXP6	373
SLC10A5	SNX16	P57768	373
SLC10A5	SLC51A	Q86UW1	360
SLC10A5	SLC51B	Q86UW2	360
SLC10A5	SLC6A16	Q9GZN6	336
SLC10A5	GPCPD1	Q9NPB8	323
SLC10A5	TXNDC8	Q6A555	318
SLC10A5	ABCB11	O95342	299
SLC10A5	SLC10A4	Q96EP9	298

IntAct

2 interactions, top by confidence:

A	B	Type	Score
SLC10A5	STXBP3	psi-mi:“MI:0914”(association)	0.350

BioGRID (92): ACVR1B (Affinity Capture-MS), ADAMTS1 (Affinity Capture-MS), ADRM1 (Affinity Capture-MS), APLP2 (Affinity Capture-MS), APOE (Affinity Capture-MS), APP (Affinity Capture-MS), BMPR1A (Affinity Capture-MS), BMPR2 (Affinity Capture-MS), CCPG1 (Affinity Capture-MS), CDH2 (Affinity Capture-MS), CLSTN3 (Affinity Capture-MS), CLU (Affinity Capture-MS), COL25A1 (Affinity Capture-MS), CPD (Affinity Capture-MS), CSGALNACT2 (Affinity Capture-MS)

ESM2 similar proteins: A0A084AFH0, A1L3G4, A1Z7R6, A5WWC6, A7YW81, B0B8F4, B0K004, D3YVE8, O04508, O74750, O84584, P0C7Q5, P0C7Q6, P39542, P40004, P53403, Q00974, Q0Q7U7, Q0Q7U8, Q0Q7U9, Q0Q7V0, Q0V9U2, Q1PFJ4, Q23444, Q24JQ0, Q3UME2, Q5F297, Q5M7A3, Q5PT55, Q5ZJZ4, Q7RTP0, Q8BHK1, Q8MXJ9, Q8N808, Q94EI9, Q96KT7, Q9C508, Q9C654, Q9C8M1, Q9FG70

Diamond homologs: A6QP84, O08705, P09131, P26435, P70172, Q12908, Q14973, Q28727, Q3KNW5, Q3UEZ8, Q4JLT5, Q5PT55, Q5PT56, Q60414, Q62633, Q70EX6, Q7XVB3, Q96EP9, Q9CXB2, B8BDK4, F4JPW1, P21129, Q0V8N6, Q5PT54, Q650U0, Q8VYY4, Q93YR2, O34524, Q1EBV7, Q5VRB2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

69 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	63
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

95 predictions. Top by Δscore:

Variant	Effect	Δscore
8:81694931:C:CT	acceptor_gain	0.9900
8:81694924:C:CC	acceptor_gain	0.9800
8:81694938:A:T	acceptor_gain	0.9700
8:81694934:A:T	acceptor_gain	0.9600
8:81694933:C:CT	acceptor_gain	0.9500
8:81694945:G:GC	acceptor_gain	0.9200
8:81694940:C:CT	acceptor_gain	0.9100
8:81694941:A:T	acceptor_gain	0.9100
8:81694921:CTT:C	acceptor_gain	0.8900
8:81694945:G:C	acceptor_gain	0.8900
8:81694922:TTC:T	acceptor_loss	0.8600
8:81694923:TCT:T	acceptor_loss	0.8600
8:81694924:C:CA	acceptor_loss	0.8600
8:81694925:T:A	acceptor_loss	0.8600
8:81694937:C:CT	acceptor_gain	0.8300
8:81694919:TTCTT:T	acceptor_gain	0.7500
8:81694922:TT:T	acceptor_gain	0.7400
8:81694857:T:TG	acceptor_gain	0.6700
8:81694926:A:C	acceptor_gain	0.6700
8:81694856:CTT:C	acceptor_gain	0.6000
8:81694926:A:AC	acceptor_gain	0.5900
8:81694920:TCTT:T	acceptor_gain	0.5400
8:81694921:CTTC:C	acceptor_gain	0.5400
8:81694922:TTCT:T	acceptor_gain	0.5400
8:81694858:T:G	acceptor_gain	0.5200
8:81694858:T:C	acceptor_gain	0.4200
8:81694881:T:TA	acceptor_loss	0.4000
8:81694882:T:TA	acceptor_loss	0.3500
8:81694878:GTC:G	acceptor_loss	0.3400
8:81694879:TCT:T	acceptor_loss	0.3400

AlphaMissense

2858 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
8:81694043:A:C	S310R	0.937
8:81694043:A:T	S310R	0.937
8:81694045:T:G	S310R	0.937
8:81694418:A:C	F185L	0.931
8:81694418:A:T	F185L	0.931
8:81694420:A:G	F185L	0.931
8:81693842:A:C	S377R	0.910
8:81693842:A:T	S377R	0.910
8:81693844:T:G	S377R	0.910
8:81694394:A:C	F193L	0.876
8:81694394:A:T	F193L	0.876
8:81694396:A:G	F193L	0.876
8:81693857:A:C	S372R	0.873
8:81693857:A:T	S372R	0.873
8:81693859:T:G	S372R	0.873
8:81694499:A:C	F158L	0.858
8:81694499:A:T	F158L	0.858
8:81694501:A:G	F158L	0.858
8:81694662:A:G	L104P	0.848
8:81694715:A:C	F86L	0.847
8:81694715:A:T	F86L	0.847
8:81694717:A:G	F86L	0.847
8:81693845:A:C	N376K	0.843
8:81693845:A:T	N376K	0.843
8:81693870:A:T	V368D	0.842
8:81693867:G:T	A369D	0.835
8:81694352:A:C	F207L	0.825
8:81694352:A:T	F207L	0.825
8:81694354:A:G	F207L	0.825
8:81694350:C:T	G208E	0.821

dbSNP variants (sampled 300 via entrez): RS1000537153 (8:81693480 C>A,G,T), RS1002013756 (8:81696084 G>A), RS1002554387 (8:81695822 C>A,T), RS1003535014 (8:81696173 G>A,C), RS1005129124 (8:81694855 T>C), RS1006124184 (8:81693319 T>C), RS1007191838 (8:81696818 T>A,G), RS1008047892 (8:81696475 T>C), RS1008678214 (8:81695294 CTTGAAT>C), RS1009323925 (8:81695329 T>A), RS1010655946 (8:81695732 G>A), RS1010711628 (8:81695322 C>T), RS1012026261 (8:81693494 T>G), RS1012999044 (8:81696425 T>A), RS1013028421 (8:81696098 C>T)

Disease associations

OMIM: gene MIM:618582 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST001941_13	Ovarian cancer	6.000000e-09
GCST001941_17	Ovarian cancer	7.000000e-10

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC10 family of sodium-bile acid co-transporters

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases expression, decreases methylation	2
Particulate Matter	increases abundance, increases expression	2
aristolochic acid I	increases expression	1
sotorasib	affects cotreatment, increases expression	1
methyleugenol	decreases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
beta-lapachone	decreases expression	1
sodium arsenite	decreases expression	1
perfluoro-n-nonanoic acid	decreases expression	1
2-palmitoylglycerol	increases expression	1
pinostrobin	increases phosphorylation	1
abrine	decreases expression	1
jinfukang	affects cotreatment, decreases expression	1
trametinib	affects cotreatment, increases expression	1
(+)-JQ1 compound	decreases expression	1
NVP-BKM120	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Arsenic	increases methylation	1
Cisplatin	affects cotreatment, decreases expression	1
Endosulfan	affects cotreatment, decreases expression	1
Tetrachlorodibenzodioxin	affects cotreatment, decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Vanadates	decreases expression	1
Aflatoxin B1	decreases methylation	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.