SLC10A6

Summary

SLC10A6 (solute carrier family 10 member 6, HGNC:30603) is a protein-coding gene on chromosome 4q21.3, encoding Sodium-dependent organic anion transporter (Q3KNW5). Transports sulfoconjugated steroid hormones from the extracellular compartment into the cytosol in a sodium-dependent manner without hydrolysis.

Predicted to enable bile acid:sodium symporter activity. Predicted to be involved in bile acid and bile salt transport. Predicted to be located in plasma membrane.

Source: NCBI Gene 345274 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 56 total
• Druggable target: yes
• MANE Select transcript: NM_197965

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30603
Approved symbol	SLC10A6
Name	solute carrier family 10 member 6
Location	4q21.3
Locus type	gene with protein product
Status	Approved
Aliases	SOAT
Ensembl gene	ENSG00000145283
Ensembl biotype	protein_coding
OMIM	613366
Entrez	345274

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 1 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000273905, ENST00000505535

RefSeq mRNA: 1 — MANE Select: NM_197965 NM_197965

CCDS: CCDS3614

Canonical transcript exons

ENST00000273905 — 6 exons

Exon	Start	End
ENSE00000969767	86827993	86828168
ENSE00001076784	86848739	86849384
ENSE00001150015	86825420	86825577
ENSE00001325051	86823468	86823902
ENSE00003627586	86833306	86833424
ENSE00003666355	86831792	86831880

Expression profiles

Bgee: expression breadth ubiquitous, 109 present calls, max score 82.03.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2199 / max 24.5561, expressed in 92 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
52988	0.0818	50
52985	0.0430	18
52986	0.0395	15
52987	0.0286	14
52984	0.0239	9
52983	0.0030	2

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skin of abdomen	UBERON:0001416	82.03	gold quality
zone of skin	UBERON:0000014	81.50	gold quality
skin of leg	UBERON:0001511	80.91	gold quality
esophagus mucosa	UBERON:0002469	75.59	gold quality
calcaneal tendon	UBERON:0003701	74.62	gold quality
lower esophagus mucosa	UBERON:0035834	73.80	gold quality
subcutaneous adipose tissue	UBERON:0002190	71.79	gold quality
adipose tissue	UBERON:0001013	71.55	gold quality
omental fat pad	UBERON:0010414	70.98	gold quality
vagina	UBERON:0000996	70.04	gold quality
thoracic mammary gland	UBERON:0005200	66.37	gold quality
esophagus	UBERON:0001043	65.98	gold quality
smooth muscle tissue	UBERON:0001135	64.07	gold quality
left testis	UBERON:0004533	63.71	gold quality
testis	UBERON:0000473	62.95	gold quality
ectocervix	UBERON:0012249	62.17	gold quality
skeletal muscle tissue	UBERON:0001134	61.79	gold quality
islet of Langerhans	UBERON:0000006	61.35	gold quality
tibial nerve	UBERON:0001323	61.31	gold quality
right testis	UBERON:0004534	61.19	gold quality
gall bladder	UBERON:0002110	60.82	gold quality
muscle tissue	UBERON:0002385	60.74	gold quality
uterine cervix	UBERON:0000002	60.67	gold quality
gastrocnemius	UBERON:0001388	59.73	gold quality
muscle of leg	UBERON:0001383	59.67	gold quality
tonsil	UBERON:0002372	59.41	gold quality
urinary bladder	UBERON:0001255	58.49	gold quality
hindlimb stylopod muscle	UBERON:0004252	58.00	gold quality
minor salivary gland	UBERON:0001830	57.88	gold quality
saliva-secreting gland	UBERON:0001044	56.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.11

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

11 targeting SLC10A6, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-345-3P	99.89	70.23	1421
HSA-MIR-670-5P	99.67	69.94	1565
HSA-MIR-519D-5P	99.41	69.30	2057
HSA-MIR-361-3P	99.19	66.45	1381
HSA-MIR-181A-2-3P	98.91	67.60	1168
HSA-MIR-3190-5P	98.87	64.89	1345
HSA-MIR-7113-3P	98.75	65.71	1120
HSA-MIR-193A-3P	98.59	66.36	769
HSA-MIR-193B-3P	98.59	66.62	748

Literature-anchored findings (GeneRIF, showing 3)

• SOAT genetic variants L44P, Q75R, P107L, G109S, S112F, N113K, S133F, G241D, G263E, G294R, and Y308N showed no transport activity for dehydroepiandrosterone sulfate at all. In the case of P107L, G241D, G263E, and Y308N, this was most likely due to significantly reduced expression in the plasma membrane. (PMID:28893621)
• SOAT-L204F polymorphism was found in men with normal spermatogenesis and with hypospermatogenesisSOAT-L204F polymorphism showed impaired membrane expression.The SOAT-L204F polymorphism showed reduced transport activity for dehydroepiandrosterone sulfate. (PMID:28951225)
• SOAT substrates from the group of sulfated steroids are characterized by a planar and lipophilic steroid backbone in trans-trans-trans conformation of the rings and a negatively charged mono-sulfate group at positions 3’ or 17’ with flexibility for alpha- or beta- orientation. Furthermore, 5alpha-reduction, 16alpha-hydroxylation, and 17alpha-hydroxylation are acceptable for SOAT substrate recognition, whereas addition … (PMID:28951227)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Slc10a6	ENSMUSG00000029321
rattus_norvegicus	Slc10a6	ENSRNOG00000002057

Paralogs (5): SLC10A1 (ENSG00000100652), SLC10A2 (ENSG00000125255), SLC10A3 (ENSG00000126903), SLC10A4 (ENSG00000145248), SLC10A5 (ENSG00000253598)

Protein

Protein identifiers

Sodium-dependent organic anion transporter — Q3KNW5 (reviewed: Q3KNW5)

Alternative names: Solute carrier family 10 member 6

All UniProt accessions (1): Q3KNW5

UniProt curated annotations — full annotation on UniProt →

Function. Transports sulfoconjugated steroid hormones from the extracellular compartment into the cytosol in a sodium-dependent manner without hydrolysis. Steroid sulfate hormones are commonly considered to be biologically inactive metabolites, that may be activated by steroid sulfatases into free steroids. May play an important role by delivering sulfoconjugated steroids to specific target cells in reproductive organs. May play a role transporting the estriol precursor 16alpha-hydroxydehydroepiandrosterone 3-sulfate (16a-OH-DHEAS) at the fetal blood vessel endothelium. Can also transport other sulfoconjugated molecules such as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes.

Subcellular location. Membrane.

Tissue specificity. Highly expressed in testis, placenta and pancreas. Moderately expressed in heart, lung and mammary gland. Weakly expressed in brain, colon, kidney, liver, ovary, prostate, small intestine, spleen and thymus.

Post-translational modifications. Glycosylated.

Miscellaneous. In humans, 3-beta-sulfooxy-androst-5-en-17-one (DHEAS) is the most abundant circulating steroid sulfate in the human body, it is mainly synthesized from adrenal glands and gonads, whereas rats and mice have low circulating concentrations of DHEAS in the periphery as they can only produce DHEAS in their gonads.

Similarity. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.

RefSeq proteins (1): NP_932069* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002657	BilAc:Na_symport/Acr3	Family
IPR004710	Bilac:Na_transpt	Family
IPR038770	Na+/solute_symporter_sf	Homologous_superfamily

Pfam: PF01758

Catalyzed reactions (Rhea), 12 shown:

• estrone 3-sulfate(out) + 2 Na(+)(out) = estrone 3-sulfate(in) + 2 Na(+)(in) (RHEA:71083)
• 17beta-estradiol 3-sulfate(out) + 2 Na(+)(out) = 17beta-estradiol 3-sulfate(in) + 2 Na(+)(in) (RHEA:71087)
• dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) = dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in) (RHEA:71091)
• pregnenolone sulfate(out) + 2 Na(+)(out) = pregnenolone sulfate(in) + 2 Na(+)(in) (RHEA:71095)
• androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out) = androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in) (RHEA:71099)
• taurolithocholate 3-sulfate(out) + 2 Na(+)(out) = taurolithocholate 3-sulfate(in) + 2 Na(+)(in) (RHEA:71275)
• androsterone 3alpha-sulfate(out) + 2 Na(+)(out) = androsterone 3alpha-sulfate(in) + 2 Na(+)(in) (RHEA:71351)
• 5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out) = 5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in) (RHEA:71355)
• 17beta-estradiol 17-sulfate(out) + 2 Na(+)(out) = 17beta-estradiol 17-sulfate(in) + 2 Na(+)(in) (RHEA:71359)
• 17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out) = 17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in) (RHEA:71363)
• epiandrosterone 3-sulfate(out) + 2 Na(+)(out) = epiandrosterone 3-sulfate(in) + 2 Na(+)(in) (RHEA:71367)
• epitestosterone 17-sulfate(out) + 2 Na(+)(out) = epitestosterone 17-sulfate(in) + 2 Na(+)(in) (RHEA:71371)

UniProt features (24 total): topological domain 10, transmembrane region 9, glycosylation site 2, sequence variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q3KNW5-F1	77.94	0.48

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 4, 157

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-9958517	SLC-mediated bile acid transport
R-HSA-425366
R-HSA-382551	Transport of small molecules
R-HSA-425407	SLC-mediated transmembrane transport

MSigDB gene sets: 75 (showing top): GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GOBP_MONOATOMIC_CATION_TRANSPORT, GOBP_ORGANIC_ACID_TRANSPORT, GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT, GOBP_ORGANIC_ANION_TRANSPORT, GOBP_BILE_ACID_AND_BILE_SALT_TRANSPORT, GOBP_MONOCARBOXYLIC_ACID_TRANSPORT, GOBP_LIPID_LOCALIZATION, GOBP_TRANSMEMBRANE_TRANSPORT, GOBP_SODIUM_ION_TRANSPORT, HAN_JNK_SINGALING_DN, chr4q21, GOMF_LIPID_TRANSPORTER_ACTIVITY, GOMF_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY

GO Biological Process (6): bile acid and bile salt transport (GO:0015721), sodium-dependent organic anion transport (GO:0043251), transmembrane transport (GO:0055085), monoatomic ion transport (GO:0006811), sodium ion transport (GO:0006814), lipid transport (GO:0006869)

GO Molecular Function (4): bile acid:sodium symporter activity (GO:0008508), obsolete sodium-dependent organic anion transmembrane transporter activity (GO:0043250), protein binding (GO:0005515), symporter activity (GO:0015293)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
SLC-mediated transport of organic anions	1
Transport of small molecules	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	3
lipid transport	1
monocarboxylic acid transport	1
organic hydroxy compound transport	1
transmembrane transport	1
cellular process	1
metal ion transport	1
lipid localization	1
organic acid:sodium symporter activity	1
bile acid transmembrane transporter activity	1
secondary active monocarboxylate transmembrane transporter activity	1
binding	1
secondary active transmembrane transporter activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

680 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC10A6	SLC10A7	Q0GE19	738
SLC10A6	SLC22A9	Q8IVM8	491
SLC10A6	B3GNT5	Q9BYG0	489
SLC10A6	SLC22A11	Q9NSA0	465
SLC10A6	STS	P08842	441
SLC10A6	SLCO2B1	O94956	418
SLC10A6	EMP1	P54849	412
SLC10A6	TM4SF1	P30408	401
SLC10A6	AMIGO2	Q86SJ2	383
SLC10A6	SLCO4A1	Q96BD0	379
SLC10A6	CLCF1	Q9UBD9	376
SLC10A6	SLCO1A2	P46721	368
SLC10A6	SLCO3A1	Q9UIG8	364
SLC10A6	SLC51B	Q86UW2	353
SLC10A6	SLCO1C1	Q9NYB5	349

IntAct

443 interactions, top by confidence:

A	B	Type	Score
MS4A1	SLC10A6	psi-mi:“MI:0915”(physical association)	0.560
PEX16	SLC10A6	psi-mi:“MI:0915”(physical association)	0.560
SFT2D2	SLC10A6	psi-mi:“MI:0915”(physical association)	0.560
TREX1	SLC10A6	psi-mi:“MI:0915”(physical association)	0.560
CYB5R3	SLC10A6	psi-mi:“MI:0915”(physical association)	0.560
SNORC	SLC10A6	psi-mi:“MI:0915”(physical association)	0.560
HTATIP2	SLC10A6	psi-mi:“MI:0915”(physical association)	0.560
SYNGR1	SLC10A6	psi-mi:“MI:0915”(physical association)	0.560
TMEM14C	SLC10A6	psi-mi:“MI:0915”(physical association)	0.560
TSPAN2	SLC10A6	psi-mi:“MI:0915”(physical association)	0.560
SLC10A6	GPT2	psi-mi:“MI:0915”(physical association)	0.400
TMEM242	SLC10A6	psi-mi:“MI:0915”(physical association)	0.000
TMEM50B	SLC10A6	psi-mi:“MI:0915”(physical association)	0.000
GLB1	SLC10A6	psi-mi:“MI:0915”(physical association)	0.000
	SLC10A6	psi-mi:“MI:0915”(physical association)	0.000
SLC30A3	SLC10A6	psi-mi:“MI:0915”(physical association)	0.000
OSMR	SLC10A6	psi-mi:“MI:0915”(physical association)	0.000
TMEM234	SLC10A6	psi-mi:“MI:0915”(physical association)	0.000
GJB6	SLC10A6	psi-mi:“MI:0915”(physical association)	0.000
TMEM60	SLC10A6	psi-mi:“MI:0915”(physical association)	0.000
ITGAM	SLC10A6	psi-mi:“MI:0915”(physical association)	0.000
SLC7A1	SLC10A6	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (189): SLC10A6 (Two-hybrid), SLC10A6 (Two-hybrid), SLC10A6 (Two-hybrid), SLC10A6 (Two-hybrid), SLC10A6 (Two-hybrid), SLC10A6 (Two-hybrid), SLC10A6 (Two-hybrid), SLC10A6 (Two-hybrid), SLC10A6 (Two-hybrid), SLC10A6 (Two-hybrid), SLC10A6 (Two-hybrid), SLC10A6 (Two-hybrid), SLC10A6 (Two-hybrid), SLC10A6 (Two-hybrid), SLC10A6 (Two-hybrid)

ESM2 similar proteins: A0AV02, A2AWR3, A2VCW5, A4QN56, A6QP84, B2RXV4, D4A7H1, F7B113, G8XYX6, O08705, O70324, P09131, P19634, P21129, P23791, P26431, P26434, P26435, P36021, P48761, P48762, P97751, Q0V8N6, Q14973, Q28036, Q3KNW5, Q3UEZ8, Q4JLT5, Q5PT54, Q5PT56, Q5R9A7, Q61165, Q70EX6, Q71RS6, Q7Z3F1, Q8BFW9, Q8BLV3, Q8BUE1, Q8BZ00, Q8C261

Diamond homologs: A6QP84, O08705, P09131, P26435, P70172, Q12908, Q14973, Q28727, Q3KNW5, Q3UEZ8, Q4JLT5, Q5PT55, Q5PT56, Q60414, Q62633, Q70EX6, Q7XVB3, Q96EP9, Q9CXB2, P21129, Q0V8N6, Q93YR2, B8BDK4, F4JPW1, O34524, Q1EBV7, Q5VRB2, Q650U0, Q6K739, Q8VYY4, Q8ZKL0, Q5PT54, Q8RXE8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

56 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	48
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

849 predictions. Top by Δscore:

Variant	Effect	Δscore
4:86823901:TG:T	acceptor_gain	1.0000
4:86823903:C:CC	acceptor_gain	1.0000
4:86831787:CTCA:C	donor_loss	1.0000
4:86831788:TCACC:T	donor_loss	1.0000
4:86831789:CAC:C	donor_loss	1.0000
4:86831790:A:C	donor_loss	1.0000
4:86831791:C:CA	donor_loss	1.0000
4:86831878:TTC:T	acceptor_gain	1.0000
4:86831879:TCC:T	acceptor_loss	1.0000
4:86831881:CTAAA:C	acceptor_loss	1.0000
4:86831882:T:C	acceptor_loss	1.0000
4:86833346:CCAGG:C	donor_gain	1.0000
4:86833425:C:CC	acceptor_gain	1.0000
4:86823898:ATATG:A	acceptor_gain	0.9900
4:86823899:TATG:T	acceptor_gain	0.9900
4:86823900:ATG:A	acceptor_gain	0.9900
4:86823907:G:C	acceptor_gain	0.9900
4:86823907:G:GC	acceptor_gain	0.9900
4:86823910:T:C	acceptor_gain	0.9900
4:86825415:CCCA:C	donor_loss	0.9900
4:86825416:CCAC:C	donor_loss	0.9900
4:86825417:CACC:C	donor_loss	0.9900
4:86825419:C:G	donor_loss	0.9900
4:86825576:ACCTA:A	acceptor_loss	0.9900
4:86825578:CTAC:C	acceptor_loss	0.9900
4:86825582:C:CT	acceptor_gain	0.9900
4:86825697:ATT:A	donor_gain	0.9900
4:86831786:ACTC:A	donor_loss	0.9900
4:86831881:C:CC	acceptor_gain	0.9900
4:86833302:AGAC:A	donor_loss	0.9900

AlphaMissense

2457 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:86825541:A:C	N266K	0.988
4:86825541:A:T	N266K	0.988
4:86828064:A:C	S230R	0.986
4:86828064:A:T	S230R	0.986
4:86828066:T:G	S230R	0.986
4:86848806:C:G	G104R	0.985
4:86828020:G:T	A245E	0.983
4:86848742:A:G	L125P	0.981
4:86831841:C:T	G179D	0.980
4:86848888:A:C	F76L	0.980
4:86848888:A:T	F76L	0.980
4:86848890:A:G	F76L	0.980
4:86833418:A:C	S128R	0.979
4:86833418:A:T	S128R	0.979
4:86833420:T:G	S128R	0.979
4:86848896:A:G	C74R	0.979
4:86828032:C:T	G241D	0.978
4:86828044:C:T	G237D	0.978
4:86848800:A:G	C106R	0.978
4:86833408:A:G	C132R	0.977
4:86848781:G:A	S112F	0.976
4:86833392:G:T	A137D	0.975
4:86848798:G:C	C106W	0.974
4:86848803:A:G	C105R	0.974
4:86848781:G:T	S112Y	0.972
4:86848805:C:T	G104D	0.970
4:86825531:A:G	C270R	0.968
4:86848754:C:T	G121E	0.968
4:86828033:C:G	G241R	0.967
4:86848868:G:T	A83D	0.967

dbSNP variants (sampled 300 via entrez): RS1000077124 (4:86836617 C>T), RS1000147274 (4:86835212 T>C), RS1000178970 (4:86834892 G>A), RS1000449434 (4:86836933 T>C,G), RS1000716360 (4:86830033 C>T), RS1000775773 (4:86842875 T>A,C), RS1000785760 (4:86828103 T>C,G), RS1000837797 (4:86849621 A>G), RS1000881301 (4:86844830 A>T), RS1000909822 (4:86824719 G>A,T), RS1000995492 (4:86844082 G>A), RS1001022835 (4:86831488 G>A,C), RS1001086612 (4:86830416 T>A), RS1001183535 (4:86833331 A>G), RS1001299993 (4:86840306 ACTT>A)

Disease associations

OMIM: gene MIM:613366 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST001604_1	Insulin-related traits	8.000000e-06
GCST003476_4	Eyebrow thickness	2.000000e-06
GCST010002_10	Refractive error	7.000000e-12

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6196094 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC10 family of sodium-bile acid co-transporters

ChEMBL bioactivities

19 potent at pChembl≥5 of 44 total, top 19 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
6.22	IC50	600	nM	CHEMBL6150871
6.10	IC50	800	nM	CHEMBL1904920
6.05	IC50	900	nM	CHEMBL6149027
5.89	IC50	1300	nM	CHEMBL6144592
5.85	IC50	1400	nM	CHEMBL6144675
5.80	IC50	1600	nM	CHEMBL6134703
5.72	IC50	1900	nM	CHEMBL6161671
5.62	IC50	2400	nM	CHEMBL6120337
5.58	IC50	2600	nM	CHEMBL6133507
5.46	IC50	3500	nM	CHEMBL6146969
5.41	IC50	3900	nM	CHEMBL6133103
5.40	IC50	4000	nM	CHEMBL1885381
5.36	IC50	4400	nM	CHEMBL6160813
5.31	IC50	4900	nM	CHEMBL6169185
5.26	IC50	5500	nM	CHEMBL6168688
5.20	IC50	6300	nM	CHEMBL6161134
5.19	IC50	6400	nM	CHEMBL6151090
5.15	IC50	7100	nM	CHEMBL1631661
5.08	IC50	8300	nM	CHEMBL6152191

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
estrone sulfate	increases response to substance, increases uptake, increases reaction, decreases reaction, increases transport	3
Sodium	increases reaction, decreases reaction, increases uptake	2
betulin	affects reaction, increases uptake, decreases reaction	1
daidzein	increases transport, decreases reaction	1
arsenite	increases expression	1
sodium arsenite	increases expression	1
pregnenolone sulfate	increases uptake, decreases reaction	1
methylarsine oxide	increases expression	1
CGP 52608	affects binding, increases reaction	1
lupenone	affects reaction, increases uptake	1
theaflavin-3,3’-digallate	affects expression	1
Troglitazone	decreases reaction, increases uptake	1
Irbesartan	decreases reaction, increases uptake	1
Betulinic Acid	affects reaction, increases uptake, decreases reaction	1
Arsenicals	increases expression	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Erythrosine	decreases reaction, increases uptake	1
Sulfobromophthalein	decreases reaction, increases uptake	1
Taurocholic Acid	affects reaction, increases uptake	1
Taurolithocholic Acid	affects reaction, increases uptake, decreases reaction	1
Tobacco Smoke Pollution	increases expression	1
Cyclosporine	decreases reaction, increases uptake	1
Aflatoxin B1	decreases methylation	1
Dehydroepiandrosterone Sulfate	affects reaction, increases uptake, decreases reaction	1
Losartan	decreases reaction, increases uptake	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL6094301	Binding	Inhibition of C-terminal GFP-fused human SOAT transfected in Flp-In-T-REx-HEK293 cells assessed as inhibition of [3H]DHEAS transport preincubated for 5 mins followed by [3H]DHEAS addition and measured after 10 mins by liquid scintillation c	Structure-Activity Relationships and Target Selectivity of Phenylsulfonylamino-Benzanilide Inhibitors Based on S1647 at the SLC10 Carriers ASBT, NTCP, and SOAT. — J Med Chem

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4V6	LS180-SLC10A6-KO-c3	Cancer cell line	Female
CVCL_D4V7	LS180-SLC10A6-KO-c8	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.