SLC12A8

Summary

SLC12A8 (solute carrier family 12 member 8, HGNC:15595) is a protein-coding gene on chromosome 3q21.2, encoding Solute carrier family 12 member 8 (A0AV02). Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation.

This gene is thought to be a candidate for psoriasis susceptibility. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Source: NCBI Gene 84561 — RefSeq curated summary.

At a glance

• GWAS associations: 17
• Clinical variants (ClinVar): 160 total
• MANE Select transcript: NM_024628

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15595
Approved symbol	SLC12A8
Name	solute carrier family 12 member 8
Location	3q21.2
Locus type	gene with protein product
Status	Approved
Aliases	CCC9
Ensembl gene	ENSG00000221955
Ensembl biotype	protein_coding
OMIM	611316
Entrez	84561

Gene structure

Transcript identifiers

Ensembl transcripts: 32 — 21 protein_coding, 8 protein_coding_CDS_not_defined, 2 retained_intron, 1 nonsense_mediated_decay

ENST00000393469, ENST00000430155, ENST00000461616, ENST00000462437, ENST00000465475, ENST00000465777, ENST00000469902, ENST00000473262, ENST00000479231, ENST00000479352, ENST00000479826, ENST00000481760, ENST00000483944, ENST00000485849, ENST00000485954, ENST00000495105, ENST00000895735, ENST00000895736, ENST00000895737, ENST00000895738, ENST00000895739, ENST00000895740, ENST00000931086, ENST00000931087, ENST00000931088, ENST00000931089, ENST00000931090, ENST00000931091, ENST00000931092, ENST00000931093, ENST00000931094, ENST00000931095

RefSeq mRNA: 2 — MANE Select: NM_024628 NM_001195483, NM_024628

CCDS: CCDS43143

Canonical transcript exons

ENST00000469902 — 14 exons

Exon	Start	End
ENSE00001515423	125212700	125212748
ENSE00001903729	125082644	125084052
ENSE00003499982	125135669	125135782
ENSE00003525270	125190375	125190521
ENSE00003545186	125092101	125092198
ENSE00003546662	125211299	125211394
ENSE00003549557	125177743	125177974
ENSE00003554076	125107481	125108126
ENSE00003555054	125118769	125118856
ENSE00003558175	125088310	125088370
ENSE00003577119	125120599	125120686
ENSE00003609659	125110189	125110335
ENSE00003617424	125091439	125091556
ENSE00003633999	125187237	125187428

Expression profiles

Bgee: expression breadth ubiquitous, 218 present calls, max score 92.60.

FANTOM5 (CAGE): breadth broad, TPM avg 2.6079 / max 131.6791, expressed in 604 samples.

FANTOM5 promoters (12 alternative TSS)

Promoter ID	TPM avg	Samples expressed
44288	1.0019	299
44290	0.5983	182
44287	0.3816	156
44289	0.2531	141
44276	0.0960	20
44286	0.0650	29
44285	0.0513	20
44277	0.0500	17
44284	0.0426	23
44278	0.0326	6

Top tissues by expression

280 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of thyroid gland	UBERON:0001119	92.60	gold quality
thyroid gland	UBERON:0002046	91.31	gold quality
left lobe of thyroid gland	UBERON:0001120	91.24	gold quality
oocyte	CL:0000023	88.35	gold quality
parotid gland	UBERON:0001831	88.02	gold quality
periodontal ligament	UBERON:0008266	86.92	gold quality
gall bladder	UBERON:0002110	86.41	gold quality
decidua	UBERON:0002450	86.02	gold quality
secondary oocyte	CL:0000655	84.28	gold quality
body of pancreas	UBERON:0001150	83.11	gold quality
saliva-secreting gland	UBERON:0001044	81.24	gold quality
pancreatic ductal cell	CL:0002079	81.02	silver quality
pancreas	UBERON:0001264	80.58	gold quality
endothelial cell	CL:0000115	80.26	silver quality
minor salivary gland	UBERON:0001830	80.18	gold quality
choroid plexus epithelium	UBERON:0003911	80.13	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.72	silver quality
mouth mucosa	UBERON:0003729	79.56	gold quality
gingival epithelium	UBERON:0001949	79.38	gold quality
gingiva	UBERON:0001828	78.30	gold quality
rectum	UBERON:0001052	78.20	gold quality
islet of Langerhans	UBERON:0000006	77.70	gold quality
middle temporal gyrus	UBERON:0002771	77.59	gold quality
buccal mucosa cell	CL:0002336	77.53	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.44	gold quality
palpebral conjunctiva	UBERON:0001812	77.40	gold quality
right lobe of liver	UBERON:0001114	76.96	gold quality
cervix squamous epithelium	UBERON:0006922	76.83	gold quality
Brodmann (1909) area 23	UBERON:0013554	75.93	gold quality
stromal cell of endometrium	CL:0002255	74.74	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-7249	yes	300.87
E-ANND-3	yes	6.27

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

76 targeting SLC12A8, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-3163	100.00	77.23	8605
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-6772-5P	99.94	67.01	577
HSA-MIR-10523-5P	99.91	69.22	2038
HSA-MIR-219A-5P	99.91	73.36	735
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-4782-3P	99.88	73.31	735
HSA-MIR-6766-3P	99.88	73.38	732
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-5010-3P	99.83	70.60	2357
HSA-MIR-609	99.82	64.26	505
HSA-MIR-374C-5P	99.80	72.06	2910
HSA-MIR-655-3P	99.80	72.19	2909

Literature-anchored findings (GeneRIF, showing 7)

• Maps to 3q21. Associated with suseptibility to psoriasis (PMID:11863360)
• SLC12A8 is a susceptibility locus for psoriasis vulgaris. (PMID:16297188)
• Molecular characterization of a human cation-Cl- cotransporter (SLC12A8A, CCC9A) that promotes polyamine and amino acid transport. (PMID:19472210)
• Review summarizes three human disorders that have been linked to the mutation/dysfunction of Na-Cl, Na-K-2Cl, and K-Cl cotransporters (Bartter’s, Gitleman’s, and Andermann’s syndromes). (PMID:23325410)
• Solute carrier family 12 member 8 (SLC12A8) is a potential biomarker and related to tumor immune cell infiltration in bladder cancer. (PMID:34365894)
• SLC12A8 mediates TKI resistance in EGFR-mutant lung cancer via PDK1/AKT axis. (PMID:37725242)
• [SLC12A8 promotes proliferation, invasiveness, migration and epithelial-mesenchymal transition of bladder cancer cells by activating JAK/STAT singaling]. (PMID:37814877)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc12a8	ENSDARG00000074384
mus_musculus	Slc12a8	ENSMUSG00000035506
rattus_norvegicus	Slc12a8	ENSRNOG00000001792
drosophila_melanogaster	CG12773	FBGN0024365
caenorhabditis_elegans		WBGENE00017350

Paralogs (8): SLC12A2 (ENSG00000064651), SLC12A3 (ENSG00000070915), SLC12A1 (ENSG00000074803), SLC12A7 (ENSG00000113504), SLC12A4 (ENSG00000124067), SLC12A5 (ENSG00000124140), SLC12A6 (ENSG00000140199), SLC12A9 (ENSG00000146828)

Protein

Protein identifiers

Solute carrier family 12 member 8 — A0AV02 (reviewed: A0AV02)

Alternative names: Cation-chloride cotransporter 9

All UniProt accessions (4): A0AV02, C9IZN2, H7C5B1, H7C5L2

UniProt curated annotations — full annotation on UniProt →

Function. Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation.

Subcellular location. Membrane.

Tissue specificity. Ubiquitous with very low level in normal skin.

Disease relevance. SLC12A8 has been identified as a possible susceptibility gene for psoriasis mapped to chromosome 3q21 (PSORS5).

Similarity. Belongs to the SLC12A transporter family.

Isoforms (5)

UniProt ID	Names	Canonical?
A0AV02-1	1	yes
A0AV02-2	2
A0AV02-3	3
A0AV02-4	4
A0AV02-5	5

RefSeq proteins (2): NP_001182412, NP_078904* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004841	AA-permease/SLC12A_dom	Domain
IPR004842	SLC12A_fam	Family

Pfam: PF00324

UniProt features (36 total): transmembrane region 13, sequence conflict 7, splice variant 6, sequence variant 5, region of interest 2, chain 1, compositionally biased region 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0AV02-F1	68.50	0.22

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 221

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 173 (showing top): GOBP_POTASSIUM_ION_TRANSPORT, GOBP_POTASSIUM_ION_HOMEOSTASIS, GOBP_INORGANIC_ANION_TRANSPORT, CAGCTG_AP4_Q5, GGCNKCCATNK_UNKNOWN, BOHN_PRIMARY_IMMUNODEFICIENCY_SYNDROM_DN, GOBP_MONOATOMIC_CATION_TRANSPORT, GOBP_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE, GOBP_CHLORIDE_TRANSPORT, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP, RIGGI_EWING_SARCOMA_PROGENITOR_DN, GOBP_MONOATOMIC_ANION_HOMEOSTASIS, GOBP_REGULATION_OF_CELL_SIZE, HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP, GOBP_MONOATOMIC_ION_HOMEOSTASIS

GO Biological Process (8): cell volume homeostasis (GO:0006884), chloride ion homeostasis (GO:0055064), potassium ion homeostasis (GO:0055075), chloride transmembrane transport (GO:1902476), potassium ion import across plasma membrane (GO:1990573), monoatomic ion transport (GO:0006811), potassium ion transport (GO:0006813), transmembrane transport (GO:0055085)

GO Molecular Function (4): potassium:chloride symporter activity (GO:0015379), protein binding (GO:0005515), symporter activity (GO:0015293), chloride:monoatomic cation symporter activity (GO:0015377)

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
inorganic ion homeostasis	2
transport	2
regulation of cell size	1
cellular homeostasis	1
monoatomic anion homeostasis	1
monoatomic cation homeostasis	1
chloride transport	1
monoatomic anion transmembrane transport	1
potassium ion transmembrane transport	1
inorganic cation import across plasma membrane	1
metal ion transport	1
cellular process	1
potassium ion transmembrane transporter activity	1
chloride:monoatomic cation symporter activity	1
binding	1
secondary active transmembrane transporter activity	1
chloride transmembrane transporter activity	1
monoatomic anion:monoatomic cation symporter activity	1
cellular anatomical structure	1

Protein interactions and networks

STRING

860 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC12A8	CSTA	P01040	958
SLC12A8	NMRK1	Q9NWW6	614
SLC12A8	BST1	Q10588	605
SLC12A8	NMNAT1	Q9HAN9	594
SLC12A8	A0A2R8YFG2	A0A2R8YFG2	564
SLC12A8	NAPRT	Q6XQN6	504
SLC12A8	MTFR1L	Q9H019	486
SLC12A8	NAMPT	P43490	461
SLC12A8	TATDN2	Q93075	440
SLC12A8	SLC25A51	Q9H1U9	422
SLC12A8	CD38	P28907	413
SLC12A8	SLC26A9	Q7LBE3	378
SLC12A8	NMNAT2	Q9BZQ4	377
SLC12A8	FBXL19	Q6PCT2	372
SLC12A8	MUC13	Q9H3R2	357

IntAct

12 interactions, top by confidence:

A	B	Type	Score
SLC12A8	PAX6	psi-mi:“MI:0915”(physical association)	0.560
SLC12A8	SLC27A3	psi-mi:“MI:0915”(physical association)	0.400
SLC12A8	E6	psi-mi:“MI:0915”(physical association)	0.370
CRY1	IGKV2D-30	psi-mi:“MI:0914”(association)	0.350
SLC12A8	NGEF	psi-mi:“MI:0914”(association)	0.350
C5AR1	SLC12A8	psi-mi:“MI:0914”(association)	0.350
FFAR1	SLC12A8	psi-mi:“MI:0914”(association)	0.350
GPR182	SLC12A8	psi-mi:“MI:0914”(association)	0.350
SLC12A8	ATE1	psi-mi:“MI:0914”(association)	0.350
SLC12A8	PAX6	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (20): NGEF (Affinity Capture-MS), SLC12A8 (Two-hybrid), SLC12A8 (Two-hybrid), NGEF (Affinity Capture-MS), EPS8L2 (Affinity Capture-MS), SLC12A8 (Affinity Capture-MS), SLC27A3 (Affinity Capture-MS), SLC12A8 (Affinity Capture-MS), SLC12A8 (Affinity Capture-MS), SLC12A8 (Affinity Capture-MS), ACAA2 (Affinity Capture-MS), ANKRD27 (Affinity Capture-MS), ATE1 (Affinity Capture-MS), RFWD2 (Affinity Capture-MS), CPT1A (Affinity Capture-MS)

ESM2 similar proteins: A0A0G2K1Q8, A0AV02, A2A6C4, A5D7L5, A6QNW6, B1MTL0, B2RXE2, C1BKZ7, O18917, P04920, P0DX17, P13808, P16283, P23347, P23348, P35523, P35524, P48746, P48751, P58295, Q0P5V9, Q14940, Q15043, Q15477, Q3MJ16, Q504Y0, Q50L42, Q5FWH7, Q5RB85, Q5RD44, Q64347, Q6A4L1, Q6SJP2, Q761V0, Q8BXR1, Q8CJI3, Q8K0H7, Q8R420, Q8VI23, Q91WD2

Diamond homologs: A0A0G2KTI4, A0AV02, A2BFP5, P38329, P55011, P55012, P55013, P55014, P55015, P55016, P55017, P55018, P55019, P59158, Q13621, Q25479, Q6A4L1, Q8CJI3, Q8VI23, Q9BXP2, O60146, Q2UVJ5, Q657W3, Q66HR0, Q99MR3, Q0VGW6, Q28677, Q5RK27, Q63632, Q63633, Q6Z0E2, Q7YRU6, Q91V14, Q924N4, Q9H2X9, Q9JIS8, Q9UHW9, Q9UP95, Q9WVL3, Q9Y666

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

160 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	121
Likely benign	8
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2627 predictions. Top by Δscore:

Variant	Effect	Δscore
3:125084048:AGCTC:A	acceptor_gain	1.0000
3:125084050:CTC:C	acceptor_gain	1.0000
3:125084051:TC:T	acceptor_gain	1.0000
3:125084052:CC:C	acceptor_gain	1.0000
3:125091437:A:AC	donor_gain	1.0000
3:125091438:C:CC	donor_gain	1.0000
3:125092300:AG:A	donor_gain	1.0000
3:125107476:CTCA:C	donor_loss	1.0000
3:125107477:TCA:T	donor_loss	1.0000
3:125107478:CA:C	donor_loss	1.0000
3:125107479:A:AC	donor_gain	1.0000
3:125107479:A:AT	donor_loss	1.0000
3:125107480:C:CC	donor_gain	1.0000
3:125107480:CCTT:C	donor_gain	1.0000
3:125108122:CCCTT:C	acceptor_gain	1.0000
3:125108123:CCTTC:C	acceptor_gain	1.0000
3:125110183:ACTC:A	donor_loss	1.0000
3:125110185:TCAC:T	donor_loss	1.0000
3:125110186:CACCC:C	donor_loss	1.0000
3:125110187:A:C	donor_loss	1.0000
3:125110187:AC:A	donor_gain	1.0000
3:125110187:ACC:A	donor_gain	1.0000
3:125110187:ACCC:A	donor_gain	1.0000
3:125110188:CC:C	donor_gain	1.0000
3:125110188:CCC:C	donor_gain	1.0000
3:125110188:CCCC:C	donor_gain	1.0000
3:125110306:C:CT	acceptor_gain	1.0000
3:125110306:C:T	acceptor_gain	1.0000
3:125118765:TCA:T	donor_loss	1.0000
3:125118766:CA:C	donor_loss	1.0000

AlphaMissense

4633 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:125120611:G:T	A271D	0.997
3:125120686:C:T	G246E	0.997
3:125135669:C:G	G246R	0.997
3:125135669:C:T	G246R	0.997
3:125110305:C:G	G315R	0.996
3:125190391:C:G	R61T	0.996
3:125190409:C:T	G55E	0.996
3:125190426:G:C	C49W	0.996
3:125108013:G:C	F391L	0.995
3:125108013:G:T	F391L	0.995
3:125108015:A:G	F391L	0.995
3:125108082:G:C	S368R	0.995
3:125108082:G:T	S368R	0.995
3:125108084:T:G	S368R	0.995
3:125190396:G:C	F59L	0.995
3:125190396:G:T	F59L	0.995
3:125190398:A:G	F59L	0.995
3:125190410:C:G	G55R	0.995
3:125190410:C:T	G55R	0.995
3:125110244:A:G	L335P	0.994
3:125110304:C:T	G315D	0.994
3:125120623:C:T	G267D	0.994
3:125135674:G:T	A244D	0.994
3:125190390:C:A	R61S	0.994
3:125190390:C:G	R61S	0.994
3:125190391:C:A	R61M	0.994
3:125190394:A:G	L60P	0.994
3:125190442:C:T	G44D	0.994
3:125120624:C:G	G267R	0.993
3:125120674:C:T	G250D	0.993

dbSNP variants (sampled 300 via entrez): RS1000002896 (3:125212560 T>TGA), RS1000008649 (3:125158146 G>A,T), RS1000020004 (3:125116182 C>A,G), RS1000021584 (3:125203151 A>G), RS1000022434 (3:125130003 G>T), RS1000035613 (3:125168589 G>A), RS1000078921 (3:125197048 A>C), RS1000082992 (3:125204443 C>A), RS1000124624 (3:125182693 G>A,C), RS1000143584 (3:125117506 G>A,T), RS1000149506 (3:125124760 G>A,C), RS1000155635 (3:125182911 C>T), RS1000208662 (3:125181266 C>T), RS1000251460 (3:125141560 G>A,T), RS1000254913 (3:125167515 G>A)

Disease associations

OMIM: gene MIM:611316 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

17 associations (top):

Study	Trait	p-value
GCST002930_18	Cobalt levels	8.000000e-06
GCST003995_16	Tonsillectomy	3.000000e-11
GCST005014_117	Tonsillectomy	3.000000e-11
GCST008144_2	Fasting plasma glucose	8.000000e-06
GCST009379_258	Type 2 diabetes	1.000000e-09
GCST010118_26	Type 2 diabetes	1.000000e-08
GCST010699_74	Brain morphology (min-P)	2.000000e-18
GCST010701_2	Cortical surface area (MOSTest)	1.000000e-08
GCST010702_122	Subcortical volume (MOSTest)	3.000000e-09
GCST010703_283	Brain morphology (MOSTest)	3.000000e-15
GCST90002385_436	High light scatter reticulocyte count	2.000000e-12
GCST90002386_559	High light scatter reticulocyte percentage of red cells	6.000000e-12
GCST90002397_661	Mean spheric corpuscular volume	6.000000e-16
GCST90002405_24	Reticulocyte count	2.000000e-13
GCST90002406_44	Reticulocyte fraction of red cells	2.000000e-12
GCST90011898_149	Alanine aminotransferase levels	5.000000e-09
GCST90026413_15	Severe insulin-deficient type 2 diabetes	2.000000e-06

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007924	tonsillectomy risk measurement
EFO:0004346	neuroimaging measurement
EFO:0007986	reticulocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB clinical annotations

1 annotations.

Variant	Type	Level	Drugs	Phenotypes
rs651630	Toxicity	3	Tumor necrosis factor alpha (TNF-alpha) inhibitors	Psoriasis

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs651630	SLC12A8	3	2.50	1	Tumor necrosis factor alpha (TNF-alpha) inhibitors

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC12 family of cation-coupled chloride transporters

CTD chemical–gene interactions

44 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression, increases expression	4
bisphenol A	affects cotreatment, decreases methylation, increases expression	2
sodium arsenite	increases expression	2
Benzo(a)pyrene	affects methylation, decreases expression, decreases methylation	2
Cisplatin	affects cotreatment, increases expression, decreases expression	2
Estradiol	decreases expression, increases expression	2
Cadmium Chloride	increases expression, increases abundance	2
aristolochic acid I	decreases expression	1
GSK-J4	decreases expression	1
FR900359	increases phosphorylation	1
chloroacetaldehyde	affects expression	1
lead acetate	increases expression	1
sulforaphane	increases expression	1
manganese chloride	increases abundance, increases expression	1
potassium chromate(VI)	increases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, decreases expression	1
chromium hexavalent ion	affects expression	1
CGP 52608	affects binding, increases reaction	1
entinostat	increases expression	1
2,2’,4,4’,5-brominated diphenyl ether	increases expression	1
ICG 001	increases expression	1
abrine	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
(+)-JQ1 compound	decreases expression	1
Temozolomide	decreases expression	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Cidofovir	affects expression	1
Acetaminophen	decreases expression	1
Cadmium	increases abundance, increases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4HS	HCT116-SLC12A8-KO-c4	Cancer cell line	Male
CVCL_D4HT	HCT116-SLC12A8-KO-c5	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.