SLC13A2

Summary

SLC13A2 (solute carrier family 13 member 2, HGNC:10917) is a protein-coding gene on chromosome 17q11.2, encoding Solute carrier family 13 member 2 (Q13183). Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule.

The protein encoded by this gene is a sodium-coupled citrate transporter that is regulated by the chaperone activity of cyclophilin b. The encoded protein may play a role in the formation of kidney stones.

Source: NCBI Gene 9058 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 92 total
• Druggable target: yes
• MANE Select transcript: NM_003984

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10917
Approved symbol	SLC13A2
Name	solute carrier family 13 member 2
Location	17q11.2
Locus type	gene with protein product
Status	Approved
Aliases	NaDC-1
Ensembl gene	ENSG00000007216
Ensembl biotype	protein_coding
OMIM	604148
Entrez	9058

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 9 protein_coding, 2 retained_intron, 1 nonsense_mediated_decay

ENST00000314669, ENST00000444914, ENST00000459818, ENST00000541739, ENST00000577903, ENST00000579281, ENST00000855215, ENST00000855216, ENST00000855217, ENST00000855218, ENST00000855219, ENST00000956184

RefSeq mRNA: 4 — MANE Select: NM_003984 NM_001145975, NM_001346683, NM_001346684, NM_003984

CCDS: CCDS11231, CCDS54098, CCDS92282

Canonical transcript exons

ENST00000314669 — 12 exons

Exon	Start	End
ENSE00000000258	28473644	28473814
ENSE00001945006	28497099	28497781
ENSE00003472809	28490454	28490590
ENSE00003512120	28490701	28490906
ENSE00003517668	28494391	28494512
ENSE00003541012	28496450	28496587
ENSE00003573228	28495655	28495816
ENSE00003593222	28491437	28491617
ENSE00003598661	28493571	28493789
ENSE00003603081	28494017	28494105
ENSE00003623178	28489214	28489342
ENSE00003653359	28491730	28491852

Expression profiles

Bgee: expression breadth broad, 94 present calls, max score 97.39.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.8771 / max 1358.1857, expressed in 60 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
160030	1.7904	57
160031	0.0372	14
160029	0.0245	12
160028	0.0172	5
160033	0.0077	2

Top tissues by expression

266 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
jejunal mucosa	UBERON:0000399	97.39	gold quality
duodenum	UBERON:0002114	95.11	gold quality
small intestine Peyer’s patch	UBERON:0003454	87.08	gold quality
small intestine	UBERON:0002108	86.55	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.13	gold quality
adult mammalian kidney	UBERON:0000082	84.42	gold quality
buccal mucosa cell	CL:0002336	82.32	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	82.21	gold quality
adult organism	UBERON:0007023	82.14	gold quality
saliva-secreting gland	UBERON:0001044	81.45	gold quality
minor salivary gland	UBERON:0001830	80.96	gold quality
mammary duct	UBERON:0001765	80.82	gold quality
ileal mucosa	UBERON:0000331	79.09	gold quality
mucosa of transverse colon	UBERON:0004991	78.75	gold quality
mucosa of sigmoid colon	UBERON:0004993	78.52	gold quality
parotid gland	UBERON:0001831	78.14	gold quality
colonic mucosa	UBERON:0000317	77.96	gold quality
epithelium of mammary gland	UBERON:0003244	77.88	gold quality
gall bladder	UBERON:0002110	77.61	gold quality
kidney	UBERON:0002113	76.61	gold quality
rectum	UBERON:0001052	76.49	gold quality
mouth mucosa	UBERON:0003729	76.26	gold quality
jejunum	UBERON:0002115	76.15	gold quality
triceps brachii	UBERON:0001509	75.85	gold quality
nasal cavity mucosa	UBERON:0001826	74.97	gold quality
trachea	UBERON:0003126	74.63	gold quality
seminal vesicle	UBERON:0000998	74.32	gold quality
gluteal muscle	UBERON:0002000	73.16	gold quality
mucosa of paranasal sinus	UBERON:0005030	71.86	silver quality
mammary gland	UBERON:0001911	71.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.49

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CTCF, FOXA1, TFAP2A

miRNA regulators (miRDB)

17 targeting SLC13A2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-4745-5P	99.98	65.95	1028
HSA-MIR-8087	99.90	69.55	1351
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-4496	99.88	68.89	2236
HSA-MIR-7161-5P	99.68	68.92	1592
HSA-MIR-548U	99.65	67.78	1463
HSA-MIR-4293	99.22	65.46	1263
HSA-MIR-8066	99.05	68.66	1532
HSA-MIR-3164	99.02	68.39	1071
HSA-MIR-6820-3P	99.02	68.50	1035
HSA-MIR-939-3P	98.97	65.07	2347
HSA-MIR-432-5P	98.00	68.13	989
HSA-MIR-6856-3P	96.47	66.27	781
HSA-MIR-6874-5P	95.73	64.94	545

Literature-anchored findings (GeneRIF, showing 13)

• This paper describes the cloning and functional characterization of the human Na(+)-coupled citrate transporter (NaCT). (PMID:12445824)
• Data show that the sodium-dependent dicarboxylate co-transporter protein 1 is located in renal proximal tubule lumenal membranes, and that the C-terminal sequence is required for delivery and targeting and may contain the signal sequence. (PMID:15620109)
• there are conformationally sensitive residues in extracellular loop 5 of the Na+/dicarboxylate co-transporter (PMID:15774465)
• B allele of I550V polymorphism of hNaDC-1 may be associated with a reduction in urinary citrate excretion and contribute to hypocitraturia in recurrent renal stone formers. (PMID:17470169)
• The Ser or Thr at position 509 is the most important determinant of functional differences in apparent affinity for substrate and cations. The cation and substrate binding sites are located in close proximity to one another. (PMID:18161988)
• study concludes most of the naturally occurring nonsynonymous SNPs affect protein processing of NaDC1; several also affect functional properties; mutations are predicted to decrease transport activity (PMID:20610529)
• cyclophilin isoform B is likely responsible for down-regulation of carrier expression by CsA and that it does so via its chaperone activity on NaDC1 (by direct interaction) rather than its rotamase activity. (PMID:21257749)
• Results point to an epistatic interaction between the VDR and the SLC13A2 alleles in the pathogenesis of idiopathic hypocitraturia in calcium-oxalate stone formers. (PMID:27639591)
• NaDC1 is present throughout the entire proximal tubule, but was not detected in kidney tumors. (PMID:27927654)
• Mapping Functionally Important Residues in the Na(+)/Dicarboxylate Cotransporter, NaDC1. (PMID:28731330)
• Homozygous GG of rs11567842 SNP in NaDC-1 gene was a protective genotype for hypocitraturia in kidney stone patients (PMID:30155711)
• SLC26A6 and NADC1: Future direction of nephrolithiasis and calculusrelated hypertension research (Review). (PMID:34458928)
• Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism. (PMID:38552027)

Cross-species orthologs

11 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc13a2	ENSDARG00000053853
mus_musculus	Slc13a2	ENSMUSG00000001095
rattus_norvegicus	Slc13a2	ENSRNOG00000010337
drosophila_melanogaster	CG7309	FBGN0032314
drosophila_melanogaster	Indy	FBGN0036816
drosophila_melanogaster	CG33934	FBGN0064119
drosophila_melanogaster	Indy-2	FBGN0260466
caenorhabditis_elegans		WBGENE00003517
caenorhabditis_elegans		WBGENE00003518
caenorhabditis_elegans		WBGENE00003519
caenorhabditis_elegans		WBGENE00007138

Paralogs (5): SLC13A1 (ENSG00000081800), OCA2 (ENSG00000104044), SLC13A5 (ENSG00000141485), SLC13A3 (ENSG00000158296), SLC13A4 (ENSG00000164707)

Protein

Protein identifiers

Solute carrier family 13 member 2 — Q13183 (reviewed: Q13183)

Alternative names: Na(+)/dicarboxylate cotransporter 1, Renal sodium/dicarboxylate cotransporter

All UniProt accessions (3): Q13183, J3QL78, J3QR70

UniProt curated annotations — full annotation on UniProt →

Function. Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule. Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic. Citrate is transported in protonated form as a divalent anion, rather than the trivalent form which is normally found in blood. Has a critical role in renal dicarboxylate transport.

Subcellular location. Apical cell membrane.

Tissue specificity. Expressed in kidney and intestine. In kidney expressed in the proximal tubule (at protein level).

Activity regulation. Li(+) decreases succinate transport in the presence of Na(+), by competing at one of the three cation binding sites.

Similarity. Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.

Isoforms (3)

UniProt ID	Names	Canonical?
Q13183-1	1	yes
Q13183-2	2
Q13183-3	3

RefSeq proteins (4): NP_001139447, NP_001333612, NP_001333613, NP_003975* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001898	SLC13A/DASS	Family
IPR031312	Na/sul_symport_CS	Conserved_site

Pfam: PF00939

Catalyzed reactions (Rhea), 3 shown:

• succinate(out) + 3 Na(+)(out) = succinate(in) + 3 Na(+)(in) (RHEA:71919)
• fumarate(out) + 3 Na(+)(out) = fumarate(in) + 3 Na(+)(in) (RHEA:71931)
• 2-oxoglutarate(out) + 3 Na(+)(out) = 2-oxoglutarate(in) + 3 Na(+)(in) (RHEA:71939)

UniProt features (25 total): transmembrane region 12, sequence variant 7, splice variant 2, chain 1, region of interest 1, compositionally biased region 1, sequence conflict 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
8W6D	ELECTRON MICROSCOPY	2.5
8W6C	ELECTRON MICROSCOPY	2.7
8W6G	ELECTRON MICROSCOPY	3.3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q13183-F1	83.42	0.53

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

ID	Pathway
R-HSA-9955298	SLC-mediated transport of organic anions
R-HSA-433137	Sodium-coupled sulphate, di- and tri-carboxylate transporters
R-HSA-382551	Transport of small molecules
R-HSA-425366
R-HSA-425407	SLC-mediated transmembrane transport

MSigDB gene sets: 111 (showing top): GSE45365_NK_CELL_VS_BCELL_DN, MORF_RAGE, MORF_FLT1, GOBP_SODIUM_ION_TRANSMEMBRANE_TRANSPORT, MODULE_45, MODULE_64, HNF1_Q6, MORF_ESR1, chr17q11, GOBP_MONOATOMIC_CATION_TRANSPORT, GOBP_ORGANIC_ACID_TRANSPORT, GOBP_RESPONSE_TO_METAL_ION, GOBP_ORGANIC_ANION_TRANSPORT, MODULE_71, GOBP_DICARBOXYLIC_ACID_TRANSPORT

GO Biological Process (8): fumarate transport (GO:0015741), alpha-ketoglutarate transport (GO:0015742), cellular response to lithium ion (GO:0071285), succinate transmembrane transport (GO:0071422), monoatomic ion transport (GO:0006811), sodium ion transport (GO:0006814), sodium ion transmembrane transport (GO:0035725), transmembrane transport (GO:0055085)

GO Molecular Function (9): fumarate transmembrane transporter activity (GO:0015138), alpha-ketoglutarate transmembrane transporter activity (GO:0015139), succinate transmembrane transporter activity (GO:0015141), low-affinity sodium:dicarboxylate symporter activity (GO:0015361), sodium:dicarboxylate symporter activity (GO:0017153), protein binding (GO:0005515), symporter activity (GO:0015293), solute:sodium symporter activity (GO:0015370), transmembrane transporter activity (GO:0022857)

GO Cellular Component (4): plasma membrane (GO:0005886), membrane (GO:0016020), apical plasma membrane (GO:0016324), extracellular exosome (GO:0070062)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
SLC-mediated transmembrane transport	1
SLC-mediated transport of inorganic anions	1
Transport of small molecules	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	2
C4-dicarboxylate transmembrane transporter activity	2
dicarboxylic acid transmembrane transporter activity	2
C4-dicarboxylate transport	1
dicarboxylic acid transport	1
response to lithium ion	1
cellular response to metal ion	1
succinate transport	1
carboxylic acid transmembrane transport	1
metal ion transport	1
sodium ion transport	1
monoatomic cation transmembrane transport	1
cellular process	1
fumarate transport	1
alpha-ketoglutarate transport	1
succinate transmembrane transport	1
sodium:dicarboxylate symporter activity	1
organic acid:sodium symporter activity	1
binding	1
secondary active transmembrane transporter activity	1
sodium ion transmembrane transporter activity	1
solute:monoatomic cation symporter activity	1
transporter activity	1
transmembrane transport	1
membrane	1
cell periphery	1
cellular anatomical structure	1
apical part of cell	1
plasma membrane region	1
extracellular vesicle	1

Protein interactions and networks

STRING

1060 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC13A2	SLC26A2	P50443	855
SLC13A2	SLC26A6	Q9BXS9	775
SLC13A2	SLC15A5	A6NIM6	730
SLC13A2	SLC26A3	P40879	716
SLC13A2	SLC5A1	P13866	541
SLC13A2	SLC36A2	Q495M3	492
SLC13A2	SLC5A8	Q8N695	481
SLC13A2	SLC26A4	O43511	466
SLC13A2	SLC25A1	P53007	459
SLC13A2	SLC46A2	Q9BY10	435
SLC13A2	SLC13A3	Q8WWT9	431
SLC13A2	SLC5A5	Q92911	422
SLC13A2	SLC44A3	Q8N4M1	412
SLC13A2	SLC9A3	P48764	407
SLC13A2	SLC3A1	Q07837	406

IntAct

14 interactions, top by confidence:

A	B	Type	Score
GJA8	SLC13A2	psi-mi:“MI:0915”(physical association)	0.560
SLC13A2	CREB3L1	psi-mi:“MI:0915”(physical association)	0.560
SLC13A2	WFS1	psi-mi:“MI:0915”(physical association)	0.560
SLC13A2	SEC24D	psi-mi:“MI:0914”(association)	0.350
SLC13A2	PGK2	psi-mi:“MI:0914”(association)	0.350
SLC13A2	LGALS8	psi-mi:“MI:0914”(association)	0.350
TRIM54	SLC13A2	psi-mi:“MI:0915”(physical association)	0.000
SLC13A2	GJA8	psi-mi:“MI:0915”(physical association)	0.000
SLC13A2	CREB3L1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (42): SLC13A2 (Biochemical Activity), UBA52 (Affinity Capture-MS), UBB (Affinity Capture-MS), SEC24D (Affinity Capture-MS), PCNXL3 (Affinity Capture-MS), SARAF (Affinity Capture-MS), TCEB3 (Affinity Capture-MS), TWISTNB (Affinity Capture-MS), SCAF4 (Affinity Capture-MS), AMFR (Affinity Capture-MS), ATG9A (Affinity Capture-MS), GJA8 (Two-hybrid), CREB3L1 (Two-hybrid), SLC13A2 (Two-hybrid), GAN (Affinity Capture-MS)

ESM2 similar proteins: A0FKN5, A4IIF2, A7MBD8, D7PC76, O04722, O13134, O70531, P30823, P30825, P31596, P40879, P43004, P43005, P43006, P50443, P51906, P55017, P55018, P58743, P59158, P70545, Q07782, Q09143, Q10901, Q13183, Q1EHB4, Q25605, Q3ZMH1, Q58DD2, Q5RAL2, Q62273, Q67BT3, Q69DJ1, Q7LBE3, Q7T2C4, Q8BU91, Q8CIW6, Q8CJ44, Q8R2Z3, Q8TE54

Diamond homologs: P0AFU2, P0AFU3, P32739, P46556, P70545, Q13183, Q21339, Q28615, Q49YW0, Q67BT3, Q86YT5, Q8CJ44, Q8WWT9, Q91Y63, Q93655, Q9ES88, Q9VDQ0, Q9VVT2, Q9Z0Z5, P39535, Q07782, Q9BZW2, Q9JHI4, O59712, P25360, P72958, Q2FFH9, Q2FWY4, Q2YU56, Q5HEK4, Q6G816, Q6GFE0, Q7A4P8, Q8LG88, Q8NVS5, Q99SX1, Q9UKG4, P0A607, P39760, P9WPD8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

92 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	83
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1919 predictions. Top by Δscore:

Variant	Effect	Δscore
17:28473810:GTAAG:G	donor_gain	1.0000
17:28473813:AGGT:A	donor_loss	1.0000
17:28473814:GGTA:G	donor_loss	1.0000
17:28473815:GTAAG:G	donor_loss	1.0000
17:28489210:GCAG:G	acceptor_loss	1.0000
17:28489211:CAG:C	acceptor_loss	1.0000
17:28489211:CAGG:C	acceptor_gain	1.0000
17:28489212:AGGA:A	acceptor_gain	1.0000
17:28489213:GGAG:G	acceptor_gain	1.0000
17:28489343:G:GA	donor_loss	1.0000
17:28490873:G:GT	donor_gain	1.0000
17:28490891:G:GT	donor_gain	1.0000
17:28490902:GCTTG:G	donor_gain	1.0000
17:28490903:C:G	donor_gain	1.0000
17:28490904:TTGGT:T	donor_loss	1.0000
17:28490908:T:A	donor_loss	1.0000
17:28491614:ACTC:A	donor_gain	1.0000
17:28491615:CTC:C	donor_gain	1.0000
17:28491616:TC:T	donor_gain	1.0000
17:28491618:G:GG	donor_gain	1.0000
17:28491724:CTTCA:C	acceptor_loss	1.0000
17:28491725:TTCAG:T	acceptor_loss	1.0000
17:28491726:TCAG:T	acceptor_loss	1.0000
17:28491727:CAGGC:C	acceptor_loss	1.0000
17:28491728:A:AG	acceptor_gain	1.0000
17:28491728:A:C	acceptor_loss	1.0000
17:28491728:AG:A	acceptor_gain	1.0000
17:28491729:G:GC	acceptor_gain	1.0000
17:28491729:GG:G	acceptor_gain	1.0000
17:28491729:GGC:G	acceptor_gain	1.0000

AlphaMissense

3866 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:28490744:T:A	W138R	0.998
17:28490744:T:C	W138R	0.998
17:28491591:C:A	N243K	0.997
17:28491591:C:G	N243K	0.997
17:28491770:T:A	W266R	0.997
17:28491770:T:C	W266R	0.997
17:28493719:T:A	W343R	0.997
17:28493719:T:C	W343R	0.997
17:28494459:T:A	W419R	0.997
17:28494459:T:C	W419R	0.997
17:28491550:A:C	S230R	0.996
17:28491552:C:A	S230R	0.996
17:28491552:C:G	S230R	0.996
17:28491556:G:T	G232W	0.996
17:28491557:G:A	G232E	0.996
17:28491577:G:C	G239R	0.996
17:28491578:G:A	G239D	0.996
17:28497203:G:C	W571C	0.996
17:28497203:G:T	W571C	0.996
17:28490750:A:C	S140R	0.995
17:28490752:C:A	S140R	0.995
17:28490752:C:G	S140R	0.995
17:28490755:C:A	N141K	0.995
17:28490755:C:G	N141K	0.995
17:28491566:C:A	A235D	0.995
17:28491578:G:T	G239V	0.995
17:28493729:G:C	R346P	0.995
17:28493752:T:A	W354R	0.995
17:28493752:T:C	W354R	0.995
17:28495769:A:C	S475R	0.995

dbSNP variants (sampled 300 via entrez): RS1000147642 (17:28483054 C>A,T), RS1000381337 (17:28494864 C>T), RS1000405952 (17:28494655 T>C), RS1000979709 (17:28477354 C>G,T), RS1001173748 (17:28489800 C>T), RS1001190507 (17:28483153 G>T), RS1001243384 (17:28477074 C>G,T), RS1001707937 (17:28489562 A>G), RS1002043454 (17:28488170 A>G), RS1002074271 (17:28494321 A>G), RS1002135581 (17:28495428 C>T), RS1002710816 (17:28490736 T>A,C), RS1002738408 (17:28496953 G>A,T), RS1002989170 (17:28474751 G>A,C), RS1003188039 (17:28473010 T>C)

Disease associations

OMIM: gene MIM:604148 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL3712851 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC13 family of sodium-dependent sulphate/carboxylate transporters

ChEMBL bioactivities

1 potent at pChembl≥5 of 2 total, top 1 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.00	IC50	1e+04	nM	CHEMBL3771118

PubChem BioAssay actives

1 with measured affinity, of 4 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
(2R)-2-hydroxy-2-[2-(2-methoxy-5-methyl-3-pyridinyl)ethyl]butanedioic acid	1280698: Inhibition of NaDC1 (unknown origin) expressed in HEK293 cells assessed as inhibition of [14C]citrate uptake by microbeta plate reader analysis	ic50	10.0000	uM

CTD chemical–gene interactions

18 total (human), top 18 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
diethylene glycol	decreases response to substance, decreases activity	1
benzo(e)pyrene	increases methylation	1
4-amylcinnamoylanthranilic acid	decreases activity, decreases response to substance	1
CGP 52608	increases reaction, affects binding	1
diglycolic acid	affects response to substance, increases uptake	1
Arbutin	decreases expression	1
Benzo(a)pyrene	decreases expression	1
Estradiol	affects expression	1
Lithium	increases reaction, increases uptake	1
Methapyrilene	increases methylation	1
Nickel	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Valproic Acid	increases methylation	1
Vanadium	decreases expression	1
Aflatoxin B1	increases methylation	1
Antirheumatic Agents	increases expression	1
Okadaic Acid	decreases expression	1
Citric Acid	increases reaction, increases uptake	1

ChEMBL screening assays

2 unique, capped per target: 2 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL3773093	Binding	Inhibition of NaDC1 (unknown origin) expressed in HEK293 cells assessed as inhibition of [14C]citrate uptake by microbeta plate reader analysis	Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family. — J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.