SLC14A2

Summary

SLC14A2 (solute carrier family 14 member 2, HGNC:10919) is a protein-coding gene on chromosome 18q12.3, encoding Urea transporter 2 (Q15849). Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism.

The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene.

Source: NCBI Gene 8170 — RefSeq curated summary.

At a glance

• GWAS associations: 42
• Clinical variants (ClinVar): 163 total
• MANE Select transcript: NM_007163

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10919
Approved symbol	SLC14A2
Name	solute carrier family 14 member 2
Location	18q12.3
Locus type	gene with protein product
Status	Approved
Aliases	HUT2, UT2
Ensembl gene	ENSG00000132874
Ensembl biotype	protein_coding
OMIM	601611
Entrez	8170

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 nonsense_mediated_decay

ENST00000255226, ENST00000323329, ENST00000586448

RefSeq mRNA: 3 — MANE Select: NM_007163 NM_001242692, NM_001371319, NM_007163

CCDS: CCDS11924

Canonical transcript exons

ENST00000255226 — 20 exons

Exon	Start	End
ENSE00000905781	45667833	45668022
ENSE00000905782	45668349	45668477
ENSE00000905783	45669306	45669498
ENSE00000905785	45673683	45673817
ENSE00000905786	45678975	45679024
ENSE00001004045	45636990	45637182
ENSE00001004046	45663785	45663907
ENSE00001004049	45666137	45666219
ENSE00001264788	45643986	45644160
ENSE00001264832	45632350	45632478
ENSE00001264838	45626958	45627147
ENSE00001264846	45625683	45625863
ENSE00001264869	45682319	45683688
ENSE00001375024	45624631	45624814
ENSE00001736834	45672900	45673047
ENSE00001863763	45615476	45615582
ENSE00003501150	45639746	45639893
ENSE00003545692	45643132	45643181
ENSE00003632842	45641209	45641343
ENSE00003737025	45666935	45667094

Expression profiles

Bgee: expression breadth broad, 100 present calls, max score 79.88.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0230 / max 20.9584, expressed in 5 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
170114	0.0230	5

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.88	gold quality
hair follicle	UBERON:0002073	69.24	gold quality
right adrenal gland	UBERON:0001233	65.95	gold quality
right adrenal gland cortex	UBERON:0035827	65.66	gold quality
Brodmann (1909) area 10	UBERON:0013541	64.96	gold quality
left adrenal gland	UBERON:0001234	64.20	gold quality
endometrium epithelium	UBERON:0004811	63.31	gold quality
left adrenal gland cortex	UBERON:0035825	61.99	gold quality
metanephros cortex	UBERON:0010533	61.20	gold quality
adrenal cortex	UBERON:0001235	61.18	gold quality
adrenal gland	UBERON:0002369	60.97	gold quality
calcaneal tendon	UBERON:0003701	60.74	gold quality
ventricular zone	UBERON:0003053	58.06	gold quality
decidua	UBERON:0002450	56.55	gold quality
tibial artery	UBERON:0007610	56.08	gold quality
popliteal artery	UBERON:0002250	56.07	gold quality
mucosa of paranasal sinus	UBERON:0005030	55.80	gold quality
adult mammalian kidney	UBERON:0000082	55.30	gold quality
lower lobe of lung	UBERON:0008949	55.01	silver quality
quadriceps femoris	UBERON:0001377	54.74	gold quality
metanephros	UBERON:0000081	54.54	gold quality
kidney	UBERON:0002113	54.48	gold quality
cerebellar vermis	UBERON:0004720	54.38	gold quality
vermiform appendix	UBERON:0001154	54.16	gold quality
subcutaneous adipose tissue	UBERON:0002190	54.15	gold quality
kidney epithelium	UBERON:0004819	54.15	gold quality
vastus lateralis	UBERON:0001379	54.12	gold quality
ganglionic eminence	UBERON:0004023	54.12	gold quality
omental fat pad	UBERON:0010414	53.36	gold quality
peritoneum	UBERON:0002358	53.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.18

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): E2F1, KLF12, NFAT5, NR3C1, TCF3

miRNA regulators (miRDB)

21 targeting SLC14A2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6740-5P	100.00	65.64	932
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-6857-5P	99.87	65.32	985
HSA-MIR-6844	99.82	70.69	2423
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-1299	99.77	71.24	2389
HSA-MIR-3150A-3P	99.76	64.44	1640
HSA-MIR-6763-5P	99.76	64.68	1767
HSA-MIR-6733-5P	99.74	67.94	2759
HSA-MIR-3153	99.55	67.59	2337
HSA-MIR-142-5P	99.48	70.92	2416
HSA-MIR-5590-3P	99.48	70.91	2429
HSA-MIR-6505-3P	99.34	67.39	1071
HSA-MIR-504-3P	99.30	67.18	1745
HSA-MIR-4293	99.22	65.46	1263
HSA-MIR-6852-5P	99.17	66.69	2073
HSA-MIR-3161	98.71	67.14	816
HSA-MIR-3188	98.58	65.60	878
HSA-MIR-12127	97.93	66.67	793

Literature-anchored findings (GeneRIF, showing 10)

• a novel UT-A urea transporter; the transcript contains a novel 129-bp exon, exon 5a, which, as a result of alternative splicing, introduces a unique 19-aa segment and a stop codon. (PMID:15189812)
• results provide new evidences that suggest the involvement of AQP9 and UT-A in the urea excretion mechanism across human term placenta from mother to fetus in physiological conditions (PMID:16480766)
• This review summarizes the published work that has accrued on the structure and regulation of these genes. (PMID:17264986)
• polymorphisms in the SLC14A2 gene can predict the antihypertensive efficacy of nifedipine GITS (gastrointestinal therapeutic system) (PMID:17344938)
• HUT2 gene may play a certain role in developing metabolic syndrome and its related traits in Asian population. (PMID:20797394)
• Studies indicate that the urea transporter SLC14a2, the UT-A group, was originally isolated from kidney inner medulla. (PMID:25298338)
• Studies indicate that osmotic diuresis, where urea concentrations are low, can prompt an increase in urea transporter abundance. (PMID:25298340)
• Studies indicate that the cell signaling pathway for vasopressin-mediated urea transporters phosphorylation and activity involves two cAMP-dependent signaling pathways. (PMID:25298341)
• UT2 is a negative regulator shared across STAT3 and mTORC2 signaling cascades, functioning as a tumor suppressor in hematologic malignancies driven by those pathways. (PMID:26927669)
• The urea transporter subtypes, UT-A1 and UT-B1, were expressed in the skin basal cell layer and exocrine sweat glands. The abundance of UT-A1 and UT-B1 in uremic sweat glands was significantly increased in UP, while the expression of AQP5 was decreased. (PMID:29279852)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc14a2	ENSDARG00000051914
mus_musculus	Slc14a2	ENSMUSG00000024552
rattus_norvegicus	Slc14a2	ENSRNOG00000061714

Paralogs (1): SLC14A1 (ENSG00000141469)

Protein

Protein identifiers

Urea transporter 2 — Q15849 (reviewed: Q15849)

Alternative names: Solute carrier family 14 member 2, Urea transporter, kidney

All UniProt accessions (2): E7EPU1, Q15849

UniProt curated annotations — full annotation on UniProt →

Function. Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism. Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism.

Subunit / interactions. Interacts with SNAPIN which enhances its urea transport activity.

Subcellular location. Apical cell membrane. Cell membrane.

Tissue specificity. Epressed in the inner medulla of the kidney (at protein level). Expressed in the kidney.

Activity regulation. Inhibited by phloretin.

Similarity. Belongs to the urea transporter family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q15849-1	1, UT-A1	yes
Q15849-2	2, UT-A2

RefSeq proteins (3): NP_001229621, NP_001358248, NP_009094* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004937	Urea_transporter	Family
IPR029020	Ammonium/urea_transptr	Homologous_superfamily

Pfam: PF03253

Catalyzed reactions (Rhea), 1 shown:

• urea(in) = urea(out) (RHEA:32799)

UniProt features (93 total): helix 44, transmembrane region 17, turn 10, sequence variant 6, sequence conflict 4, strand 4, region of interest 2, compositionally biased region 2, chain 1, modified residue 1, glycosylation site 1, splice variant 1

Structure

Experimental structures (PDB)

9 structures.

PDB	Method	Resolution (Å)
8XDE	ELECTRON MICROSCOPY	2.3
8XD7	ELECTRON MICROSCOPY	2.6
8XD9	ELECTRON MICROSCOPY	2.8
8BLO	ELECTRON MICROSCOPY	2.9
8XDA	ELECTRON MICROSCOPY	3
8XDC	ELECTRON MICROSCOPY	3
8XDD	ELECTRON MICROSCOPY	3
9LHT	ELECTRON MICROSCOPY	3
8XDB	ELECTRON MICROSCOPY	3.3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q15849-F1	81.96	0.71

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 477

Glycosylation sites (1): 733

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-549127	SLC-mediated transport of organic cations
R-HSA-425366

MSigDB gene sets: 75 (showing top): GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, MORF_RAD51L3, chr18q12, MORF_CTSB, GOBP_ONE_CARBON_COMPOUND_TRANSPORT, MORF_IL4, BROWNE_HCMV_INFECTION_14HR_DN, MARTIN_NFKB_TARGETS_DN, GOCC_APICAL_PLASMA_MEMBRANE, MORF_ATF2, MODULE_20, GOBP_TRANSMEMBRANE_TRANSPORT, SHEN_SMARCA2_TARGETS_DN, GOCC_APICAL_PART_OF_CELL, GOCC_PLASMA_MEMBRANE_REGION

GO Biological Process (3): urea transport (GO:0015840), transmembrane transport (GO:0055085), urea transmembrane transport (GO:0071918)

GO Molecular Function (3): urea transmembrane transporter activity (GO:0015204), cell adhesion molecule binding (GO:0050839), protein binding (GO:0005515)

GO Cellular Component (3): plasma membrane (GO:0005886), membrane (GO:0016020), apical plasma membrane (GO:0016324)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
SLC-mediated transmembrane transport	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
one-carbon compound transport	1
nitrogen compound transport	1
transport	1
cellular process	1
urea transport	1
transmembrane transport	1
transmembrane transporter activity	1
urea transmembrane transport	1
protein binding	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1
apical part of cell	1
plasma membrane region	1

Protein interactions and networks

STRING

918 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC14A2	AQP1	P29972	641
SLC14A2	KLK1	P06870	639
SLC14A2	DBH	P09172	631
SLC14A2	CLCNKA	P51800	607
SLC14A2	KLK4	Q9Y5K2	581
SLC14A2	AQP2	P41181	572
SLC14A2	KNG1	P01042	547
SLC14A2	TTR	P02766	493
SLC14A2	ACSM3	Q53FZ2	480
SLC14A2	CCDC172	P0C7W6	473
SLC14A2	AVPR2	P30518	451
SLC14A2	SLC12A1	Q13621	450
SLC14A2	SPAG8	Q99932	449
SLC14A2	Q3MI93	Q3MI93	447
SLC14A2	ACE	P12821	430

IntAct

42 interactions, top by confidence:

A	B	Type	Score
SLC14A2	TMEM97	psi-mi:“MI:0915”(physical association)	0.600
LAT	SLC14A2	psi-mi:“MI:0915”(physical association)	0.560
PLP2	SLC14A2	psi-mi:“MI:0915”(physical association)	0.560
VAMP5	SLC14A2	psi-mi:“MI:0915”(physical association)	0.560
SLC14A2	LRP10	psi-mi:“MI:0915”(physical association)	0.560
EHHADH	SLC14A2	psi-mi:“MI:0915”(physical association)	0.560
TNF	SLC14A2	psi-mi:“MI:0915”(physical association)	0.560
PLN	SLC14A2	psi-mi:“MI:0915”(physical association)	0.560
SLC14A2	ARLN	psi-mi:“MI:0915”(physical association)	0.560
SLC14A2	CMTM7	psi-mi:“MI:0915”(physical association)	0.560
SLC14A2	SEC22A	psi-mi:“MI:0915”(physical association)	0.560
TUSC5	SLC14A2	psi-mi:“MI:0915”(physical association)	0.560
SLC14A2	PKP2	psi-mi:“MI:0915”(physical association)	0.400
SLC14A2	MLF1	psi-mi:“MI:0915”(physical association)	0.400
SLC14A2	SMCHD1	psi-mi:“MI:0914”(association)	0.350
LAT	SLC14A2	psi-mi:“MI:0915”(physical association)	0.000
PLP2	SLC14A2	psi-mi:“MI:0915”(physical association)	0.000
ARLN	SLC14A2	psi-mi:“MI:0915”(physical association)	0.000
CMTM7	SLC14A2	psi-mi:“MI:0915”(physical association)	0.000
SLC14A2	LAT	psi-mi:“MI:0915”(physical association)	0.000
VAMP5	SLC14A2	psi-mi:“MI:0915”(physical association)	0.000
LRP10	SLC14A2	psi-mi:“MI:0915”(physical association)	0.000
EHHADH	SLC14A2	psi-mi:“MI:0915”(physical association)	0.000
TNF	SLC14A2	psi-mi:“MI:0915”(physical association)	0.000
PLN	SLC14A2	psi-mi:“MI:0915”(physical association)	0.000
SEC22A	SLC14A2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (143): PKP2 (Affinity Capture-MS), SLC14A2 (Two-hybrid), SLC14A2 (Two-hybrid), SLC14A2 (Two-hybrid), SLC14A2 (Two-hybrid), CMTM7 (Two-hybrid), C4orf3 (Two-hybrid), VAMP5 (Two-hybrid), TUSC5 (Two-hybrid), LRP10 (Two-hybrid), PLN (Two-hybrid), LAT (Two-hybrid), TNF (Two-hybrid), MDM2 (Affinity Capture-Western), SLC14A2 (Co-fractionation)

ESM2 similar proteins: A0A0R4IQZ2, A1KSH5, A6V3A0, A9M2A8, A9RA88, B7UZU0, C4LD54, C5MK33, D3INW7, E9PXX9, O00337, O43868, O62667, O88575, O88627, O97681, P15920, P20715, P97689, Q02PG0, Q13336, Q15849, Q28614, Q28GF5, Q4V7N7, Q5F410, Q5F6X7, Q5QF96, Q5R687, Q5U4Q2, Q62668, Q62674, Q62773, Q6C741, Q6PQZ3, Q6UPR8, Q72CX3, Q7EYH7, Q7Z2K6, Q8R4T9

Diamond homologs: C5MK33, D3INW7, P97689, Q13336, Q15849, Q28614, Q5QF96, Q62668, Q72CX3, Q8R4T9, Q8VHL0

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

163 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	142
Likely benign	5
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

4800 predictions. Top by Δscore:

Variant	Effect	Δscore
18:45213188:GACC:G	donor_gain	1.0000
18:45213192:G:GG	donor_gain	1.0000
18:45624624:C:CA	acceptor_gain	1.0000
18:45624627:CTA:C	acceptor_loss	1.0000
18:45624628:TAGTC:T	acceptor_loss	1.0000
18:45624629:A:AG	acceptor_gain	1.0000
18:45624629:A:C	acceptor_loss	1.0000
18:45624630:G:GT	acceptor_gain	1.0000
18:45624630:GT:G	acceptor_gain	1.0000
18:45624630:GTC:G	acceptor_gain	1.0000
18:45624630:GTCC:G	acceptor_gain	1.0000
18:45624630:GTCCA:G	acceptor_gain	1.0000
18:45624812:AAGG:A	donor_loss	1.0000
18:45624815:GTG:G	donor_loss	1.0000
18:45625678:AAAAG:A	acceptor_gain	1.0000
18:45625862:AGGT:A	donor_loss	1.0000
18:45625864:GTAGG:G	donor_loss	1.0000
18:45625865:T:G	donor_loss	1.0000
18:45626956:A:AG	acceptor_gain	1.0000
18:45626957:G:GG	acceptor_gain	1.0000
18:45636989:GCCCA:G	acceptor_gain	1.0000
18:45643179:GTG:G	donor_gain	1.0000
18:45644158:GCG:G	donor_gain	1.0000
18:45644180:G:GT	donor_gain	1.0000
18:45644180:G:T	donor_gain	1.0000
18:45666129:A:AG	acceptor_gain	1.0000
18:45666130:A:G	acceptor_gain	1.0000
18:45666135:A:AG	acceptor_gain	1.0000
18:45666136:G:GA	acceptor_gain	1.0000
18:45666136:GT:G	acceptor_gain	1.0000

AlphaMissense

5985 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
18:45667910:A:C	S599R	0.990
18:45667912:C:A	S599R	0.990
18:45667912:C:G	S599R	0.990
18:45627035:A:C	S137R	0.988
18:45627037:C:A	S137R	0.988
18:45627037:C:G	S137R	0.988
18:45644110:G:C	R434P	0.988
18:45639870:G:A	G323D	0.979
18:45641298:T:C	F361L	0.979
18:45641300:C:A	F361L	0.979
18:45641300:C:G	F361L	0.979
18:45667872:G:C	R586P	0.979
18:45673005:T:C	C779R	0.979
18:45673739:A:C	S812R	0.979
18:45673741:C:A	S812R	0.979
18:45673741:C:G	S812R	0.979
18:45639851:T:C	C317R	0.978
18:45639869:G:C	G323R	0.978
18:45644103:G:C	A432P	0.976
18:45667874:G:C	G587R	0.973
18:45673023:G:A	G785R	0.973
18:45673023:G:C	G785R	0.973
18:45673035:G:A	G789R	0.973
18:45673035:G:C	G789R	0.973
18:45626999:G:T	G125W	0.972
18:45673024:G:A	G785E	0.972
18:45682340:T:A	W862R	0.972
18:45682340:T:C	W862R	0.972
18:45626999:G:A	G125R	0.971
18:45626999:G:C	G125R	0.971

dbSNP variants (sampled 300 via entrez): RS1000004871 (18:45524307 A>C), RS1000006994 (18:45296450 G>A,C), RS1000008899 (18:45650712 A>T), RS1000013901 (18:45436460 A>G), RS1000025666 (18:45218700 A>G), RS1000035494 (18:45641149 C>G,T), RS1000037185 (18:45483840 G>A,C), RS1000042961 (18:45322128 G>A), RS1000047777 (18:45680577 T>G), RS1000047878 (18:45516840 G>A,T), RS1000054111 (18:45180353 C>T), RS1000069475 (18:45570813 A>G), RS1000071877 (18:45362163 G>A), RS1000072168 (18:45522776 A>G), RS1000079771 (18:45243827 T>C)

Disease associations

OMIM: gene MIM:601611 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

42 associations (top):

Study	Trait	p-value
GCST000328_14	Biochemical measures	7.000000e-06
GCST000583_20	Hematological and biochemical traits	2.000000e-10
GCST000880_36	Menarche (age at onset)	3.000000e-07
GCST001233_16	Metabolite levels	8.000000e-14
GCST001610_15	Renal function-related traits (BUN)	7.000000e-18
GCST002240_8	Bladder cancer	6.000000e-08
GCST002643_9	Follicular lymphoma	4.000000e-07
GCST003134_5	Cerebrospinal fluid clusterin levels	2.000000e-06
GCST003455_3	Spherical equivalent (joint analysis main effects and education interaction)	8.000000e-06
GCST003455_4	Spherical equivalent (joint analysis main effects and education interaction)	3.000000e-08
GCST003983_14	Male-pattern baldness	8.000000e-15
GCST004278_55	Pulse pressure	2.000000e-18
GCST005986_42	Blood urea nitrogen levels	6.000000e-37
GCST006291_43	Spherical equivalent or myopia (age of diagnosis)	6.000000e-12
GCST006303_24	Nicotine withdrawal symptom count	4.000000e-08
GCST006661_284	Male-pattern baldness	3.000000e-27
GCST006869_16	Nicotine withdrawal	5.000000e-07
GCST006979_271	Heel bone mineral density	9.000000e-10
GCST007096_97	Pulse pressure	9.000000e-24
GCST007097_133	Pulse pressure	3.000000e-12
GCST007097_134	Pulse pressure	1.000000e-12
GCST007099_83	Systolic blood pressure	2.000000e-08
GCST007327_35	Smoking status (ever vs never smokers)	7.000000e-09
GCST007429_88	Lung function (FVC)	5.000000e-07
GCST007431_62	Lung function (FEV1/FVC)	5.000000e-10
GCST007432_98	FEV1	1.000000e-13
GCST008062_6	Blood urea nitrogen levels	4.000000e-49
GCST008399_5	Cocaine dependence	4.000000e-06
GCST008759_25	Intake of total sugars	1.000000e-06
GCST008971_127	Urate levels	2.000000e-06

EFO canonical traits (20, from GWAS)

EFO ID	Trait name
EFO:0004761	uric acid measurement
EFO:0004703	age at menarche
EFO:0004784	self reported educational attainment
EFO:0005763	pulse pressure measurement
EFO:0004847	age at onset
EFO:0009263	nicotine withdrawal symptom count
EFO:0009362	nicotine withdrawal measurement
EFO:0009270	heel bone mineral density
EFO:0006335	systolic blood pressure
EFO:0004318	smoking behavior
EFO:0004312	vital capacity
EFO:0004713	FEV/FVC ratio
EFO:0004314	forced expiratory volume
EFO:0010158	sugar consumption measurement
EFO:0004531	urate measurement
EFO:0010504	inositol measurement
EFO:0006501	carotid plaque build
EFO:0004348	hematocrit
EFO:0004509	hemoglobin measurement
EFO:0004305	erythrocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB clinical annotations

2 annotations.

Variant	Type	Level	Drugs	Phenotypes
rs1123617	Efficacy	3	nifedipine	Hypertension
rs3745009	Efficacy	3	nifedipine	Hypertension

PharmGKB variants

3 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs1123617	SLC14A2	3	4.50	1	nifedipine
rs3745009	SLC14A2	3	4.50	1	nifedipine
rs12456693	SLC14A2		0.00	0

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC14 family of facilitative urea transporters

Most potent curated ligand interactions (2 total), top 2:

Ligand	Action	Affinity	Parameter
compound E3	Inhibition	7.72	pIC50
compound 8ay [PMID: 29589443]	Inhibition	6.82	pIC50

CTD chemical–gene interactions

22 total (human), top 22 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, increases methylation, decreases expression, decreases methylation	2
Benzo(a)pyrene	affects methylation, increases methylation	2
Aflatoxin B1	decreases methylation, increases methylation	2
benzo(e)pyrene	increases methylation	1
aflatoxin B2	increases methylation	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, increases expression	1
CGP 52608	affects binding, increases reaction	1
Resveratrol	affects cotreatment, decreases expression	1
Arsenic Trioxide	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Amiodarone	increases expression	1
Atrazine	increases expression	1
Chloroquine	decreases reaction, affects localization	1
Hydroxyurea	increases uptake	1
Lipopolysaccharides	affects cotreatment, increases expression	1
Methapyrilene	increases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1
Silicon Dioxide	increases expression	1
Valproic Acid	increases methylation	1
Vanadium	increases expression	1
Zinc	increases expression	1
Coal Ash	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 spontaneously immortalized cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A6IW	MDCK-UT-A1	Spontaneously immortalized cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.