SLC15A3

Summary

SLC15A3 (solute carrier family 15 member 3, HGNC:18068) is a protein-coding gene on chromosome 11q12.2, encoding Solute carrier family 15 member 3 (Q8IY34). Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response.

Enables dipeptide transmembrane transporter activity. Involved in dipeptide import across plasma membrane. Located in intracellular membrane-bounded organelle.

Source: NCBI Gene 51296 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 108 total
• MANE Select transcript: NM_016582

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18068
Approved symbol	SLC15A3
Name	solute carrier family 15 member 3
Location	11q12.2
Locus type	gene with protein product
Status	Approved
Aliases	PHT2, hPTR3
Ensembl gene	ENSG00000110446
Ensembl biotype	protein_coding
OMIM	610408
Entrez	51296

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 12 protein_coding, 4 retained_intron, 2 nonsense_mediated_decay

ENST00000227880, ENST00000536491, ENST00000536784, ENST00000537307, ENST00000538739, ENST00000540272, ENST00000541505, ENST00000543406, ENST00000544101, ENST00000679573, ENST00000681015, ENST00000681275, ENST00000681882, ENST00000681951, ENST00000930270, ENST00000930271, ENST00000952095, ENST00000952096

RefSeq mRNA: 1 — MANE Select: NM_016582 NM_016582

CCDS: CCDS7998

Canonical transcript exons

ENST00000227880 — 8 exons

Exon	Start	End
ENSE00000851448	60950994	60952176
ENSE00001628194	60941122	60941290
ENSE00002486964	60943689	60943836
ENSE00002506773	60942035	60942145
ENSE00003505725	60937084	60937373
ENSE00003635633	60946532	60946821
ENSE00003649038	60939480	60939638
ENSE00003677854	60937870	60938025

Expression profiles

Bgee: expression breadth ubiquitous, 188 present calls, max score 97.33.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.1394 / max 814.7836, expressed in 977 samples.

FANTOM5 promoters (13 alternative TSS)

Promoter ID	TPM avg	Samples expressed
119932	5.5579	466
119927	0.7500	151
119934	0.7163	388
119924	0.7098	181
119935	0.4822	243
119931	0.3666	112
119923	0.3331	95
119928	0.3288	100
119930	0.2399	103
119929	0.2236	74

Top tissues by expression

271 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	97.33	gold quality
monocyte	CL:0000576	97.10	gold quality
leukocyte	CL:0000738	96.61	gold quality
tibial nerve	UBERON:0001323	96.59	gold quality
mononuclear cell	CL:0000842	96.54	gold quality
upper lobe of left lung	UBERON:0008952	96.47	gold quality
right lung	UBERON:0002167	96.23	gold quality
spleen	UBERON:0002106	96.05	gold quality
apex of heart	UBERON:0002098	95.41	gold quality
upper lobe of lung	UBERON:0008948	95.28	gold quality
gall bladder	UBERON:0002110	94.52	gold quality
right ovary	UBERON:0002118	93.78	gold quality
muscle layer of sigmoid colon	UBERON:0035805	93.74	gold quality
mucosa of stomach	UBERON:0001199	93.56	gold quality
right coronary artery	UBERON:0001625	93.18	gold quality
left ovary	UBERON:0002119	93.17	gold quality
omental fat pad	UBERON:0010414	92.80	gold quality
peritoneum	UBERON:0002358	92.72	gold quality
lower esophagus muscularis layer	UBERON:0035833	92.45	gold quality
lower esophagus	UBERON:0013473	92.43	gold quality
left coronary artery	UBERON:0001626	92.26	gold quality
vermiform appendix	UBERON:0001154	92.22	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	92.12	gold quality
blood	UBERON:0000178	91.92	gold quality
small intestine Peyer’s patch	UBERON:0003454	91.86	gold quality
lymph node	UBERON:0000029	91.74	gold quality
left uterine tube	UBERON:0001303	91.65	gold quality
adipose tissue of abdominal region	UBERON:0007808	91.56	gold quality
endocervix	UBERON:0000458	91.33	gold quality
coronary artery	UBERON:0001621	91.13	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	22.77
E-MTAB-2983	no	341.37
E-MTAB-5061	no	3.85

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

8 targeting SLC15A3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4496	99.88	68.89	2236
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-762	99.58	66.61	1994
HSA-MIR-4498	99.47	67.42	2360
HSA-MIR-210-5P	98.57	64.37	832
HSA-MIR-3652	97.71	65.43	1890
HSA-MIR-4430	97.47	65.61	1813
HSA-MIR-4749-3P	96.40	66.24	798

Literature-anchored findings (GeneRIF, showing 5)

• PEPT1,PEPT2, PHT1, and PHT2 are expressed in human nasal epithelium. (PMID:21366347)
• Our results demonstrate that SLC15A3 is induced by viral infection to participate in intracellular RNA and DNA receptor-mediated interferon production (PMID:30069489)
• The transporters PEPT2, PHT1, and PHT2 are responsible for the uptake of carnosine into glioblastoma cells and full function of all three transporters is required for maximum uptake. (PMID:31073693)
• Substrate Transport Properties of the Human Peptide/Histidine Transporter PHT2 in Transfected MDCK Cells. (PMID:31254495)
• Oligopeptide/Histidine Transporter PHT1 and PHT2 - Function, Regulation, and Pathophysiological Implications Specifically in Immunoregulation. (PMID:37610621)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
mus_musculus	Slc15a3	ENSMUSG00000024737
rattus_norvegicus	Slc15a3	ENSRNOG00000021644
drosophila_melanogaster	CG2930	FBGN0028491
drosophila_melanogaster	CG9444	FBGN0037730
drosophila_melanogaster	yin	FBGN0265575
caenorhabditis_elegans		WBGENE00003877

Paralogs (4): SLC15A1 (ENSG00000088386), SLC15A4 (ENSG00000139370), SLC15A2 (ENSG00000163406), SLC15A5 (ENSG00000188991)

Protein

Protein identifiers

Solute carrier family 15 member 3 — Q8IY34 (reviewed: Q8IY34)

Alternative names: Osteoclast transporter, Peptide transporter 3, Peptide/histidine transporter 2

All UniProt accessions (10): Q8IY34, A0A7P0T8B5, A0A7P0T8H0, A0A7P0TAX8, A0A7P0Z4G8, F5GZ36, F5H1C8, F5H251, H0YFC1, H0YG40

UniProt curated annotations — full annotation on UniProt →

Function. Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response. Preferably binds to short peptides with a basic residue at the first position and a hydrophobic residue at the second position. Also able to transport carnosine. Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand.

Subunit / interactions. May form a homodimer.

Subcellular location. Lysosome membrane. Endosome membrane.

Similarity. Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

RefSeq proteins (1): NP_057666* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000109	POT_fam	Family
IPR036259	MFS_trans_sf	Homologous_superfamily

Pfam: PF00854

Catalyzed reactions (Rhea), 4 shown:

• N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) + n H(+)(out) = N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in) + n H(+)(in) (RHEA:76371)
• L-histidine(out) + n H(+)(out) = L-histidine(in) + n H(+)(in) (RHEA:76379)
• carnosine(out) + n H(+)(out) = carnosine(in) + n H(+)(in) (RHEA:76383)
• glycylglycylglycine(out) + n H(+)(out) = glycylglycylglycine(in) + n H(+)(in) (RHEA:76391)

UniProt features (59 total): helix 20, topological domain 13, transmembrane region 12, glycosylation site 5, strand 3, turn 2, chain 1, region of interest 1, compositionally biased region 1, sequence variant 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
8WX2	ELECTRON MICROSCOPY	3.44
8ZAT	ELECTRON MICROSCOPY	3.54

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IY34-F1	80.88	0.42

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (5): 61, 66, 223, 356, 439

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-427975	Proton/oligopeptide cotransporters
R-HSA-382551	Transport of small molecules
R-HSA-425393
R-HSA-425407	SLC-mediated transmembrane transport

MSigDB gene sets: 297 (showing top): GSE45365_NK_CELL_VS_CD11B_DC_DN, GOCC_VACUOLAR_MEMBRANE, GOBP_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_SIGNALING_PATHWAY, GOBP_MONOATOMIC_CATION_TRANSPORT, MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP, GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS, TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP, GOBP_REGULATION_OF_IMMUNE_RESPONSE, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, GOBP_REGULATION_OF_RESPONSE_TO_STRESS, GOMF_PROTON_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, IRF_Q6, GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, BROWN_MYELOID_CELL_DEVELOPMENT_UP, VALK_AML_CLUSTER_5

GO Biological Process (10): monoatomic ion transport (GO:0006811), protein transport (GO:0015031), peptidoglycan transport (GO:0015835), innate immune response (GO:0045087), positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway (GO:0070434), dipeptide import across plasma membrane (GO:0140206), immune system process (GO:0002376), peptide transport (GO:0015833), transmembrane transport (GO:0055085), proton transmembrane transport (GO:1902600)

GO Molecular Function (6): peptide:proton symporter activity (GO:0015333), peptidoglycan transmembrane transporter activity (GO:0015647), dipeptide transmembrane transporter activity (GO:0071916), protein binding (GO:0005515), symporter activity (GO:0015293), transmembrane transporter activity (GO:0022857)

GO Cellular Component (5): lysosomal membrane (GO:0005765), endosome membrane (GO:0010008), lysosome (GO:0005764), endosome (GO:0005768), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
SLC-mediated transport of oligopeptides	1
Transport of small molecules	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	4
dipeptide transmembrane transport	2
intracellular protein localization	1
establishment of protein localization	1
nitrogen compound transport	1
carbohydrate derivative transport	1
immune response	1
defense response to symbiont	1
positive regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	1
nucleotide-binding oligomerization domain containing 2 signaling pathway	1
regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	1
oligopeptide import across plasma membrane	1
biological_process	1
cellular process	1
monoatomic cation transmembrane transport	1
solute:proton symporter activity	1
peptide transmembrane transporter activity	1
peptidoglycan transport	1
macromolecule transmembrane transporter activity	1
carbohydrate derivative transmembrane transporter activity	1
oligopeptide transmembrane transporter activity	1
binding	1
secondary active transmembrane transporter activity	1
transporter activity	1
transmembrane transport	1
lysosome	1
lytic vacuole membrane	1
endosome	1
cytoplasmic vesicle membrane	1
bounding membrane of organelle	1
lytic vacuole	1
endomembrane system	1
cytoplasmic vesicle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1824 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC15A3	CD6	P30203	783
SLC15A3	CD5	P06127	640
SLC15A3	CARNS1	A5YM72	528
SLC15A3	SLC47A1	Q96FL8	429
SLC15A3	SULT1A2	P50226	426
SLC15A3	SLC6A6	P31641	418
SLC15A3	SLC7A4	O43246	409
SLC15A3	NOD1	Q9Y239	408
SLC15A3	NOD2	Q9HC29	403
SLC15A3	SLC38A5	Q8WUX1	402
SLC15A3	OR6X1	Q8NH79	397
SLC15A3	CNDP2	Q96KP4	367
SLC15A3	SLC15A2	Q16348	354
SLC15A3	SLC38A7	Q9NVC3	347
SLC15A3	CNDP1	Q96KN2	342

IntAct

25 interactions, top by confidence:

A	B	Type	Score
KRTAP12-2	SLC15A3	psi-mi:“MI:0915”(physical association)	0.600
SLC15A3	KRTAP12-2	psi-mi:“MI:0915”(physical association)	0.600
SLC15A3	MDFI	psi-mi:“MI:0915”(physical association)	0.560
KRTAP5-9	SLC15A3	psi-mi:“MI:0915”(physical association)	0.560
SLC15A3	KRTAP9-8	psi-mi:“MI:0915”(physical association)	0.560
HOXA1	SLC15A3	psi-mi:“MI:0915”(physical association)	0.560
KRTAP19-2	SLC15A3	psi-mi:“MI:0915”(physical association)	0.560
SLC15A3	NOD2	psi-mi:“MI:0915”(physical association)	0.400
SLC15A3	SLC15A4	psi-mi:“MI:0915”(physical association)	0.400
SLC15A3	GXYLT2	psi-mi:“MI:0914”(association)	0.350
SLC15A3	MDFI	psi-mi:“MI:0915”(physical association)	0.000
SLC15A3	KRTAP5-9	psi-mi:“MI:0915”(physical association)	0.000
KRTAP12-2	SLC15A3	psi-mi:“MI:0915”(physical association)	0.000
SLC15A3	HOXA1	psi-mi:“MI:0915”(physical association)	0.000
SLC15A3	KRTAP9-8	psi-mi:“MI:0915”(physical association)	0.000
SLC15A3	KRTAP19-2	psi-mi:“MI:0915”(physical association)	0.000
SLC15A3	KRTAP12-2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (414): SLC15A3 (Two-hybrid), SLC15A3 (Two-hybrid), SLC15A3 (Two-hybrid), SLC15A3 (Two-hybrid), GMCL1 (Two-hybrid), LZTS2 (Two-hybrid), KRTAP10-3 (Two-hybrid), ABCC1 (Affinity Capture-MS), ACAD9 (Affinity Capture-MS), ADAM10 (Affinity Capture-MS), ADCK4 (Affinity Capture-MS), AGPAT2 (Affinity Capture-MS), AIFM1 (Affinity Capture-MS), ALDH3A2 (Affinity Capture-MS), ALDOA (Affinity Capture-MS)

ESM2 similar proteins: A1A5Z0, A6NM10, F6S3G9, O19133, O42153, O42154, O62735, P34080, P35575, P35576, P41181, P43428, P51802, P56402, P58355, P79099, Q05B81, Q06393, Q0VC03, Q10M80, Q148G2, Q19KA1, Q29RU6, Q4LE88, Q5U2T1, Q6AZ83, Q6NSQ9, Q6RZ07, Q71B07, Q7ZVP8, Q866G7, Q8BHH1, Q8BMD6, Q8BPX9, Q8CHJ2, Q8CHM1, Q8IXF9, Q8IY34, Q8NBQ7, Q924V4

Diamond homologs: A6QQL0, O09014, Q68F72, Q8BPX9, Q8IY34, Q8N697, Q91W98, Q924V4, P91679, O01840

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

108 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	90
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1123 predictions. Top by Δscore:

Variant	Effect	Δscore
11:60937866:TCA:T	donor_loss	1.0000
11:60937867:CACCA:C	donor_loss	1.0000
11:60937868:A:AC	donor_gain	1.0000
11:60937868:A:T	donor_loss	1.0000
11:60937869:C:CC	donor_gain	1.0000
11:60937869:C:T	donor_loss	1.0000
11:60939474:GGGTA:G	donor_loss	1.0000
11:60939475:GGTAC:G	donor_loss	1.0000
11:60939476:GTACC:G	donor_loss	1.0000
11:60939477:TA:T	donor_loss	1.0000
11:60939478:A:AG	donor_loss	1.0000
11:60939502:A:AC	donor_gain	1.0000
11:60939503:C:CC	donor_gain	1.0000
11:60939634:GACTC:G	acceptor_gain	1.0000
11:60939636:CTC:C	acceptor_gain	1.0000
11:60939637:TC:T	acceptor_gain	1.0000
11:60939638:CC:C	acceptor_gain	1.0000
11:60939639:C:CC	acceptor_gain	1.0000
11:60939639:CTGGT:C	acceptor_loss	1.0000
11:60939642:G:C	acceptor_gain	1.0000
11:60939642:G:GC	acceptor_gain	1.0000
11:60939651:C:CT	acceptor_gain	1.0000
11:60943684:CTCA:C	donor_loss	1.0000
11:60943685:TCA:T	donor_loss	1.0000
11:60943686:CAC:C	donor_loss	1.0000
11:60943687:A:AC	donor_gain	1.0000
11:60943687:A:T	donor_loss	1.0000
11:60943688:C:CC	donor_gain	1.0000
11:60943688:C:CT	donor_loss	1.0000
11:60943837:C:CC	acceptor_gain	1.0000

AlphaMissense

3719 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:60939620:C:G	R432P	0.995
11:60939502:A:C	S471R	0.994
11:60939502:A:T	S471R	0.994
11:60939504:T:G	S471R	0.994
11:60939629:T:A	E429V	0.994
11:60939621:G:T	R432S	0.993
11:60942111:A:G	L344P	0.992
11:60937972:C:G	G497R	0.991
11:60938013:G:T	A483D	0.991
11:60939487:G:C	S476R	0.991
11:60939487:G:T	S476R	0.991
11:60939489:T:G	S476R	0.991
11:60941278:A:G	W374R	0.991
11:60941278:A:T	W374R	0.991
11:60938016:A:G	F482S	0.990
11:60951033:G:C	S173R	0.990
11:60951033:G:T	S173R	0.990
11:60951035:T:G	S173R	0.990
11:60951231:G:C	S107R	0.990
11:60951231:G:T	S107R	0.990
11:60951233:T:G	S107R	0.990
11:60937950:C:T	G504E	0.989
11:60942122:C:A	Q340H	0.989
11:60942122:C:G	Q340H	0.989
11:60939630:C:T	E429K	0.988
11:60946765:G:C	S205R	0.987
11:60946765:G:T	S205R	0.987
11:60946767:T:G	S205R	0.987
11:60937944:C:T	G506D	0.986
11:60939628:C:A	E429D	0.986

dbSNP variants (sampled 300 via entrez): RS1000073951 (11:60944643 T>C), RS1000239315 (11:60938416 T>C,G), RS1000377494 (11:60940713 A>G), RS1000901961 (11:60948621 C>T), RS1001007311 (11:60952386 AT>A,ATT), RS1001124587 (11:60952158 C>A,G,T), RS1001422974 (11:60939865 A>G), RS1001481018 (11:60943467 G>A), RS1001685647 (11:60946972 A>G), RS1001754682 (11:60938327 A>C,G), RS1002032320 (11:60944026 G>C), RS1002216677 (11:60953996 G>A), RS1002364085 (11:60948360 G>A), RS1002411402 (11:60951953 C>A), RS1002632140 (11:60942882 G>A)

Disease associations

OMIM: gene MIM:610408 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST006192_46	Systolic blood pressure x smoking status (ever vs never) interaction (2df test)	3.000000e-06
GCST006195_89	Systolic blood pressure x smoking status (current vs non-current) interaction (2df test)	3.000000e-09
GCST010002_239	Refractive error	2.000000e-24

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0006335	systolic blood pressure
EFO:0006527	smoking status measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC15 family of peptide transporters

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases mutagenesis, affects methylation, increases expression, increases methylation	3
Air Pollutants	affects expression, increases abundance, decreases expression	2
Nickel	increases expression	2
Valproic Acid	affects expression, increases methylation	2
aristolochic acid I	increases expression	1
triphenyl phosphate	affects expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
di-n-butylphosphoric acid	affects expression	1
entinostat	affects cotreatment, increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
ICG 001	increases expression	1
dorsomorphin	increases expression, affects cotreatment	1
(+)-JQ1 compound	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Temozolomide	increases expression	1
Acetaminophen	decreases expression	1
Arbutin	decreases expression	1
Benzene	increases expression	1
Doxorubicin	decreases expression	1
Lipopolysaccharides	affects response to substance, increases expression	1
Ozone	affects expression, increases abundance	1
Dronabinol	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	increases expression	1
Asbestos, Serpentine	decreases expression	1
Antirheumatic Agents	decreases expression	1
Okadaic Acid	increases expression	1
Particulate Matter	increases abundance, decreases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B1HK	Abcam A-549 SLC15A3 KO	Cancer cell line	Male
CVCL_E0NK	Ubigene HeLa SLC15A3 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.