SLC16A1-AS1

Summary

SLC16A1-AS1 (SLC16A1 antisense RNA 1, HGNC:49445) is a long non-coding RNA gene on chromosome 1p13.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49445
Approved symbol	SLC16A1-AS1
Name	SLC16A1 antisense RNA 1
Location	1p13.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	ENST00000421157.1
Ensembl gene	ENSG00000226419
Ensembl biotype	lncRNA
Entrez	100506392
RNAcentral	URS000075C4CF — lncRNA, 1522 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 54 — 54 lncRNA

ENST00000413231, ENST00000416193, ENST00000420168, ENST00000428411, ENST00000435800, ENST00000451149, ENST00000627431, ENST00000654334, ENST00000659961, ENST00000662044, ENST00000662852, ENST00000664314, ENST00000665960, ENST00000715663, ENST00000715664, ENST00000715665, ENST00000715666, ENST00000764794, ENST00000764795, ENST00000764796, ENST00000764797, ENST00000764798, ENST00000764799, ENST00000764800, ENST00000764801, ENST00000764802, ENST00000764803, ENST00000764804, ENST00000764805, ENST00000764806, ENST00000764807, ENST00000764808, ENST00000764809, ENST00000764810, ENST00000764811, ENST00000764812, ENST00000764813, ENST00000764814, ENST00000764815, ENST00000764816, ENST00000764817, ENST00000764818, ENST00000764819, ENST00000764820, ENST00000764821, ENST00000764822, ENST00000764823, ENST00000764824, ENST00000764825, ENST00000764826, ENST00000764827, ENST00000764828, ENST00000764829, ENST00000764830

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000413231 — 5 exons

Exon	Start	End
ENSE00004027526	112960477	112960575
ENSE00004122050	113046786	113047058
ENSE00004122052	112998930	112999109
ENSE00004122081	113008130	113008360
ENSE00004122098	112849866	112850427

Expression profiles

Bgee: expression breadth ubiquitous, 192 present calls, max score 88.88.

FANTOM5 (CAGE): breadth broad, TPM avg 1.4025 / max 32.6028, expressed in 661 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
4712	6.5741	1599
4707	1.3455	655
4710	0.6226	315
4711	0.6107	320
4713	0.2535	107
4705	0.0290	10
4706	0.0281	11

Top tissues by expression

235 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	88.88	gold quality
sural nerve	UBERON:0015488	86.25	gold quality
cerebellar hemisphere	UBERON:0002245	80.44	gold quality
cerebellar cortex	UBERON:0002129	80.30	gold quality
right hemisphere of cerebellum	UBERON:0014890	79.11	gold quality
left ovary	UBERON:0002119	78.85	gold quality
body of uterus	UBERON:0009853	78.73	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.32	gold quality
cerebellum	UBERON:0002037	78.30	gold quality
right ovary	UBERON:0002118	78.29	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.52	gold quality
buccal mucosa cell	CL:0002336	76.46	gold quality
cortical plate	UBERON:0005343	76.31	gold quality
muscle layer of sigmoid colon	UBERON:0035805	75.64	gold quality
ectocervix	UBERON:0012249	75.52	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	75.32	gold quality
putamen	UBERON:0001874	75.22	gold quality
calcaneal tendon	UBERON:0003701	75.15	gold quality
caudate nucleus	UBERON:0001873	75.07	gold quality
lower esophagus mucosa	UBERON:0035834	75.05	gold quality
adrenal tissue	UBERON:0018303	74.97	gold quality
tibial nerve	UBERON:0001323	74.73	gold quality
right testis	UBERON:0004534	74.73	gold quality
ovary	UBERON:0000992	74.47	gold quality
nucleus accumbens	UBERON:0001882	74.44	gold quality
Brodmann (1909) area 9	UBERON:0013540	74.44	gold quality
colonic epithelium	UBERON:0000397	74.13	gold quality
endocervix	UBERON:0000458	74.07	gold quality
left testis	UBERON:0004533	73.97	gold quality
ascending aorta	UBERON:0001496	73.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.34

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• Long non-coding RNA SLC16A1-AS1: its multiple tumorigenesis features and regulatory role in cell cycle in oral squamous cell carcinoma. (PMID:32450050)
• LncRNA SLC16A1-AS1 contributes to the progression of hepatocellular carcinoma cells by modulating miR-411/MITD1 axis. (PMID:35293026)
• LncRNA SLC16A1-AS1 regulates the miR-182/PDCD4 axis and inhibits the triple-negative breast cancer cell cycle. (PMID:35316129)
• MicroRNA-1269 is downregulated in glioblastoma and its maturation is regulated by long non-coding RNA SLC16A1 Antisense RNA 1. (PMID:35609320)
• Analysis of the subcellular location of lncRNA SLC16A1-AS1 and its interaction with premature miR-5088-5p in oral squamous cell carcinoma. (PMID:35829849)
• MiR-526b targets lncRNA SLC16A1-AS1 to suppress cell proliferation in triple-negative breast cancer. (PMID:36654514)
• Exosomal SLC16A1-AS1-induced M2 macrophages polarization facilitates hepatocellular carcinoma progression. (PMID:39247822)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.