SLC16A6

Summary

SLC16A6 (solute carrier family 16 member 6, HGNC:10927) is a protein-coding gene on chromosome 17q24.2, encoding Monocarboxylate transporter 7 (O15403). Monocarboxylate transporter selective for taurine.

Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be located in basolateral plasma membrane. Predicted to be active in plasma membrane.

Source: NCBI Gene 9120 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 1 total
• MANE Select transcript: NM_004694

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10927
Approved symbol	SLC16A6
Name	solute carrier family 16 member 6
Location	17q24.2
Locus type	gene with protein product
Status	Approved
Aliases	MCT6, MCT7
Ensembl gene	ENSG00000108932
Ensembl biotype	protein_coding
OMIM	603880
Entrez	9120

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 protein_coding

ENST00000327268, ENST00000580666, ENST00000582867, ENST00000583477, ENST00000957248, ENST00000957249

RefSeq mRNA: 2 — MANE Select: NM_004694 NM_001174166, NM_004694

CCDS: CCDS11675

Canonical transcript exons

ENST00000580666 — 6 exons

Exon	Start	End
ENSE00000742977	68273927	68274070
ENSE00000742978	68272639	68272767
ENSE00001269891	68270839	68271654
ENSE00001269953	68278089	68278327
ENSE00001369414	68267026	68269346
ENSE00002705229	68291086	68291127

Expression profiles

Bgee: expression breadth ubiquitous, 234 present calls, max score 93.58.

FANTOM5 (CAGE): breadth broad, TPM avg 5.0838 / max 328.4024, expressed in 805 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
167726	2.9600	529
167730	1.4408	462
167728	0.4809	271
167729	0.0827	24
167725	0.0776	38
167727	0.0418	14

Top tissues by expression

262 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus epididymis	UBERON:0004359	93.58	gold quality
esophagus squamous epithelium	UBERON:0006920	91.92	gold quality
gingiva	UBERON:0001828	89.74	gold quality
gingival epithelium	UBERON:0001949	89.34	gold quality
stromal cell of endometrium	CL:0002255	88.94	gold quality
oral cavity	UBERON:0000167	88.91	gold quality
cauda epididymis	UBERON:0004360	87.84	gold quality
Brodmann (1909) area 23	UBERON:0013554	87.17	gold quality
monocyte	CL:0000576	86.87	gold quality
leukocyte	CL:0000738	86.56	gold quality
oviduct epithelium	UBERON:0004804	85.96	gold quality
pigmented layer of retina	UBERON:0001782	84.79	gold quality
endometrium epithelium	UBERON:0004811	84.53	gold quality
blood	UBERON:0000178	84.45	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.84	gold quality
mammalian vulva	UBERON:0000997	82.07	gold quality
granulocyte	CL:0000094	81.77	gold quality
seminal vesicle	UBERON:0000998	81.65	gold quality
penis	UBERON:0000989	81.58	gold quality
primary visual cortex	UBERON:0002436	80.81	gold quality
esophagus mucosa	UBERON:0002469	80.38	gold quality
lower esophagus mucosa	UBERON:0035834	80.29	gold quality
upper leg skin	UBERON:0004262	80.09	gold quality
pharyngeal mucosa	UBERON:0000355	79.80	gold quality
buccal mucosa cell	CL:0002336	79.73	gold quality
tibialis anterior	UBERON:0001385	79.58	silver quality
middle temporal gyrus	UBERON:0002771	78.94	gold quality
endothelial cell	CL:0000115	78.16	silver quality
bone marrow	UBERON:0002371	78.10	gold quality
upper arm skin	UBERON:0004263	77.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.32

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

104 targeting SLC16A6, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-512-3P	99.97	67.35	1049
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-106A-5P	99.90	73.94	2683
HSA-MIR-17-5P	99.89	73.83	2665
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-106B-5P	99.88	74.72	2795
HSA-MIR-20A-5P	99.88	74.76	2769
HSA-MIR-20B-5P	99.88	74.01	2621
HSA-MIR-519D-3P	99.88	73.97	2607
HSA-MIR-526B-3P	99.88	74.06	2587

Literature-anchored findings (GeneRIF, showing 3)

• MCT6 is involved in the disposition of various drugs, including bumetanide. (PMID:16174808)
• Genetic variants in PDSS1 and SLC16A6 of the ketone body metabolic pathway predict cutaneous melanoma-specific survival. (PMID:32232919)
• Mammalian monocarboxylate transporter 7 (MCT7/Slc16a6) is a novel facilitative taurine transporter. (PMID:35257743)

Cross-species orthologs

19 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc16a6b	ENSDARG00000060246
		ENSDARG00000102793
danio_rerio	slc16a6a	ENSDARG00000104629
mus_musculus	Slc16a6	ENSMUSG00000041920
rattus_norvegicus	Slc16a6	ENSRNOG00000000245
drosophila_melanogaster	Mct1	FBGN0023549
drosophila_melanogaster	CG14196	FBGN0031002
drosophila_melanogaster	CG8051	FBGN0031012
drosophila_melanogaster	Sln	FBGN0033657
drosophila_melanogaster	CG8468	FBGN0033913
drosophila_melanogaster	Targ	FBGN0033955
drosophila_melanogaster	CG13907	FBGN0035173
drosophila_melanogaster	out	FBGN0259834
caenorhabditis_elegans		WBGENE00003986
caenorhabditis_elegans		WBGENE00010834
caenorhabditis_elegans		WBGENE00015273
caenorhabditis_elegans		WBGENE00015676
caenorhabditis_elegans		WBGENE00020168
caenorhabditis_elegans		WBGENE00021227

Paralogs (13): SLC16A8 (ENSG00000100156), SLC16A10 (ENSG00000112394), SLC16A7 (ENSG00000118596), SLC16A3 (ENSG00000141526), SLC16A2 (ENSG00000147100), SLC16A12 (ENSG00000152779), SLC16A1 (ENSG00000155380), SLC16A14 (ENSG00000163053), SLC16A9 (ENSG00000165449), SLC16A4 (ENSG00000168679), SLC16A5 (ENSG00000170190), SLC16A11 (ENSG00000174326), SLC16A13 (ENSG00000174327)

Protein

Protein identifiers

Monocarboxylate transporter 7 — O15403 (reviewed: O15403)

Alternative names: Monocarboxylate transporter 6, Solute carrier family 16 member 6

All UniProt accessions (3): O15403, J3KS02, J3KTN2

UniProt curated annotations — full annotation on UniProt →

Function. Monocarboxylate transporter selective for taurine. May associate with BSG/CD147 or EMB/GP70 ancillary proteins to mediate facilitative efflux or influx of taurine across the plasma membrane. The transport is pH- and sodium-independent. Rather low-affinity, is likely effective for taurine transport in tissues where taurine is present at high concentrations.

Subunit / interactions. Forms functional complexes with BSG/CD147 or EMB/GP70 ancillary proteins.

Subcellular location. Basolateral cell membrane.

Similarity. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.

RefSeq proteins (2): NP_001167637, NP_004685* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011701	MFS	Family
IPR020846	MFS_dom	Domain
IPR030766	MCT7	Family
IPR036259	MFS_trans_sf	Homologous_superfamily
IPR050327	Proton-linked_MCT	Family

Pfam: PF07690

Catalyzed reactions (Rhea), 1 shown:

• taurine(out) = taurine(in) (RHEA:66328)

UniProt features (35 total): topological domain 13, transmembrane region 12, modified residue 4, sequence variant 4, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O15403-F1	76.08	0.49

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 234, 237, 240, 247

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 328 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_UP, CREL_01, SHEPARD_BMYB_MORPHOLINO_UP, WWTAAGGC_UNKNOWN, NKX25_02, SHEPARD_CRASH_AND_BURN_MUTANT_UP, MODULE_45, AREB6_03, GOZGIT_ESR1_TARGETS_DN, AREB6_01, TGACCTY_ERR1_Q2, GOBP_ORGANIC_ACID_TRANSPORT, SRF_Q5_01, WANG_ESOPHAGUS_CANCER_VS_NORMAL_DN, AP1_Q4_01

GO Biological Process (5): monocarboxylic acid transport (GO:0015718), obsolete organic anion transport (GO:0015711), taurine transmembrane transport (GO:0015734), organic acid transport (GO:0015849), transmembrane transport (GO:0055085)

GO Molecular Function (4): taurine transmembrane transporter activity (GO:0005368), monocarboxylic acid transmembrane transporter activity (GO:0008028), protein binding (GO:0005515), transmembrane transporter activity (GO:0022857)

GO Cellular Component (3): plasma membrane (GO:0005886), membrane (GO:0016020), basolateral plasma membrane (GO:0016323)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	2
carboxylic acid transport	1
alkanesulfonate transmembrane transport	1
nitrogen compound transport	1
cellular process	1
taurine transmembrane transport	1
sulfur compound transmembrane transporter activity	1
monocarboxylic acid transport	1
carboxylic acid transmembrane transporter activity	1
binding	1
transporter activity	1
transmembrane transport	1
membrane	1
cell periphery	1
cellular anatomical structure	1
basal plasma membrane	1
plasma membrane region	1

Protein interactions and networks

STRING

776 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC16A6	ARSG	Q96EG1	457
SLC16A6	AREG	P15514	436
SLC16A6	BRDT	Q58F21	429
SLC16A6	EGR1	P18146	423
SLC16A6	C4BPB	P20851	416
SLC16A6	ANGPTL4	Q9BY76	409
SLC16A6	RIMBP2	O15034	396
SLC16A6	MCTS1	Q9ULC4	389
SLC16A6	ALDH1A1	P00352	377
SLC16A6	SLC2A6	Q9UGQ3	341
SLC16A6	PNLIPRP3	Q17RR3	333
SLC16A6	SLC5A8	Q8N695	332
SLC16A6	SLC6A6	P31641	329
SLC16A6	TNFAIP6	P98066	322
SLC16A6	SLC28A3	Q9HAS3	312
SLC16A6	NDUFAF4	Q9P032	312

IntAct

11 interactions, top by confidence:

A	B	Type	Score
SLC16A6	WFS1	psi-mi:“MI:0915”(physical association)	0.560
SLC16A6	H1-5	psi-mi:“MI:0915”(physical association)	0.400
SLC16A6	ZNF768	psi-mi:“MI:0914”(association)	0.350
NS3	C15orf61	psi-mi:“MI:0914”(association)	0.350
	NBAS	psi-mi:“MI:0914”(association)	0.350
	SHTN1	psi-mi:“MI:0914”(association)	0.350
	TMEM223	psi-mi:“MI:0914”(association)	0.350
SLC16A6	RER1	psi-mi:“MI:0914”(association)	0.350

BioGRID (42): AFF1 (Affinity Capture-MS), CASK (Affinity Capture-MS), ERC1 (Affinity Capture-MS), ZNF768 (Affinity Capture-MS), CEP78 (Affinity Capture-MS), SLC16A6 (Affinity Capture-MS), SLC16A6 (Affinity Capture-MS), HIST1H1B (Proximity Label-MS), SLC16A6 (Affinity Capture-RNA), SLC16A6 (Affinity Capture-MS), ANO10 (Affinity Capture-MS), ATP2C1 (Affinity Capture-MS), USMG5 (Affinity Capture-MS), ATP5I (Affinity Capture-MS), ATP5L (Affinity Capture-MS)

ESM2 similar proteins: A0A6I8PMZ8, A1Z7R6, A4IHK6, A4QN56, A7Y2X0, A9JTG4, B1AT66, B2RXV4, F5H094, M0RCI4, O15403, O75387, P34711, P58295, P81721, Q08280, Q08C75, Q0VCM6, Q497L8, Q5BIZ0, Q5R5M4, Q5RCN7, Q5RF58, Q5ZJU0, Q5ZJZ4, Q68EU6, Q6A4L1, Q6PDC8, Q761V0, Q7RTX9, Q7RTY1, Q7SXB7, Q7TM99, Q7TMR7, Q86UG4, Q8BSM7, Q8C0X7, Q8CGA3, Q8K1C7, Q8N370

Diamond homologs: A0LNN5, B1AT66, I1RV24, O15375, O15403, O15427, O35440, O35910, O60669, O70451, O95907, P53985, P53986, P53987, P53988, P57787, P57788, Q03064, Q17QR6, Q3MHW6, Q63344, Q66HE2, Q7RTY0, Q7TMR7, Q8CE94, Q90632, A0A0C4VYV1, A0A2U8U2M7, A0A411PQP0, A0A4P8GFD0, A5ABG1, B8N0F1, Q08777, Q0CZG9, Q5ATG7, Q5AUY2, S7Z7Z3, S8AKG0, W7MTI3, D4A734

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1576 predictions. Top by Δscore:

Variant	Effect	Δscore
17:68269342:CAAAC:C	acceptor_gain	1.0000
17:68269348:T:A	acceptor_loss	1.0000
17:68270834:ATTAC:A	donor_loss	1.0000
17:68270836:TA:T	donor_loss	1.0000
17:68270837:A:C	donor_loss	1.0000
17:68271660:A:AC	acceptor_gain	1.0000
17:68271665:C:CT	acceptor_gain	1.0000
17:68271666:A:T	acceptor_gain	1.0000
17:68271670:G:GC	acceptor_gain	1.0000
17:68272767:CCTG:C	acceptor_loss	1.0000
17:68272769:T:G	acceptor_loss	1.0000
17:68273923:TTA:T	donor_loss	1.0000
17:68273924:TACCA:T	donor_loss	1.0000
17:68273925:A:AC	donor_gain	1.0000
17:68273925:A:AT	donor_loss	1.0000
17:68273925:AC:A	donor_gain	1.0000
17:68273926:C:CA	donor_gain	1.0000
17:68273926:CC:C	donor_gain	1.0000
17:68273926:CCA:C	donor_gain	1.0000
17:68273926:CCAG:C	donor_gain	1.0000
17:68273926:CCAGA:C	donor_gain	1.0000
17:68274066:GGGAG:G	acceptor_gain	1.0000
17:68274067:GGAG:G	acceptor_gain	1.0000
17:68274068:GAG:G	acceptor_gain	1.0000
17:68274069:AG:A	acceptor_gain	1.0000
17:68274069:AGC:A	acceptor_loss	1.0000
17:68274070:GC:G	acceptor_loss	1.0000
17:68274071:C:CA	acceptor_loss	1.0000
17:68274071:C:CC	acceptor_gain	1.0000
17:68274075:C:CT	acceptor_gain	1.0000

AlphaMissense

3412 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:68270870:G:C	S430R	0.998
17:68270870:G:T	S430R	0.998
17:68270872:T:G	S430R	0.998
17:68272712:A:C	F144L	0.994
17:68272712:A:T	F144L	0.994
17:68272714:A:G	F144L	0.994
17:68272748:A:C	S132R	0.991
17:68272748:A:T	S132R	0.991
17:68272750:T:G	S132R	0.991
17:68272680:G:T	A155D	0.989
17:68272761:C:T	G128E	0.988
17:68270982:C:T	G393E	0.987
17:68270993:G:C	S389R	0.987
17:68270993:G:T	S389R	0.987
17:68270995:T:G	S389R	0.987
17:68273997:G:C	S102R	0.987
17:68273997:G:T	S102R	0.987
17:68273999:T:G	S102R	0.987
17:68278203:C:G	G40R	0.986
17:68270940:A:T	L407H	0.985
17:68272671:C:T	G158E	0.985
17:68272762:C:G	G128R	0.985
17:68272762:C:T	G128R	0.985
17:68269306:G:C	F454L	0.984
17:68269306:G:T	F454L	0.984
17:68269308:A:G	F454L	0.984
17:68270970:C:T	G397E	0.984
17:68270971:C:G	G397R	0.984
17:68270971:C:T	G397R	0.984
17:68272767:C:T	G126D	0.984

dbSNP variants (sampled 300 via entrez): RS1000592033 (17:68277267 A>C), RS1000849561 (17:68284550 T>C,G), RS1000901843 (17:68284348 C>A,T), RS1001233243 (17:68285562 C>G,T), RS1001397969 (17:68292099 G>T), RS1001649831 (17:68279110 A>G), RS1002083925 (17:68280533 T>C), RS1003237503 (17:68288538 C>A), RS1003313456 (17:68275071 C>T), RS1003367491 (17:68275506 T>C), RS1004085580 (17:68283690 A>G), RS1004158304 (17:68281831 G>A), RS1004543609 (17:68283378 A>G), RS1004966158 (17:68289662 C>G), RS1005242885 (17:68291876 G>A,T)

Disease associations

OMIM: gene MIM:603880 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST006030_17	Chloride levels	1.000000e-08
GCST006032_14	Sodium levels	1.000000e-08
GCST006922_1	Regular attendance at a religious group	2.000000e-06
GCST006923_7	Loneliness	6.000000e-09
GCST006924_5	Loneliness (MTAG)	1.000000e-09

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0009282	sodium measurement
EFO:0009592	social interaction measurement
EFO:0007865	loneliness measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC16 family of monocarboxylate transporters

CTD chemical–gene interactions

83 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, affects cotreatment, increases expression	8
Benzo(a)pyrene	affects reaction, increases expression, affects expression	6
Estradiol	affects cotreatment, decreases expression, increases expression	6
Tetrachlorodibenzodioxin	affects expression, increases expression	4
Air Pollutants	decreases expression, increases abundance, increases expression, affects cotreatment	3
Progesterone	affects cotreatment, decreases expression	3
Cyclosporine	increases expression	3
Particulate Matter	increases expression, increases abundance	3
(+)-JQ1 compound	decreases expression	2
Fluorouracil	decreases expression, increases expression, affects response to substance	2
Oxygen	increases expression	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	2
FR900359	decreases phosphorylation	1
methylmercuric chloride	increases expression	1
alpha-pinene	affects cotreatment, decreases expression, increases abundance	1
propionaldehyde	increases expression	1
bisphenol A	increases expression	1
trichostatin A	increases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
2,4,5,2’,4’,5’-hexachlorobiphenyl	affects expression	1
3,4-dichloroaniline	increases expression	1
butyraldehyde	increases expression	1
perfluorooctanoic acid	increases expression	1
benzo(e)pyrene	increases methylation	1
hydroquinone	decreases expression	1
methacrylaldehyde	affects cotreatment, decreases expression, increases abundance	1
pentanal	increases expression	1
CGP 52608	affects binding, increases reaction	1
motexafin gadolinium	increases expression, affects cotreatment	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.