SLC16A9

Summary

SLC16A9 (solute carrier family 16 member 9, HGNC:23520) is a protein-coding gene on chromosome 10q21.2, encoding Monocarboxylate transporter 9 (Q7RTY1). Extracellular pH-and Na(+)-sensitive low-affinity creatine transporter.

Enables carnitine transmembrane transporter activity and creatine transmembrane transporter activity. Involved in carnitine transmembrane transport; creatine transmembrane transport; and urate metabolic process. Located in plasma membrane.

Source: NCBI Gene 220963 — RefSeq curated summary.

At a glance

• GWAS associations: 28
• Clinical variants (ClinVar): 67 total
• MANE Select transcript: NM_194298

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23520
Approved symbol	SLC16A9
Name	solute carrier family 16 member 9
Location	10q21.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ43803, MCT9
Ensembl gene	ENSG00000165449
Ensembl biotype	protein_coding
OMIM	614242
Entrez	220963

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 21 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000395347, ENST00000395348, ENST00000490066, ENST00000881708, ENST00000881709, ENST00000881710, ENST00000881711, ENST00000881712, ENST00000881713, ENST00000881714, ENST00000881715, ENST00000881716, ENST00000881717, ENST00000881718, ENST00000881719, ENST00000936198, ENST00000936199, ENST00000947927, ENST00000947928, ENST00000947929, ENST00000947930, ENST00000947931

RefSeq mRNA: 6 — MANE Select: NM_194298 NM_001323977, NM_001323978, NM_001323979, NM_001323980, NM_001323981, NM_194298

CCDS: CCDS7256

Canonical transcript exons

ENST00000395348 — 6 exons

Exon	Start	End
ENSE00001134378	59653675	59654589
ENSE00001381348	59672770	59672913
ENSE00001391372	59664227	59664322
ENSE00001521427	59684096	59684327
ENSE00001521430	59709479	59709850
ENSE00003719961	59650764	59652950

Expression profiles

Bgee: expression breadth ubiquitous, 196 present calls, max score 99.91.

FANTOM5 (CAGE): breadth broad, TPM avg 1.9814 / max 71.5713, expressed in 645 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
109468	1.1593	451
109466	0.5837	315
109467	0.1626	86
109459	0.0759	43

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney epithelium	UBERON:0004819	99.91	gold quality
adrenal tissue	UBERON:0018303	98.34	gold quality
left adrenal gland cortex	UBERON:0035825	98.00	gold quality
adrenal cortex	UBERON:0001235	97.89	gold quality
right adrenal gland	UBERON:0001233	97.79	gold quality
right adrenal gland cortex	UBERON:0035827	97.79	gold quality
left adrenal gland	UBERON:0001234	97.71	gold quality
nasal cavity epithelium	UBERON:0005384	97.24	gold quality
adrenal gland	UBERON:0002369	96.56	gold quality
adult organism	UBERON:0007023	94.05	gold quality
colonic mucosa	UBERON:0000317	92.59	gold quality
mucosa of sigmoid colon	UBERON:0004993	92.11	gold quality
ileal mucosa	UBERON:0000331	91.24	gold quality
adult mammalian kidney	UBERON:0000082	91.23	gold quality
kidney	UBERON:0002113	89.81	gold quality
gingiva	UBERON:0001828	89.52	gold quality
esophagus squamous epithelium	UBERON:0006920	89.46	gold quality
gingival epithelium	UBERON:0001949	89.15	gold quality
ventricular zone	UBERON:0003053	88.90	gold quality
oviduct epithelium	UBERON:0004804	87.94	gold quality
right hemisphere of cerebellum	UBERON:0014890	87.48	gold quality
cerebellar hemisphere	UBERON:0002245	87.37	gold quality
cerebellar cortex	UBERON:0002129	87.18	gold quality
fallopian tube	UBERON:0003889	87.18	gold quality
cerebellum	UBERON:0002037	86.47	gold quality
rectum	UBERON:0001052	85.99	gold quality
palpebral conjunctiva	UBERON:0001812	85.91	gold quality
bronchial epithelial cell	CL:0002328	85.88	gold quality
left ovary	UBERON:0002119	85.38	gold quality
right uterine tube	UBERON:0001302	85.25	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-GEOD-131882	yes	2032.79
E-CURD-119	yes	2014.31
E-ANND-3	yes	6.08
E-CURD-135	no	1365.49
E-GEOD-124858	no	77.97

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

132 targeting SLC16A9, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548P	99.98	72.25	3784
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-3617-3P	99.98	67.86	918
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-548AN	99.97	70.91	2817
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-6825-5P	99.96	69.81	3431

Literature-anchored findings (GeneRIF, showing 7)

• it has a possible physiological role in urate excretion from human intestinal epithelial cells. (PMID:23990105)
• Strong association of SLC16A9 gene variation with HBsAg loss was identified in Chronic Hepatitis B patients treated with peginterferon and adefovir. (PMID:24824278)
• Molecular characterization of the orphan transporter SLC16A9, an extracellular pH- and Na(+)-sensitive creatine transporter. (PMID:31784090)
• SLC1A1, SLC16A9, and CNTN3 Are Potential Biomarkers for the Occurrence of Colorectal Cancer. (PMID:32566650)
• Monocarboxylate transporter 9 (MCT9) is down-regulated in renal cell carcinoma. (PMID:33555501)
• The tissue expression of MCT3, MCT8, and MCT9 genes in women with breast cancer. (PMID:34097251)
• Molecular characteristic analysis of single-nucleotide polymorphisms in SLC16A9/hMCT9. (PMID:37879602)

Cross-species orthologs

18 orthologs

Organism	Symbol	Gene ID
danio_rerio	slc16a9a	ENSDARG00000013926
danio_rerio	slc16a9b	ENSDARG00000104687
mus_musculus	Slc16a9	ENSMUSG00000037762
rattus_norvegicus	Slc16a9	ENSRNOG00000049063
drosophila_melanogaster	Mct1	FBGN0023549
drosophila_melanogaster	CG14196	FBGN0031002
drosophila_melanogaster	CG8051	FBGN0031012
drosophila_melanogaster	Sln	FBGN0033657
drosophila_melanogaster	CG8468	FBGN0033913
drosophila_melanogaster	Targ	FBGN0033955
drosophila_melanogaster	CG13907	FBGN0035173
drosophila_melanogaster	out	FBGN0259834
caenorhabditis_elegans		WBGENE00003986
caenorhabditis_elegans		WBGENE00010834
caenorhabditis_elegans		WBGENE00015273
caenorhabditis_elegans		WBGENE00015676
caenorhabditis_elegans		WBGENE00020168
caenorhabditis_elegans		WBGENE00021227

Paralogs (13): SLC16A8 (ENSG00000100156), SLC16A6 (ENSG00000108932), SLC16A10 (ENSG00000112394), SLC16A7 (ENSG00000118596), SLC16A3 (ENSG00000141526), SLC16A2 (ENSG00000147100), SLC16A12 (ENSG00000152779), SLC16A1 (ENSG00000155380), SLC16A14 (ENSG00000163053), SLC16A4 (ENSG00000168679), SLC16A5 (ENSG00000170190), SLC16A11 (ENSG00000174326), SLC16A13 (ENSG00000174327)

Protein

Protein identifiers

Monocarboxylate transporter 9 — Q7RTY1 (reviewed: Q7RTY1)

Alternative names: Solute carrier family 16 member 9

All UniProt accessions (1): Q7RTY1

UniProt curated annotations — full annotation on UniProt →

Function. Extracellular pH-and Na(+)-sensitive low-affinity creatine transporter. Also functions as a pH-independent carnitine efflux transporter.

Subcellular location. Cell membrane.

Activity regulation. 4-guanidinobutyrate and guanidinoethyl sulfonate inhibit the transport activity.

Similarity. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.

RefSeq proteins (6): NP_001310906, NP_001310907, NP_001310908, NP_001310909, NP_001310910, NP_919274* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011701	MFS	Family
IPR020846	MFS_dom	Domain
IPR030767	MCT9	Family
IPR036259	MFS_trans_sf	Homologous_superfamily
IPR050327	Proton-linked_MCT	Family

Pfam: PF07690

Catalyzed reactions (Rhea), 2 shown:

• (R)-carnitine(in) = (R)-carnitine(out) (RHEA:34959)
• creatine(in) = creatine(out) (RHEA:73043)

UniProt features (18 total): transmembrane region 12, sequence variant 3, topological domain 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7RTY1-F1	76.70	0.41

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 137 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_MCMV_INFECTION_DN, GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_UP, GOBP_MODIFIED_AMINO_ACID_TRANSPORT, chr10q21, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP, GOBP_AMINO_ACID_BETAINE_TRANSPORT, GOBP_ORGANIC_ACID_TRANSPORT, GOBP_QUATERNARY_AMMONIUM_GROUP_TRANSPORT, GOBP_ORGANIC_ANION_TRANSPORT, GOBP_MONOCARBOXYLIC_ACID_TRANSPORT, GOBP_ORGANIC_CATION_TRANSPORT, GOBP_URATE_METABOLIC_PROCESS, CART1_01, GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS, GRADE_COLON_AND_RECTAL_CANCER_DN

GO Biological Process (5): creatine transmembrane transport (GO:0015881), urate metabolic process (GO:0046415), carnitine transmembrane transport (GO:1902603), carboxylic acid transmembrane transport (GO:1905039), transmembrane transport (GO:0055085)

GO Molecular Function (6): creatine transmembrane transporter activity (GO:0005308), monocarboxylic acid transmembrane transporter activity (GO:0008028), carnitine transmembrane transporter activity (GO:0015226), symporter activity (GO:0015293), protein binding (GO:0005515), transmembrane transporter activity (GO:0022857)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane transport	3
monocarboxylic acid transport	2
modified amino acid transmembrane transporter activity	2
modified amino acid transport	1
carboxylic acid transmembrane transport	1
small molecule metabolic process	1
purine-containing compound metabolic process	1
carnitine transport	1
carboxylic acid transport	1
transport	1
cellular process	1
monocarboxylic acid transmembrane transporter activity	1
creatine transmembrane transport	1
carboxylic acid transmembrane transporter activity	1
quaternary ammonium group transmembrane transporter activity	1
carnitine transmembrane transport	1
secondary active transmembrane transporter activity	1
binding	1
transporter activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

784 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLC16A9	SLC22A11	Q9NSA0	757
SLC16A9	SLC17A1	Q14916	737
SLC16A9	SLC2A9	Q9NRM0	730
SLC16A9	SLC22A12	Q96S37	729
SLC16A9	SLC17A3	O00476	713
SLC16A9	CARMIL1	Q5VZK9	667
SLC16A9	PDZK1	Q5T2W1	667
SLC16A9	SLC17A4	Q9Y2C5	657
SLC16A9	INHBC	P55103	545
SLC16A9	SLC22A5	O76082	544
SLC16A9	ABCG2	Q9UNQ0	536
SLC16A9	SLC22A4	Q9H015	502
SLC16A9	SLC22A6	Q4U2R8	481
SLC16A9	SLC23A3	Q6PIS1	470
SLC16A9	A1CF	Q9NQ94	460

IntAct

12 interactions, top by confidence:

A	B	Type	Score
EIF4A2	SLC16A9	psi-mi:“MI:0915”(physical association)	0.560
KLC4	SLC16A9	psi-mi:“MI:0915”(physical association)	0.560
SLC16A9	MRPL11	psi-mi:“MI:0915”(physical association)	0.560
SLC16A9	EIF4A2	psi-mi:“MI:0915”(physical association)	0.560
SLC16A9	KLC4	psi-mi:“MI:0915”(physical association)	0.560
MRPL11	SLC16A9	psi-mi:“MI:0915”(physical association)	0.560
SLC16A9	PB1	psi-mi:“MI:0915”(physical association)	0.370
SLC16A9	RIOK3	psi-mi:“MI:0914”(association)	0.350

BioGRID (20): SLC16A9 (Two-hybrid), SLC16A9 (Two-hybrid), SLC16A9 (Two-hybrid), SLC16A9 (Affinity Capture-RNA), SLC16A9 (Affinity Capture-RNA), ARL13B (Affinity Capture-MS), CHCHD3 (Affinity Capture-MS), CLCC1 (Affinity Capture-MS), EPHB2 (Affinity Capture-MS), HECTD1 (Affinity Capture-MS), HIGD1A (Affinity Capture-MS), IFNGR1 (Affinity Capture-MS), MRS2 (Affinity Capture-MS), PTPN2 (Affinity Capture-MS), RIOK3 (Affinity Capture-MS)

ESM2 similar proteins: A0A6I8PMZ8, A1Z7R6, A4IHK6, A4QN56, A7Y2X0, A9JTG4, B1AT66, B2RXV4, F5H094, M0RCI4, O15403, O75387, P34711, P58295, P81721, Q08280, Q08C75, Q0VCM6, Q497L8, Q5BIZ0, Q5R5M4, Q5RCN7, Q5RF58, Q5ZJU0, Q5ZJZ4, Q68EU6, Q6A4L1, Q6PDC8, Q761V0, Q7RTX9, Q7RTY1, Q7SXB7, Q7TM99, Q7TMR7, Q86UG4, Q8BSM7, Q8C0X7, Q8CGA3, Q8K1C7, Q8N370

Diamond homologs: A0LNN5, D4A734, G5E8K6, M0RCI4, O15375, O15427, O35308, O35440, O35910, O60669, O70451, O70461, O95907, P53985, P53986, P53987, P53988, P57787, P57788, Q03064, Q17QR6, Q3MHW6, Q503M4, Q5NC32, Q5R5M4, Q5ZJU0, Q63344, Q6GM59, Q6P2X9, Q6ZSM3, Q7RTY0, Q7RTY1, Q7TM99, Q8BGC3, Q8NCK7, Q90632, A0A2U8U2M7, G8XYX6, O70324, P36021

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

67 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	54
Likely benign	2
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

2152 predictions. Top by Δscore:

Variant	Effect	Δscore
10:59672827:A:C	donor_gain	1.0000
10:59684094:A:AC	donor_gain	1.0000
10:59684095:C:CC	donor_gain	1.0000
10:59684095:CTTG:C	donor_gain	1.0000
10:59664222:TATAC:T	donor_loss	0.9900
10:59664223:ATACC:A	donor_loss	0.9900
10:59664224:TA:T	donor_loss	0.9900
10:59664225:A:C	donor_loss	0.9900
10:59664226:C:CA	donor_loss	0.9900
10:59664227:C:A	donor_loss	0.9900
10:59664321:ACC:A	acceptor_loss	0.9900
10:59664323:CT:C	acceptor_loss	0.9900
10:59664324:T:A	acceptor_loss	0.9900
10:59672911:GACC:G	acceptor_loss	0.9900
10:59672912:ACC:A	acceptor_loss	0.9900
10:59672914:CT:C	acceptor_loss	0.9900
10:59684089:CACTT:C	donor_loss	0.9900
10:59684090:ACTTA:A	donor_loss	0.9900
10:59684091:CTTAC:C	donor_loss	0.9900
10:59684092:TTAC:T	donor_loss	0.9900
10:59684093:TACTT:T	donor_loss	0.9900
10:59684094:AC:A	donor_loss	0.9900
10:59684095:C:A	donor_loss	0.9900
10:59684119:G:A	donor_gain	0.9900
10:59684210:C:CT	acceptor_gain	0.9900
10:59684210:C:T	acceptor_gain	0.9900
10:59714390:CTA:C	donor_gain	0.9900
10:59735925:TTTAC:T	donor_loss	0.9900
10:59735926:TTA:T	donor_loss	0.9900
10:59735927:TACCT:T	donor_loss	0.9900

AlphaMissense

3296 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:59654582:G:C	S148R	0.998
10:59654582:G:T	S148R	0.998
10:59654584:T:G	S148R	0.998
10:59672822:G:C	S96R	0.998
10:59672822:G:T	S96R	0.998
10:59672824:T:G	S96R	0.998
10:59672855:A:C	S85R	0.998
10:59672855:A:T	S85R	0.998
10:59672857:T:G	S85R	0.998
10:59654589:C:T	G146D	0.997
10:59664267:A:C	F132L	0.997
10:59664267:A:T	F132L	0.997
10:59664269:A:G	F132L	0.997
10:59684174:A:G	W40R	0.997
10:59684174:A:T	W40R	0.997
10:59684209:C:T	G28E	0.997
10:59653702:C:G	G442R	0.996
10:59653702:C:T	G442R	0.996
10:59653809:C:T	G406E	0.996
10:59653810:C:G	G406R	0.996
10:59653810:C:T	G406R	0.996
10:59653960:C:G	G356R	0.996
10:59654503:C:G	G175R	0.996
10:59654577:C:T	G150D	0.996
10:59654578:C:G	G150R	0.996
10:59672912:A:C	S66R	0.996
10:59672912:A:T	S66R	0.996
10:59684096:T:G	S66R	0.996
10:59684137:G:T	A52D	0.996
10:59653701:C:T	G442E	0.995

dbSNP variants (sampled 300 via entrez): RS1000126693 (10:59660772 A>G), RS1000136761 (10:59682920 A>G), RS1000144812 (10:59703609 G>T), RS1000189746 (10:59689853 G>A), RS1000199639 (10:59689653 C>T), RS1000266709 (10:59709642 C>A,G,T), RS1000298269 (10:59651254 G>A), RS1000327246 (10:59650958 A>G), RS1000405245 (10:59695505 A>G), RS1000422252 (10:59672453 A>G), RS1000466590 (10:59683294 C>T), RS1000537060 (10:59688094 C>T), RS1000563039 (10:59679993 T>A), RS1000698017 (10:59701822 T>C), RS1000750236 (10:59701359 A>T)

Disease associations

OMIM: gene MIM:614242 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

28 associations (top):

Study	Trait	p-value
GCST000418_1	Uric acid levels	1.000000e-08
GCST001217_37	Metabolic traits	3.000000e-14
GCST001791_32	Urate levels	2.000000e-28
GCST002307_1	Systolic blood pressure (alcohol consumption interaction)	1.000000e-08
GCST002307_10	Systolic blood pressure (alcohol consumption interaction)	4.000000e-08
GCST002308_9	Mean arterial pressure (alcohol consumption interaction)	9.000000e-07
GCST002932_31	Manganese levels	2.000000e-06
GCST004866_1	Alopecia areata	6.000000e-06
GCST005648_7	Serum metabolite concentrations in chronic kidney disease	3.000000e-15
GCST005650_210	Serum metabolite ratios in chronic kidney disease	3.000000e-12
GCST006249_33	Serum metabolite levels	1.000000e-14
GCST006631_9	Nicotine dependence and major depression (severity of comorbidity)	5.000000e-06
GCST007733_43	Serum uric acid levels	3.000000e-17
GCST008970_2	Gout	2.000000e-16
GCST008971_128	Urate levels	2.000000e-66
GCST008972_180	Urate levels	2.000000e-77
GCST008972_95	Urate levels	1.000000e-10
GCST009391_1650	Metabolite levels	6.000000e-07
GCST010242_205	HDL cholesterol levels	6.000000e-09
GCST010244_162	Triglyceride levels	2.000000e-11
GCST011436_3	Total carotid plaque area (excess vs minimal atherosclerosis)	7.000000e-06
GCST012020_411	Serum metabolite levels	2.000000e-12
GCST012020_412	Serum metabolite levels	5.000000e-11
GCST012020_413	Serum metabolite levels	3.000000e-48
GCST012338_25	Gout	7.000000e-20
GCST90000025_431	Appendicular lean mass	1.000000e-13
GCST90002384_189	Hemoglobin	1.000000e-09
GCST90002401_211	Platelet distribution width	7.000000e-16

EFO canonical traits (15, from GWAS)

EFO ID	Trait name
EFO:0004761	uric acid measurement
EFO:0004725	metabolite measurement
EFO:0004531	urate measurement
EFO:0004329	alcohol drinking
EFO:0006335	systolic blood pressure
EFO:0006340	mean arterial pressure
EFO:0007006	depressive symptom measurement
EFO:0009262	nicotine dependence symptom count
EFO:0010469	carnitine measurement
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:0004530	triglyceride measurement
EFO:0006501	carotid plaque build
EFO:0004980	appendicular lean mass
EFO:0004509	hemoglobin measurement
EFO:0007984	platelet component distribution width

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLC16 family of monocarboxylate transporters

CTD chemical–gene interactions

53 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
trichostatin A	affects cotreatment, decreases expression	3
(+)-JQ1 compound	decreases expression	3
bisphenol A	affects cotreatment, increases methylation, increases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Aflatoxin B1	decreases methylation, increases expression	2
Cadmium Chloride	decreases expression, increases abundance	2
aristolochic acid I	decreases expression	1
testosterone undecanoate	affects cotreatment, decreases expression	1
mono-(2-ethylhexyl)phthalate	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	affects expression	1
sodium arsenite	affects cotreatment, increases abundance, increases expression	1
manganese chloride	increases expression, affects cotreatment, increases abundance	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
beta-methylcholine	affects expression	1
avobenzone	decreases expression	1
perfluoro-n-nonanoic acid	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
licochalcone B	decreases expression	1
NSC 689534	affects binding, decreases expression	1
Temozolomide	increases expression	1
Sunitinib	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Leflunomide	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Ethanol	increases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Cadmium	decreases expression, increases abundance	1

Cellosaurus cell lines

5 cell lines: 4 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4DT	HEK-SLC16A9-KO-c4	Transformed cell line	Female
CVCL_D4IB	HCT116-SLC16A9-KO-c10	Cancer cell line	Male
CVCL_D4IC	HCT116-SLC16A9-KO-c7	Cancer cell line	Male
CVCL_TL70	HAP1 SLC16A9 (-) 1	Cancer cell line	Male
CVCL_XS89	HAP1 SLC16A9 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.